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Jiang-Peng Cao,1– 3 Yuan-Hao Du,1,2,4 Lan-Yu Jia,5 Xiu-Mei Yin,1– 3 Li-Hong Yang,1,2 Lin-Ling Chen,6 Tao Jiang,1,2 Man Zhang,4 Tian Qiu1– 3 1Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, People’s Republic of China; 3Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 4School of acupuncture & moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 5Department of Geriatric medicine, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, People’s Republic of China; 6Department of Traditional Chinese Medicine, Huzhou Central Hospital, Huzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Yuan-Hao Du, Email jpjs_cn@sina.comBackground: Cerebral blood flow and vascular structures serve as the fundamental components of brain metabolism and circulation. Acupuncture, an alternative and complementary medical approach, has demonstrated efficacy in treating cerebral ischemic stroke (CIS). Nevertheless, the mechanisms underlying the impact of acupuncture on vascular smooth muscle cell (VSMC) function remain uncertain. The objective of this systematic review and meta-analysis is to assess the alterations in VSMC function following acupuncture stimulation in CIS models.Methods: The databases PubMed, Web of Science, SCOPUS, and EMBASE were queried until November 2022 using a predetermined search strategy. The FORMAT BY SYRCLE guidelines were adhered to, and the risk of bias of the included studies was evaluated using the Risk of Bias tool developed by the Systematic Review Centre for Laboratory Animal Experimentation. The random-effects model was employed to estimate the standardized mean difference (SMD).Results: Eightee

Cao J, Li L, Han X, et al. Onco Targets Ther. 2019;12:433–441. At the authors request, the Editor and Publisher of OncoTargets and Therapy are retracting the published article. The authors were made aware of data concerns relating to their paper and an investigation found images in Figure 5 had been duplicated with those from Yang C, Zheng J, Xue Y, Yu H, Liu X, Ma J, Liu L, Wang P, Li Z, Cai H, Liu Y. The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis. Frontiers in Molecular Neuroscience. 2018; 10:437 (https://doi.org/10.3389/fnmol.2017.00437). Specifically, From the published article, Figure 5E, pcDNA 3.1, pcDNA 3.1-VEGFA; pcDNA 3.1-VEGF+miRNA NC; pcDNA 3.1-VEGFA+miR-302a mimics; pcDNA 3.1-VEGFA+miR-302b mimics; pcDNA 3.1-VEGFA+miR-302c mimics and pcDNA 3.1-VEGFA+miR-302d mimics have been duplicated with images in Figure 2F, Control and anti-miR-211; Figure 6E, Control; Figure 2F, pre-NC and anti-NC; Figure 4E, KLF5 (-)-NC and Figure 6E, AGGF1 (-)-NC, respectively from Yang et al, 2018. The authors advised that data relating to the original study was no longer available and they were unable to explain how the images came to be duplicated. As the validity of the published work cannot not be verified the Editor and Publisher have agreed to retract the article. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

Spectral approximation and variational inducing learning for the Gaussian process are two popular methods to reduce computational complexity. However, in previous research, those methods always tend to adopt the orthonormal basis functions, such as eigenvectors in the Hilbert space, in the spectrum method, or decoupled orthogonal components in the variational framework. In this paper, inspired by quantum physics, we introduce a novel basis function, which is tunable, local and bounded, to approximate the kernel function in the Gaussian process. There are two adjustable parameters in these functions, which control their orthogonality to each other and limit their boundedness. And we conduct extensive experiments on open-source datasets to testify its performance. Compared to several state-of-the-art methods, it turns out that the proposed method can obtain satisfactory or even better results, especially with poorly chosen kernel functions., Comment: 10 figures

Reducing our overwhelming dependence on fossil fuels requires groundbreaking innovations in increasing our efficiency in energy consumption for current technologies and moving towards renewable energy sources. Thermoelectric materials can help in achieving both goals. Moreover, because of recent advances in high-performance computing, researchers more increasingly rely on computational methods in discovering new thermoelectric materials with economically feasible performance. In this article, significant thermoelectric materials discovered through these computational methods are systematically reviewed. Furthermore, the primary computational tools that aid the design of the next-generation thermoelectric materials are introduced and discussed. These techniques include various levels of density functional theory, electronic transport simulations, and phonon calculations., This work was supported by the Japanese Society for Promotion of Science. J.J.G.M. acknowledges financial support from the Postdoctoral Science Foundation of China under Grant no. 2018M643152. J.C. acknowledges the financial support from the Natural Science Foundation of Jiangsu Province under Grant number BK20180456., Peer Reviewed, Postprint (published version)

