1. Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories
- Author
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Kaufmann, Marco; https://orcid.org/0000-0002-4810-7734, Salmen, Anke, Barin, Laura, Puhan, Milo A; https://orcid.org/0000-0001-7284-1317, Calabrese, Pasquale, Kamm, Christian Philipp, Gobbi, Claudio, Kuhle, Jens, Manjaly, Zina-Mary, Ajdacic-Gross, Vladeta, Schafroth, Sandra, Bottignole, Britta, Ammann, Sabin, Zecca, Chiara, D'Souza, Marcus, von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797, Kaufmann, Marco; https://orcid.org/0000-0002-4810-7734, Salmen, Anke, Barin, Laura, Puhan, Milo A; https://orcid.org/0000-0001-7284-1317, Calabrese, Pasquale, Kamm, Christian Philipp, Gobbi, Claudio, Kuhle, Jens, Manjaly, Zina-Mary, Ajdacic-Gross, Vladeta, Schafroth, Sandra, Bottignole, Britta, Ammann, Sabin, Zecca, Chiara, D'Souza, Marcus, and von Wyl, Viktor; https://orcid.org/0000-0002-8754-9797
- Abstract
BACKGROUND: Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories. METHODS: We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4-6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity. RESULTS: Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62-0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4-6.5 and ≥7, respectively. CONCLUSIONS: Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.
- Published
- 2020