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Climate change is a threat to sustainable livestock production and livelihoods in the tropics. It has adverse impacts on feed and water availability, disease prevalence, production, environmental temperature, and biodiversity. Unravelling the drivers of local adaptation and understanding the underlying genetic variation in random mating indigenous livestock populations informs the design of genetic improvement programmes that aim to increase productivity and resilience. In the present study, we combined environmental, genomic, and phenotypic information of Ethiopian indigenous chickens to investigate their environmental adaptability. Through a hybrid sampling strategy, we captured wide biological and ecological variabilities across the country. Our environmental dataset comprised mean values of 34 climatic, vegetation and soil variables collected over a thirty-year period for 260 geolocations. Our biological dataset included whole genome sequences and quantitative measurements (on eight traits) from 513 individuals, representing 26 chicken populations spread along 4 elevational gradients (6–7 populations per gradient). We performed signatures of selection analyses (and XP-EHH) to detect footprints of natural selection, and redundancy analyses (RDA) to determine genotype-environment and genotype-phenotype-associations. RDA identified 1909 outlier SNPs linked with six environmental predictors, which have the highest contributions as ecological drivers of adaptive phenotypic variation. The same method detected 2430 outlier SNPs that are associated with five traits. A large overlap has been observed between signatures of selection identified byand XP-EHH showing that both methods target similar selective sweep regions. Average genetic differences measured by are low between gradients, but XP-EHH signals are the strongest between agroecologies. Genes in the calcium signalling pathway, those associated with the hypoxia-inducible factor (HIF) transcription factors, and spo

BACKGROUND: The domesticated turkey (Meleagris gallopavo) is a species of significant agricultural importance and is the second largest contributor, behind broiler chickens, to world poultry meat production. The previous genome is of draft quality and partly based on the chicken (Gallus gallus) genome. A high-quality reference genome of M. gallopavo is essential for turkey genomics and genetics research and the breeding industry. RESULTS: By adopting the trio-binning approach, we were able to assemble a high-quality chromosome-level F1 assembly and 2 parental haplotype assemblies, leveraging long-read technologies and genome-wide chromatin interaction data (Hi-C). From a total of 40 chromosomes (2n = 80), we captured 35 chromosomes in a single scaffold, showing much improved genome completeness and continuity compared to the old assembly build. The 3 assemblies are of higher quality than the previous draft quality assembly and comparable to the chicken assemblies (GRCg7) shown by the largest contig N50 (26.6 Mb) and comparable BUSCO gene set completeness scores (96-97%). Comparative analyses confirm a previously identified large inversion of around 19 Mbp on the Z chromosome not found in other Galliformes. Structural variation between the parent haplotypes was identified, which poses potential new target genes for breeding. CONCLUSIONS: We contribute a new high-quality turkey genome at the chromosome level, benefiting turkey genetics and other avian genomics research as well as the turkey breeding industry.

Background: Saliva modulates the environment of the oral biofilm through pH buffer, microbial attachment to host surfaces, and nutritional source. The ecology of stress occurs when a physical factor adversely impacts an ecosystem or its biotic components. Therefore, reduced salivary flow can affect oral-host balance. The leading causes of hyposalivation include disease-associated Sjögren’s syndrome (SS) and menopausal women as aging-associated. However, little is known about the oral microbiome integrated with sex hormones in hyposalivation. This study aimed to characterize the hyposalivation microbiome caused by aging or disease affecting the salivary glands in women. Methods: We included 50 women older than 40 years of age in any menopausal phase. We collected stimulated saliva from 25 women diagnosed with SS (SS) and 25 without SS (non-SS). The bacterial profile of the patients was obtained by 16S rRNA sequencing. Bioinformatics analysis used machine learning to analyze the cohort’s signs, symptoms, and bacterial profile. Salivary estradiol as a sex hormone variation level was determined. Results: We obtained that 79% of the SS group, and 52% of the non-SS group had hyposalivation. We found a negatively correlated Prevotella-age and Rothia-estradiol in the SS group. Highlight, we found that the cause of the hyposalivation in the study did not explain differences in microbial diversity comparing non-SS and SS groups. Therefore, microbial communities found in hyposalivation but not related to systemic conditions suggest that changes in the oral environment might underpin host-microbial balance. Conclusion: The salivary microbiome was similar in women with and without SS. However, hyposalivation showed two distinctive clusters associated with the bacterial population profiles. Our study suggests that local ecological disturbances could drive the change in the microbiome.

