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28 results on '"Clemens, Eva"'

1. The impact of the temporal sequence of cranial radiotherapy and platin-based chemotherapy on hearing impairment in pediatric and adolescent CNS and head-and-neck cancer patients: A report from the PanCareLIFE consortium

Author

Zorg en O&O, Cancer, Child Health, Speerpunt, Scobioala, Sergiu, Parfitt, Ross, Matulat, Peter, Byrne, Julianne, Langer, Thorsten, Troschel, Fabian M., Hesping, Amélie E., Clemens, Eva, Kaatsch, Peter, Grabow, Desiree, Kaiser, Melanie, Spix, Claudia, Kremer, Leontien C., Calaminus, Gabriele, Baust, Katja, Kuehni, Claudia E., Weiss, Annette, Strebel, Sven, Kuonen, Rahel, Elsner, Susanne, Haupt, Riccardo, Garré, Maria Luisa, Gruhn, Bernd, Kepak, Tomas, Kepakova, Katerina, Winther, Jeanette Falck, Kenborg, Line, Rechnitzer, Catherine, Hasle, Henrik, Kruseova, Jarmila, Luks, Ales, Lackner, Herwig, Bielack, Stefan, Beck, Jörn Dirk, Jürgens, Heribert, van den Heuvel-Eibrink, Marry M., Zolk, Oliver, Eich, Hans Theodor, am Zehnhoff-Dinnesen, Antoinette, Zorg en O&O, Cancer, Child Health, Speerpunt, Scobioala, Sergiu, Parfitt, Ross, Matulat, Peter, Byrne, Julianne, Langer, Thorsten, Troschel, Fabian M., Hesping, Amélie E., Clemens, Eva, Kaatsch, Peter, Grabow, Desiree, Kaiser, Melanie, Spix, Claudia, Kremer, Leontien C., Calaminus, Gabriele, Baust, Katja, Kuehni, Claudia E., Weiss, Annette, Strebel, Sven, Kuonen, Rahel, Elsner, Susanne, Haupt, Riccardo, Garré, Maria Luisa, Gruhn, Bernd, Kepak, Tomas, Kepakova, Katerina, Winther, Jeanette Falck, Kenborg, Line, Rechnitzer, Catherine, Hasle, Henrik, Kruseova, Jarmila, Luks, Ales, Lackner, Herwig, Bielack, Stefan, Beck, Jörn Dirk, Jürgens, Heribert, van den Heuvel-Eibrink, Marry M., Zolk, Oliver, Eich, Hans Theodor, and am Zehnhoff-Dinnesen, Antoinette

Published
2024

2. Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE

Author

MS VPG/Gynaecologie, Cancer, Speerpunt, Zorg en O&O, Child Health, van der Perk, M E Madeleine, Broer, Linda, Yasui, Yutaka, Laven, Joop S E, Robison, Leslie L, Tissing, Wim J E, Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J L, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, Beerendonk, Catharina C M, Byrne, Julianne, Berger, Claire, Clemens, Eva, van Dulmen-den Broeder, Eline, Dirksen, Uta, van der Pal, Helena J, de Vries, Andrica C H, Winther, Jeanette Falck, Ranft, Andreas, Fosså, Sophie D, Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Kremer, Leontien C M, Brooke, Russell J, Wang, Fan, Baedke, Jessica L, Uitterlinden, André G, Bos, Annelies M E, van Leeuwen, Flora E, Ness, Kirsten K, Hudson, Melissa M, van der Kooi, Anne-Lotte L F, van den Heuvel-Eibrink, Marry M, PanCareLIFE Consortium, MS VPG/Gynaecologie, Cancer, Speerpunt, Zorg en O&O, Child Health, van der Perk, M E Madeleine, Broer, Linda, Yasui, Yutaka, Laven, Joop S E, Robison, Leslie L, Tissing, Wim J E, Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J L, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, Beerendonk, Catharina C M, Byrne, Julianne, Berger, Claire, Clemens, Eva, van Dulmen-den Broeder, Eline, Dirksen, Uta, van der Pal, Helena J, de Vries, Andrica C H, Winther, Jeanette Falck, Ranft, Andreas, Fosså, Sophie D, Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Kremer, Leontien C M, Brooke, Russell J, Wang, Fan, Baedke, Jessica L, Uitterlinden, André G, Bos, Annelies M E, van Leeuwen, Flora E, Ness, Kirsten K, Hudson, Melissa M, van der Kooi, Anne-Lotte L F, van den Heuvel-Eibrink, Marry M, and PanCareLIFE Consortium

