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1. Spatial distribution, carbon stocks and diversity of peat swamp forests in the central Congo Basin

Author: Crezee, Bart Jonathan, Lewis, Simon L., and Baker, Timothy R.
Published: 2022

2. Occupational physical activity and health: is occupational physical activity health-enhancing? What strategies could improve the health of workers in physically demanding jobs?

Author: Cillekens, Bart Leonardus Gerardus and Cillekens, Bart Leonardus Gerardus
Published: 2025
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3. Design of experiments optimized OMEx-diesel blends on a heavy-duty engine − Part 1: Combustion and emissions analysis with EGR and injection timing variation

Author: Sun, Zhongcheng, van Beers, Harold, Cuijpers, Michel, Somers, Bart, Maes, Noud, Sun, Zhongcheng, van Beers, Harold, Cuijpers, Michel, Somers, Bart, and Maes, Noud
Abstract: Oxymethylene dimethyl ether (OME) as a renewable E-fuel provides huge potential for simultaneous soot and NOx reduction on heavy-duty engines, but a thorough optimization of combustion and emission characteristics of great interest to achieve that potential. To achieve that goal, diesel-oxymethylene dimethyl ethers (OMEx) blends are investigated on a single-cylinder heavy-duty research engine with different operating strategies using the design of experiments (DOE) method. A representative truck cruising condition with engine speed of 1425 RPM and 30 % load was targeted, because of the relatively high particulate matter (PM) emissions with regular B7 diesel. In general, the required injection duration at a fixed load increases with OMEx addition related to its reduced lower heating value, hence limiting the available energy before the decreased ignition delay, and resulting in a reduced premixed heat release peak. The ignition delay becomes shorter with increasing OMEx content due to its higher reactivity. Because of the higher reactivity of OMEx and higher oxygen content leading to a lower stoichiometric air–fuel ratio, the burn duration is inversely proportional to OMEx addition at this relatively low-load condition, and seemingly independent of injection duration. Subsequently, the combustion phasing (CA50, the crank angle where 50 % of the heat has been released) is advanced with increasing OMEx. In addition to combustion analysis, the particle number concentration is measured using an engine exhaust particle sizer. To obtain good consistency with the well-established AVL smoke meter results an appropriate particle mass density array of EEPS needed to be adopted. Using the DOE approach methodology, a response surface of PM emissions based on the experimental data indicates that the soot emissions strongly correlate to OMEx content in the blends, satisfying EU VI regulation
Published: 2025

4. Source attribution of Listeria monocytogenes in the Netherlands

Author: Mughini-Gras, Lapo, Paganini, Julian A, Guo, Ruoshui, Coipan, Claudia E, Friesema, Ingrid H M, van Hoek, Angela H A M, van den Beld, Maaike, Kuiling, Sjoerd, Bergval, Indra, Wullings, Bart, van der Voort, Menno, Franz, Eelco, Dallman, Timothy J, Mughini-Gras, Lapo, Paganini, Julian A, Guo, Ruoshui, Coipan, Claudia E, Friesema, Ingrid H M, van Hoek, Angela H A M, van den Beld, Maaike, Kuiling, Sjoerd, Bergval, Indra, Wullings, Bart, van der Voort, Menno, Franz, Eelco, and Dallman, Timothy J
Abstract: The aim of this study was to determine the relative contributions of various potential food sources of human listeriosis and to identify source-specific risk factors, at exposure level, for human Listeria monocytogenes (Lm) infection. To achieve this, available Lm isolates from human cases (n = 756) and food/animal sources (n = 950) from national surveillance systems in the Netherlands (2010-2020) were whole genome sequenced. Additionally, questionnaire-based exposure data for human cases was collected. Source attribution analysis was performed using a Random Forest model based on core-genome multilocus sequence typing (cgMLST). Risk factors for human Lm infection of cattle, chicken and seafood origin were determined using beta regression analysis on the cgMLST-based attribution estimates. Results indicated that the 756 human Lm isolates were mainly attributed to cattle (62.3 %), chicken (19.4 %), and seafood (16.9 %). Specifically, fresh meat (86.2 %), including fresh bovine meat (43.7 %) and fresh chicken meat (39.3 %), accounted for most cases. These attributions stemmed from Lm contamination of either the food products or their production environments. Consumption of steak tartare and smoked salmon was associated with an increased risk of human Lm infections attributed to cattle and seafood, respectively, while no specific risk factors for chicken-borne listeriosis were identified. This study indicated that Lm isolates of cattle origin, particularly those from fresh bovine meat and associated production environments, are estimated to be the primary cause of human listeriosis in the Netherlands. This aligns with several other European source attribution studies on Lm. Moreover, the identified risk factors for human Lm infection from cattle (i.e. steak tartare) and seafood (i.e. smoked salmon) clearly indicated their attributable sources. This joint analysis of core genome and epidemiological data provided novel insights into the origins and transmission pathwa
Published: 2025

5. Single-exponential FPT algorithms for enumerating secluded F-free subgraphs and deleting to scattered graph classes

Author: Jansen, Bart M.P., de Kroon, Jari J.H., Wlodarczyk, Michal, Jansen, Bart M.P., de Kroon, Jari J.H., and Wlodarczyk, Michal
Abstract: The celebrated notion of important separators bounds the number of small (S,T)-separators in a graph which are ‘farthest from S’ in a technical sense. In this paper, we introduce a generalization of this powerful algorithmic primitive, tailored to undirected graphs, that is phrased in terms of k-secluded vertex sets: sets with an open neighborhood of size at most k. In this terminology, the bound on important separators says that there are at most 4 k maximal k-secluded connected vertex sets C containing S but disjoint from T. We generalize this statement significantly: even when we demand that G[C] avoids a finite set F of forbidden induced subgraphs, the number of such maximal subgraphs is 2 O(k) and they can be enumerated efficiently. This enumeration algorithm allows us to give improved parameterized algorithms for CONNECTED k-SECLUDED F-FREE SUBGRAPH and for deleting into scattered graph classes.
Published: 2025

6. Scientific machine learning: A symbiosis

Author: Keith, B. (Brendan), O'Leary-Roseberry, T. (Thomas), Sanderse, B. (Benjamin), Scheichl, R. (Robert), Van Bloemen Waanders, B. (Bart), Keith, B. (Brendan), O'Leary-Roseberry, T. (Thomas), Sanderse, B. (Benjamin), Scheichl, R. (Robert), and Van Bloemen Waanders, B. (Bart)
Abstract: This editorial serves as a preface to the "Scientific Machine Learning" (SciML) special issue of the AIMS Foundations of Data Science journal. In this piece, we contend that SciML exists in a symbiotic relationship with the fields of computational science and engineering (CSE) and machine learning (ML). We highlight the progress (and limitations) of CSE and reflect on the recent successes of ML. While ML creates significant possibilities for advancing simulation techniques, it lacks the mathematical guarantees that are typically found in CSE. We argue that as SciML develops and embraces the remarkable capabilities of ML, it will support, not replace, traditional methods of CSE. We then overview some existing challenges and opportunities in this interdisciplinary field and close by introducing the special issue papers.
Published: 2025
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7. Growing mismatches of supply and demand of ecosystem services in the Netherlands

Author: de Knegt, Bart, Lof, Marjolein E., Le Clec'h, Solen, Alkemade, Rob, de Knegt, Bart, Lof, Marjolein E., Le Clec'h, Solen, and Alkemade, Rob
Abstract: A sufficient supply of goods and services from ecosystems is vital to ensure human well-being. This study evaluates whether the demand for goods and services within the Netherlands is met by Dutch ecosystems, could otherwise be provided through technology and/or by imports, or remains (partially) unmet. Additionally, this study shows the dynamics of supply and demand of these services over time. The results reveal that no ecosystem service supply is fully meeting the total demand provided by Dutch ecosystems. Additionally, for the majority of the services (10 out of 17), the gap between supply and demand widened over the last two decades, indicating a growing mismatch. Imports and technology only partly close the gap between supply and demand. The growing mismatch between supply and demand is expected to lead to increasing negative impacts on human well-being, such as poor air and water quality, heat stress in urban areas, increasing flood risks, limiting opportunities for outdoor recreation and loss of biodiversity. Our findings show that current policy goals to maintain and restore ecosystem services are not on track in the Netherlands. Urgent action is necessary to enhance the sustainable utilization of natural resources and to optimize the balance between supply and demand. Priority should be given to goods and services facing unmet demand where imports or technological solutions are not feasible, particularly those where the gap between supply and demand is widening.
Published: 2025

8. Design and evaluation of a robotic prototype for gerbera harvesting, performing actions at never-seen locations

Author: Sytsma, Menno, van Marrewijk, Bart M., Tielen, Toon, Vroegop, Arjan, Ruizendaal, Jos, Sytsma, Menno, van Marrewijk, Bart M., Tielen, Toon, Vroegop, Arjan, and Ruizendaal, Jos
Abstract: The harvesting of gerbera flowers, like many horticultural products, is a labor-intensive task for which automated solutions are highly desirable. While robotic harvesting of gerbera flowers has previously been attempted, it has not been tested under commercial greenhouse conditions. This study presents a design process based on realistic requirements derived from detailed measurements of the crop. We introduce a specialized end-effector for gerbera flower harvesting that leverages passive components alongside specific plant characteristics to enable precise positioning and effective cutting. An integrated testing setup is also presented, combining the end-effector with a robust, high-speed sensing and processing pipeline for field trials. Performance evaluations of the complete system under real greenhouse conditions indicate an overall harvest success rate of 78%, with minimal flower collisions and reliable positioning and cutting actions by the end-effector.
Published: 2025

9. The contribution of macrophages to tumour growth and metastasis

Author: Bart, Valentina
Abstract: Triple negative breast cancer (TNBC) accounts for 10 to 20 percent of breast cancers diagnosed and with a poor response to therapeutic options is associated with high mortality. The immune cell infiltrate of breast cancers is dominated by tumour associated macrophages (TAMs), which have the potential to eliminate tumour cells, but have also been implicated in various processes supporting tumour growth. For the work summarisedin this thesis, it was hypothesised that different types of TAMs exist in TNBC that could differently affect tumour outcome. Single cell sequencing of immune cells in the 4T1 mouse model of breast cancer allowed the identification of four different TAM subsets, some of which have not been described before. The work summarised in this thesis indicates that a global reduction of all TAM populations is not beneficial in reducing primary tumour growth, but does reduce metastatic burden in the lungs. While the effects of TAMs and regulatory T cells (Tregs) on each other could not be deciphered, the data do suggest that acombination of immune-targeting therapeutics affecting these two cell populations needs careful consideration, as a combined inhibition of both TAMs and Tregs resulted in the loss of all effects observed with either therapeutic on its own.
Published: 2021

