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10 results on '"Alvisi, P"'

1. Induction of Remission with Exclusive Enteral Nutrition in Children with Crohn's Disease: Determinants of Higher Adherence and Response

Author

Cuomo, M, Carobbio, A, Aloi, M, Alvisi, P, Banzato, C, Bosa, L, Bramuzzo, M, Campanozzi, A, Catassi, G, D'Antiga, L, Di Paola, M, Felici, E, Fioretti, M, Gatti, S, Graziano, F, Lega, S, Lionetti, P, Marseglia, A, Martinelli, M, Musto, F, Sansotta, N, Scarallo, L, Zuin, G, Norsa, L, Cuomo M., Carobbio A., Aloi M., Alvisi P., Banzato C., Bosa L., Bramuzzo M., Campanozzi A., Catassi G., D'Antiga L., Di Paola M., Felici E., Fioretti M. T., Gatti S., Graziano F., Lega S., Lionetti P., Marseglia A., Martinelli M., Musto F., Sansotta N., Scarallo L., Zuin G., Norsa L., Cuomo, M, Carobbio, A, Aloi, M, Alvisi, P, Banzato, C, Bosa, L, Bramuzzo, M, Campanozzi, A, Catassi, G, D'Antiga, L, Di Paola, M, Felici, E, Fioretti, M, Gatti, S, Graziano, F, Lega, S, Lionetti, P, Marseglia, A, Martinelli, M, Musto, F, Sansotta, N, Scarallo, L, Zuin, G, Norsa, L, Cuomo M., Carobbio A., Aloi M., Alvisi P., Banzato C., Bosa L., Bramuzzo M., Campanozzi A., Catassi G., D'Antiga L., Di Paola M., Felici E., Fioretti M. T., Gatti S., Graziano F., Lega S., Lionetti P., Marseglia A., Martinelli M., Musto F., Sansotta N., Scarallo L., Zuin G., and Norsa L.

Published
2023

2. Therapies for inflammatory bowel disease do not pose additional risks for adverse outcomes of SARS-CoV-2 infection: an IG-IBD study

Author

Bezzio, C., Armuzzi, Alessandro, Furfaro, F., Ardizzone, S., Milla, M., Carparelli, S., Orlando, Ambrogio, Caprioli, F. A., Castiglione, F., Vigano, C., Ribaldone, D. G., Zingone, F., Monterubbianesi, R., Imperatore, N., Festa, Stefano, Daperno, M., Scucchi, L., Ferronato, A., Pastorelli, L., Balestrieri, P., Ricci, Chiara, Cappello, M., Felice, Carla, Fiorino, G., Saibeni, S., Coppini, F., Alvisi, P., Gerardi, Viviana, Variola, A., Mazzuoli, S., Lenti, M. V., Pugliese, Daniela, Allocca, Marialuisa, Ferretti, Ferretto, Roselli, J., Bossa, F., Giuliano, Alessandro, Piazza, N., Manes, G., Sartini, A., Buda, Alessandro, Micheli, F., Ciardo, V., Casella, Giovanni, Viscido, Aniello, Bodini, G., Casini, V., Soriano, A., Amato, A., Grossi, Luigi, Onali, Sebastiano, Rottoli, M., Spagnuolo, Rocco, Baroni, Silvia, Cortelezzi, C. C., Baldoni, Michele, Vernero, M., Scaldaferri, Franco, Maconi, G., Guarino, A. D., Palermo, Ofelia Anna, D'Inca, R., Scribano, M. L., Biancone, L., Carrozza, L., Ascolani, M., Costa, F., Di Sabatino, A., Zammarchi, I., Gottin, M., Conforti, F. S., Armuzzi A. (ORCID:0000-0003-1572-0118), Festa S., Felice C., Gerardi V., Pugliese D., Allocca M., Ferretti F., Giuliano A., Buda A., Casella G., Viscido A., Grossi L., Onali S., Spagnuolo R., Baroni S. (ORCID:0000-0002-3410-2617), Baldoni M., Scaldaferri F. (ORCID:0000-0001-8334-7541), Palermo A., Bezzio, C., Armuzzi, Alessandro, Furfaro, F., Ardizzone, S., Milla, M., Carparelli, S., Orlando, Ambrogio, Caprioli, F. A., Castiglione, F., Vigano, C., Ribaldone, D. G., Zingone, F., Monterubbianesi, R., Imperatore, N., Festa, Stefano, Daperno, M., Scucchi, L., Ferronato, A., Pastorelli, L., Balestrieri, P., Ricci, Chiara, Cappello, M., Felice, Carla, Fiorino, G., Saibeni, S., Coppini, F., Alvisi, P., Gerardi, Viviana, Variola, A., Mazzuoli, S., Lenti, M. V., Pugliese, Daniela, Allocca, Marialuisa, Ferretti, Ferretto, Roselli, J., Bossa, F., Giuliano, Alessandro, Piazza, N., Manes, G., Sartini, A., Buda, Alessandro, Micheli, F., Ciardo, V., Casella, Giovanni, Viscido, Aniello, Bodini, G., Casini, V., Soriano, A., Amato, A., Grossi, Luigi, Onali, Sebastiano, Rottoli, M., Spagnuolo, Rocco, Baroni, Silvia, Cortelezzi, C. C., Baldoni, Michele, Vernero, M., Scaldaferri, Franco, Maconi, G., Guarino, A. D., Palermo, Ofelia Anna, D'Inca, R., Scribano, M. L., Biancone, L., Carrozza, L., Ascolani, M., Costa, F., Di Sabatino, A., Zammarchi, I., Gottin, M., Conforti, F. S., Armuzzi A. (ORCID:0000-0003-1572-0118), Festa S., Felice C., Gerardi V., Pugliese D., Allocca M., Ferretti F., Giuliano A., Buda A., Casella G., Viscido A., Grossi L., Onali S., Spagnuolo R., Baroni S. (ORCID:0000-0002-3410-2617), Baldoni M., Scaldaferri F. (ORCID:0000-0001-8334-7541), and Palermo A.