The domesticated turkey (Meleagris gallopavo) is a species of significant agricultural importance and is the second largest contributor, behind broiler chickens, to world poultry meat production. The previous genome is of draft quality and partly based on the chicken (Gallus gallus) genome. A high-quality reference genome of Meleagris gallopavo is essential for turkey genomics and genetics research and the breeding industry. By adopting the trio-binning approach, we were able to assemble a high-quality chromosome-level F1 assembly and two parental haplotype assemblies, leveraging long-read technologies and genome-wide chromatin interaction data (Hi-C). From a total of 40 chromosomes (2n=80), we capture 35 chromosomes in a single scaffold, and show much improved genome completeness and continuity compared to the old assembly build. The three assemblies are of higher quality than the previous draft quality assembly and comparable to the chicken assemblies (GRCg7) shown by the largest contig N50 (26.6 Mb) and comparable BUSCO gene set completeness scores (96-97%). Comparative analyses confirms a previously identified large inversion of around 19 Mbp on the Z chromosome not found in other Galliformes. Structural variation between the parent haplotypes were identified which pose potential new target genes for breeding. We contribute a new high-quality turkey genome at chromosome-level, benefiting turkey genetics and other avian genomics research as well as turkey breeding industry., The domesticated turkey (Meleagris gallopavo) is a species of significant agricultural importance and is the second largest contributor, behind broiler chickens, to world poultry meat production. The previous genome is of draft quality and partly based on the chicken (Gallus gallus) genome. A high-quality reference genome of Meleagris gallopavo is essential for turkey genomics and genetics research and the breeding industry. By adopting the trio-binning approach, we were able to assemble a high-quality chromosome-level F1 assembly and two parental haplotype assemblies, leveraging long-read technologies and genome-wide chromatin interaction data (Hi-C). From a total of 40 chromosomes (2n=80), we capture 35 chromosomes in a single scaffold, and show much improved genome completeness and continuity compared to the old assembly build. The three assemblies are of higher quality than the previous draft quality assembly and comparable to the chicken assemblies (GRCg7) shown by the largest contig N50 (26.6 Mb) and comparable BUSCO gene set completeness scores (96-97%). Comparative analyses confirms a previously identified large inversion of around 19 Mbp on the Z chromosome not found in other Galliformes. Structural variation between the parent haplotypes were identified which pose potential new target genes for breeding. We contribute a new high-quality turkey genome at chromosome-level, benefiting turkey genetics and other avian genomics research as well as turkey breeding industry.

The dataset is based on the landscape genomic study of the Ethiopian indigenous chickens which aims to identify candidate genes, genomic regions and quantitative traits linked with environmental adaptation. We genotyped 513 chickens, the data has geographic information, signatures of selection analyses (Fst and XP-EHH), and redundancy analysis (RDA) outputs on 26 sample populations. Environmental values for chicken sampling sites (e.g., mean temperature of the coldest quarter) were downloaded from WorldClim.