10. Gene therapy for axon regeneration

Author: Nieuwenhuis, Bart, Fawcett, James, and Verhaagen, Joost
Subjects: Axon regeneration, Integrins, CRISPR-Cas9, Axon initial segment, Phosphoinositide 3-kinases, Adeno-associated viral vectors, Corticospinal tract
Abstract: Injury to the brain and spinal cord has devastating consequences because adult neurons in the central nervous system (CNS) do not regenerate. Traumatic CNS injuries are a significant clinical problem and have life-changing consequences for patients. There are 130.000 new cases of spinal cord injury (SCI) per year worldwide and currently affects more than 2.5 million people (International Spinal Research Trust). Spinal cord injury often results in loss of essential bodily functions including sexual function, bladder control, and motor and sensory function. There are many factors that contribute to the failure of axon regeneration in the CNS. Generally speaking, the problem of axon regeneration can be subdivided in at least two aspects: 1) the growth-repulsive environment surrounding the injured axon and 2) the low intrinsic regeneration potential of adult CNS neurons. In this dissertation, the focus is on the biology inside neurons and genetic approaches to enhance the axonal regeneration capacity of cortical neurons. Gene therapy is a promising strategy to promote axon regeneration. Gene therapy could be described as the delivery of a foreign gene into cells to treat a genetic disease or acquired condition. In this dissertation, adeno-associated viral (AAV) vectors were used to deliver transgenes into cortical neurons and the corticospinal tract, because regeneration of this neuronal pathway is a key event to restore motor function. One of the advantages of gene therapy is the local and long-term expression of transgenes following direct injection. To achieve a successful gene therapy for axonal regeneration, it is important to have good transduction efficiency in neurons and to deliver a transgene (or a combination of transgenes) that promotes axon regeneration over long distances and past the site of injury. The overall objective of this dissertation was to optimize AAV-mediated transduction of the corticospinal tract, and to enhance axon regeneration in cortical neurons by using vectors containing CRISPR-Cas9 and phosphoinositide 3-kinases. Chapter I is a literature review about cell surface receptors called integrins and their role in axonal regeneration. Integrins contribute to the spontaneous axon regeneration in the peripheral nervous system by interacting with ligands in the extracellular matrix. Integrin biology is different in the CNS. These receptors are transported into the axon of developing neurons, but selective axonal transport limits the regenerative response in adult CNS neurons. Targeting integrins and related molecules that control their transport and activation state is therefore a promising tool to promote robust regeneration in the CNS. The platforms and experimental therapies used in integrin research are also relevant for other mechanisms limiting axon regeneration. Chapter II is based on the hypothesis that the axon initial segment is a barrier for the axonal transport of integrins and other growth-promoting receptors. The aim was to dismantle the axon initial segment by knockout of the cytoskeletal scaffolding protein Ankyrin-G. Two genetic tools were made and tested to knockout Ankyrin-G: (1) a short hairpin RNA, and (2) a dual promoter AAV viral vector that drives the expression of a CRISPR-associated endonuclease 9 from Staphylococcus aures and one guide RNA targeting Ankyrin-G. The preliminary data shows that the vector-mediated RNA interference results in cellular toxicity in cultured cortical neurons, and that knockout of the axon initial segment was achieved in a proportion of neurons following CRISPR interference. Chapter III is based on the hypothesis that low axonal PtdIns-3,4,5-P3 (PIP3) signalling, due to the absence of growth-promoting receptors in the axon, contributes to regenerative failure in the CNS. This chapter investigates whether overexpression of phosphoinositide 3-kinases (PI3Ks), which generates PIP3, can promote axon regeneration in cultured cortical neurons. The first immunocytochemistry experiment confirmed our hypothesis that there is a decline of PIP3 levels in the axon in line with maturation. Expression of activated PI3Ks in developing neurons resulted in increased axonal growth, and expression in maturing neurons enlarged the soma size and resulted in more complex dendritic morphology in vitro. Consistently, the expression of constitutively activated PI3K, but not wild type PI3K, enhanced the PIP3 signaling pathway in these neurons. Importantly, overexpression of PI3Ks increased the success rate of axon regeneration in cortical neurons that underwent in vitro laser axotomy. Chapter IV aimed to identify the best method to deliver transgenes into the corticospinal tract by using AAVs. The choice of serotype and promoter has a crucial impact on gene therapy as it can ultimately depict whether it will be successful or unsuccessful. This study consisted of a direct comparison between the AAV1 and AAV5 viral vector serotypes and four promoters (CMV, mPGK, sCAG, synapsin) in their efficiency to express eGFP following injection at the sensory-motor cortex in mice and rats. The data suggests that AAV1 is the superior serotype to target layer V cortical neurons. Furthermore, the mPGK and synapsin promoters are superior over the other promoters to transduce the corticospinal tract. Chapter V is a summary and general discussion of the obtained results in dissertation. It highlights future perspectives of the current work and how the research contributes to advance the field of gene therapy and axon regeneration.
Published: 2019
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11. Essays on cross-sectionally dependent panel data with an application to fiscal policy in the European Monetary Union

Author: Van-Ark, Bart
Subjects: 339.5094
Abstract: In the past two decades, macroeconomists have used panel data to study the merits of fiscal policy for economic stabilisation. The datasets considered in these studies typically consist of a small number of time series corresponding to countries. This configuration does not match with the archetypical survey-style panel ataset for which a large literature concerning estimation and hypothesis testing exists. This PhD develops an estimation methodology that is catered towards macroeconomists: in four self-contained chapters, we develop a methodology for the estimation of dynamic models in the small N, large T framework in the presence of cross-sectional dependence in the error term. In the first chapter we examine the effect of factors on the point estimates of several commonly-used estimators in the empirical literature and we find that these estimators are inconsistent. We also propose an estimator that is consistent for the parameters for of the model studied in that chapter. In the second chapter we develop consistent quasi-difference GMM estimators and inferential procedures for the small N, large T dynamic panel data model with factor error structures. We also prove consistency and mixed-normality of the estimator when the number of factors is over-estimated. In the third chapter we consider the large N, large T framework and show the first eigenvalues of the covariance matrix of an approximate factor model are dominated by the factors whereas the remainder is controlled by the residual noise. We show that this result is the basis for any consistent inferential procedure about R and continues to hold when R grows large, when the factors are weak and, importantly, in the large N, large T interactive fixed effects model. In the fourth chapter we study fiscal policy using the methods developed in the thesis. We estimate vector autoregressions from European countries and restrict the impulse-response functions to adhere to the Stability and Growth Pact. We find that this one-size-fits-all approach is not appropriate for stabilization of the European economy.
Published: 2019

12. Induction of in vivo-like ciliation in confluent monolayers of re-differentiated equine oviduct epithelial cells

Author: Leemans, Bart, Gadella, Bart M, Marchand, Josephine H E A M, Van Soom, Ann, Stout, Tom A E, Leemans, Bart, Gadella, Bart M, Marchand, Josephine H E A M, Van Soom, Ann, and Stout, Tom A E
Abstract: We recently developed re-differentiated equine oviduct epithelial cell (REOEC) monolayers demonstrating various in vivo morphological characteristics, but lacking secondary ciliation. In this study, we evaluated the effects of fetal bovine serum, reproductive steroid hormones, Wnt- and Notch ligands and inhibitors, and different EOEC seeding densities, in both conventional wells and on microporous membranes, on EOEC morphology and, in particular, secondary ciliation. REOEC monolayers were assessed by confocal microscopy after combined staining of nuclei, cilia, and the cytoskeleton. Only Wnt ligands, Notch inhibitors and oviduct explant cell concentration affected EOEC morphology. Undesirable epithelial-mesenchymal transition was observed in REOEC monolayers exposed to Wnt3a containing medium and Wnt ligand CHIR 99021. With respect to secondary ciliation, only the combined effect of oviduct explant cell concentration and Notch inhibition steered REOEC monolayers to in vivo-like ciliation patterns. De-differentiated EOECs, formed 10 days after oviduct explant cell seeding, were reseeded on inserts; only at initial oviduct explant cell concentrations of 1 and 5 × 106 cells per well was the formation of REOEC monolayers with a high rate of diffuse ciliation supported. Within 1 month after air-liquid interface introduction, >40% and >20% of the REOECs showed secondary cilia, respectively. At higher oviduct explant cell seeding densities secondary ciliation was not supported after re-differentiation. Additionally, Notch inhibition helped boost secondary ciliation rates to >60% in REOEC monolayers with diffuse ciliation only. These monolayers demonstrated higher clathrin expression under follicular phase conditions. Overall, the ciliated REOEC monolayers better resemble in vivo oviduct epithelial cells than previous models.
Published: 2024

13. Symmetric Cryptography (Dagstuhl Seminar 24041)

Author: Christof Beierle and Bart Mennink and María Naya-Plasencia and Yu Sasaki and Rachelle Heim Boissier, Beierle, Christof, Mennink, Bart, Naya-Plasencia, María, Sasaki, Yu, Boissier, Rachelle Heim, Christof Beierle and Bart Mennink and María Naya-Plasencia and Yu Sasaki and Rachelle Heim Boissier, Beierle, Christof, Mennink, Bart, Naya-Plasencia, María, Sasaki, Yu, and Boissier, Rachelle Heim
Abstract: This report documents the program and the outcomes of Dagstuhl Seminar "Symmetric Cryptography" (24041). The seminar was held on January 21-26, 2024 in Schloss Dagstuhl - Leibniz Center for Informatics. This was the ninth seminar in the series "Symmetric Cryptography". Previous editions were held in 2007, 2009, 2012, 2014, 2016, 2018, 2020 and 2022. Participants of the seminar presented their ongoing work and new results on topics of cryptanalysis and (post-quantum) provable security of symmetric cryptographic primitives. Participants also worked together within seven research group dedicated to various topics (Cryptanalysis of Poseidon, Cryptanalysis of TEA-3, Exploitation of the wrong key randomization hypothesis non-conformity in key recovery attacks, Cryptanalysis of SCARF, Differential cryptanalysis and more, Key control security and Security of sponge combiners). In this report, a brief summary of the seminar is given, followed by the abstracts of given talks and a summary of the progress of each research group.
Published: 2024
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14. Certifying Without Loss of Generality Reasoning in Solution-Improving Maximum Satisfiability

Author: Jeremias Berg and Bart Bogaerts and Jakob Nordström and Andy Oertel and Tobias Paxian and Dieter Vandesande, Berg, Jeremias, Bogaerts, Bart, Nordström, Jakob, Oertel, Andy, Paxian, Tobias, Vandesande, Dieter, Jeremias Berg and Bart Bogaerts and Jakob Nordström and Andy Oertel and Tobias Paxian and Dieter Vandesande, Berg, Jeremias, Bogaerts, Bart, Nordström, Jakob, Oertel, Andy, Paxian, Tobias, and Vandesande, Dieter
Abstract: Proof logging has long been the established method to certify correctness of Boolean satisfiability (SAT) solvers, but has only recently been introduced for SAT-based optimization (MaxSAT). The focus of this paper is solution-improving search (SIS), in which a SAT solver is iteratively queried for increasingly better solutions until an optimal one is found. A challenging aspect of modern SIS solvers is that they make use of complex "without loss of generality" arguments that are quite involved to understand even at a human meta-level, let alone to express in a simple, machine-verifiable proof. In this work, we develop pseudo-Boolean proof logging methods for solution-improving MaxSAT solving, and use them to produce a certifying version of the state-of-the-art solver Pacose with VeriPB proofs. Our experimental evaluation demonstrates that this approach works in practice. We hope that this is yet another step towards general adoption of proof logging in MaxSAT solving.
Published: 2024
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15. A biophysical model of apple (Malus domestica Borkh.) and pear (Pyrus communis L.) fruit growth

Author: Dequeker, Bart, Šalagovič, Jakub, Retta, Moges, Verboven, Pieter, Nicolaï, Bart M., Dequeker, Bart, Šalagovič, Jakub, Retta, Moges, Verboven, Pieter, and Nicolaï, Bart M.
Abstract: Fruit mass and sugar content are important quality attributes of apple and pear fruit. During fruit growth, water and sugars accumulate as a result of the coordination of water and solid fluxes. This causes expansive growth driven by turgor pressure and controlled by cell mechanical properties. To analyse the effect of environmental conditions on fruit growth dynamics, a biophysical model of apple (Malus domestica Borkh.) and pear (Pyrus communis L.) fruit growth was developed and adapted from the Fishman-Génard model. Dynamically changing patterns of average fruit fresh mass, dry mass and soluble solid mass in response to the environmental conditions during multiple seasons of varying environmental conditions were well captured by a parameterised model for apple and pear fruit growth. Sensitivity analyses showed that the model was most sensitive to variations in parameters related to active transport, cell wall extensibility and plant water status. The model enabled the analysis of how fruit growth dynamics were affected by stress conditions. This model, which integrates biophysical laws and parameters governing fruit water and solute dynamics, may serve as a basis to investigate the role of the processes involved in the complex growing behavior of pome fruit, and to optimise and predict fruit growth and quality.
Published: 2024

16. A prediction model for electroconvulsive therapy effectiveness in patients with major depressive disorder from the Dutch ECT Consortium (DEC)