Published
2024

3. Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors – a genome-wide association study:results from PanCareLIFE

Author

van der Perk, M. E.Madeleine, Broer, Linda, Yasui, Yutaka, Laven, Joop S.E., Robison, Leslie L., Tissing, Wim J.E., Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J.L., Lambalk, Cornelis B., Overbeek, Annelies, Loonen, Jacqueline J., Beerendonk, Catharina C.M., Byrne, Julianne, Berger, Claire, Clemens, Eva, van Dulmen-den Broeder, Eline, Dirksen, Uta, van der Pal, Helena J., de Vries, Andrica C.H., Winther, Jeanette Falck, Ranft, Andreas, Fosså, Sophie D., Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Kremer, Leontien C.M., Brooke, Russell J., Wang, Fan, Baedke, Jessica L., Uitterlinden, André G., Bos, Annelies M.E., van Leeuwen, Flora E., Ness, Kirsten K., Hudson, Melissa M., van der Kooi, Anne Lotte L.F., van den Heuvel-Eibrink, Marry M., van der Perk, M. E.Madeleine, Broer, Linda, Yasui, Yutaka, Laven, Joop S.E., Robison, Leslie L., Tissing, Wim J.E., Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J.L., Lambalk, Cornelis B., Overbeek, Annelies, Loonen, Jacqueline J., Beerendonk, Catharina C.M., Byrne, Julianne, Berger, Claire, Clemens, Eva, van Dulmen-den Broeder, Eline, Dirksen, Uta, van der Pal, Helena J., de Vries, Andrica C.H., Winther, Jeanette Falck, Ranft, Andreas, Fosså, Sophie D., Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Kremer, Leontien C.M., Brooke, Russell J., Wang, Fan, Baedke, Jessica L., Uitterlinden, André G., Bos, Annelies M.E., van Leeuwen, Flora E., Ness, Kirsten K., Hudson, Melissa M., van der Kooi, Anne Lotte L.F., and van den Heuvel-Eibrink, Marry M.

Abstract

Objective: To discover new variants associated with low ovarian reserve after gonadotoxic treatment among adult female childhood cancer survivors using a genome-wide association study approach. Design: Genome-wide association study. Setting: Not applicable. Patients: A discovery cohort of adult female childhood cancer survivors from the pan-European PanCareLIFE cohort (n = 743; median age: 25.8 years), excluding those who received bilateral ovarian irradiation, bilateral oophorectomy, central nervous system or total body irradiation, or stem cell transplantation. Replication was attempted in the US-based St. Jude Lifetime Cohort (n = 391; median age: 31.3 years). Exposure: Female childhood cancer survivors are at risk of therapy-related gonadal impairment. Alkylating agents are well-established risk factors, and the interindividual variability in gonadotoxicity may be explained by genetic polymorphisms. Data were collected in real-life conditions, and cyclophosphamide equivalent doses were used to quantify alkylation agent exposure. Main Outcome Measure: Anti-Müllerian hormone (AMH) levels served as a proxy for ovarian function, and the findings were combined in a meta-analysis. Results: Three genome-wide significant (<5.0 × 10−8) and 16 genome-wide suggestive (<5.0 × 10−6) loci were associated with log-transformed AMH levels, adjusted for cyclophosphamide equivalent dose of alkylating agents, age at diagnosis, and age at study in the PanCareLIFE cohort. On the basis of the effect allele frequency (EAF) (>0.01 if not genome-wide significant), and biologic relevance, 15 single nucleotide polymorphisms were selected for replication. None of the single nucleotide polymorphisms were statistically significantly associated with AMH levels. A meta-analysis indicated that rs78861946 was associated with borderline genome-wide statistical significance (reference/effect allele: C/T; effect allele frequency: 0.04, beta (SE): −0.484 (0.091). Con

