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10 results on '"BONDANZA , ATTILIO"'

1. Hematopoietic stem cell transplantation in its 60s : A platform for cellular therapies

Author

Chabannon, Christian, Kuball, Jurgen, Bondanza, Attilio, Dazzi, Francesco, Pedrazzoli, Paolo, Toubert, Antoine, Ruggeri, Annalisa, Fleischhauer, Katharina, Bonini, Chiara, Chabannon, Christian, Kuball, Jurgen, Bondanza, Attilio, Dazzi, Francesco, Pedrazzoli, Paolo, Toubert, Antoine, Ruggeri, Annalisa, Fleischhauer, Katharina, and Bonini, Chiara

Published
2018

2. Immune monitoring in allogeneic hematopoietic stem cell transplant recipients : a survey from the EBMT-CTIWP

Author

Greco, Raffaella, Ciceri, Fabio, Noviello, Maddalena, Bondanza, Attilio, Vago, Luca, Oliveira, Giacomo, Peccatori, Jacopo, Cieri, Nicoletta, Ruggeri, Annalisa, Koehl, Ulrike, Fleischhauer, Katharina, Rocha, Vanderson, Dazzi, Francesco, van der Werf, Steffie Maria, Eikema, Dirk-Jan, Terwel, Sofie Rosanne, Kuball, Jürgen, Toubert, Antoine, Chabannon, Christian, Bonini, Chiara, EBMT Cellular Therapy and Immunobiology Working Party (CTIWP), Greco, Raffaella, Ciceri, Fabio, Noviello, Maddalena, Bondanza, Attilio, Vago, Luca, Oliveira, Giacomo, Peccatori, Jacopo, Cieri, Nicoletta, Ruggeri, Annalisa, Koehl, Ulrike, Fleischhauer, Katharina, Rocha, Vanderson, Dazzi, Francesco, van der Werf, Steffie Maria, Eikema, Dirk-Jan, Terwel, Sofie Rosanne, Kuball, Jürgen, Toubert, Antoine, Chabannon, Christian, Bonini, Chiara, and EBMT Cellular Therapy and Immunobiology Working Party (CTIWP)

Published
2018

3. Hematopoietic stem cell transplantation in its 60s : A platform for cellular therapies

Author

Chabannon, Christian, Kuball, Jurgen, Bondanza, Attilio, Dazzi, Francesco, Pedrazzoli, Paolo, Toubert, Antoine, Ruggeri, Annalisa, Fleischhauer, Katharina, Bonini, Chiara, Chabannon, Christian, Kuball, Jurgen, Bondanza, Attilio, Dazzi, Francesco, Pedrazzoli, Paolo, Toubert, Antoine, Ruggeri, Annalisa, Fleischhauer, Katharina, and Bonini, Chiara

Published
2018

4. Immune monitoring in allogeneic hematopoietic stem cell transplant recipients : a survey from the EBMT-CTIWP

Author

Greco, Raffaella, Ciceri, Fabio, Noviello, Maddalena, Bondanza, Attilio, Vago, Luca, Oliveira, Giacomo, Peccatori, Jacopo, Cieri, Nicoletta, Ruggeri, Annalisa, Koehl, Ulrike, Fleischhauer, Katharina, Rocha, Vanderson, Dazzi, Francesco, van der Werf, Steffie Maria, Eikema, Dirk-Jan, Terwel, Sofie Rosanne, Kuball, Jürgen, Toubert, Antoine, Chabannon, Christian, Bonini, Chiara, EBMT Cellular Therapy and Immunobiology Working Party (CTIWP), Greco, Raffaella, Ciceri, Fabio, Noviello, Maddalena, Bondanza, Attilio, Vago, Luca, Oliveira, Giacomo, Peccatori, Jacopo, Cieri, Nicoletta, Ruggeri, Annalisa, Koehl, Ulrike, Fleischhauer, Katharina, Rocha, Vanderson, Dazzi, Francesco, van der Werf, Steffie Maria, Eikema, Dirk-Jan, Terwel, Sofie Rosanne, Kuball, Jürgen, Toubert, Antoine, Chabannon, Christian, Bonini, Chiara, and EBMT Cellular Therapy and Immunobiology Working Party (CTIWP)