This paper has been retracted. Cao J, Li L, Han X, et al. Onco Targets Ther. 2019;12:433–441. At the authors request, the Editor and Publisher of OncoTargets and Therapy are retracting the published article. The authors were made aware of data concerns relating to their paper and an investigation found images in Figure 5 had been duplicated with those from Yang C, Zheng J, Xue Y, Yu H, Liu X, Ma J, Liu L, Wang P, Li Z, Cai H, Liu Y. The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis. Frontiers in Molecular Neuroscience. 2018; 10:437 (https://doi.org/10.3389/fnmol.2017.00437). Specifically, From the published article, Figure 5E, pcDNA 3.1, pcDNA 3.1-VEGFA; pcDNA 3.1-VEGF+miRNA NC; pcDNA 3.1-VEGFA+miR-302a mimics; pcDNA 3.1-VEGFA+miR-302b mimics; pcDNA 3.1-VEGFA+miR-302c mimics and pcDNA 3.1-VEGFA+miR-302d mimics have been duplicated with images in Figure 2F, Control and anti-miR-211; Figure 6E, Control; Figure 2F, pre-NC and anti-NC; Figure 4E, KLF5 (-)-NC and Figure 6E, AGGF1 (-)-NC, respectively from Yang et al, 2018. The authors advised that data relating to the original study was no longer available and they were unable to explain how the images came to be duplicated. As the validity of the published work cannot not be verified the Editor and Publisher have agreed to retract the article. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

Muhammad Saif Ur Rahman,1 Ling Zhang,2 Lingyan Wu,1 Yuqiong Xie,1 Chunchun Li,1 Jiang Cao1 1Clinical Research Center, 2Cardiovascular Key Laboratory of Zhejiang Province, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China Abstract: Severe side effects are major problems with chemotherapy of gastric cancer (GC). These side effects can be reduced by using sensitizing agents in combination with therapeutic drugs. In this study, the low/nontoxic dosage of glaucocalyxin B (GLB) was used with other DNA linker agents mitomycin C (MMC), cisplatin (DDP), or cyclophosphamide (CTX) to treat GC cells. Combined effectiveness of GLB with drugs was determined by proliferation assay. The molecular mechanisms associated with cell proliferation, migration, invasion, cell cycle, DNA repair/replication, apoptosis, and autophagy were investigated by immunoblotting for key proteins involved. Cell cycle and apoptosis analysis were performed by flow cytometry. Reactive oxygen species level was also examined for identification of its role in apoptosis. Proliferation assay revealed that the addition of 5 µM GLB significantly sensitizes gastric cancer SGC-7901 cells to MMC, DDP, and CTX by decreasing half-maximal inhibitory concentration (IC50) by up to 75.40%±5%, 45.10%±5%, and 52.10%±5%, respectively. GLB + drugs decreased the expression level of proteins involved in proliferation and migration, suggesting the anticancer potential of GLB + drugs. GLB + MMC, GLB + CTX, and GLB + DDP arrest the cells in G0/G1 and G1/S phase, respectively, which may be the consequence of significant decrease in the level of enzymes responsible for DNA replication and telomerase shortening. Combined use of GLB with these drugs also induces DNA damage and apoptosis by activating caspase/PARP pathways and increased production of reactive oxygen species and increased autophagy in GC cel

Zhonghai Guan,1 Xiongfei Yu,1 Haohao Wang,1 Haiyong Wang,1 Jing Zhang,1 Guangliang Li,2 Jiang Cao,3 Lisong Teng1 1Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, 2Department of Medicine Oncology, Zhejiang Cancer Hospital, 3Clinical Research Center, The 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China Abstract: Liposarcoma (LPS) is the most common type of soft-tissue sarcoma. Complete surgical resection is the only curative means for localized disease; however, both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. An increasing number of trials with novel targeted therapy of LPS have provided encouraging data during recent years. This review will provide an overview of the advances in our understanding of LPS and summarize the results of recent trials with novel therapies targeting different genetic and molecular aberrations for different subtypes of LPS. Keywords: well-/dedifferentiated, myxoid/round cell, pleomorphic, soft-tissue sarcoma