Published
2024

4. The impact of the temporal sequence of cranial radiotherapy and platin-based chemotherapy on hearing impairment in pediatric and adolescent CNS and head-and-neck cancer patients:A report from the PanCareLIFE consortium

Author

Scobioala, Sergiu, Parfitt, Ross, Matulat, Peter, Byrne, Julianne, Langer, Thorsten, Troschel, Fabian M., Hesping, Amélie E., Clemens, Eva, Kaatsch, Peter, Grabow, Desiree, Kaiser, Melanie, Spix, Claudia, Kremer, Leontien C., Calaminus, Gabriele, Baust, Katja, Kuehni, Claudia E., Weiss, Annette, Strebel, Sven, Kuonen, Rahel, Elsner, Susanne, Haupt, Riccardo, Garré, Maria Luisa, Gruhn, Bernd, Kepak, Tomas, Kepakova, Katerina, Winther, Jeanette Falck, Kenborg, Line, Rechnitzer, Catherine, Hasle, Henrik, Kruseova, Jarmila, Luks, Ales, Lackner, Herwig, Bielack, Stefan, Beck, Jörn Dirk, Jürgens, Heribert, van den Heuvel-Eibrink, Marry M., Zolk, Oliver, Eich, Hans Theodor, am Zehnhoff-Dinnesen, Antoinette, Scobioala, Sergiu, Parfitt, Ross, Matulat, Peter, Byrne, Julianne, Langer, Thorsten, Troschel, Fabian M., Hesping, Amélie E., Clemens, Eva, Kaatsch, Peter, Grabow, Desiree, Kaiser, Melanie, Spix, Claudia, Kremer, Leontien C., Calaminus, Gabriele, Baust, Katja, Kuehni, Claudia E., Weiss, Annette, Strebel, Sven, Kuonen, Rahel, Elsner, Susanne, Haupt, Riccardo, Garré, Maria Luisa, Gruhn, Bernd, Kepak, Tomas, Kepakova, Katerina, Winther, Jeanette Falck, Kenborg, Line, Rechnitzer, Catherine, Hasle, Henrik, Kruseova, Jarmila, Luks, Ales, Lackner, Herwig, Bielack, Stefan, Beck, Jörn Dirk, Jürgens, Heribert, van den Heuvel-Eibrink, Marry M., Zolk, Oliver, Eich, Hans Theodor, and am Zehnhoff-Dinnesen, Antoinette

Abstract

The impact of the temporal sequence by which cranial radiotherapy (CRT) and platin-based chemotherapy (PCth) are administered on sensorineural hearing loss (SNHL) in pediatric and adolescent central nervous system (CNS) and head-and-neck (HN) cancer patients has not yet been studied in detail. We examined the ototoxic effects of sequentially applied CRT and PCth. This study included children and adolescents with CNS and HN tumors who participated in the multicountry PanCareLIFE (PCL) consortium. Audiological outcomes were compared between patients who received CRT prior to PCth and those who received it afterwards. The incidence, degree and posttreatment progression of SNHL, defined as Muenster classification grade ≥MS2b, were evaluated in 141 patients. One hundred and nineteen patients were included in a time-to-onset analysis. Eighty-eight patients received CRT prior to PCth (Group 1) and 53 patients received PCth before CRT (Group 2). Over a median follow-up time of 1.6 years, 72.7% of patients in Group 1 experienced SNHL ≥ MS2b compared to 33.9% in Group 2 (P <.01). A time-to-onset analysis was performed for 74 patients from Group 1 and 45 patients from Group 2. Median time to hearing loss (HL) ≥ MS2b was 1.2 years in Group 1 and 4.4 years in Group 2 (P <.01). Thus, audiological outcomes were better for patients who received CRT after PCth than before. This finding should be further evaluated and considered within clinical practice in order to minimize hearing loss in children and adolescents with CNS and HN tumors.