Published
2018

5. Immune monitoring in allogeneic hematopoietic stem cell transplant recipients : a survey from the EBMT-CTIWP

Author

Greco, Raffaella, Ciceri, Fabio, Noviello, Maddalena, Bondanza, Attilio, Vago, Luca, Oliveira, Giacomo, Peccatori, Jacopo, Cieri, Nicoletta, Ruggeri, Annalisa, Koehl, Ulrike, Fleischhauer, Katharina, Rocha, Vanderson, Dazzi, Francesco, van der Werf, Steffie Maria, Eikema, Dirk-Jan, Terwel, Sofie Rosanne, Kuball, Jürgen, Toubert, Antoine, Chabannon, Christian, Bonini, Chiara, EBMT Cellular Therapy and Immunobiology Working Party (CTIWP), Greco, Raffaella, Ciceri, Fabio, Noviello, Maddalena, Bondanza, Attilio, Vago, Luca, Oliveira, Giacomo, Peccatori, Jacopo, Cieri, Nicoletta, Ruggeri, Annalisa, Koehl, Ulrike, Fleischhauer, Katharina, Rocha, Vanderson, Dazzi, Francesco, van der Werf, Steffie Maria, Eikema, Dirk-Jan, Terwel, Sofie Rosanne, Kuball, Jürgen, Toubert, Antoine, Chabannon, Christian, Bonini, Chiara, and EBMT Cellular Therapy and Immunobiology Working Party (CTIWP)

Published
2018

6. Hematopoietic stem cell transplantation in its 60s : A platform for cellular therapies

Author

Chabannon, Christian, Kuball, Jurgen, Bondanza, Attilio, Dazzi, Francesco, Pedrazzoli, Paolo, Toubert, Antoine, Ruggeri, Annalisa, Fleischhauer, Katharina, Bonini, Chiara, Chabannon, Christian, Kuball, Jurgen, Bondanza, Attilio, Dazzi, Francesco, Pedrazzoli, Paolo, Toubert, Antoine, Ruggeri, Annalisa, Fleischhauer, Katharina, and Bonini, Chiara

Published
2018

7. Immune monitoring in allogeneic hematopoietic stem cell transplant recipients: a survey from the EBMT-CTIWP

Author

CTI Kuball, MS Hematologie, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Greco, Raffaella, Ciceri, Fabio, Noviello, Maddalena, Bondanza, Attilio, Vago, Luca, Oliveira, Giacomo, Peccatori, Jacopo, Cieri, Nicoletta, Ruggeri, Annalisa, Koehl, Ulrike, Fleischhauer, Katharina, Rocha, Vanderson, Dazzi, Francesco, van der Werf, Steffie Maria, Eikema, Dirk-Jan, Terwel, Sofie Rosanne, Kuball, Jürgen, Toubert, Antoine, Chabannon, Christian, Bonini, Chiara, EBMT Cellular Therapy and Immunobiology Working Party (CTIWP), CTI Kuball, MS Hematologie, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Greco, Raffaella, Ciceri, Fabio, Noviello, Maddalena, Bondanza, Attilio, Vago, Luca, Oliveira, Giacomo, Peccatori, Jacopo, Cieri, Nicoletta, Ruggeri, Annalisa, Koehl, Ulrike, Fleischhauer, Katharina, Rocha, Vanderson, Dazzi, Francesco, van der Werf, Steffie Maria, Eikema, Dirk-Jan, Terwel, Sofie Rosanne, Kuball, Jürgen, Toubert, Antoine, Chabannon, Christian, Bonini, Chiara, and EBMT Cellular Therapy and Immunobiology Working Party (CTIWP)

Published
2018

8. Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

Author

CTI Kuball, MS Hematologie, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Chabannon, Christian, Kuball, Jurgen, Bondanza, Attilio, Dazzi, Francesco, Pedrazzoli, Paolo, Toubert, Antoine, Ruggeri, Annalisa, Fleischhauer, Katharina, Bonini, Chiara, CTI Kuball, MS Hematologie, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Chabannon, Christian, Kuball, Jurgen, Bondanza, Attilio, Dazzi, Francesco, Pedrazzoli, Paolo, Toubert, Antoine, Ruggeri, Annalisa, Fleischhauer, Katharina, and Bonini, Chiara

Published
2018

9. Autologous hematopoietic stem cell transplantation in neuromyelitis optica : A registry study of the EBMT Autoimmune Diseases Working Party

