1. Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
- Author
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Irma Karabegović, E.C. (Eliana) Portilla Fernández, Y. (Yang) Li, Jiantao Ma, S.C.E. (Silvana) Maas, Daokun Sun, Emily A. Hu, Brigitte Kühnel, Yan Zhang, Srikant Ambatipudi, Giovanni Fiorito, Jian Huang, Juan E. Castillo-Fernandez, Kerri L. Wiggins, Niek de Klein, Sara Grioni, Brenton R. Swenson, Silvia Polidoro, Jorien L. Treur, Cyrille Cuenin, Pei Chien Tsai, Ricardo Costeira, Veronique Chajes, K.V.E. (Kim) Braun, N (Niek) Verweij, Anja Kretschmer, Lude Franke, J.B.J. (Joyce) van Meurs, A.G. (André) Uitterlinden, R.J. (Rob) de Knegt, M.A. (Arfan) Ikram, A. (Abbas) Dehghan, Annette Peters, Ben Schöttker, Sina A. Gharib, Nona Sotoodehnia, JT (Jordana) Bell, Paul Elliott, Paolo Vineis, Caroline Relton, Zdenko Herceg, Hermann Brenner, Melanie Waldenberger, Casey M. Rebholz, R.G. (Trudy) Voortman, Q. (Qiuwei) Pan, Myriam Fornage, Daniel Levy, M.H. (Manfred) Kayser, M. (Mohsen) Ghanbari, Irma Karabegović, E.C. (Eliana) Portilla Fernández, Y. (Yang) Li, Jiantao Ma, S.C.E. (Silvana) Maas, Daokun Sun, Emily A. Hu, Brigitte Kühnel, Yan Zhang, Srikant Ambatipudi, Giovanni Fiorito, Jian Huang, Juan E. Castillo-Fernandez, Kerri L. Wiggins, Niek de Klein, Sara Grioni, Brenton R. Swenson, Silvia Polidoro, Jorien L. Treur, Cyrille Cuenin, Pei Chien Tsai, Ricardo Costeira, Veronique Chajes, K.V.E. (Kim) Braun, N (Niek) Verweij, Anja Kretschmer, Lude Franke, J.B.J. (Joyce) van Meurs, A.G. (André) Uitterlinden, R.J. (Rob) de Knegt, M.A. (Arfan) Ikram, A. (Abbas) Dehghan, Annette Peters, Ben Schöttker, Sina A. Gharib, Nona Sotoodehnia, JT (Jordana) Bell, Paul Elliott, Paolo Vineis, Caroline Relton, Zdenko Herceg, Hermann Brenner, Melanie Waldenberger, Casey M. Rebholz, R.G. (Trudy) Voortman, Q. (Qiuwei) Pan, Myriam Fornage, Daniel Levy, M.H. (Manfred) Kayser, and M. (Mohsen) Ghanbari
- Abstract
Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value <1.1×10−7), which annotated to the AHRR, F2RL3, FLJ43663
- Published
- 2021
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