Published
2024

5. Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function

Author

Van Der Kooi, Anne Lotte L.F., Van Dijk, Marloes, Broer, Linda, Van Den Berg, Marleen H., Laven, Joop S.E., Van Leeuwen, Flora E., Lambalk, Cornelis B., Overbeek, Annelies, Loonen, Jacqueline J., Van Der Pal, Helena J., Tissing, Wim J., Versluys, Birgitta, Bresters, Dorine, Beerendonk, Catharina C.M., Ronckers, Cécile R., Van Der Heiden-Van Der Loo, Margriet, Kaspers, Gertjan L., De Vries, Andrica C.H., Robison, Leslie L., Hudson, Melissa M., Chemaitilly, Wassim, Byrne, Julianne, Berger, Claire, Clemens, Eva, Dirksen, Uta, Falck Winther, Jeanette, Fosså, Sophie D., Grabow, Desiree, Haupt, Riccardo, Kaiser, Melanie, Kepak, Tomas, Kruseova, Jarmila, Modan-Moses, Dalit, Pluijm, Saskia M.F., Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Krijthe, Jesse H., Kremer, Leontien C., Yasui, Yutaka, Brooke, Russell J., Uitterlinden, André G., Van Den Heuvel-Eibrink, Marry M., Van Dulmen-Den Broeder, Eline, Van Der Kooi, Anne Lotte L.F., Van Dijk, Marloes, Broer, Linda, Van Den Berg, Marleen H., Laven, Joop S.E., Van Leeuwen, Flora E., Lambalk, Cornelis B., Overbeek, Annelies, Loonen, Jacqueline J., Van Der Pal, Helena J., Tissing, Wim J., Versluys, Birgitta, Bresters, Dorine, Beerendonk, Catharina C.M., Ronckers, Cécile R., Van Der Heiden-Van Der Loo, Margriet, Kaspers, Gertjan L., De Vries, Andrica C.H., Robison, Leslie L., Hudson, Melissa M., Chemaitilly, Wassim, Byrne, Julianne, Berger, Claire, Clemens, Eva, Dirksen, Uta, Falck Winther, Jeanette, Fosså, Sophie D., Grabow, Desiree, Haupt, Riccardo, Kaiser, Melanie, Kepak, Tomas, Kruseova, Jarmila, Modan-Moses, Dalit, Pluijm, Saskia M.F., Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Krijthe, Jesse H., Kremer, Leontien C., Yasui, Yutaka, Brooke, Russell J., Uitterlinden, André G., Van Den Heuvel-Eibrink, Marry M., and Van Dulmen-Den Broeder, Eline

Abstract

STUDY QUESTION: Do genetic variations in the DNA damage response pathway modify the adverse effect of alkylating agents on ovarian function in female childhood cancer survivors (CCS)? SUMMARY ANSWER: Female CCS carrying a common BR serine/threonine kinase 1 (BRSK1) gene variant appear to be at 2.5-fold increased odds of reduced ovarian function after treatment with high doses of alkylating chemotherapy. WHAT IS KNOWN ALREADY: Female CCS show large inter-individual variability in the impact of DNA-damaging alkylating chemotherapy, given as treatment of childhood cancer, on adult ovarian function. Genetic variants in DNA repair genes affecting ovarian function might explain this variability. STUDY DESIGN, SIZE, DURATION: CCS for the discovery cohort were identified from the Dutch Childhood Oncology Group (DCOG) LATER VEVO-study, a multi-centre retrospective cohort study evaluating fertility, ovarian reserve and risk of premature menopause among adult female 5-year survivors of childhood cancer. Female 5-year CCS, diagnosed with cancer and treated with chemotherapy before the age of 25 years, and aged 18 years or older at time of study were enrolled in the current study. Results from the discovery Dutch DCOG-LATER VEVO cohort (n = 285) were validated in the pan-European PanCareLIFE (n = 465) and the USA-based St. Jude Lifetime Cohort (n = 391). PARTICIPANTS/MATERIALS, SETTING, METHODS: To evaluate ovarian function, anti-Müllerian hormone (AMH) levels were assessed in both the discovery cohort and the replication cohorts. Using additive genetic models in linear and logistic regression, five genetic variants involved in DNA damage response were analysed in relation to cyclophosphamide equivalent dose (CED) score and their impact on ovarian function. Results were then examined using fixed-effect meta-analysis. MAIN RESULTS AND THE ROLE OF CHANCE: Meta-analysis across the three independent cohorts showed a significant interaction effect (P = 3.0 × 10-4) between rs116683