In this article, we reflect on linguistic variation and prejudice in Brazilian Portuguese and Spanish varieties. We also analyze the representation of the ways of treating the varieties of Spanish in teaching material for High Schools, in order, later, to propose a didactic unit that develops this reflection. We created an organized didactic unit with an emphasis on synopsis and short film genres to sensitize learners about the relationships we have and can have and learn about some forms of treatment in use of three varieties of Spanish. At the end of the didactic unit, we hope that the learner will be the protagonist of his written and oral production when planning and directing a short film in Spanish., Neste artigo, refletimos sobre a variação e o preconceito linguístico no português brasileiro e nas variedades do espanhol. Também analisamos a representação das formas de tratamento das variedades do espanhol em um material didático para o Ensino Médio para, posteriormente, propor uma unidade didática que desenvolva essa reflexão. Elaboramos uma unidade didática organizada com ênfase nos gêneros sinopse e curta-metragem para sensibilizar os aprendizes a respeito das relações que temos e podemos ter e também conhecer algumas formas de tratamento em uso de três variedades do espanhol. Ao final da unidade didática, esperamos que o aprendiz seja protagonista de sua produção escrita e oral ao planejar e realizar um curta-metragem em espanhol., En este artículo, reflexionamos respecto a la variación y los prejuicios lingüísticos en portugués brasileño y en variedades del español. También analizamos la representación de las formas de tratar las variedades del español en el material didáctico de Bachillerato, para, posteriormente, proponer una unidad didáctica que desarrolle esta reflexión. Creamos una unidad didáctica organizada con énfasis en la sinopsis y los géneros de cortometrajes para sensibilizar a los alumnos sobre las relaciones que entablamos y podemos entablar, y también conocer algunas formas de tratamiento en uso de tres variedades del español. Al final de la unidad didáctica, esperamos que el alumno sea el protagonista de su producción escrita y oral a la hora de planificar y realizar un cortometraje en español.

We performed high-coverage long read PacBio sequencing to produce a high quality assembly (Mgal_WUR_HG_1.0) of the Meleagris gallopavo (Turkey) using the Trio-Binning approach. We used the Trio-binning approach to create two high quality parental haplotype assemblies, Mgal_WUR_HG_1.0_p1 and Mgal_WUR_HG_1.0_p2, for parent 1 and parent 2, respectively.

El objetivo del presente trabajo consiste en analizar la introducción del modelo de empresa social en la construcción de una industria textil con dinámicas de producción y consumo coherentes con el desarrollo humano. Para ello se realiza una revisión de literatura sobre la empresa social, la industria textil y su relación con el desarrollo humano. Primero, se analiza el marco de la economía social, los llamados ecosistemas de empresas sociales y sus emprendedores. Después, se busca la relación entre empresa social y desarrollo humano, tratando de comprender el impacto que puede tener la una sobre el otro. A continuación, se plantea el panorama actual de la industria textil, partiendo de las críticas que se lanzan sobre él. Por último, se incluyen los ejemplos de una muestra de empresas sociales de los cinco continentes. Se concluye, que este es un tiempo de búsqueda de respuestas multidimensionales, de innovación social y de alianzas complejas. La empresa social, a caballo entre lo público y lo privado, se perfila como un agente del cambio con herramientas para construir un nuevo paradigma. La industria textil moviliza una sexta parte del empleo mundial y nos viste a todos. Su transformación de contaminante a sostenible parece ir más rápido de lo que podíamos imaginar siendo tan ejemplarizante como esperanzador., The objective of this work is to analyze the social enterprise model possibilities to build in the textile industry, production and consumption dynamics consistent with human development. To do this, a literature review on social enterprise, the textile industry and its relationship with human development is carried out. First, the framework of the social economy is analyzed, the so-called ecosystems of social enterprises and their entrepreneurs. Then the relationship between social enterprise and human development is sought, trying to understand the impact that one can have on the other. The current panorama of the textile industry is presented below, based on the criticisms that are thrown about it. Finally, the examples of a sample of social enterprises from the five continents are included. It is concluded that this is a time of search for multidimensional answers, social innovation and complex alliances. The social enterprise, straddling the public and the private, is emerging as an agent of change with tools to build a new paradigm. The textile industry mobilizes one sixth of the world's employment and clothes us all. Its transformation from polluting to sustainable seems to go faster than we could imagine being as exemplary as it is hopeful., Departamento de Geografía, Máster en Cooperación Internacional para el Desarrollo