Author: Loef, Dore, Hoogendoorn, Adriaan W, Somers, Metten, Mocking, Roel J T, Scheepens, Dominique S, Scheepstra, Karel W F, Blijleven, Maaike, Hegeman, Johanna M, van den Berg, Karen S, Schut, Bart, Birkenhager, Tom K, Heijnen, Willemijn, Rhebergen, Didi, Oudega, Mardien L, Schouws, Sigfried N T M, van Exel, Eric, Rutten, Bart P F, Broekman, Birit F P, Vergouwen, Anton C M, Zoon, Thomas J C, Kok, Rob M, Somers, Karina, Verwijk, Esmée, Rovers, Jordy J E, Schuur, Gijsbert, van Waarde, Jeroen A, Verdijk, Joey P A J, Bloemkolk, Dieneke, Gerritse, Frank L, van Welie, Hanneke, Haarman, Bartholomeus C M, van Belkum, Sjoerd M, Vischjager, Maurice, Hagoort, Karin, van Dellen, Edwin, Tendolkar, Indira, van Eijndhoven, Philip F P, Dols, Annemiek, Loef, Dore, Hoogendoorn, Adriaan W, Somers, Metten, Mocking, Roel J T, Scheepens, Dominique S, Scheepstra, Karel W F, Blijleven, Maaike, Hegeman, Johanna M, van den Berg, Karen S, Schut, Bart, Birkenhager, Tom K, Heijnen, Willemijn, Rhebergen, Didi, Oudega, Mardien L, Schouws, Sigfried N T M, van Exel, Eric, Rutten, Bart P F, Broekman, Birit F P, Vergouwen, Anton C M, Zoon, Thomas J C, Kok, Rob M, Somers, Karina, Verwijk, Esmée, Rovers, Jordy J E, Schuur, Gijsbert, van Waarde, Jeroen A, Verdijk, Joey P A J, Bloemkolk, Dieneke, Gerritse, Frank L, van Welie, Hanneke, Haarman, Bartholomeus C M, van Belkum, Sjoerd M, Vischjager, Maurice, Hagoort, Karin, van Dellen, Edwin, Tendolkar, Indira, van Eijndhoven, Philip F P, and Dols, Annemiek
Abstract: Reliable predictors for electroconvulsive therapy (ECT) effectiveness would allow a more precise and personalized approach for the treatment of major depressive disorder (MDD). Prediction models were created using a priori selected clinical variables based on previous meta-analyses. Multivariable linear regression analysis was used, applying backwards selection to determine predictor variables while allowing non-linear relations, to develop a prediction model for depression outcome post-ECT (and logistic regression for remission and response as secondary outcome measures). Internal validation and internal-external cross-validation were used to examine overfitting and generalizability of the model's predictive performance. In total, 1892 adult patients with MDD were included from 22 clinical and research cohorts of the twelve sites within the Dutch ECT Consortium. The final primary prediction model showed several factors that significantly predicted a lower depression score post-ECT: higher age, shorter duration of the current depressive episode, severe MDD with psychotic features, lower level of previous antidepressant resistance in the current episode, higher pre-ECT global cognitive functioning, absence of a comorbid personality disorder, and a lower level of failed psychotherapy in the current episode. The optimism-adjusted R² of the final model was 19%. This prediction model based on readily available clinical information can reduce uncertainty of ECT outcomes and hereby inform clinical decision-making, as prompt referral for ECT may be particularly beneficial for individuals with the above-mentioned characteristics. However, despite including a large number of pretreatment factors, a large proportion of the variance in depression outcome post-ECT remained unpredictable.
Published: 2024

17. Blastobotrys nigripullensis, a new yeast species isolated from a fungal outbreak on an ancient Roman shipwreck in the Netherlands

Author: Visagie, Cobus M., Meijer, Martin, Kraak, Bart, Groenewald, Marizeth, Houbraken, Jos, Theelen, Bart, Vorst, Yardeni, Boekhout, Teun, Visagie, Cobus M., Meijer, Martin, Kraak, Bart, Groenewald, Marizeth, Houbraken, Jos, Theelen, Bart, Vorst, Yardeni, and Boekhout, Teun
Published: 2024

18. Nociceptive, neuropathic, or nociplastic low back pain?: The low back pain phenotyping (BACPAP) consortium's international and multidisciplinary consensus recommendations

Author: Nijs, Jo, Kosek, Eva, Chiarotto, Alessandro, Cook, Chad, Danneels, Lieven A, Fernández-de-Las-Peñas, César, Hodges, Paul W, Koes, Bart, Louw, Adriaan, Ostelo, Raymond, Scholten-Peeters, Gwendolyne G M, Sterling, Michele, Alkassabi, Othman, Alsobayel, Hana, Beales, Darren, Bilika, Paraskevi, Clark, Jacqui R, De Baets, Liesbet, Demoulin, Christophe, de Zoete, Rutger M J, Elma, Ömer, Gutke, Annelie, Hanafi, Rikard, Hotz Boendermaker, Sabina, Huysmans, Eva, Kapreli, Eleni, Lundberg, Mari, Malfliet, Anneleen, Meziat Filho, Ney, Reis, Felipe J J, Voogt, Lennard, Zimney, Kory, Smeets, Rob, Morlion, Bart, de Vlam, Kurt, George, Steven Z, Nijs, Jo, Kosek, Eva, Chiarotto, Alessandro, Cook, Chad, Danneels, Lieven A, Fernández-de-Las-Peñas, César, Hodges, Paul W, Koes, Bart, Louw, Adriaan, Ostelo, Raymond, Scholten-Peeters, Gwendolyne G M, Sterling, Michele, Alkassabi, Othman, Alsobayel, Hana, Beales, Darren, Bilika, Paraskevi, Clark, Jacqui R, De Baets, Liesbet, Demoulin, Christophe, de Zoete, Rutger M J, Elma, Ömer, Gutke, Annelie, Hanafi, Rikard, Hotz Boendermaker, Sabina, Huysmans, Eva, Kapreli, Eleni, Lundberg, Mari, Malfliet, Anneleen, Meziat Filho, Ney, Reis, Felipe J J, Voogt, Lennard, Zimney, Kory, Smeets, Rob, Morlion, Bart, de Vlam, Kurt, and George, Steven Z
Abstract: The potential to classify low back pain as being characterised by dominant nociceptive, neuropathic, or nociplastic mechanisms is a clinically relevant issue. Preliminary evidence suggests that these low back pain phenotypes might respond differently to treatments; however, more research must be done before making specific recommendations. Accordingly, the low back pain phenotyping (BACPAP) consortium was established as a group of 36 clinicians and researchers from 13 countries (five continents) and 29 institutions, to apply a modified Nominal Group Technique methodology to develop international and multidisciplinary consensus recommendations to provide guidance for identifying the dominant pain phenotype in patients with low back pain, and potentially adapt pain management strategies. The BACPAP consortium's recommendations are also intended to provide direction for future clinical research by building on the established clinical criteria for neuropathic and nociplastic pain. The BACPAP consortium's consensus recommendations are a necessary early step in the process to determine if personalised pain medicine based on pain phenotypes is feasible for low back pain management. Therefore, these recommendations are not ready to be implemented in clinical practice until additional evidence is generated that is specific to these low back pain phenotypes.
Published: 2024
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19. Contesting the BACPAP consortium's consensus – Authors' reply

Author: Kosek, Eva, Nijs, Jo, Chiarotto, Alessandro, Cook, Chad, Danneels, Lieven A., Fernández-de-las-Peñas, César, Hodges, Paul W., Koes, Bart, Louw, Adriaan, Ostelo, Raymond, Scholten-Peeters, Gwendolyne G.M., Sterling, Michele, Alkassabi, Othman, Alsobayel, Hana, Beales, Darren, Bilika, Paraskevi, Clark, Jacqui R., De Baets, Liesbet, Demoulin, Christophe, de Zoete, Rutger M.J., Elma, Ömer, Gutke, Annelie, Hanafi, Rikard, Boendermaker, Sabina Hotz, Huysmans, Eva, Kapreli, Eleni, Lundberg, Mari, Malfliet, Anneleen, Filho, Ney Meziat, Reis, Felipe J.J., Voogt, Lennard, Zimney, Kory, Smeets, Rob, Morlion, Bart, de Vlam, Kurt, George, Steven Z., Kosek, Eva, Nijs, Jo, Chiarotto, Alessandro, Cook, Chad, Danneels, Lieven A., Fernández-de-las-Peñas, César, Hodges, Paul W., Koes, Bart, Louw, Adriaan, Ostelo, Raymond, Scholten-Peeters, Gwendolyne G.M., Sterling, Michele, Alkassabi, Othman, Alsobayel, Hana, Beales, Darren, Bilika, Paraskevi, Clark, Jacqui R., De Baets, Liesbet, Demoulin, Christophe, de Zoete, Rutger M.J., Elma, Ömer, Gutke, Annelie, Hanafi, Rikard, Boendermaker, Sabina Hotz, Huysmans, Eva, Kapreli, Eleni, Lundberg, Mari, Malfliet, Anneleen, Filho, Ney Meziat, Reis, Felipe J.J., Voogt, Lennard, Zimney, Kory, Smeets, Rob, Morlion, Bart, de Vlam, Kurt, and George, Steven Z.
Published: 2024

20. Nociceptive, neuropathic, or nociplastic low back pain?:The low back pain phenotyping (BACPAP) consortium's international and multidisciplinary consensus recommendations

Author: Nijs, Jo, Kosek, Eva, Chiarotto, Alessandro, Cook, Chad, Danneels, Lieven A, Fernández-de-Las-Peñas, César, Hodges, Paul W, Koes, Bart, Louw, Adriaan, Ostelo, Raymond, Scholten-Peeters, Gwendolyne G M, Sterling, Michele, Alkassabi, Othman, Alsobayel, Hana, Beales, Darren, Bilika, Paraskevi, Clark, Jacqui R, De Baets, Liesbet, Demoulin, Christophe, de Zoete, Rutger M J, Elma, Ömer, Gutke, Annelie, Hanafi, Rikard, Hotz Boendermaker, Sabina, Huysmans, Eva, Kapreli, Eleni, Lundberg, Mari, Malfliet, Anneleen, Meziat Filho, Ney, Reis, Felipe J J, Voogt, Lennard, Zimney, Kory, Smeets, Rob, Morlion, Bart, de Vlam, Kurt, George, Steven Z, Nijs, Jo, Kosek, Eva, Chiarotto, Alessandro, Cook, Chad, Danneels, Lieven A, Fernández-de-Las-Peñas, César, Hodges, Paul W, Koes, Bart, Louw, Adriaan, Ostelo, Raymond, Scholten-Peeters, Gwendolyne G M, Sterling, Michele, Alkassabi, Othman, Alsobayel, Hana, Beales, Darren, Bilika, Paraskevi, Clark, Jacqui R, De Baets, Liesbet, Demoulin, Christophe, de Zoete, Rutger M J, Elma, Ömer, Gutke, Annelie, Hanafi, Rikard, Hotz Boendermaker, Sabina, Huysmans, Eva, Kapreli, Eleni, Lundberg, Mari, Malfliet, Anneleen, Meziat Filho, Ney, Reis, Felipe J J, Voogt, Lennard, Zimney, Kory, Smeets, Rob, Morlion, Bart, de Vlam, Kurt, and George, Steven Z
Abstract: The potential to classify low back pain as being characterised by dominant nociceptive, neuropathic, or nociplastic mechanisms is a clinically relevant issue. Preliminary evidence suggests that these low back pain phenotypes might respond differently to treatments; however, more research must be done before making specific recommendations. Accordingly, the low back pain phenotyping (BACPAP) consortium was established as a group of 36 clinicians and researchers from 13 countries (five continents) and 29 institutions, to apply a modified Nominal Group Technique methodology to develop international and multidisciplinary consensus recommendations to provide guidance for identifying the dominant pain phenotype in patients with low back pain, and potentially adapt pain management strategies. The BACPAP consortium's recommendations are also intended to provide direction for future clinical research by building on the established clinical criteria for neuropathic and nociplastic pain. The BACPAP consortium's consensus recommendations are a necessary early step in the process to determine if personalised pain medicine based on pain phenotypes is feasible for low back pain management. Therefore, these recommendations are not ready to be implemented in clinical practice until additional evidence is generated that is specific to these low back pain phenotypes.
Published: 2024

21. Non-Standard Errors

Author: Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, Van Dijk, Matthijs A., Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, and Van Dijk, Matthijs A.
Abstract: In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty—nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
Published: 2024

22. Endovascular treatment of patients with stroke caused by anterior cerebral artery occlusions

Author: Neurologen, Brain, Circulatory Health, Stroke, Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., van den Wijngaard, Ido R., Neurologen, Brain, Circulatory Health, Stroke, Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., and van den Wijngaard, Ido R.
Published: 2024

23. Using Smartphone Sensors for Ataxia Trials: Consensus Guidance by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers.

