Search

Purpose. To review the clinical and radiographic features of the available data published on adenomatoid odontogenic tumor (AOT) with special emphasis on the comparison of its variants. Methods. An electronic search was undertaken in July/2018. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. Results. 436 publications reporting 1558 cases were included, of which 739 follicular, 247 extrafollicular, and 30 peripheral AOTs. Impacted canine is associated with follicular AOTs in almost 70% of the cases. AOTs were more prevalent in females, in the second decade of life, in maxillae, in anterior region of the jaws, and most are asymptomatic, with a considerable number of lesions presenting cortical bone perforation. Most of the lesions were treated by enucleation. Some cases of recurrence were reported in the literature, but only one was well documented. No difference was found when comparing the clinical/radiological features of the follicular, extrafollicular and peripheral variants. Conclusions. AOT variants do not show distinctive clinical radiological features. Recurrence of AOT is very rare, which justify its conservative management.

Purpose. To review the clinical and radiographic features of the available data published on adenomatoid odontogenic tumor (AOT) with special emphasis on the comparison of its variants. Methods. An electronic search was undertaken in July/2018. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. Results. 436 publications reporting 1558 cases were included, of which 739 follicular, 247 extrafollicular, and 30 peripheral AOTs. Impacted canine is associated with follicular AOTs in almost 70% of the cases. AOTs were more prevalent in females, in the second decade of life, in maxillae, in anterior region of the jaws, and most are asymptomatic, with a considerable number of lesions presenting cortical bone perforation. Most of the lesions were treated by enucleation. Some cases of recurrence were reported in the literature, but only one was well documented. No difference was found when comparing the clinical/radiological features of the follicular, extrafollicular and peripheral variants. Conclusions. AOT variants do not show distinctive clinical radiological features. Recurrence of AOT is very rare, which justify its conservative management.

We report a case of adenomatoid odontogenic tumor in the maxillary bone. The patient was an 11-year-old girl who complained of cheek swelling. X-ray examination revealed that the tumor involved an impacted canine in its cystic lesion and occupied most of the space of left maxillary sinus, and contained microcalcifications. The lesion was extirpated under general anesthesia and examined histopathologically, to be diagnosed as adenomatoid odontogenic tumor. On histologic examination, it showed characteristic duct-like structures and whorled or rosette masses of tumor cells. The rim and amorphous contents of duct-like structures and eosinophilic droplets among solid nests of columnar cells were much of eosinophilic and argyrophilic materials. In immunohistochemical staining, they also showed strong immunoreactivity for heparan sulfate proteoglycan, laminin, and collagen type IV., 11歳、女児に認められた腺様歯原性腫瘍の1症例を報告する。主訴は頬部の腫脹で、Ⅹ線診査で左側上顎洞部に埋伏犬歯と小石灰化物を含む嚢胞様病変を認めた｡全身麻酔下、病変を摘出し、病理組織学的検索を行った｡腺様歯原性腫瘍の病理診断が得られ、特徴的な管腔様構造と塊状胞巣を認めた。管腔様構造内面の縁取りと内部の無定型内容物及び充実性胞巣内滴状物は好酸性及び好銀性多糖類に富み、また、免疫染色ではヘパラン硫酸プロテオグリカン、ラミニン、Ⅳ型コラゲンに強陽性であった｡