Published
2021

6. A comparison of genotyping arrays

Author

Verlouw, Joost A.M., Clemens, Eva, de Vries, Jard H., Zolk, Oliver, Verkerk, Annemieke J.M.H., am Zehnhoff-Dinnesen, Antoinette, Medina-Gomez, Carolina, Lanvers-Kaminsky, Claudia, Rivadeneira, Fernando, Langer, Thorsten, van Meurs, Joyce B.J., van den Heuvel-Eibrink, Marry M., Uitterlinden, André G., Broer, Linda, Verlouw, Joost A.M., Clemens, Eva, de Vries, Jard H., Zolk, Oliver, Verkerk, Annemieke J.M.H., am Zehnhoff-Dinnesen, Antoinette, Medina-Gomez, Carolina, Lanvers-Kaminsky, Claudia, Rivadeneira, Fernando, Langer, Thorsten, van Meurs, Joyce B.J., van den Heuvel-Eibrink, Marry M., Uitterlinden, André G., and Broer, Linda

Abstract

Array technology to genotype single-nucleotide variants (SNVs) is widely used in genome-wide association studies (GWAS), clinical diagnostics, and linkage studies. Arrays have undergone a tremendous growth in both number and content over recent years making a comprehensive comparison all the more important. We have compared 28 genotyping arrays on their overall content, genome-wide coverage, imputation quality, presence of known GWAS loci, mtDNA variants and clinically relevant genes (i.e., American College of Medical Genetics (ACMG) actionable genes, pharmacogenetic genes, human leukocyte antigen (HLA) genes and SNV density). Our comparison shows that genome-wide coverage is highly correlated with the number of SNVs on the array but does not correlate with imputation quality, which is the main determinant of GWAS usability. Average imputation quality for all tested arrays was similar for European and African populations, indicating that this is not a good criterion for choosing a genotyping array. Rather, the additional content on the array, such as pharmacogenetics or HLA variants, should be the deciding factor. As the research question of a study will in large part determine which class of genes are of interest, there is not just one perfect array for all different research questions. This study can thus help as a guideline to determine which array best suits a study’s requirements.

Published
2021

7. Effect of Genetic Variation in CYP450 on Gonadal Impairment in a European Cohort of Female Childhood Cancer Survivors, Based on a Candidate Gene Approach: Results from the PanCareLIFE Study

Author

SCT patientenzorg, MS VPG/Gynaecologie, Child Health, Cancer, van der Perk, M E Madeleine, Broer, Linda, Yasui, Yutaka, Robison, Leslie L, Hudson, Melissa M, Laven, Joop S E, van der Pal, Helena J, Tissing, Wim J E, Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J L, de Vries, Andrica C H, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, Beerendonk, Catharina C M, Byrne, Julianne, Berger, Claire, Clemens, Eva, Dirksen, Uta, Falck Winther, Jeanette, Fosså, Sophie D, Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Krijthe, Jesse H, Kremer, Leontien C M, Brooke, Russell J, Baedke, Jessica L, van Schaik, Ron H N, van den Anker, John N, Uitterlinden, André G, Bos, Annelies M E, van Leeuwen, Flora E, van Dulmen-den Broeder, Eline, van der Kooi, Anne-Lotte L F, van den Heuvel-Eibrink, Marry M, On Behalf Of The PanCareLIFE Consortium, SCT patientenzorg, MS VPG/Gynaecologie, Child Health, Cancer, van der Perk, M E Madeleine, Broer, Linda, Yasui, Yutaka, Robison, Leslie L, Hudson, Melissa M, Laven, Joop S E, van der Pal, Helena J, Tissing, Wim J E, Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J L, de Vries, Andrica C H, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, Beerendonk, Catharina C M, Byrne, Julianne, Berger, Claire, Clemens, Eva, Dirksen, Uta, Falck Winther, Jeanette, Fosså, Sophie D, Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Krijthe, Jesse H, Kremer, Leontien C M, Brooke, Russell J, Baedke, Jessica L, van Schaik, Ron H N, van den Anker, John N, Uitterlinden, André G, Bos, Annelies M E, van Leeuwen, Flora E, van Dulmen-den Broeder, Eline, van der Kooi, Anne-Lotte L F, van den Heuvel-Eibrink, Marry M, and On Behalf Of The PanCareLIFE Consortium