Author: Németh, Andrea, Németh, Andrea, Antoniades, Chrystalina, Dukart, Juergen, Minnerop, Martina, Rentz, Clara, Schuman, Bart-Jan, van de Warrenburg, Bart, Willemse, Ilse, Bertini, Enrico, Gupta, Anoopum, de Mello Monteiro, Carlos, Almoajil, Hajar, Quinn, Lori, Horak, Fay, Ilg, Winfried, Traschütz, Andreas, Vogel, Adam, Dawes, Helen, Perlman, Susan, Németh, Andrea, Németh, Andrea, Antoniades, Chrystalina, Dukart, Juergen, Minnerop, Martina, Rentz, Clara, Schuman, Bart-Jan, van de Warrenburg, Bart, Willemse, Ilse, Bertini, Enrico, Gupta, Anoopum, de Mello Monteiro, Carlos, Almoajil, Hajar, Quinn, Lori, Horak, Fay, Ilg, Winfried, Traschütz, Andreas, Vogel, Adam, Dawes, Helen, and Perlman, Susan
Abstract: Smartphone sensors are used increasingly in the assessment of ataxias. To date, there is no specific consensus guidance regarding a priority set of smartphone sensor measurements, or standard assessment criteria that are appropriate for clinical trials. As part of the Ataxia Global Initiative Digital-Motor Biomarkers Working Group (AGI WG4), aimed at evaluating key ataxia clinical domains (gait/posture, upper limb, speech and oculomotor assessments), we provide consensus guidance for use of internal smartphone sensors to assess key domains. Guidance was developed by means of a literature review and a two stage Delphi study conducted by an Expert panel, which surveyed members of AGI WG4, representing clinical, research, industry and patient-led experts, and consensus meetings by the Expert panel to agree on standard criteria and map current literature to these criteria. Seven publications were identified that investigated ataxias using internal smartphone sensors. The Delphi 1 survey ascertained current practice, and systems in use or under development. Wide variations in smartphones sensor use for assessing ataxia were identified. The Delphi 2 survey identified seven measures that were strongly endorsed as priorities in assessing 3/4 domains, namely gait/posture, upper limb, and speech performance. The Expert panel recommended 15 standard criteria to be fulfilled in studies. Evaluation of current literature revealed that none of the studies met all criteria, with most being early-phase validation studies. Our guidance highlights the importance of consensus, identifies priority measures and standard criteria, and will encourage further research into the use of internal smartphone sensors to measure ataxia digital-motor biomarkers.
Published: 2024

24. Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study

Author: Communicatie, Cardiovasculaire Epi Team 5, Neurologen, Brain, Circulatory Health, Stroke, Zonneveld, Thomas P., Vermeer, Sarah E., van Zwet, Erik W., Groot, Adrien E.D., Algra, Ale, Aerden, Leo A.M., Alblas, Kees C.L., de Beer, Frank, Brouwers, Paul J.A.M., de Gans, Koen, van Gemert, H. Maarten A., van Ginneken, Bart C.A.M., Grooters, Gerke S., Halkes, Patricia H.A., van der Heijden-Montfroy, Tonny A.M.H.G., Jellema, Korné, de Jong, Sonja W., Lövenich-Ciccarello, Harry, van der Meulen, Willem D.M., Peters, Edwin W., van der Ree, Taco C., Remmers, Michel J.M., Richard, Edo, Rovers, Jörgen M.P., Saxena, Ritu, van Schaik, Sander M., Schonewille, Wouter J., Schreuder, Tobien A.H.C.M.L., de Schryver, Els L.L.M., Schuiling, Wouter J., Spaander, Fianne H., van Tuijl, Julia H., Visser, Marieke C., Zinkstok, Sanne M., Zock, Elles, Dippel, Diederik W.J., Kappelle, L. Jaap, van Oostenbrugge, Robert J., Roos, Yvo B.W.E.M., Vermeij, Frederique H., Wermer, Marieke J.H., van der Worp, H. Bart, Nederkoorn, Paul J., Kruyt, Nyika D., Communicatie, Cardiovasculaire Epi Team 5, Neurologen, Brain, Circulatory Health, Stroke, Zonneveld, Thomas P., Vermeer, Sarah E., van Zwet, Erik W., Groot, Adrien E.D., Algra, Ale, Aerden, Leo A.M., Alblas, Kees C.L., de Beer, Frank, Brouwers, Paul J.A.M., de Gans, Koen, van Gemert, H. Maarten A., van Ginneken, Bart C.A.M., Grooters, Gerke S., Halkes, Patricia H.A., van der Heijden-Montfroy, Tonny A.M.H.G., Jellema, Korné, de Jong, Sonja W., Lövenich-Ciccarello, Harry, van der Meulen, Willem D.M., Peters, Edwin W., van der Ree, Taco C., Remmers, Michel J.M., Richard, Edo, Rovers, Jörgen M.P., Saxena, Ritu, van Schaik, Sander M., Schonewille, Wouter J., Schreuder, Tobien A.H.C.M.L., de Schryver, Els L.L.M., Schuiling, Wouter J., Spaander, Fianne H., van Tuijl, Julia H., Visser, Marieke C., Zinkstok, Sanne M., Zock, Elles, Dippel, Diederik W.J., Kappelle, L. Jaap, van Oostenbrugge, Robert J., Roos, Yvo B.W.E.M., Vermeij, Frederique H., Wermer, Marieke J.H., van der Worp, H. Bart, Nederkoorn, Paul J., and Kruyt, Nyika D.
Published: 2024

25. Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study

Author: de Veer, Rozanne C., van Hooff, Maria C., Werner, Ellen, Beuers, Ulrich, Drenth, Joost P.H., Cuperus, Frans J.C., van Hoek, Bart, Veldt, Bart J., Klemt-Kropp, Michael, van Meer, Suzanne, Verdonk, Robert C., Flink, Hajo J., Vrolijk, Jan Maarten, Gevers, Tom J.G., Ponsioen, Cyriel Y., ter Borg, Martijn J., Soufidi, Khalida, Boersma, Femke, de Jonge, Hendrik J.M., Wolfhagen, Frank H.J., Baak, L. C., Onderwater, Susanne L., van Bergeijk, Jeroen D., van Putten, Paul G., Adang, Rob P.R., Aparicio-Pages, Maria N., de Boer, Wink, ter Borg, Frank, van Soest, Hanneke, Janssen, Harry L.A., Hansen, Bettina E., Erler, Nicole S., van der Meer, Adriaan J., de Veer, Rozanne C., van Hooff, Maria C., Werner, Ellen, Beuers, Ulrich, Drenth, Joost P.H., Cuperus, Frans J.C., van Hoek, Bart, Veldt, Bart J., Klemt-Kropp, Michael, van Meer, Suzanne, Verdonk, Robert C., Flink, Hajo J., Vrolijk, Jan Maarten, Gevers, Tom J.G., Ponsioen, Cyriel Y., ter Borg, Martijn J., Soufidi, Khalida, Boersma, Femke, de Jonge, Hendrik J.M., Wolfhagen, Frank H.J., Baak, L. C., Onderwater, Susanne L., van Bergeijk, Jeroen D., van Putten, Paul G., Adang, Rob P.R., Aparicio-Pages, Maria N., de Boer, Wink, ter Borg, Frank, van Soest, Hanneke, Janssen, Harry L.A., Hansen, Bettina E., Erler, Nicole S., and van der Meer, Adriaan J.
Abstract: Background & Aims: Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through the nationwide Dutch PBC Cohort Study (DPCS). Methods: DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals. Incidence and prevalence were assessed between 2008-2018 by Poisson regression between sex and age groups over time. Results: On the 1st of January 2008, there were 1,458 patients with PBC in the Netherlands. Between 2008-2018, 2,187 individuals were newly diagnosed, 46 were transplanted and 468 died. The yearly incidence of PBC in 2008 was 1.38, increasing to 1.74 per 100,000 persons in 2018. When compared to those aged <45 years, females aged 45-64 years (adjusted incidence rate ratio 4.21, 95% CI 3.76-4.71, p <0.001) and males ≥65 years (adjusted incidence rate ratio 14.41, 95% CI 9.62-21.60, p <0.001) were at the highest risk of being diagnosed with PBC. The male-to-female ratio of patients newly diagnosed with PBC during the study period was 1:14 in those <45 years, 1:10 in patients aged 45-64 years, and 1:4 in those ≥65 years. Point prevalence increased from 11.9 in 2008 to 21.5 per 100,000 persons in 2018. Average annual percent change in this time period was 5.94% (95% CI 5.77-6.15, p <0.05), and was the highest among the population aged ≥65 years (5.69%, 95% CI 5.32-6.36, p <0.001). Conclusions: In this nationwide cohort study, we observed an increase in both the incidence and prevalence of PBC in the Netherlands over the past decade, with marked age and sex differences. Impact and implications: This nationwide Dutch primary biliary
Published: 2024