El objetivo del presente trabajo consiste en analizar la introducción del modelo de empresa social en la construcción de una industria textil con dinámicas de producción y consumo coherentes con el desarrollo humano. Para ello se realiza una revisión de literatura sobre la empresa social, la industria textil y su relación con el desarrollo humano. Primero, se analiza el marco de la economía social, los llamados ecosistemas de empresas sociales y sus emprendedores. Después, se busca la relación entre empresa social y desarrollo humano, tratando de comprender el impacto que puede tener la una sobre el otro. A continuación, se plantea el panorama actual de la industria textil, partiendo de las críticas que se lanzan sobre él. Por último, se incluyen los ejemplos de una muestra de empresas sociales de los cinco continentes. Se concluye, que este es un tiempo de búsqueda de respuestas multidimensionales, de innovación social y de alianzas complejas. La empresa social, a caballo entre lo público y lo privado, se perfila como un agente del cambio con herramientas para construir un nuevo paradigma. La industria textil moviliza una sexta parte del empleo mundial y nos viste a todos. Su transformación de contaminante a sostenible parece ir más rápido de lo que podíamos imaginar siendo tan ejemplarizante como esperanzador., The objective of this work is to analyze the social enterprise model possibilities to build in the textile industry, production and consumption dynamics consistent with human development. To do this, a literature review on social enterprise, the textile industry and its relationship with human development is carried out. First, the framework of the social economy is analyzed, the so-called ecosystems of social enterprises and their entrepreneurs. Then the relationship between social enterprise and human development is sought, trying to understand the impact that one can have on the other. The current panorama of the textile industry is presented below, based on the criticisms that are thrown about it. Finally, the examples of a sample of social enterprises from the five continents are included. It is concluded that this is a time of search for multidimensional answers, social innovation and complex alliances. The social enterprise, straddling the public and the private, is emerging as an agent of change with tools to build a new paradigm. The textile industry mobilizes one sixth of the world's employment and clothes us all. Its transformation from polluting to sustainable seems to go faster than we could imagine being as exemplary as it is hopeful., Departamento de Geografía, Máster en Cooperación Internacional para el Desarrollo

El objetivo del presente trabajo consiste en analizar la introducción del modelo de empresa social en la construcción de una industria textil con dinámicas de producción y consumo coherentes con el desarrollo humano. Para ello se realiza una revisión de literatura sobre la empresa social, la industria textil y su relación con el desarrollo humano. Primero, se analiza el marco de la economía social, los llamados ecosistemas de empresas sociales y sus emprendedores. Después, se busca la relación entre empresa social y desarrollo humano, tratando de comprender el impacto que puede tener la una sobre el otro. A continuación, se plantea el panorama actual de la industria textil, partiendo de las críticas que se lanzan sobre él. Por último, se incluyen los ejemplos de una muestra de empresas sociales de los cinco continentes. Se concluye, que este es un tiempo de búsqueda de respuestas multidimensionales, de innovación social y de alianzas complejas. La empresa social, a caballo entre lo público y lo privado, se perfila como un agente del cambio con herramientas para construir un nuevo paradigma. La industria textil moviliza una sexta parte del empleo mundial y nos viste a todos. Su transformación de contaminante a sostenible parece ir más rápido de lo que podíamos imaginar siendo tan ejemplarizante como esperanzador., The objective of this work is to analyze the social enterprise model possibilities to build in the textile industry, production and consumption dynamics consistent with human development. To do this, a literature review on social enterprise, the textile industry and its relationship with human development is carried out. First, the framework of the social economy is analyzed, the so-called ecosystems of social enterprises and their entrepreneurs. Then the relationship between social enterprise and human development is sought, trying to understand the impact that one can have on the other. The current panorama of the textile industry is presented below, based on the criticisms that are thrown about it. Finally, the examples of a sample of social enterprises from the five continents are included. It is concluded that this is a time of search for multidimensional answers, social innovation and complex alliances. The social enterprise, straddling the public and the private, is emerging as an agent of change with tools to build a new paradigm. The textile industry mobilizes one sixth of the world's employment and clothes us all. Its transformation from polluting to sustainable seems to go faster than we could imagine being as exemplary as it is hopeful., Departamento de Geografía, Máster en Cooperación Internacional para el Desarrollo