Published
2021

8. Association of candidate pharmacogenetic markers with platinum-induced ototoxicity: PanCareLIFE dataset

Author

Langer, T, Clemens, Eva, Broer, Linda, Maier, L, Uitterlinden, André, Vries, ACH, van Grotel, Martine, Pluijm, Saskia F.M., Binder, H, Mayer, Benjamin, von dem Knesebeck, A, Byrne, J, van Dulmen-den Broeder, E, Crocco, M, Grabow, D, Kaatsch, P, Kaiser, M, Spix, C, Kenborg, L, Winther, JF, Rechnitzer, C, Hasle, H, Kepak, T, Kooi, Anne-Lotte, Kremer, LC, Kruseova, J, Bielack, S, Sorg, B, Hecker-Nolting, S, Kuehni, CE, Ansari, M, Kompis, M, van der Pal, HJ, Parfitt, R, Deuster, D, Matulat, P, Tillmanns, A, Tissing, WJ, Beck, JD, Elsner, S, am Zehnhoff-Dinnesen, A, Eibrink, Marry, Zolk, O, Langer, T, Clemens, Eva, Broer, Linda, Maier, L, Uitterlinden, André, Vries, ACH, van Grotel, Martine, Pluijm, Saskia F.M., Binder, H, Mayer, Benjamin, von dem Knesebeck, A, Byrne, J, van Dulmen-den Broeder, E, Crocco, M, Grabow, D, Kaatsch, P, Kaiser, M, Spix, C, Kenborg, L, Winther, JF, Rechnitzer, C, Hasle, H, Kepak, T, Kooi, Anne-Lotte, Kremer, LC, Kruseova, J, Bielack, S, Sorg, B, Hecker-Nolting, S, Kuehni, CE, Ansari, M, Kompis, M, van der Pal, HJ, Parfitt, R, Deuster, D, Matulat, P, Tillmanns, A, Tissing, WJ, Beck, JD, Elsner, S, am Zehnhoff-Dinnesen, A, Eibrink, Marry, and Zolk, O

Published
2020

9. Risk factors associated with tinnitus in 2948 Dutch survivors of childhood cancer: a Dutch LATER questionnaire study

Author

MS Radiotherapie, Cancer, PMC Medisch specialisten, Child Health, Zorgeenheid KNO Medisch, Brain, Audiologen, Meijer, Annelot J M, Fiocco, Marta F, Janssens, Geert O, Clemens, Eva, Tissing, Wim J E, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, de Vries, Andrica C H, Bresters, Dorine, Versluys, Birgitta, Ronckers, Cécile M, Kremer, Leontien C M, van der Pal, Helena J, Neggers, Sebastian J C M M, van der Heiden-van der Loo, Margriet, Stokroos, Robert J, Hoetink, Alex E, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, MS Radiotherapie, Cancer, PMC Medisch specialisten, Child Health, Zorgeenheid KNO Medisch, Brain, Audiologen, Meijer, Annelot J M, Fiocco, Marta F, Janssens, Geert O, Clemens, Eva, Tissing, Wim J E, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, de Vries, Andrica C H, Bresters, Dorine, Versluys, Birgitta, Ronckers, Cécile M, Kremer, Leontien C M, van der Pal, Helena J, Neggers, Sebastian J C M M, van der Heiden-van der Loo, Margriet, Stokroos, Robert J, Hoetink, Alex E, van Grotel, Martine, and van den Heuvel-Eibrink, Marry M