26. Nonstandard Errors

Author: Universidad de Alicante. Departamento de Economía Financiera y Contabilidad, Menkveld, Albert J., Dreber, Anna, Holzmeister, Felix, Huber, Juergen, Johannesson, Magnus, Kirchler, Michael, Neusüß, Sebastian, Razen, Michael, Weitzel, Utz, Abad, David, Abudy, Menachem (Meni), Adrian, Tobias, Ait-Sahalia, Yacine, Akmansoy, Olivier, Alcock, Jamie T., Alexeev, Vitali, Aloosh, Arash, Amato, Livia, Amaya, Diego, Angel, James J., Avetikian, Alejandro T., Bach, Amadeus, Baidoo, Edwin, Bakalli, Gaetan, Bao, Li, Barbon, Andrea, Bashchenko, Oksana, Bindra, Parampreet C., Bjønnes, Geir H., Black, Jeffrey R., Black, Bernard S., Bogoev, Dimitar, Bohorquez Correa, Santiago, Bondarenko, Oleg, Bos, Charles S., Bosch-Rosa, Ciril, Bouri, Elie, Brownlees, Christian, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera Romero, Laura M., Caporin, Massimiliano, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chen, Jian, Chernov, Mikhail, Cheung, William, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung-Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca F., Declerck, Fany, Deev, Oleg, Degryse, Hans, Deku, Solomon Y., Desagre, Christophe, Van Dijk, Mathijs A., Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip A., Dudda, Tom, Duevski, Teodor, Dumitrescu, Ariadna, Dyakov, Teodor, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, Ellen, Saskia Ter, Eugster, Nicolas, Evans, Martin D. D., Farrell, Michael, Felez-Vinas, Ester, Ferrara, Gerardo, Ferrouhi, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan T., Foley, Sean D. V., Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco, Frijns, Bart, Frömmel, Michael, Fu, Servanna M., Füllbrunn, Sascha C., Gan, Baoqing, Gao, Ge, Gehrig, Thomas P., Gemayel, Roland, Gerritsen, Dirk, Gil-Bazo, Javier, Gilder, Dudley, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Grammig, Joachim, Grégoire, Vincent, Güçbilmez, Ufuk, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, He, Xue-Zhong (Tony), Heath, Davidson, Hediger, Simon, Hendershott, Terrence, Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth A., Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ilczuk, Konrad, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylhä, Petri, Kaeck, Andreas T., Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, Van Kervel, Vincent, Khan, Saad A., Khomyn, Marta K., Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Krahnen, Jan P., Kuhle, Paul, Kwan, Amy, Lajaunie, Quentin, Lam, F. Y. Eric C., Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, Hui, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver, Liu, Jiacheng, Liu, Anqi, Llorente, Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis, Lopez-Lira, Alejandro, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah, Mi, Michael G., Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Norden, Lars L., O'neill, Peter, Obaid, Khaled, Ødegaard, Bernt A., Östberg, Per, Pagnotta, Emiliano, Painter, Marcus, Palan, Stefan, Palit, Imon J., Park, Andreas, Pascual, Roberto, Pasquariello, Paolo, Pastor, Lubos, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelli, Michele, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Press, Oliver-Alexander, Prodromou, Tina, Prokopczuk, Marcel, Putnins, Talis, Qian, Ya, Raizada, Gaurav, Rakowski, David, Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Renjie, Rex W., Reno, Roberto, Riddiough, Steven J., Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Roesch, Dominik, Rognone, Lavinia, Roseman, Brian, Roşu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen R., Rzayev, Khaladdin, Rzeźnik, Aleksandra A., Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus R., Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Seeger, Norman J., Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Sönksen, Jantje, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nick, Tham, Wing Wah, Theissen, Erik, Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Vaduva, M. Andreea, Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, Van Der Wel, Michel, Werner, Ingrid M., Westerholm, P. Joakim, Westheide, Christian, Wika, Hans C., Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Wu, Zhen-Xing, Xia, Shuo, Xiu, Dacheng, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Yihe, Yu, Shihao, Yueshen, Bart Z., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan M., Zhang, Lu, Zhang, S. Sarah, Zhang, Xiaoyu, Zhao, Lu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu S., Zoican, Marius, Zwinkels, Remco, Universidad de Alicante. Departamento de Economía Financiera y Contabilidad, Menkveld, Albert J., Dreber, Anna, Holzmeister, Felix, Huber, Juergen, Johannesson, Magnus, Kirchler, Michael, Neusüß, Sebastian, Razen, Michael, Weitzel, Utz, Abad, David, Abudy, Menachem (Meni), Adrian, Tobias, Ait-Sahalia, Yacine, Akmansoy, Olivier, Alcock, Jamie T., Alexeev, Vitali, Aloosh, Arash, Amato, Livia, Amaya, Diego, Angel, James J., Avetikian, Alejandro T., Bach, Amadeus, Baidoo, Edwin, Bakalli, Gaetan, Bao, Li, Barbon, Andrea, Bashchenko, Oksana, Bindra, Parampreet C., Bjønnes, Geir H., Black, Jeffrey R., Black, Bernard S., Bogoev, Dimitar, Bohorquez Correa, Santiago, Bondarenko, Oleg, Bos, Charles S., Bosch-Rosa, Ciril, Bouri, Elie, Brownlees, Christian, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera Romero, Laura M., Caporin, Massimiliano, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chen, Jian, Chernov, Mikhail, Cheung, William, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung-Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca F., Declerck, Fany, Deev, Oleg, Degryse, Hans, Deku, Solomon Y., Desagre, Christophe, Van Dijk, Mathijs A., Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip A., Dudda, Tom, Duevski, Teodor, Dumitrescu, Ariadna, Dyakov, Teodor, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, Ellen, Saskia Ter, Eugster, Nicolas, Evans, Martin D. D., Farrell, Michael, Felez-Vinas, Ester, Ferrara, Gerardo, Ferrouhi, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan T., Foley, Sean D. V., Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco, Frijns, Bart, Frömmel, Michael, Fu, Servanna M., Füllbrunn, Sascha C., Gan, Baoqing, Gao, Ge, Gehrig, Thomas P., Gemayel, Roland, Gerritsen, Dirk, Gil-Bazo, Javier, Gilder, Dudley, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Grammig, Joachim, Grégoire, Vincent, Güçbilmez, Ufuk, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, He, Xue-Zhong (Tony), Heath, Davidson, Hediger, Simon, Hendershott, Terrence, Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth A., Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ilczuk, Konrad, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylhä, Petri, Kaeck, Andreas T., Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, Van Kervel, Vincent, Khan, Saad A., Khomyn, Marta K., Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Krahnen, Jan P., Kuhle, Paul, Kwan, Amy, Lajaunie, Quentin, Lam, F. Y. Eric C., Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, Hui, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver, Liu, Jiacheng, Liu, Anqi, Llorente, Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis, Lopez-Lira, Alejandro, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah, Mi, Michael G., Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Norden, Lars L., O'neill, Peter, Obaid, Khaled, Ødegaard, Bernt A., Östberg, Per, Pagnotta, Emiliano, Painter, Marcus, Palan, Stefan, Palit, Imon J., Park, Andreas, Pascual, Roberto, Pasquariello, Paolo, Pastor, Lubos, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelli, Michele, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Press, Oliver-Alexander, Prodromou, Tina, Prokopczuk, Marcel, Putnins, Talis, Qian, Ya, Raizada, Gaurav, Rakowski, David, Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Renjie, Rex W., Reno, Roberto, Riddiough, Steven J., Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Roesch, Dominik, Rognone, Lavinia, Roseman, Brian, Roşu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen R., Rzayev, Khaladdin, Rzeźnik, Aleksandra A., Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus R., Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Seeger, Norman J., Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Sönksen, Jantje, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nick, Tham, Wing Wah, Theissen, Erik, Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Vaduva, M. Andreea, Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, Van Der Wel, Michel, Werner, Ingrid M., Westerholm, P. Joakim, Westheide, Christian, Wika, Hans C., Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Wu, Zhen-Xing, Xia, Shuo, Xiu, Dacheng, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Yihe, Yu, Shihao, Yueshen, Bart Z., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan M., Zhang, Lu, Zhang, S. Sarah, Zhang, Xiaoyu, Zhao, Lu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu S., Zoican, Marius, and Zwinkels, Remco
Abstract: In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty—nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
Published: 2024

27. Microscopic model for a Brownian translator

Author: Wijns, Bart, Eichhorn, Ralf, Cleuren, Bart, Wijns, Bart, Eichhorn, Ralf, and Cleuren, Bart
Abstract: A microscopic model for a translational Brownian motor, dubbed a Brownian translator, is introduced. It is inspired by the Brownian gyrator described by Filliger and Reimann (2007 Phys. Rev. Lett. 99 230602). The Brownian translator consists of a spatially asymmetric object moving freely along a line due to perpetual collisions with a surrounding ideal gas. When this gas has an anisotropic temperature, both spatial and temporal symmetries are broken and the object acquires a nonzero drift. Onsager reciprocity implies the opposite phenomenon, that is dragging a spatially asymmetric object into an (initially at) equilibrium gas induces an energy flow that results in anisotropic gas temperatures. Expressions for the dynamical and energetic properties are derived as a series expansion in the mass ratio (of gas particle vs. object). These results are in excellent agreement with molecular dynamics simulations., QC 20240516
Published: 2024
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28. In-hospital stroke care pathways: possibilities for improvement

Author: AIOS Anesthesiologie, Kalkman, Cor, van der Worp, Bart, Arbous, M.S., Geerts, Bart, van Valburg, Mariel, AIOS Anesthesiologie, Kalkman, Cor, van der Worp, Bart, Arbous, M.S., Geerts, Bart, and van Valburg, Mariel
Published: 2024

29. Surgical versus conservative treatment for odontoid fractures in older people: an international prospective comparative study

Author: MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Neurochirurgen, Huybregts, Jeroen G.J., Polak, Samuel B., Jacobs, Wilco C., Arts, Mark P., Meyer, Bernhard, Wostrack, Maria, Butenschön, Vicki M., Osti, Michael, Öner, F. Cumhur, Slooff, Willem Bart M., Feller, Ricardo E., Bouma, Gert Joan, Harhangi, Biswadjiet S., Depreitere, Bart, Nygaard, Øystein P., Weber, Clemens, Müller, Kay, Timothy, Jake, Pellisé, Ferran, Rasmussen, Mikkel M., van Zwet, Erik W., Steyerberg, Ewout W., Peul, Wilco C., Vleggeert-Lankamp, Carmen L.A., MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Neurochirurgen, Huybregts, Jeroen G.J., Polak, Samuel B., Jacobs, Wilco C., Arts, Mark P., Meyer, Bernhard, Wostrack, Maria, Butenschön, Vicki M., Osti, Michael, Öner, F. Cumhur, Slooff, Willem Bart M., Feller, Ricardo E., Bouma, Gert Joan, Harhangi, Biswadjiet S., Depreitere, Bart, Nygaard, Øystein P., Weber, Clemens, Müller, Kay, Timothy, Jake, Pellisé, Ferran, Rasmussen, Mikkel M., van Zwet, Erik W., Steyerberg, Ewout W., Peul, Wilco C., and Vleggeert-Lankamp, Carmen L.A.
Published: 2024

30. Surgical versus conservative treatment for odontoid fractures in older people:an international prospective comparative study

Author: Huybregts, Jeroen G.J., Polak, Samuel B., Jacobs, Wilco C., Arts, Mark P., Meyer, Bernhard, Wostrack, Maria, Butenschön, Vicki M., Osti, Michael, Öner, F. Cumhur, Slooff, Willem Bart M., Feller, Ricardo E., Bouma, Gert Joan, Harhangi, Biswadjiet S., Depreitere, Bart, Nygaard, Øystein P., Weber, Clemens, Müller, Kay, Timothy, Jake, Pellisé, Ferran, Rasmussen, Mikkel M., van Zwet, Erik W., Steyerberg, Ewout W., Peul, Wilco C., Vleggeert-Lankamp, Carmen L.A., Huybregts, Jeroen G.J., Polak, Samuel B., Jacobs, Wilco C., Arts, Mark P., Meyer, Bernhard, Wostrack, Maria, Butenschön, Vicki M., Osti, Michael, Öner, F. Cumhur, Slooff, Willem Bart M., Feller, Ricardo E., Bouma, Gert Joan, Harhangi, Biswadjiet S., Depreitere, Bart, Nygaard, Øystein P., Weber, Clemens, Müller, Kay, Timothy, Jake, Pellisé, Ferran, Rasmussen, Mikkel M., van Zwet, Erik W., Steyerberg, Ewout W., Peul, Wilco C., and Vleggeert-Lankamp, Carmen L.A.
Abstract: Background: The optimal treatment for odontoid fractures in older people remains debated. Odontoid fractures are increasingly relevant to clinical practice due to ageing of the population.Methods: An international prospective comparative study was conducted in fifteen European centres, involving patients aged ≥55 years with type II/III odontoid fractures. The surgeon and patient jointly decided on the applied treatment. Surgical and conservative treatments were compared. Primary outcomes were Neck Disability Index (NDI) improvement, fracture union and stability at 52 weeks. Secondary outcomes were Visual Analogue Scale neck pain, Likert patient-perceived recovery and EuroQol-5D-3L at 52 weeks. Subgroup analyses considered age, type II and displaced fractures. Multivariable regression analyses adjusted for age, gender and fracture characteristics. Results: The study included 276 patients, of which 144 (52%) were treated surgically and 132 (48%) conservatively (mean (SD) age 77.3 (9.1) vs. 76.6 (9.7), P = 0.56). NDI improvement was largely similar between surgical and conservative treatments (mean (SE) −11 (2.4) vs. −14 (1.8), P = 0.08), as were union (86% vs. 78%, aOR 2.3, 95% CI 0.97–5.7) and stability (99% vs. 98%, aOR NA). NDI improvement did not differ between patients with union and persistent non-union (mean (SE) −13 (2.0) vs. −12 (2.8), P = 0.78). There was no difference for any of the secondary outcomes or subgroups. Conclusions: Clinical outcome and fracture healing at 52 weeks were similar between treatments. Clinical outcome and fracture union were not associated. Treatments should prioritize favourable clinical over radiological outcomes.
Published: 2024