El objetivo del presente trabajo consiste en analizar la introducción del modelo de empresa social en la construcción de una industria textil con dinámicas de producción y consumo coherentes con el desarrollo humano. Para ello se realiza una revisión de literatura sobre la empresa social, la industria textil y su relación con el desarrollo humano. Primero, se analiza el marco de la economía social, los llamados ecosistemas de empresas sociales y sus emprendedores. Después, se busca la relación entre empresa social y desarrollo humano, tratando de comprender el impacto que puede tener la una sobre el otro. A continuación, se plantea el panorama actual de la industria textil, partiendo de las críticas que se lanzan sobre él. Por último, se incluyen los ejemplos de una muestra de empresas sociales de los cinco continentes. Se concluye, que este es un tiempo de búsqueda de respuestas multidimensionales, de innovación social y de alianzas complejas. La empresa social, a caballo entre lo público y lo privado, se perfila como un agente del cambio con herramientas para construir un nuevo paradigma. La industria textil moviliza una sexta parte del empleo mundial y nos viste a todos. Su transformación de contaminante a sostenible parece ir más rápido de lo que podíamos imaginar siendo tan ejemplarizante como esperanzador., The objective of this work is to analyze the social enterprise model possibilities to build in the textile industry, production and consumption dynamics consistent with human development. To do this, a literature review on social enterprise, the textile industry and its relationship with human development is carried out. First, the framework of the social economy is analyzed, the so-called ecosystems of social enterprises and their entrepreneurs. Then the relationship between social enterprise and human development is sought, trying to understand the impact that one can have on the other. The current panorama of the textile industry is presented below, based on the criticisms that are thrown about it. Finally, the examples of a sample of social enterprises from the five continents are included. It is concluded that this is a time of search for multidimensional answers, social innovation and complex alliances. The social enterprise, straddling the public and the private, is emerging as an agent of change with tools to build a new paradigm. The textile industry mobilizes one sixth of the world's employment and clothes us all. Its transformation from polluting to sustainable seems to go faster than we could imagine being as exemplary as it is hopeful., Departamento de Geografía, Máster en Cooperación Internacional para el Desarrollo

One of the main goals of genetics has been to understand the link between genotype and phenotype. Using yeast (Saccharomyces cerevisiae) as our model organism, we take a closer look at the connection between genetic variation and gene expression to learn more about the mechanisms of gene regulation. We propose an algorithm based on ANOVA to detect causal relationships between coexpressed genes. We first identify expression quantitative trait loci (eQTLs) with strong effects on gene expression. The algorithm then uses these eQTLs with strong effects and the expression of all genes to identify how genes are affecting each other. This is done by analysing coexpressed gene pairs where both genes have an eQTL and finding if the eQTL of one gene affects the expression of the other. Genes that were found to affect the expression of other genes were named “causal genes”. We evaluate our method by comparing its results with known causal genes and conclude that it is a good predictor of known interactions. Using this algorithm, we found 741 genes having causal effects on gene expression, many of which affected the gene expression of many other genes across the genome (2278 total affected genes). Some of the causal genes clustered at six hotspot regions in the genome. Genes in hotspot regions were found to have lower heritability than genes outside these regions. We hypothesize that hotspot regions may be enriched for essential and/or fitness related genes.

One of the main goals of genetics has been to understand the link between genotype and phenotype. Using yeast (Saccharomyces cerevisiae) as our model organism, we take a closer look at the connection between genetic variation and gene expression to learn more about the mechanisms of gene regulation. We propose an algorithm based on ANOVA to detect causal relationships between coexpressed genes. We first identify expression quantitative trait loci (eQTLs) with strong effects on gene expression. The algorithm then uses these eQTLs with strong effects and the expression of all genes to identify how genes are affecting each other. This is done by analysing coexpressed gene pairs where both genes have an eQTL and finding if the eQTL of one gene affects the expression of the other. Genes that were found to affect the expression of other genes were named “causal genes”. We evaluate our method by comparing its results with known causal genes and conclude that it is a good predictor of known interactions. Using this algorithm, we found 741 genes having causal effects on gene expression, many of which affected the gene expression of many other genes across the genome (2278 total affected genes). Some of the causal genes clustered at six hotspot regions in the genome. Genes in hotspot regions were found to have lower heritability than genes outside these regions. We hypothesize that hotspot regions may be enriched for essential and/or fitness related genes.

