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4 results on '"C. Munshi"'

1. Genomic profiling of smoldering multiple myeloma identifies patients at a high risk of disease progression

Author

Bustoros, Mark Sklavenitis-Pistofidis, Romanos Park, Jihye and Redd, Robert Zhitomirsky, Binyamin Stewart, Chip Tai, Yu-Tzu and Barbera, Alex Aguet, Francois Mouhieddine, Tarek and Chavada, Selina Soong, David Boehner, Cody Neuse, Carl and Dunford, Andrew Rahmat, Mahshid Glen, Adriana Peilla Van Allen, Eliezer Kumar, Shaji Kastritis, Efstathios Morgan, Elizabeth Laubach, Jacob Dimopoulos, Meletios A. Chiu, Chris and Richardson, Paul G. Anderson, Kenneth C. Munshi, Nikhil and Yong, Kwee Trippa, Lorenzo Ghobrial, Irene Manier, Salomon and Getz, Gad and Bustoros, Mark Sklavenitis-Pistofidis, Romanos Park, Jihye and Redd, Robert Zhitomirsky, Binyamin Stewart, Chip Tai, Yu-Tzu and Barbera, Alex Aguet, Francois Mouhieddine, Tarek and Chavada, Selina Soong, David Boehner, Cody Neuse, Carl and Dunford, Andrew Rahmat, Mahshid Glen, Adriana Peilla Van Allen, Eliezer Kumar, Shaji Kastritis, Efstathios Morgan, Elizabeth Laubach, Jacob Dimopoulos, Meletios A. Chiu, Chris and Richardson, Paul G. Anderson, Kenneth C. Munshi, Nikhil and Yong, Kwee Trippa, Lorenzo Ghobrial, Irene Manier, Salomon and Getz, Gad

Published
2019

2. DNA repair of myeloma plasma cells correlates with clinical outcome: The effect of the nonhomologous end-joining inhibitor SCR7

Author

Gkotzamanidou, M. Terpos, E. Bamia, C. Munshi, N.C. Dimopoulos, M.A. Souliotis, V.L. and Gkotzamanidou, M. Terpos, E. Bamia, C. Munshi, N.C. Dimopoulos, M.A. Souliotis, V.L.

Abstract

DNA repair activity of malignant cells seems to influence therapeutic outcome and patients' survival. Herein, we investigated the mechanistic basis for the link between DNA repair efficiency and response to antimyeloma therapy. Nucleotide excision repair (NER), interstrand cross-links repair (ICL/R), double-strand breaks repair (DSB/R), and chromatin structure were evaluated in multiple myeloma (MM) cell lines (melphalan-sensitive RPMI8226; melphalan-resistant LR5) and bone marrow plasma cells (BMPCs) from MM patients who responded (n = 17) or did not respond (n = 9) to subsequent melphalan therapy. The effect of DSB/R inhibition was also evaluated. Responders' BMPCs showed slower rates of NER and DSB/R (P < .0022), similar rates of ICL/R, and more condensed chromatin structure compared with nonresponders. Moreover, apoptosis rates of BMPCs were inversely correlated with individual DNA repair efficiency and were higher in responders' cells compared with those of nonresponders (P = .0011). Similarly, RPMI8226 cells showed slower rates of NER and DSB/R, comparable rates of ICL/R, more condensed chromatin structure, and higher sensitivity than LR5 cells. Interestingly, cotreatment of BMPCs or cell lines with DSB/R inhibitors significantly reduced the rates ofDSB/R and increasedmelphalan sensitivity of the cells, with the nonhomologous end-joining inhibitor SCR7 showing the strongest effect. Together, responders' BMPCs are characterized by lower efficiencies of NER and DSB/R mechanisms, resulting in higher accumulation of the extremely cytotoxic ICLs andDSBs lesions,which in turn triggers the induction of the apoptotic pathway. Moreover, the enhancement of melphalan cytotoxicity by DSB/R inhibition offers a promising strategy toward improvement of existing antimyeloma regimens. © 2016 by The American Society of Hematology.

Published
2016

3. HDAC8 is recruited to DNA double strand breaks sites and affects the homologous recombination efficiency in multiple myeloma

Author

Gkotzamanidou, Maria Shammas, Masood Sanchez, Jesus Martin and Samur, Mehmet Kemal Minvielle, Stephane Magrangeas, Florence and Avet-Loiseau, Herve Dimopoulos, Athanasios-Meletios Anderson, Kenneth C. Munshi, Nikhil C. and Gkotzamanidou, Maria Shammas, Masood Sanchez, Jesus Martin and Samur, Mehmet Kemal Minvielle, Stephane Magrangeas, Florence and Avet-Loiseau, Herve Dimopoulos, Athanasios-Meletios Anderson, Kenneth C. Munshi, Nikhil C.

Published
2015

4. Deficient double strand breaks repair of bone marrow plasma cells correlates with better clinical outcome of multiple myeloma patients

Author

Gkotzamanidou, Maria Shammas, Masood Terpos, Evangelos and Raghavan, Sathees C. Anderson, Kenneth C. Munshi, Nikhil C. and Dimopoulos, Meletios-Athanasios Souliotis, Vassilis L. and Gkotzamanidou, Maria Shammas, Masood Terpos, Evangelos and Raghavan, Sathees C. Anderson, Kenneth C. Munshi, Nikhil C. and Dimopoulos, Meletios-Athanasios Souliotis, Vassilis L.

Published
2014

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