Search

Pathogenic variants in the LRP2 gene, encoding the multiligand receptor megalin, cause a rare autosomal recessive syndrome: Donnai-Barrow/Facio-Oculo-Acoustico-Renal (DB/FOAR) syndrome. Because of the rarity of the syndrome, the long-term consequences of the tubulopathy on human renal health have been difficult to ascertain, and the human clinical condition has hitherto been characterized as a benign tubular condition with asymptomatic low-molecularweight proteinuria. We investigated renal function and morphology in a murine model of DB/FOAR syndrome and in patients with DB/FOAR. We analyzed glomerular filtration rate in mice by FETC-inulin clearance and clinically characterized six families, including nine patients with DB/FOAR and nine family members. Urine samples from patients were analyzed by Western blot analysis and biopsy materials were analyzed by histology. In the mouse model, we used histological methods to assess nephrogenesis and postnatal renal structure and contrast-enhanced magnetic resonance imaging to assess glomerular number. In megalin-deficient mice, we found a lower glomerular filtration rate and an increase in the abundance of injury markers, such as kidney injury molecule-1 and N-acetyl-11-n-glucosaminidase. Renal injury was validated in patients, who presented with increased urinary kidney injury molecule-1, classical markers of chronic kidney disease, and glomerular proteinuria early in life. Megalin-deficient mice had normal nephrogenesis, but they had 19% fewer nephrons in early adulthood and an increased fraction of nephrons with disconnected glomerulotubular junction. In conclusion, megalin dysfunction, as present in DB/FOAR syndrome, confers an increased risk of progression into chronic kidney disease.

MBA Professional Project, The 2016 Navy Pregnancy and Parenthood Survey conducted by Naval Air Warfare Center Training Systems Division (NAWCTSD) cited that the primary retention influencer for female naval officers is the “ability to have a family.” This project is a policy proposal that targets the primary reason female naval officers are leaving the military. The researchers assessed the viability of implementing EF/IVF (egg freezing and in vitro fertilization) as a retention tool for competitive female naval officers in the unrestricted line (URL) communities. The researchers proposed an EF/IVF pilot program that was analyzed from the ethical and financial perspectives. The ethical perspective justified why the policy proposal should be implemented on the basis of equality, equity, and need. The financial perspective supported the ethical perspective by estimating an overall average program price to implement the proposed EF/IVF pilot program., http://archive.org/details/womenretentionth1094562237, Lieutenant Commander, United States Navy, Lieutenant, United States Navy

The 2016 Navy Pregnancy and Parenthood Survey conducted by Naval Air Warfare Center Training Systems Division (NAWCTSD) cited that the primary retention influencer for female naval officers is the “ability to have a family.” This project is a policy proposal that targets the primary reason female naval officers are leaving the military. The researchers assessed the viability of implementing EF/IVF (egg freezing and in vitro fertilization) as a retention tool for competitive female naval officers in the unrestricted line (URL) communities. The researchers proposed an EF/IVF pilot program that was analyzed from the ethical and financial perspectives. The ethical perspective justified why the policy proposal should be implemented on the basis of equality, equity, and need. The financial perspective supported the ethical perspective by estimating an overall average program price to implement the proposed EF/IVF pilot program.

The 2016 Navy Pregnancy and Parenthood Survey conducted by Naval Air Warfare Center Training Systems Division (NAWCTSD) cited that the primary retention influencer for female naval officers is the “ability to have a family.” This project is a policy proposal that targets the primary reason female naval officers are leaving the military. The researchers assessed the viability of implementing EF/IVF (egg freezing and in vitro fertilization) as a retention tool for competitive female naval officers in the unrestricted line (URL) communities. The researchers proposed an EF/IVF pilot program that was analyzed from the ethical and financial perspectives. The ethical perspective justified why the policy proposal should be implemented on the basis of equality, equity, and need. The financial perspective supported the ethical perspective by estimating an overall average program price to implement the proposed EF/IVF pilot program.