Abstract

Background: Older age and comorbidities are the main risk factors for adverse COVID-19 outcomes in patients with inflammatory bowel disease (IBD). The impact of IBD medications is still under investigation. Aims: To assess risk factors for adverse outcomes of COVID-19 in IBD patients and use the identified risk factors to build risk indices. Methods: Observational cohort study. Univariable and multivariable logistic regression was used to identify risk factors associated with pneumonia, hospitalisation, need for ventilatory support, and death. Results: Of the 937 patients (446 with ulcerative colitis [UC]) evaluated, 128 (13.7%) had asymptomatic SARS-CoV-2 infection, 664 (70.8%) had a favourable course, and 135 (15.5%) had moderate or severe COVID-19. In UC patients, obesity, active disease and comorbidities were significantly associated with adverse outcomes. In patients with Crohn's disease (CD), age, obesity, comorbidities and an additional immune-mediated inflammatory disease were identified as risk factors. These risk factors were incorporated into two indices to identify patients with UC or CD with a higher risk of adverse COVID-19 outcomes. In multivariable analyses, no single IBD medication was associated with poor COVID-19 outcomes, but anti-TNF agents were associated with a lower risk of pneumonia in UC, and lower risks of hospitalisation and severe COVID-19 in CD. Conclusion: The course of COVID-19 in patients with IBD is similar to that in the general population. IBD patients with active disease and comorbidities are at greater risk of adverse COVID-19 outcomes. IBD medications do not pose additional risks. The risk indices may help to identify patients who should be prioritised for COVID-19 re-vaccination or for therapies for SARS-CoV-2 infection.

Published
2021

3. Cancer Risk in Inflammatory Bowel Disease: A 6-Year Prospective Multicenter Nested Case-Control IG-IBD Study

Author

Biancone, L., Armuzzi, Alessandro, Scribano, M. L., Castiglione, F., D'Inca, R., Orlando, A., Papi, C., Daperno, M., Vecchi, M., Riegler, G., Fries, W., Alvisi, P., Meucci, G., Mocciaro, F., Rogai, F., Festa, S., Guidi, Luisa, Testa, A., Spina, L., Renna, S., Viola, A., Patturelli, M., Di Mitri, R., Frankovic, I., Calabrese, E., Petruzziello, C., De Cristofaro, E., Sena, G., Ruffa, A., Neri, B., Rossi, A., Armuzzi A. (ORCID:0000-0003-1572-0118), Guidi L. (ORCID:0000-0003-3320-7094), Biancone, L., Armuzzi, Alessandro, Scribano, M. L., Castiglione, F., D'Inca, R., Orlando, A., Papi, C., Daperno, M., Vecchi, M., Riegler, G., Fries, W., Alvisi, P., Meucci, G., Mocciaro, F., Rogai, F., Festa, S., Guidi, Luisa, Testa, A., Spina, L., Renna, S., Viola, A., Patturelli, M., Di Mitri, R., Frankovic, I., Calabrese, E., Petruzziello, C., De Cristofaro, E., Sena, G., Ruffa, A., Neri, B., Rossi, A., Armuzzi A. (ORCID:0000-0003-1572-0118), and Guidi L. (ORCID:0000-0003-3320-7094)