31. Diagnosis and management of isolated serous tubal intraepithelial carcinoma: A qualitative focus group study

Author: Negri, S, Fisch, C, de Hullu, J, van Bommel, M, Simons, M, Bogaerts, J, Apperloo, M, Baiocchi, G, Bakker, J, Bart, J, van Beekhuizen, H, Bernardini, M, Boere, I, Bulten, J, Chen, L, Chrzan, A, Dorum, A, Ewing-Graham, P, Ferrero, A, Floter Radestad, A, Fruscio, R, Gaarenstroom, K, Garcia, C, Harter, P, Hoogstad-van Evert, J, de Iaco, P, Klooster, A, Kooreman, L, Jacobsen, M, Kruse, A, Kwon, J, Lawson, B, Lax, S, van Lonkhuijzen, L, Lu, K, Manchanda, R, Marchetti, C, Mccluggage, W, Mcnally, O, Mourits, M, Nicum, S, Norquist, B, Perrone, A, Piek, J, Polastro, L, Polee, M, Rabban, J, Reesink, N, de los Reyes Oliver Perez, M, Roes, E, Rychlik, A, Shih, I, Soong, T, Speiser, P, Stone, R, Tamussino, K, Tognon, G, Tuninetti, V, Valabrega, G, Vos, M, Welz, J, Zizioli, V, Hermens, R, Steenbeek, M, Negri S., Fisch C., de Hullu J. A., van Bommel M., Simons M., Bogaerts J., Apperloo M. J. A., Baiocchi G., Bakker J. L., Bart J., van Beekhuizen H. J., Bernardini M. Q., Boere I., Bulten J., Chen L. -M., Chrzan A., Dorum A., Ewing-Graham P. C., Ferrero A., Floter Radestad A., Fruscio R., Gaarenstroom K. N., Garcia C., Harter P., Hoogstad-van Evert J. S., de Iaco P., Klooster A., Kooreman L. F. S., Jacobsen M., Kruse A. -J., Kwon J. S., Lawson B. C., Lax S. F., van Lonkhuijzen L. R. C. W., Lu K. H., Manchanda R., Marchetti C., McCluggage W. G., McNally O. M., Mourits M. J. E., Nicum S., Norquist B. M., Perrone A. M., Piek J. M. J., Polastro L., Polee M. B., Rabban J. T., Reesink N., de los Reyes Oliver Perez M., Roes E. -M., Rychlik A., Shih I. -M., Soong T. R., Speiser P., Stone R. L., Tamussino K., Tognon G., Tuninetti V., Valabrega G., Vos M. C., Welz J., Zizioli V., Hermens R. P. M. G., Steenbeek M. P., Negri, S, Fisch, C, de Hullu, J, van Bommel, M, Simons, M, Bogaerts, J, Apperloo, M, Baiocchi, G, Bakker, J, Bart, J, van Beekhuizen, H, Bernardini, M, Boere, I, Bulten, J, Chen, L, Chrzan, A, Dorum, A, Ewing-Graham, P, Ferrero, A, Floter Radestad, A, Fruscio, R, Gaarenstroom, K, Garcia, C, Harter, P, Hoogstad-van Evert, J, de Iaco, P, Klooster, A, Kooreman, L, Jacobsen, M, Kruse, A, Kwon, J, Lawson, B, Lax, S, van Lonkhuijzen, L, Lu, K, Manchanda, R, Marchetti, C, Mccluggage, W, Mcnally, O, Mourits, M, Nicum, S, Norquist, B, Perrone, A, Piek, J, Polastro, L, Polee, M, Rabban, J, Reesink, N, de los Reyes Oliver Perez, M, Roes, E, Rychlik, A, Shih, I, Soong, T, Speiser, P, Stone, R, Tamussino, K, Tognon, G, Tuninetti, V, Valabrega, G, Vos, M, Welz, J, Zizioli, V, Hermens, R, Steenbeek, M, Negri S., Fisch C., de Hullu J. A., van Bommel M., Simons M., Bogaerts J., Apperloo M. J. A., Baiocchi G., Bakker J. L., Bart J., van Beekhuizen H. J., Bernardini M. Q., Boere I., Bulten J., Chen L. -M., Chrzan A., Dorum A., Ewing-Graham P. C., Ferrero A., Floter Radestad A., Fruscio R., Gaarenstroom K. N., Garcia C., Harter P., Hoogstad-van Evert J. S., de Iaco P., Klooster A., Kooreman L. F. S., Jacobsen M., Kruse A. -J., Kwon J. S., Lawson B. C., Lax S. F., van Lonkhuijzen L. R. C. W., Lu K. H., Manchanda R., Marchetti C., McCluggage W. G., McNally O. M., Mourits M. J. E., Nicum S., Norquist B. M., Perrone A. M., Piek J. M. J., Polastro L., Polee M. B., Rabban J. T., Reesink N., de los Reyes Oliver Perez M., Roes E. -M., Rychlik A., Shih I. -M., Soong T. R., Speiser P., Stone R. L., Tamussino K., Tognon G., Tuninetti V., Valabrega G., Vos M. C., Welz J., Zizioli V., Hermens R. P. M. G., and Steenbeek M. P.
Abstract: Objective: A Serous Tubal Intraepithelial Carcinoma (STIC) without concomitant invasive carcinoma is occasionally identified and associated with a high risk of subsequent peritoneal carcinomatosis. Management needs optimisation. This study explores professionals' opinions and clinical practices regarding the diagnosis, counselling, treatment and follow-up of isolated STIC to facilitate clinical decision making and optimise the direction of future research. A secondary aim is to assess international clinical guidelines. Design: Focus group study. Setting: Four online sessions. Population: International panel (n = 12 countries) of gynaecologists, gynaecologic oncologists, pathologists and medical oncologists (n = 49). Methods: A semi-structured interview guide was used. Two independent researchers analysed transcripts by open and axial coding. Results were organised in domains. Relevant (inter)national guidelines were screened for recommendations regarding isolated STIC. Main Outcome Measures: Professionals' opinions and clinical practices regarding isolated STIC management. Results: Regarding pathology, most professionals identified the SEE-FIM protocol as standard of care for high-risk patients, whereas variation exists in the histopathological examination of fallopian tubes in the general population. Confirmation of STIC diagnosis by a specialised pathologist was recommended. Regarding work-up and follow-up after STIC diagnosis, there was variety and discordance. Data on outcomes is limited. As for treatment, chemotherapy and PARP inhibitors were not recommended by most. Eleven guidelines provided limited recommendations. Conclusions: We identified recommendations and highlighted knowledge gaps in the diagnosis and management of isolated STIC. Moreover, recommendations in clinical guidelines are limited. There is an agreed need for international collaboration for the prospective registration of isolated STIC.
Published: 2024

32. Endovascular treatment of patients with stroke caused by anterior cerebral artery occlusions

Author: Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., van den Wijngaard, Ido R., Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., and van den Wijngaard, Ido R.
Abstract: Background: Occlusion of the anterior cerebral artery (ACA) is uncommon but may lead to significant disability. The benefit of endovascular treatment (EVT) for ACA occlusions remains uncertain. Methods: We included patients treated with EVT and compared patients with ACA occlusions with patients who had internal carotid artery (ICA) or proximal (M1/M2) middle cerebral artery (MCA) occlusions from the MR CLEAN Registry. Primary outcome was the modified Rankin Scale score (mRS). Secondary outcomes were functional independence (mRS 0–2), National Institutes of Health Stroke Scale (NIHSS) score, delta-NIHSS (baseline minus NIHSS score at 24–48 h), and successful recanalization (expanded thrombolysis in cerebral infarction (eTICI) score 2b-3). Safety outcomes were symptomatic intracranial hemorrhage (sICH), periprocedural complications, and mortality. Results: Of 5193 patients, 11 (0.2%) had primary ACA occlusions. Median NIHSS at baseline was lower in patients with ACA versus ICA/MCA occlusions (11, IQR 9–14; versus 15, IQR 11–19). Functional outcome did not differ from patients with ICA/MCA occlusions. Functional independence was 4/11 (36%) in patients with ACA versus 1949/4815 (41%) in ICA/MCA occlusions; median delta-NIHSS was − 1 (IQR − 7 to 2) and − 4 (IQR − 9 to 0), respectively. Successful recanalization was 4/9 (44%), versus 3083/4787 (64%) in ICA/MCA occlusions. Mortality was 3/11 (27%) versus 1263/4815 (26%). One patient with ACA occlusion had sICH; no other complications occurred. Conclusion: In this cohort ACA occlusions were uncommon. Functional outcome did not differ between patients with ACA occlusions and ICA/MCA occlusions. Prospective research is needed to determine feasibility, safety, and outcomes of EVT for ACA occlusions.
Published: 2024

33. Fireworks disturbance across bird communities

Author: Hoekstra, Bart, Bouten, Willem, Dokter, Adriaan, van Gasteren, Hans, van Turnhout, Chris, Kranstauber, Bart, van Loon, Emiel, Leijnse, Hidde, Shamoun-Baranes, Judy, Hoekstra, Bart, Bouten, Willem, Dokter, Adriaan, van Gasteren, Hans, van Turnhout, Chris, Kranstauber, Bart, van Loon, Emiel, Leijnse, Hidde, and Shamoun-Baranes, Judy
Abstract: Fireworks are important elements of celebrations globally, but little is known about their effects on wildlife. The synchronized and extraordinary use of fireworks on New Year's Eve triggers strong flight responses in birds. We used weather radar and systematic bird counts to quantify how flight responses differed across habitats and corresponding bird communities, and determined the distance-dependence of this relationship. On average, approximately 1000 times as many birds were in flight on New Year's Eve than on other nights. We found that fireworks-related disturbance decreased with distance, most strongly in the first five kilometers, but overall flight activity remained elevated tenfold at distances up to about 10 km. Communities of large-bodied species displayed a stronger response than communities of small-bodied species. Given the pervasive nature of this disturbance, the establishment of large fireworks-free zones or centralizing fireworks within urban centers could help to mitigate their effects on birds. Conservation action should prioritize avian communities with the most disturbance-prone, large-bodied bird species.
Published: 2024

34. The Additional Value of Somatostatin Receptor Positron Emission Computed Tomography ([68Ga]Ga-DOTATOC PET/CT) Compared with Magnetic Resonance Imaging of the Head and Neck Region in Paraganglioma Patients: A Pilot Study

Author: Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, MS Radiologie, Cancer, MS Endocriene Oncologie, Brain, MS Radiotherapie, MS Hoofd-Hals Chirurgische Oncologie, Regenerative Medicine and Stem Cells, MS KNO, de Bresser, Carolijn J.M., Petri, Bart Jeroen, Braat, Arthur J.A.T., de Keizer, Bart, van Treijen, Mark J.C., Dankbaar, Jan Willem, Pameijer, Frank A., Kok, Marius G.J., de Ridder, Mischa, van Nesselrooij, Bernadette P.M., de Bree, Remco, de Borst, Gert J., Rijken, Johannes A., Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, MS Radiologie, Cancer, MS Endocriene Oncologie, Brain, MS Radiotherapie, MS Hoofd-Hals Chirurgische Oncologie, Regenerative Medicine and Stem Cells, MS KNO, de Bresser, Carolijn J.M., Petri, Bart Jeroen, Braat, Arthur J.A.T., de Keizer, Bart, van Treijen, Mark J.C., Dankbaar, Jan Willem, Pameijer, Frank A., Kok, Marius G.J., de Ridder, Mischa, van Nesselrooij, Bernadette P.M., de Bree, Remco, de Borst, Gert J., and Rijken, Johannes A.
Published: 2024

35. Non-Standard Errors

Author: Leerstoel Stigchel, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), Finance, UU LEG Research UUSE Multidisciplinary Economics, Sub General Pharmaceutics, Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, Van Dijk, Matthijs A., Leerstoel Stigchel, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), Finance, UU LEG Research UUSE Multidisciplinary Economics, Sub General Pharmaceutics, Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, and Van Dijk, Matthijs A.
Published: 2024

36. Dynamic Capabilities: History and an Extension

Author: Nooteboom, Bart
Published: 2022
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37. What Artistry Can Do: Essays on Art and Beauty