O presente trabalho é fruto de relatório de pesquisa desenvolvida durante o Programa Institucional de Bolsas de Iniciação Científica (PIBIC) no ano de 2016/2017 sobre a pesquisa para investigar a relação existente entre a ansiedade e o otimismo em pacientes com diagnóstico de Doença Arterial Coronariana (DAC) e pacientes sem DAC obstrutiva. Para tal pesquisa utilizamos a aplicação dos testes Inventário de Ansiedade de Greenberger e Padesky (1995) e o Teste de Orientação da Vida-R (TOV –R, 2002) em pacientes do Hospital Universitário Francisca Mendes, Manaus – AM. Os sujeitos da pesquisa foram divididos em grupo controle e grupo teste; buscando observar os índices de sentimentos positivos nos grupos participantes, como também ansiedade elevada. A pesquisa demonstrou que os pacientes ambulatoriais (grupo controle) apresentavam níveis graves de ansiedade em apenas 6% da amostra, enquanto na enfermaria essa mesma classificação representava 15% da população. Os níveis de otimismo mostraram-se altos nas duas populações. Enquanto no ambulatório 75% dos pacientes consideraram-se otimistas, na enfermaria 56% classificou-se da mesma forma. Palavras – Chave: Psicologia Positiva; Ansiedade; Otimismo; Cardíacos. Abstract – This existing paper is the result of an research report conducted during the Institutional Program of Cientific Iniciation Schoolarships (PIBIC) over 2016/2017 about a study to investigate the connexion between anxiety and optimism in patients diagnosed with Coronary Artery Disease (DAC) and without DAC. For said reseach we applied Greenberger and Padesky’s Anxiety Inventory (1995) and the Life-R’s Orientation Test (TOV –R, 2002) in patients from the University Hospital Francisca Mendes, Manaus – AM. The subjects were split in control group and test group; seeking to observe positive feelings rates among the participants , and also high anxiety levels. The study demonstrated that just 6% of ambulatory patients (control group) showed severe levels of anxiety, w

This work intends to present a legal panorama of the discussions involving the collective management of copyright and the musical streaming platforms in Brazil, considering the technological revolution and the changes in the consumption of entertainment products, specifically related to the Phonographic market. Content analysis was used through indirect documentation to identify recent changes in Brazilian legislation and trends evidenced by judicial decisions and official manifestations of the Ministry of Culture, in a clear conjuncture of major changes related to collective management., Este trabalho pretende apresentar um panorama jurídico das discussões envolvendo a gestão coletiva de direitos autorais e as plataformas de streaming musical no Brasil, tendo em vista a revolução tecnológica e as mudanças no consumo de produtos do entretenimento, especificamente relacionados ao mercado fonográfico. Foi utilizada a análise de conteúdo através de documentação indireta para identificar recentes alterações na legislação brasileira e as tendências evidenciadas por decisões judiciais e manifestações oficiais do Ministério da Cultura, em uma clara conjuntura de grandes mudanças relacionadas à gestão coletiva.