Abstract

Background: In a 6-year, multicenter, prospective nested case-control study, we aimed to evaluate risk factors for incident cancer in inflammatory bowel disease (IBD), when considering clinical characteristics of IBD and immunomodulator use. The secondary end point was to provide characterization of incident cancer types. Methods: All incident cases of cancer occurring in IBD patients from December 2011-2017 were prospectively recorded in 16 Italian Group for the Study of Inflammatory Bowel Disease units. Each of the IBD patients with a new diagnosis of cancer was matched with 2 IBD patients without cancer, according to IBD phenotype (ulcerative colitis [UC] vs Crohn's disease [CD]), age (±5 years), sex. Risk factors were assessed by multivariate logistic regression analysis. Results: Cancer occurred in 403 IBD patients: 204 CD (CD cases), 199 UC (UC cases). The study population included 1209 patients (403 IBD cases, 806 IBD controls). Cancer (n = 403) more frequently involved the digestive system (DS; 32%), followed by skin (14.9%), urinary tract (9.7%), lung (6.9%), genital tract (6.5%), breast (5.5%), thyroid (1.9%), lymphoma (2.7%, only in CD), adenocarcinoma of the small bowel (SBA; 3.9%, 15 CD, 1 pouch in UC), other cancers (15.9%). Among cancers of the DS, colorectal cancer (CRC) more frequently occurred in UC (29% vs 17%; P < 0.005), whereas SBA more frequently occurred in CD (13% vs 6.3% P = 0.039). In CD, perforating (B3) vs non-stricturing non-perforating (B1) behavior represented the only risk factor for any cancer (odds ratio [OR], 2.33; 95% confidence interval [CI], 1.33-4.11). In CD, risk factors for extracolonic cancer (ECC) were a B3 vs B1 and a stricturing (B2) vs B1 behavior (OR, 2.95; 95% CI, 1.62-5.43; OR, 1.79; 95% CI, 1.09-2.98). In UC, risk factors for ECC and for overall cancer were abdominal surgery for UC (OR, 4.63; 95% CI, 2.62-8.42; OR, 3.34; 95% CI, 1.88-5.92) and extensive vs distal UC (OR, 1.73; 95% CI, 1.10-2.75; OR, 1.99; 95% CI

Published
2020

7. Cytomegalovirus infection in pediatric acute severe ulcerative colitis - a multicenter case-controlled study from the Pediatric IBD Porto group of ESPGHAN

Author

MDL patientenzorg, Child Health, Cohen, S., Martinez-Vinson, C., Aloi, M., Turner, D., Assa, Amit, de Ridder, L., Wolters, V. M., de Meij, Tim, Alvisi, P., Bronsky, Jiri, Kopylov, U., MDL patientenzorg, Child Health, Cohen, S., Martinez-Vinson, C., Aloi, M., Turner, D., Assa, Amit, de Ridder, L., Wolters, V. M., de Meij, Tim, Alvisi, P., Bronsky, Jiri, and Kopylov, U.

Published
2017

8. Inflammatory Bowel Disease Phenotype as Risk Factor for Cancer in a Prospective Multicentre Nested Case-Control IG-IBD Study.

Author

Biancone, L, Armuzzi, Alessandro, Scribano, Ml, D'Inca, R, Castiglione, F, Papi, C, Angelucci, E, Daperno, M, Mocciaro, F, Riegler, G, Fries, W, Meucci, G, Alvisi, P, Spina, L, Ardizzone, S, Petruzziello, C, Ruffa, A, Kohn, A, Vecchi, M, Guidi, Luisa, Di Mitri, R, Renna, S, Emma, C, Rogai, F, Rossi, A, Orlando, A, Pallone, F., Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), Guidi, Luisa (ORCID:0000-0003-3320-7094), Biancone, L, Armuzzi, Alessandro, Scribano, Ml, D'Inca, R, Castiglione, F, Papi, C, Angelucci, E, Daperno, M, Mocciaro, F, Riegler, G, Fries, W, Meucci, G, Alvisi, P, Spina, L, Ardizzone, S, Petruzziello, C, Ruffa, A, Kohn, A, Vecchi, M, Guidi, Luisa, Di Mitri, R, Renna, S, Emma, C, Rogai, F, Rossi, A, Orlando, A, Pallone, F., Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), and Guidi, Luisa (ORCID:0000-0003-3320-7094)