Author: Verschaffel, Bart
Published: 2022

38. Nutrient limitation in Clostridium autoethanogenum and characterisation of its carbonic anhydrase

Author: Pander, Bart
Subjects: 579.3, QP501 Animal biochemistry
Abstract: Clostridium autoethanogenum is an anaerobic, facultative autotrophic bacterium that was isolated from rabbit faces in the last decennium of the twentieth century. It is used to convert carbon monoxide rich waste gas in to compounds such as acetate, ethanol, 2,3-butanediol and lactate. Carbon dioxide reacts with water to form carbonic acid and bicarbonate. This reaction is catalysed by enzymes called carbonic anhydrases. It was unknown if these enzymes were present in C. autoethanogenum. Genes encoding putative carbonic anhydrases were cloned and heterologous expressed. One gene encoded an active enzyme of a novel sub-clade of β-carbonic anhydrases. This gene was disrupted in the genome of C. autoethanogenum. The mutant was unable to grow at low pH and low carbon dioxide concentrations. Production of ethanol and 2,3-butanediol by WT C. autoethanogenum in carbon monoxide fed chemostat cultures was improved by employing phosphate limitation. A pilot study on the effect of phosphate limitation on rhamnose based growth showed 1,2-propanol and 1-propanol as native products of C. autoethanogenum. Acetolactate is the metabolic branch point for both branched chain amino acid and 2,3-butanediol production. An acetolactate synthase gene was deleted. The resulting mutant shows a subtle growth difference in media containing amino acids. Finally the strength of a series of heterologous promoters was determined in C. autoethanogenum. The research presented in this thesis improves our knowledge on C. autoethanogenum’s metabolism and offers tools to optimise it for product formation. This will enable improved exploitation of this organism for a carbon neutral future.
Published: 2018

39. Variability in neuromotor control of the musculoskeletal system dynamics : a stochastic modelling approach

Author: van Veen, Bart, Viceconti, Marco, and Mazzà, Claudia
Subjects: 612
Abstract: Pain, injuries or diseases might affect how we (are able to) coordinate movement. Therefore, an in-depth understanding of motor control, human movement dynamics and how pathologies affect movement coordination is essential to inform clinical practice that aims to improve the quality of movement in patients and therewith their quality of life. Musculoskeletal models allow for efficient simulations of human movement dynamics to predict the forces in muscles and joints in a non-invasive manner. However, assumptions on motor control are required to solve Bernstein's problem of muscle redundancy: the large number of muscles relative to the number of joints requires the controller, our central nervous system, to choose how each muscle contributes to the forces that result in the intended movement. For healthy people, it seems reasonable to assume that we control our muscles following an optimality principle: to minimize the amount of metabolic energy spent on the task. However, a disease, pain or instability are likely to influence a patient's control strategy; muscle control might be less optimal and more, or less, variable, depending on a person's ability or need to control force production. Therefore, the general aim of this thesis was to explore the variability in motor control of the musculoskeletal dynamics during walking through a stochastic modelling approach. Firstly, I discussed the theoretical framework to model human movement dynamics and the current efforts to verify and validate musculoskeletal models, with the aim to quantify the errors in their predictions. Secondly, I aimed to explore the influence of motor control on the mechanical load experienced by the joints of the lower limb during level walking. An optimization approach to motor control showed that alternative motor control strategies have the potential to reduce the loading in the knee and the hip, but not in the ankle, during level walking. These results suggest that neuromuscular rehabilitation can be targeted as a conservative treatment when the mechanical load on joints is a determinant of the onset and/or progression of a disease. However, these alternative motor control strategies come at a cost of a moderate increase in the loading at non-targeted joints. Subsequently, the assumption of a lightly sub-optimal motor control strategy to predict knee contact forces, through a stochastic approach to model motor control, captured the measured intra-subject variability in these forces during multiple gait cycles of a patient with a knee replacement. Therefore, the assumption of sub-optimal control can predict a range of plausible joint contact forces, representative of the uncertainty in terms of measurement inaccuracies, modelling errors and inherent variability, which is likely to contain the true force. However, if a higher accuracy of predicted muscle and joint contact forces is required or in case of severely sub-optimal motor control, I believe the only solution is to include an explicit model of motor control. A refined mechanistic model would allow for the differentiation between hierarchical levels of motor control, as proposed by Bernstein, such as the involuntary spinal control and the cognition-driven anticipatory control.
Published: 2018

40. Investigation of the dose and temporal effects of intravenous iron on human cardiopulmonary physiology

Author: Bart, Nicole, Robbins, Peter, and Dorrington, Keith
Subjects: 612.1
Abstract: Sustained hypoxia induces a progressive rise in pulmonary artery systolic pressure (PASP). Intravenous (IV) iron administered immediately prior to the hypoxic exposure attenuates this effect, suggesting that manipulation of iron stores may modify hypoxia-induced pulmonary hypertension. Not yet understood is the duration of effect of IV iron, or the dose-response relationship between clinical indices of iron status and modest loading of iron in non-iron deficient individuals. To address this, two placebo-controlled, double-blind, sustained isocapnic hypoxia studies were conducted in healthy iron-replete participants. In Study A, 22 participants were randomised to a single intravenous bolus dose of iron as ferric carboxymaltose (FCM), or saline on day 1 and exposed to six hours of hypoxia on days 0, 1, 8 and 43. Following the administration of FCM the concentrations of ferritin and hepcidin plus transferrin saturation rose significantly (p &LT; 0.001, p &LT; 0.005, p &LT; 0.001 respectively), and transferrin concentration decreased significantly (p &LT; 0.001); changes that persisted for the study. FCM significantly attenuated the rise in PASP in response to hypoxia (p &LT; 0.001), an effect that persisted at day 43. In Study B, 18 participants were randomised to saline or 250 mg FCM, administered monthly for six months. To avoid iron overload, FCM was only administered to participants who had a ferritin &LT; 300 μg/L and transferrin saturation &LT; 45%. PASP was measured during eight hours of hypoxia, before and after the six month period. Serum ferritin concentration was robustly elevated by FCM by 0.21 μg/L/mg of iron delivered (95% CI: 0.15-0.26 μg/L/mg). Both iron dose and increase in ferritin concentration correlated with an attenuation in PASP rise with hypoxia (p &LT; 0.05 and p &LT; 0.01, respectively). In summary, a bolus dose of iron resulted in an increase in iron indices and altered the cardiorespiratory response to hypoxia for at least 43 days. This was also achieved by incremental doses of iron that did not cause iron overload. The persistent effect of intravenous iron suggests that it may be of therapeutic benefit in some forms of pulmonary hypertension and other hypoxic cardiorespiratory diseases.
Published: 2017

41. Process Philosophy: A Synthesis

Author: Nooteboom, Bart
Published: 2021

42. CO2 emissions of drained coastal peatlands in the Netherlands and potential emission reduction by water infiltration systems

Author: Aben, Ralf C.H., Van De Craats, Daniël, Boonman, Jim, Peeters, Stijn H., Vriend, Bart, Boonman, Coline C.F., Van Der Velde, Ype, Erkens, Gilles, Van Den Berg, Merit, Aben, Ralf C.H., Van De Craats, Daniël, Boonman, Jim, Peeters, Stijn H., Vriend, Bart, Boonman, Coline C.F., Van Der Velde, Ype, Erkens, Gilles, and Van Den Berg, Merit
Abstract: Worldwide, the drainage of peatlands has turned these systems from CO2 sinks into sources. In the Netherlands, where ĝ1/47 % of the land surface consists of peatlands, drained peat soils contribute >90 % and ĝ1/43 % to the country's soil-derived and total CO2 emissions, respectively. Hence, the Dutch National Climate Agreement has set targets to cut these emissions. One potential mitigation measure is the application of subsurface water infiltration systems (WISs) consisting of subsurface pipes connected to ditchwater. WISs aim to raise the water table depth (WTD) in dry periods to limit peat oxidation while maintaining current land-use practices. Here, we used automated transparent chambers in 12 peat pasture plots across the Netherlands to measure CO2 fluxes at high frequency and assess (1) the relationship between WTD and CO2 emissions for Dutch peatlands and (2) the effectiveness of WISs in mitigating emissions. Net ecosystem carbon balances (NECBs) (up to 4 years per site, 2020-2023) averaged 3.77 and 2.66 tCO2-Cha-1yr-1 for control and WIS sites, respectively. The magnitude of NECBs and the slope of the WTD-NECB relationship fall within the range of observations of earlier studies in Europe, though they were notably lower than those based on campaign-wise, closed-chamber measurements. The relationship between annual exposed carbon (C; defined as the total amount of carbon within the soil above the average annual WTD) and NECB explained more variance than the WTD-NECB relationship. The magnitude of the NECB represented 1.0 % of the annual exposed C on average, with a maximum of 2.4 %. We found strong evidence for a reducing effect of WISs on CO2 emissions, reducing emissions by 2.1 (95 % confidence interval 1.2-3.0) tCO2-Cha-1yr-1, and no evidence for an effect of WISs on the WTD-NECB and annual exposed carbon-NECB relationships. This means that relationships between either WTD or exposed carbon and NECB can be used to estimate the emission reduction for
Published: 2024

43. Slim laden met flexibele nettarieven in Utrecht: Openbare eindrapportage

Author: Brinkel, Nico, van der Ree, Bart, Markotic, Peter, Fidder, Henk, Kuiper, Leon, Berg, Robin, Refa, Nazir, van der Poel, Seléne, Brinkel, Nico, van der Ree, Bart, Markotic, Peter, Fidder, Henk, Kuiper, Leon, Berg, Robin, Refa, Nazir, and van der Poel, Seléne
Published: 2024

44. K and Na Promotion Enables High-Pressure Low-Temperature Reverse Water Gas Shift over Copper-Based Catalysts

Author: Barberis, Laura, Versteeg, Christiaan I., Meeldijk, Johannes D., Stewart, Joseph A., Vandegehuchte, Bart D., de Jongh, Petra E., Barberis, Laura, Versteeg, Christiaan I., Meeldijk, Johannes D., Stewart, Joseph A., Vandegehuchte, Bart D., and de Jongh, Petra E.
Abstract: The conversion of CO2 and clean H2 to CO and H2O via the reverse water-gas shift reaction (rWGS) yields sustainable synthesis gas and opens up routes to low-carbon fuels via subsequent conventional processes such as Fischer-Tropsch synthesis which typically takes place between 200 and 350 °C. However, other CO2 hydrogenation products, such as methane and methanol, are thermodynamically much more stable at temperatures below 600-700 °C and at higher pressures. It is hence highly desirable to develop CO-selective rWGS catalysts that are active at low temperatures to facilitate process integration. We studied alkali-promoted Cu-based catalysts at varying pressure (20-40 bar(g)), temperature (180-260 °C), and H2:CO2 feed ratio (1:1, 3:1, 9:1). The addition of either K or Na boosted the CO2 conversion about 3-fold for carbon-supported Cu catalysts reaching equilibrium conversion at 260 °C, an effect that was not observed for silica-supported catalysts. Even at high pressures and high H2 content in the feed, the selectivity to CO remained close to 100%, showing that the K and Na promoters completely suppressed methanol and methane formation in these systems. The remarkable overall performance of these catalysts opens perspectives on the low-temperature operation of the rWGS reaction to produce sustainable fuels and building blocks.
Published: 2024

45. Intelligent Support Systems for Lifestyle Change: Integrating Dialogue, Information Extraction, and Reasoning

Author: Chen, Pei Yu, Baez Santamaria, Selene, De Boer, Maaike H.T., Den Hengst, Floris, Kamphorst, Bart A., Smit, Quirine, Wang, Shihan, Wolff, Johanna, Chen, Pei Yu, Baez Santamaria, Selene, De Boer, Maaike H.T., Den Hengst, Floris, Kamphorst, Bart A., Smit, Quirine, Wang, Shihan, and Wolff, Johanna
Abstract: Behavior change support systems need to take into account individual needs and preferences to provide appropriate support. In this demonstration, we illustrate how this might be achieved through the explicit modeling of user characteristics within knowledge graphs (KG), captured in a dialogue between the system and the user. We demonstrate how up-to-date information enables reasoning for providing personalized support.
Published: 2024

46. Cognitive impairment in young adults following cerebellar stroke: Prevalence and longitudinal course

Author: ODYSSEY study group, Reumers, Stacha F.I., Schellekens, Mijntje M.I., Lugtmeijer, Selma, Maas, Roderick P.P.W.M., Verhoeven, Jamie I., Boot, Esther M., Ekker, Merel S., Tuladhar, Anil M., van de Warrenburg, Bart P.C., Schutter, Dennis J.L.G., Kessels, Roy P.C., de Leeuw, Frank Erik, ODYSSEY study group, Reumers, Stacha F.I., Schellekens, Mijntje M.I., Lugtmeijer, Selma, Maas, Roderick P.P.W.M., Verhoeven, Jamie I., Boot, Esther M., Ekker, Merel S., Tuladhar, Anil M., van de Warrenburg, Bart P.C., Schutter, Dennis J.L.G., Kessels, Roy P.C., and de Leeuw, Frank Erik
Published: 2024