Author

Greco, Raffaella, Bondanza, Attilio, Oliveira, Maria Carolina, Badoglio, Manuela, Burman, Joachim, Piehl, Fredrik, Hägglund, Hans, Krasulova, Eva, Simões, Belinda Pinto, Carlson, Kristina, Pohlreich, David, Labopin, Myriam, Saccardi, Riccardo, Comi, Giancarlo, Mancardi, Gian Luigi, Bacigalupo, Andrea, Ciceri, Fabio, Farge, Dominique, Greco, Raffaella, Bondanza, Attilio, Oliveira, Maria Carolina, Badoglio, Manuela, Burman, Joachim, Piehl, Fredrik, Hägglund, Hans, Krasulova, Eva, Simões, Belinda Pinto, Carlson, Kristina, Pohlreich, David, Labopin, Myriam, Saccardi, Riccardo, Comi, Giancarlo, Mancardi, Gian Luigi, Bacigalupo, Andrea, Ciceri, Fabio, and Farge, Dominique

Abstract

BACKGROUND: Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the central nervous system, hallmarked by pathogenic anti-aquaporin 4 antibodies. NMO prognosis is worse compared with multiple sclerosis. OBJECTIVE: The European Group for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) conducted a retrospective survey to analyze disease outcome following autologous stem cell transplantation (ASCT). METHODS: This retrospective multicenter study assessed the efficacy and safety of ASCT in 16 patients suffering from refractory NMO reported to the EBMT registry between 2001 and 2011. RESULTS: Fifteen patients were successfully mobilized with cyclophosphamide (Cy) and G-CSF, one with G-CSF alone. All patients received an unmanipulated autologous peripheral blood stem cell graft, after conditioning with BEAM plus anti-thymocyte globulin (ATG, n = 9 patients), thiotepa-Cy (n = 3) or Cy (200 mg/kg) plus ATG (n = 4). After a median follow-up of 47 months, three of 16 cases were progression and treatment free, while in the remaining 13 patients further treatments were administered for disability progression or relapse after ASCT. Altogether, relapse-free survival at three and five years was 31% and 10%, respectively, while progression-free survival remained 48% at three and five years. CONCLUSIONS: In these NMO patients, highly resistant to conventional treatment, ASCT allows for temporary control of the disease, despite a tendency to progress or relapse in the long term.

Published
2015
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10. A novel self-lipid antigen targets human T cells against CD1c(+) leukemias

Author

Lepore, Marco, de Lalla, Claudia, Gundimeda, S Ramanjaneyulu, Gsellinger, Heiko, Consonni, Michela, Garavaglia, Claudio, Sansano, Sebastiano, Piccolo, Francesco, Scelfo, Andrea, Häussinger, Daniel, Montagna, Daniela, Locatelli, Franco, Bonini, Chiara, Bondanza, Attilio, Forcina, Alessandra, Li, Zhiyuan, Ni, Guanghui, Ciceri, Fabio, Jenö, Paul, Xia, Chengfeng, Mori, Lucia, Dellabona, Paolo, Casorati, Giulia, De Libero, Gennaro, Locatelli, Franco (ORCID:0000-0002-7976-3654), Lepore, Marco, de Lalla, Claudia, Gundimeda, S Ramanjaneyulu, Gsellinger, Heiko, Consonni, Michela, Garavaglia, Claudio, Sansano, Sebastiano, Piccolo, Francesco, Scelfo, Andrea, Häussinger, Daniel, Montagna, Daniela, Locatelli, Franco, Bonini, Chiara, Bondanza, Attilio, Forcina, Alessandra, Li, Zhiyuan, Ni, Guanghui, Ciceri, Fabio, Jenö, Paul, Xia, Chengfeng, Mori, Lucia, Dellabona, Paolo, Casorati, Giulia, De Libero, Gennaro, and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects. We report that CD1c self-reactive T cells recognize a novel class of self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which are accumulated in leukemia cells. Primary acute myeloid and B cell acute leukemia blasts express CD1 molecules. mLPA-specific T cells efficiently kill CD1c(+) acute leukemia cells, poorly recognize nontransformed CD1c-expressing cells, and protect immuno-deficient mice against CD1c+ human leukemia cells. The identification of immunogenic self-lipid antigens accumulated in leukemia cells and the observed leukemia control by lipid-specific T cells in vivo provide a new conceptual framework for leukemia immune surveillance and possible immunotherapy.

Published
2014

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