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Sihua Wen,1,* Kai Yang,1,* Yunfeng Bai,2 Yanan Wu,1 Ding Liu,1 Xu Wu,1 Xiaofei Zhang,1 Jing Sun1 1Department of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, People’s Republic of China; 2Shaanxi Dongtai Pharmaceutical Co., Ltd, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaofei Zhang; Jing Sun, Department of Pharmaceutics, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, People’s Republic of China, Tel +86 177 7003 7322, Fax +86 029-38185333, Email 2051028@sntcm.edu.cn; sunjing202203@126.comPurpose: To study the active components, drug targets and mechanism of Schisandra chinensis (S.chinensis) combined with coenzyme Q10 (CQ10) in the treatment of heart failure (HF).Methods: Network pharmacology combined with the gene expression omnibus chip method to analyze the main pathways by which S.chinensis combined with CQ10 functioned to treat heart failure. Subsequently, the biological activities of the major pathway key proteins and their corresponding compounds were verified by molecular docking techniques. Finally, the molecular mechanism of S. chinensis combined with CQ10 for the treatment of heart failure was verified using a rat heart failure model induced by isoproterenol hydrochloride and using hematoxylin-eosin staining, TUNEL, immunohistochemistry and Western blot.Results: Network pharmacology combined with experimental validation suggests that the mechanism of action of S.chinensis combined with CQ10 in the treatment of heart failure may involve CQ10, Citral, Schisandrone, Schisanhenol B, Gomisin O, Schisandrin C and other components, which may synergistically inhibit the PI3K-AKT signaling pathway and affect the expression of AKT1, PIK3CG and other targets on this pathway. In addition, S. chinensis combined with CQ10 could effectively improve the cardiac c

Simultaneous wireless information and power transfer (SWIPT) is a prospective technology that can handle the energy consumption and communication requirements in the Internet of Things. Resonant beam SWIPT (RB-SWIPT) scheme utilizes narrow optical beam as carrier and with spatially separated resonator structure, which can support high power and high rate SWIPT for mobile devices. However, the performance of original RB-SWIPT systems is limited by returning beam interference and transmission loss. In this paper, we propose a RB-SWIPT scheme for transmission-enhanced and anti-interference. The telescope internal modulator (TIM) and second harmonic generator (SHG) are adopted in the proposed system. The TIM can compress beams to reduce the transmission loss. The SHG can generate frequency-doubled beams to avoid interference. To evaluate the proposed system, we establish mathematical models to depict the beam transmission, energy conversion, electric power output and data receiving. Numerical results illustrate that the proposed system can achieve 18 bit/s/Hz spectral efficiency and deliver 8 W power over 100 m distance. IEEE

To satisfy the long-range and energy self-sustaining communication needs of electronic devices in the Internet of Things (IoT), we introduce a simultaneous wireless information and power transfer (SWIPT) system using the resonant beam that incorporates a telescope modulator inside a cavity for suppressing diffraction losses. We theoretically analyze power transfer in the resonant beam system with telescope internal modulator (TIM-RBS) considering the electromagnetic field propagation, the end-to-end (E2E) power transfer, and power and information reception. The numerical evaluation demonstrates that the TIM can effectively compress the beam spot, which allows the TIM-RBS to transmit energy twice as far as the RBS without TIM at higher power. Additionally, the largest transmission distance and maximum output power are proportional to the input power, and about 34m transmission distance, 4W electric power, and 12bps/Hz spectral efficiency can be achieved in the TIM-RBS with 200W input power. Hence, TIM-RBS can be considered as a promising option for realizing long-range, high-power, and high-rate SWIPT.

Simultaneous wireless information and power transfer (SWIPT) is a remarkable technology to support both the data and the energy transfer in the era of Internet of Things (IoT). In this paper, we proposed a long-range optical wireless information and power transfer system utilizing retro-reflectors, a gain medium, a telescope internal modulator to form the resonant beam, achieving high-power and high-rate SWIPT. We adopt the transfer matrix, which can depict the beam modulated, resonator stability, transmission loss, and beam distribution. Then, we provide a model for energy harvesting and data receiving, which can evaluate the SWIPT performance. Numerical results illustrate that the proposed system can simultaneously supply 0$\sim$9 W electrical power and 18 bit/s/Hz spectral efficiency over 20 m distance.

With the development of Internet of Things (IoT), demands of power and data for IoT devices increase drastically. In order to resolve the supply-demand contradiction, simultaneous wireless information and power transfer (SWIPT) has been envisioned as an enabling technology by providing high-power energy transfer and high-rate data delivering concurrently. In this paper, we introduce a high-efficiency resonant beam (RB) charging and communication scheme. The scheme utilizes the semiconductor materials as gain medium, which has a better energy absorption capacity compared with the traditional solid-state one. Moreover, the telescope internal modulator (TIM) are adopted in the scheme which can concentrate beams to match the gain size, reducing the transmission loss. To evaluate the scheme SWIPT performance, we establish an analytical model and study the influence factors of its beam transmission, energy conversion, output power, and spectral efficiency. Numerical results shows that the proposed RB system can realize 16 W electric power output with 11 % end-to-end conversion efficiency, and support 18 bit/s/Hz spectral efficiency for communication.