47. The IAHS Science for Solutions decade, with Hydrology Engaging Local People IN one Global world (HELPING)

Author: Arheimer, Berit, Cudennec, Christophe, Castellarin, Attilio, Grimaldi, Salvatore, Heal, Kate V., Lupton, Claire, Sarkar, Archana, Tian, Fuqiang, Kileshye Onema, Jean Marie, Archfield, Stacey, Blöschl, Günter, Chaffe, Pedro L.Borges, Croke, Barry F.W., Dembélé, Moctar, Leong, Chris, Mijic, Ana, Mosquera, Giovanny M., Nlend, Bertil, Olusola, Adeyemi O., Polo, María J., Sandells, Melody, Sheffield, Justin, van Hateren, Theresa C., Shafiei, Mojtaba, Adla, Soham, Agarwal, Ankit, Aguilar, Cristina, Andersson, Jafet C.M., Andraos, Cynthia, Andreu, Ana, Avanzi, Francesco, Bart, Ryan R., Bartosova, Alena, Batelaan, Okke, Bennett, James C., Bertola, Miriam, Bezak, Nejc, Boekee, Judith, Bogaard, Thom, Booij, Martijn J., Brigode, Pierre, Buytaert, Wouter, Bziava, Konstantine, Castelli, Giulio, Castro, Cyndi V., Ceperley, Natalie C., Chidepudi, Sivarama K.R., Chiew, Francis H.S., Chun, Kwok P., Dagnew, Addisu G., Dekongmen, B. W., Del Jesus, Manuel, Dezetter, Alain, Do Nascimento Batista, José A., Doble, Rebecca C., Dogulu, Nilay, Eekhout, Joris P.C., Elçi, Alper, Elenius, Maria, Finger, David C., Fiori, Aldo, Fischer, Svenja, Förster, Kristian, Ganora, Daniele, Gargouri Ellouze, Emna, Ghoreishi, Mohammad, Harvey, Natasha, Hrachowitz, Markus, Jampani, Mahesh, Jaramillo, Fernando, Jongen, Harro J., Kareem, Kola Y., Khan, Usman T., Khatami, Sina, Kingston, Daniel G., Koren, Gerbrand, Krause, Stefan, Kreibich, Heidi, Lerat, Julien, Liu, Junguo, Liu, Suxia, Madruga de Brito, Mariana, Mahé, Gil, Makurira, Hodson, Mazzoglio, Paola, Merheb, Mohammad, Mishra, Ashish, Mohammad, Hiba, Montanari, Alberto, Mujere, Never, Nabavi, Ehsan, Nkwasa, Albert, Orduna Alegria, Maria E., Orieschnig, Christina, Ovcharuk, Valeriya, Palmate, Santosh S., Pande, Saket, Pandey, Shachi, Papacharalampous, Georgia, Pechlivanidis, Ilias, Penny, Gopal, Pimentel, Rafael, Post, David A., Prieto, Cristina, Razavi, Saman, Salazar-Galán, Sergio, Sankaran Namboothiri, Adarsh, Santos, Pedro P., Savenije, Hubert, Shanono, Nura J., Sharma, Ashutosh, Sivapalan, Murugesu, Smagulov, Zhanibek, Szolgay, Jan, Teng, Jin, Teuling, Adriaan J., Teutschbein, Claudia, Tyralis, Hristos, Griensven, Ann van, van Schalkwyk, Andries J., van Tiel, Marit, Viglione, Alberto, Volpi, Elena, Wagener, Thorsten, Wang, Xiaojun, Wang-Erlandsson, Lan, Wens, Marthe, Xia, Jun, Arheimer, Berit, Cudennec, Christophe, Castellarin, Attilio, Grimaldi, Salvatore, Heal, Kate V., Lupton, Claire, Sarkar, Archana, Tian, Fuqiang, Kileshye Onema, Jean Marie, Archfield, Stacey, Blöschl, Günter, Chaffe, Pedro L.Borges, Croke, Barry F.W., Dembélé, Moctar, Leong, Chris, Mijic, Ana, Mosquera, Giovanny M., Nlend, Bertil, Olusola, Adeyemi O., Polo, María J., Sandells, Melody, Sheffield, Justin, van Hateren, Theresa C., Shafiei, Mojtaba, Adla, Soham, Agarwal, Ankit, Aguilar, Cristina, Andersson, Jafet C.M., Andraos, Cynthia, Andreu, Ana, Avanzi, Francesco, Bart, Ryan R., Bartosova, Alena, Batelaan, Okke, Bennett, James C., Bertola, Miriam, Bezak, Nejc, Boekee, Judith, Bogaard, Thom, Booij, Martijn J., Brigode, Pierre, Buytaert, Wouter, Bziava, Konstantine, Castelli, Giulio, Castro, Cyndi V., Ceperley, Natalie C., Chidepudi, Sivarama K.R., Chiew, Francis H.S., Chun, Kwok P., Dagnew, Addisu G., Dekongmen, B. W., Del Jesus, Manuel, Dezetter, Alain, Do Nascimento Batista, José A., Doble, Rebecca C., Dogulu, Nilay, Eekhout, Joris P.C., Elçi, Alper, Elenius, Maria, Finger, David C., Fiori, Aldo, Fischer, Svenja, Förster, Kristian, Ganora, Daniele, Gargouri Ellouze, Emna, Ghoreishi, Mohammad, Harvey, Natasha, Hrachowitz, Markus, Jampani, Mahesh, Jaramillo, Fernando, Jongen, Harro J., Kareem, Kola Y., Khan, Usman T., Khatami, Sina, Kingston, Daniel G., Koren, Gerbrand, Krause, Stefan, Kreibich, Heidi, Lerat, Julien, Liu, Junguo, Liu, Suxia, Madruga de Brito, Mariana, Mahé, Gil, Makurira, Hodson, Mazzoglio, Paola, Merheb, Mohammad, Mishra, Ashish, Mohammad, Hiba, Montanari, Alberto, Mujere, Never, Nabavi, Ehsan, Nkwasa, Albert, Orduna Alegria, Maria E., Orieschnig, Christina, Ovcharuk, Valeriya, Palmate, Santosh S., Pande, Saket, Pandey, Shachi, Papacharalampous, Georgia, Pechlivanidis, Ilias, Penny, Gopal, Pimentel, Rafael, Post, David A., Prieto, Cristina, Razavi, Saman, Salazar-Galán, Sergio, Sankaran Namboothiri, Adarsh, Santos, Pedro P., Savenije, Hubert, Shanono, Nura J., Sharma, Ashutosh, Sivapalan, Murugesu, Smagulov, Zhanibek, Szolgay, Jan, Teng, Jin, Teuling, Adriaan J., Teutschbein, Claudia, Tyralis, Hristos, Griensven, Ann van, van Schalkwyk, Andries J., van Tiel, Marit, Viglione, Alberto, Volpi, Elena, Wagener, Thorsten, Wang, Xiaojun, Wang-Erlandsson, Lan, Wens, Marthe, and Xia, Jun
Abstract: The new scientific decade (2023-2032) of the International Association of Hydrological Sciences (IAHS) aims at searching for sustainable solutions to undesired water conditions–whether it be too little, too much or too polluted. Many of the current issues originate from global change, while solutions to problems must embrace local understanding and context. The decade will explore the current water crises by searching for actionable knowledge within three themes: global and local interactions, sustainable solutions and innovative cross-cutting methods. We capitalise on previous IAHS Scientific Decades shaping a trilogy; from Hydrological Predictions (PUB) to Change and Interdisciplinarity (Panta Rhei) to Solutions (HELPING). The vision is to solve fundamental water-related environmental and societal problems by engaging with other disciplines and local stakeholders. The decade endorses mutual learning and co-creation to progress towards UN sustainable development goals. Hence, HELPING is a vehicle for putting science in action, driven by scientists working on local hydrology in coordination with local, regional, and global processes.
Published: 2024

48. A Cost–Benefit Analysis of Reinterview Designs for Estimating and Adjusting Mode Measurement Effects: A Case Study for the Dutch Health Survey and Labour Force Survey

Author: Schouten, Barry, Klausch, Thomas, Buelens, Bart, Van Den Brakel, Jan, Schouten, Barry, Klausch, Thomas, Buelens, Bart, and Van Den Brakel, Jan
Abstract: Reinterview designs are a potential tool to estimate and adjust for mode measurement effects, that is, relative differences in mode-specific measurement error bias. In 2011, a reinterview design was successfully applied to the Dutch Crime Victimization Survey, which led to a redesign of the survey. Reinterview designs may, however, be very costly, especially when face to face is included as a survey mode. The crucial question is whether benefits outweigh costs, that is, whether the potential increase in the accuracy of survey statistics is worth the investment. The answer to this question depends heavily on the purpose of the reinterview, that is, assessment versus adjustment, the size of the measurement effects, and the relative cost of the modes. Reinterview designs also make a number of assumptions that will not hold for every setting. In this article, we perform a cost-benefit analysis for two surveys, the Dutch Health Survey and the Dutch Labour Force Survey, and discuss the utility and validity of reinterviews. We conclude that a reinterview may not be useful due to relatively small measurement differences for the Labour Force Survey, whereas it may be useful for the Health Survey.
Published: 2024

49. Outcome One Year after Acetabular Rim Extension Using a Customized Titanium Implant for Treating Hip Dysplasia in Dogs

Author: Kwananocha, Irin, Magré, Joëll, Kamali, Amir, Verseijden, Femke, Willemsen, Koen, Ji, Yuntao, van der Wal, Bart C.H., Sakkers, Ralph J.B., Tryfonidou, Marianna A., Meij, Björn P., Kwananocha, Irin, Magré, Joëll, Kamali, Amir, Verseijden, Femke, Willemsen, Koen, Ji, Yuntao, van der Wal, Bart C.H., Sakkers, Ralph J.B., Tryfonidou, Marianna A., and Meij, Björn P.
Abstract: The acetabular rim extension (ACE-X) implant is a custom-made three-dimensionally printed titanium device designed for the treatment of canine hip dysplasia. In this study, 34 dogs (61 hips) underwent ACE-X implantation, and assessments were conducted using computed tomography, force plate analysis, Ortolani’s test, and the Helsinki chronic pain index (HCPI) questionnaires at five intervals: the pre-operative day, the surgery day, and the 1.5-month, 3-month, and 12-month follow-ups. Statistically significant increases in femoral head coverage with a negative Ortolani subluxation test were observed immediately after surgery and persisted throughout the study. Osteoarthritis (OA) scores remained stable, but osteophyte size significantly increased between the surgery day and the 12-month follow-up, especially in hips with a baseline OA score of 2 compared to those with a score of 1. The force plate data showed no significant changes during the study. The HCPI demonstrated a significant decrease in pain score from pre-operative value to six-week follow-up and gradually decreased over time. Major complications were identified in six hips (9.8%) of four dogs. In conclusion, the ACE-X implant effectively increased femoral head coverage, eliminated subluxation, and provided long-term pain relief with minimal complications, benefiting over 90% of the study population. The study supports the ACE-X implant as a valuable alternative treatment for canine hip dysplasia.
Published: 2024

50. Exploring the 3D printing of molybdenum carbide-based catalysts for the reverse water gas shift reaction: A multi scale study

Author: Pajares, Arturo, Andrade-Arvizu, Jacob, Jain, Disha, Monai, Matteo, Lefevere, Jasper, de la Piscina, Pilar Ramírez, Homs, Narcís, Michielsen, Bart, Pajares, Arturo, Andrade-Arvizu, Jacob, Jain, Disha, Monai, Matteo, Lefevere, Jasper, de la Piscina, Pilar Ramírez, Homs, Narcís, and Michielsen, Bart
Published: 2024

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