Published
2020

14. Genetic Determinants of Ototoxicity During and After Childhood Cancer Treatment: Protocol for the PanCareLIFE Study

Author

Clemens, Eva, Meijer, AJM, Broer, Linda, Langer, T, van der Kooi, Anne-Lotte, Uitterlinden, André, de Vries, A.C.H., Kuehni, CE, Garre, ML, Kepak, T, Kruseova, J, Winther, JF, Kremer, LC, van Dulmen-den Broeder, E, Tissing, WJ, Rechnitzer, C, Kenborg, L, Hasle, H, Grabow, D, Parfitt, R, Binder, H, Carleton, BC, Byrne, J, Kaatsch, P, Zehnhoff-Dinnesen, AA, Zolk, O, Van den Heuvel - Eibrink, Marry, Clemens, Eva, Meijer, AJM, Broer, Linda, Langer, T, van der Kooi, Anne-Lotte, Uitterlinden, André, de Vries, A.C.H., Kuehni, CE, Garre, ML, Kepak, T, Kruseova, J, Winther, JF, Kremer, LC, van Dulmen-den Broeder, E, Tissing, WJ, Rechnitzer, C, Kenborg, L, Hasle, H, Grabow, D, Parfitt, R, Binder, H, Carleton, BC, Byrne, J, Kaatsch, P, Zehnhoff-Dinnesen, AA, Zolk, O, and Van den Heuvel - Eibrink, Marry

Published
2019

16. PanCareLIFE:The scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents

Author

Byrne, Julianne, Grabow, Desiree, Campbell, Helen, O'Brien, Kylie, Bielack, Stefan, Zehnhoff-Dinnesen, Antoinette Am, Calaminus, Gabriele, Kremer, Leontien, Langer, Thorsten, van den Heuvel-Eibrink, Marry M., van Dulmen-den Broeder, Eline, Baust, Katja, Bautz, Andrea, Beck, Jörn D., Berger, Claire, Binder, Harald, Borgmann-Staudt, Anja, Broer, Linda, Cario, Holger, Casagranda, Leonie, Clemens, Eva, Deuster, Dirk, de Vries, Andrica, Dirksen, Uta, Winther, Jeanette Falck, Fossa, Sophie, Font-Gonzalez, Anna, Grandage, Victoria, Haupt, Riccardo, Hecker-Nolting, Stefanie, Hjorth, Lars, Kaiser, Melanie, Kenborg, Line, Kepak, Tomas, Kepakova, Katerina, Knudsen, Lisbeth E., Krawczuk-Rybak, Maryna, Kruseova, Jarmila, Kuehni, Claudia E., Kunstreich, Marina, Kuonen, Rahel, Lackner, Herwig, Leiper, Alison, Loeffen, Erik A. H., Luks, Ales, Modan-Moses, Dalit, Mulder, Renee, Parfitt, Ross, Paul, Norbert W., Ranft, Andreas, Ruud, Ellen, Schilling, Ralph, Spix, Claudia, Stefanowicz, Joanna, Strauss, Gabriele, Uitterlinden, Andre G., van den Berg, Marleen, van der Kooi, Anne-Lotte, van Dijk, Marloes, van Leeuwen, Flora, Zolk, Oliver, Zoeller, Daniela, Kaatsch, Peter, Byrne, Julianne, Grabow, Desiree, Campbell, Helen, O'Brien, Kylie, Bielack, Stefan, Zehnhoff-Dinnesen, Antoinette Am, Calaminus, Gabriele, Kremer, Leontien, Langer, Thorsten, van den Heuvel-Eibrink, Marry M., van Dulmen-den Broeder, Eline, Baust, Katja, Bautz, Andrea, Beck, Jörn D., Berger, Claire, Binder, Harald, Borgmann-Staudt, Anja, Broer, Linda, Cario, Holger, Casagranda, Leonie, Clemens, Eva, Deuster, Dirk, de Vries, Andrica, Dirksen, Uta, Winther, Jeanette Falck, Fossa, Sophie, Font-Gonzalez, Anna, Grandage, Victoria, Haupt, Riccardo, Hecker-Nolting, Stefanie, Hjorth, Lars, Kaiser, Melanie, Kenborg, Line, Kepak, Tomas, Kepakova, Katerina, Knudsen, Lisbeth E., Krawczuk-Rybak, Maryna, Kruseova, Jarmila, Kuehni, Claudia E., Kunstreich, Marina, Kuonen, Rahel, Lackner, Herwig, Leiper, Alison, Loeffen, Erik A. H., Luks, Ales, Modan-Moses, Dalit, Mulder, Renee, Parfitt, Ross, Paul, Norbert W., Ranft, Andreas, Ruud, Ellen, Schilling, Ralph, Spix, Claudia, Stefanowicz, Joanna, Strauss, Gabriele, Uitterlinden, Andre G., van den Berg, Marleen, van der Kooi, Anne-Lotte, van Dijk, Marloes, van Leeuwen, Flora, Zolk, Oliver, Zoeller, Daniela, and Kaatsch, Peter