Published
2016

9. Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease

Author

Pecci, A., Panza, E., Pujol-Moix, N., Klersy, C., Di, Bari F., Bozzi, V., Gresele, P., Lethagen, S., Fabris, F., Dufour, C., Granata, A., Doubek, M., Pecoraro, C., Koivisto, P.A., Heller, P.G., Iolascon, A., Alvisi, P., Schwabe, D., De, Candia E., Rocca, B., Russo, U., Ramenghi, U., Noris, P., Seri, M., Balduini, C.L., Savoia, A., Pecci, A., Panza, E., Pujol-Moix, N., Klersy, C., Di, Bari F., Bozzi, V., Gresele, P., Lethagen, S., Fabris, F., Dufour, C., Granata, A., Doubek, M., Pecoraro, C., Koivisto, P.A., Heller, P.G., Iolascon, A., Alvisi, P., Schwabe, D., De, Candia E., Rocca, B., Russo, U., Ramenghi, U., Noris, P., Seri, M., Balduini, C.L., and Savoia, A.

Abstract

MYH9-related disease (MYH9-RD) is a rare autosomal-dominant disorder caused by mutations in MYH9, the gene for the heavy chain of nonmuscle myosin IIA (NMMHC-IIA). All patients present from birth with macrothrombocytopenia, but in infancy or adult life, some of them develop sensorineural deafness, presenile cataracts, and/or progressive nephritis leading to end-stage renal failure. No consistent correlations have been identified between the 27 different MYH9 mutations identified so far and the variable clinical evolution of the disease. We have evaluated 108 consecutive MYH9-RD patients belonging to 50 unrelated pedigrees. The risk of noncongenital manifestations associated with different genotypes was estimated over time by event-free survival analysis. We demonstrated that all subjects with mutations in the motor domain of NMMHC-IIA present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. We also evaluated the clinical course of patients with mutations in the four most frequently affected residues of NMMHC-IIA (responsible for 70% of MYH9-RD cases). We concluded that mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures. These findings are relevant not only to patients' clinical management but also to the elucidation of the pathogenesis of the disease Udgivelsesdato: 2008/3

Published
2008

10. Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease

Author

Pecci, A., Panza, E., Pujol-Moix, N., Klersy, C., Di, Bari F., Bozzi, V., Gresele, P., Lethagen, S., Fabris, F., Dufour, C., Granata, A., Doubek, M., Pecoraro, C., Koivisto, P.A., Heller, P.G., Iolascon, A., Alvisi, P., Schwabe, D., De, Candia E., Rocca, B., Russo, U., Ramenghi, U., Noris, P., Seri, M., Balduini, C.L., Savoia, A., Pecci, A., Panza, E., Pujol-Moix, N., Klersy, C., Di, Bari F., Bozzi, V., Gresele, P., Lethagen, S., Fabris, F., Dufour, C., Granata, A., Doubek, M., Pecoraro, C., Koivisto, P.A., Heller, P.G., Iolascon, A., Alvisi, P., Schwabe, D., De, Candia E., Rocca, B., Russo, U., Ramenghi, U., Noris, P., Seri, M., Balduini, C.L., and Savoia, A.

Abstract

MYH9-related disease (MYH9-RD) is a rare autosomal-dominant disorder caused by mutations in MYH9, the gene for the heavy chain of nonmuscle myosin IIA (NMMHC-IIA). All patients present from birth with macrothrombocytopenia, but in infancy or adult life, some of them develop sensorineural deafness, presenile cataracts, and/or progressive nephritis leading to end-stage renal failure. No consistent correlations have been identified between the 27 different MYH9 mutations identified so far and the variable clinical evolution of the disease. We have evaluated 108 consecutive MYH9-RD patients belonging to 50 unrelated pedigrees. The risk of noncongenital manifestations associated with different genotypes was estimated over time by event-free survival analysis. We demonstrated that all subjects with mutations in the motor domain of NMMHC-IIA present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. We also evaluated the clinical course of patients with mutations in the four most frequently affected residues of NMMHC-IIA (responsible for 70% of MYH9-RD cases). We concluded that mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures. These findings are relevant not only to patients' clinical management but also to the elucidation of the pathogenesis of the disease Udgivelsesdato: 2008/3

Published
2008

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