Zhonghai Guan,1 Xiongfei Yu,1 Haohao Wang,1 Haiyong Wang,1 Jing Zhang,1 Guangliang Li,2 Jiang Cao,3 Lisong Teng1 1Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, 2Department of Medicine Oncology, Zhejiang Cancer Hospital, 3Clinical Research Center, The 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China Abstract: Liposarcoma (LPS) is the most common type of soft-tissue sarcoma. Complete surgical resection is the only curative means for localized disease; however, both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. An increasing number of trials with novel targeted therapy of LPS have provided encouraging data during recent years. This review will provide an overview of the advances in our understanding of LPS and summarize the results of recent trials with novel therapies targeting different genetic and molecular aberrations for different subtypes of LPS. Keywords: well-/dedifferentiated, myxoid/round cell, pleomorphic, soft-tissue sarcoma

Xingyun Su,1 Xin Xu,1 Guangliang Li,1,4 Bingyi Lin,2 Jiang Cao,3 Lisong Teng1 1Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China; 2Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang, People’s Republic of China; 3Clinical Research Center, The 2nd Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China; 4Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, People’s Republic of China Abstract: Estrogen receptor-alpha36 (ER-α36) is a 36-kDa variant of estrogen receptor-alpha (ER-α) firstly identified and cloned by Wang et al in 2005. It lacks both transactivation domains (activation function 1 and activation function 2) and has different biological characteristics compared to traditional ER-α (ER-α66). ER-α36 primarily locates on plasma membrane and cytoplasm and functions as a mediator in the rapid membrane-initiated non-genomic signaling pathway. Additionally, it inhibits the traditional genomic signaling pathway mediated by ER-α66 in a dominant-negative pattern. Accumulating evidence has demonstrated that ER-α36 regulates the physiological function of various tissues. Thus, dysregulation of ER-α36 is closely associated with plenty of diseases including cancers. ER-α36 is recognized as a molecular abnormality which solidly correlates to carcinogenesis, aggressiveness, and therapeutic response of breast cancer. Additionally, special attention has been paid to the role of ER-α36 in endocrine therapy resistance. Therefore, ER-α36 provides a novel biomarker of great value for diagnosis, prognosis, and treatment of breast cancer. It may also be a potential therapeutic target for breast cancer

Suspended-membrane 19-missing-hole microcavities in triangular lattice photonic crystals are numerically modeled by a three-dimensional finite-difference time-domain method. The resonance frequencies and the quality factors are calculated by interpolation of the discrete Fourier transformation series of the field with a Pad polynomial. The numerical results are compared with the photoluminescent spectra measured on the cavity of a nearly identical dimension. The symmetry properties of the defect modes are analyzed with the group theory, and resonance modes in the photonic-crystal cavities are identified as irreducible representations of the C6v point group. The far-field radiations of the identified modes in the free space are also calculated by use of a vector Green's function. It is found that the numerical results agree very well with the experimental measurement in various aspects., See also ADM001923. Pub. in the Jnl. of Optical Society of America, v22, n5 p1092-1099, May 2005.

We present quality factors of single-defect photonic-crystal resonant cavities with asymmetric cladding layers. The resonators studied here are dielectric slabs patterned with two-dimensional photonic crystals on a sapphire substrate. Three-dimensional finite-element and finite-difference time-domain routines were used to analyze the electromagnetic properties of these cavities. We observe that high quality factors (~800) can be obtained in these cavities for reasonable structures with thick enough dielectric slabs. This work was motivated by the need to place photonic-crystal resonators on a substrate to improve heat dissipation in photonic-crystal lasers., See also ADM001923. Pub. in J. Opt. Soc. Am. B., v19 n8 p1777-1781, Aug 2002. Supported in part by ARL and ARO under contract DAAD19-99-1-0121.