This work intends to present a legal panorama of the discussions involving the collective management of copyright and the musical streaming platforms in Brazil, considering the technological revolution and the changes in the consumption of entertainment products, specifically related to the Phonographic market. Content analysis was used through indirect documentation to identify recent changes in Brazilian legislation and trends evidenced by judicial decisions and official manifestations of the Ministry of Culture, in a clear conjuncture of major changes related to collective management., Este trabalho pretende apresentar um panorama jurídico das discussões envolvendo a gestão coletiva de direitos autorais e as plataformas de streaming musical no Brasil, tendo em vista a revolução tecnológica e as mudanças no consumo de produtos do entretenimento, especificamente relacionados ao mercado fonográfico. Foi utilizada a análise de conteúdo através de documentação indireta para identificar recentes alterações na legislação brasileira e as tendências evidenciadas por decisões judiciais e manifestações oficiais do Ministério da Cultura, em uma clara conjuntura de grandes mudanças relacionadas à gestão coletiva.

O texto foi escrito a partir da investigação dedicada a mapear a “para-formalidade” no centro da cidade de Salvador/Bahia/Brasil, através de cartografias urbanas, fazendo uso de recursos infográficos e sendo divulgado em tempo real por meio de website. A oficina foi realizada no "Corpocidade 3", e dividiu-se em errâncias e intervenções. A pesquisa se volta para os espaços não regulados, onde se produzem atividades que tendem a subverter as leis da economia tradicional, do urbanismo e das relações humanas, gerando mudanças importantes, tanto teóricas como práticas, na maneira de pensar e planejar a cidade. Para essa pesquisa, o para-formal são todas as atividades (comerciais, culturais, moradia, etc.) encontradas no espaço público da cidade, que não faz parte de seu desenho urbano (original), mas que “agora” – na contemporaneidade – fazem parte de seu cotidiano. Até agora, os principais resultados obtidos giram em torno do corpo, do espaço e do tempo no centro das cidades., The text was written from research devoted to map the "para-formalidade" in the center of Salvador/Bahia/Brazil, through urban cartography, making use of infographics and being released in real time via the website. The workshop was held in "Corpocidade 3", and divided into walkers and interventions. The research turns to the unregulated spaces where activities occur that tend to subvert the traditional laws of economics, urban planning and human relations, generating important changes, both theoretical and practical, in thinking and planning the city. For this research, the "para-formal" are all activities (commercial, cultural, housing, etc.) found in the public space of the city, which is not part of its urban design (original), but that "now" - nowadays - do part of their daily lives. Until now, the main results revolve around the body, space and time in the center of the cities., Peer Reviewed

Este proyecto nace como intención de abordar los nuevos escenarios en que se mueve el actualmente le mundo online en cuanto a tecnologías, diseño, marketing y desarrollo Web. Para esto nos hemos conseguido un cliente que quiera lanzar una marca y que desee posicionarse en la red, incluyendo herramientas de última generación. Nuestro cliente se trata de un centro de Terapia Ayurvéda, para el cual diseñaremos su página Web y su estrategia de marketing dentro y fuera de la red ayudándonos de una investigación previa de las tecnologías actuales utilizadas en Marketing Online y en desarrollo Web y del mercado en referencia.

Este proyecto nace como intención de abordar los nuevos escenarios en que se mueve el actualmente le mundo online en cuanto a tecnologías, diseño, marketing y desarrollo Web. Para esto nos hemos conseguido un cliente que quiera lanzar una marca y que desee posicionarse en la red, incluyendo herramientas de última generación. Nuestro cliente se trata de un centro de Terapia Ayurvéda, para el cual diseñaremos su página Web y su estrategia de marketing dentro y fuera de la red ayudándonos de una investigación previa de las tecnologías actuales utilizadas en Marketing Online y en desarrollo Web y del mercado en referencia.

Este proyecto nace como intención de abordar los nuevos escenarios en que se mueve el actualmente le mundo online en cuanto a tecnologías, diseño, marketing y desarrollo Web. Para esto nos hemos conseguido un cliente que quiera lanzar una marca y que desee posicionarse en la red, incluyendo herramientas de última generación. Nuestro cliente se trata de un centro de Terapia Ayurvéda, para el cual diseñaremos su página Web y su estrategia de marketing dentro y fuera de la red ayudándonos de una investigación previa de las tecnologías actuales utilizadas en Marketing Online y en desarrollo Web y del mercado en referencia.