Published
2018

17. Genetic variation in gonadal impairment in female survivors of childhood cancer: a PanCareLIFE study protocol

Author

van der Kooi, Anne-Lotte, Clemens, Eva, Broer, Linda, Zolk, O, Byrne, J, Campbell, H, Berg, M, Berger, C, Calaminus, G, Dirksen, U, Winther, JF, Fossa, SD, Grabow, D, Haupt, R, Kaiser, M, Kepak, T, Kremer, L, Kruseova, J, Modan-Moses, D, Ranft, A, Spix, C, Kaatsch, P, Laven, Joop, van Dulmen-den Broeder, E, Uitterlinden, André, Van den Heuvel - Eibrink, Marry, van der Kooi, Anne-Lotte, Clemens, Eva, Broer, Linda, Zolk, O, Byrne, J, Campbell, H, Berg, M, Berger, C, Calaminus, G, Dirksen, U, Winther, JF, Fossa, SD, Grabow, D, Haupt, R, Kaiser, M, Kepak, T, Kremer, L, Kruseova, J, Modan-Moses, D, Ranft, A, Spix, C, Kaatsch, P, Laven, Joop, van Dulmen-den Broeder, E, Uitterlinden, André, and Van den Heuvel - Eibrink, Marry

Published
2018

18. The influence of genetic variation on late toxicities in childhood cancer survivors: A review

Author

Clemens, Eva, van der Kooi, Anne-Lotte, Broer, Linda, van Dulmen-den Broeder, E, Visscher, H, Kremer, L, Tissing, W, Loonen, J, Ronckers, CM, Pluijm, Saskia, Neggers, S.J.C.M.M., Zolk, O, Langer, T, Zehnhoff-Dinnese, AA, Wilson, CL, Hudson, MM, Carleton, B, Laven, Joop, Uitterlinden, André, Van den Heuvel - Eibrink, Marry, Clemens, Eva, van der Kooi, Anne-Lotte, Broer, Linda, van Dulmen-den Broeder, E, Visscher, H, Kremer, L, Tissing, W, Loonen, J, Ronckers, CM, Pluijm, Saskia, Neggers, S.J.C.M.M., Zolk, O, Langer, T, Zehnhoff-Dinnese, AA, Wilson, CL, Hudson, MM, Carleton, B, Laven, Joop, Uitterlinden, André, and Van den Heuvel - Eibrink, Marry

Published
2018

19. Socio-demographic impact of platinum-induced ototoxicity in long-term survivors of childhood cancer

Author

Clemens, Eva, van Doorn, Martijn, Neggers, S.J.C.M.M., de Vries, Andrica C.H., van den Heuvel-Eibrink, M. M., Clemens, Eva, van Doorn, Martijn, Neggers, S.J.C.M.M., de Vries, Andrica C.H., and van den Heuvel-Eibrink, M. M.

Abstract

Objective: Childhood cancer survivors (CCS) treated with platinum-based chemotherapy are at risk of treatment-induced ototoxicity. To date, there is limited knowledge on the effect of ototoxicity on socio-demographic factors, the burden to obtain insurances and psychological distress in CCS. Design: Of the 653 CCS with completed questionnaires, 54 survivors had been treated with platinum. Ototoxicity (Münster score ≥ 2b) data were retrieved from pure-tone audiometry. All survivors completed a questionnaire consisting of the Distress Thermometer (DT), measuring the severity of distress and was recoded to a 0 (no distress)-10 (extreme distress) scale. The Hospital Anxiety and Depression Scale (HADS) was used to study the psychological distress (a score ≥ 15 is indicative for clinically significant distress). Results: Median age at diagnosis was 6.2 years (range: 0.01-17.8) and median follow-up time from end of treatment to questionnaire was 15.6 years (range: 3.2-43.7). There were no differences in attempts to obtain insurances, highest education achievement and (un) employment between platinum-treated survivors and non-platinum treated survivors. Among the 54 platinum-treated CCS, median HADS score of hearing impaired survivors (n=22 (median score: 4.5, range: 0.0-29)) was not significantly different from survivors without ototoxicity (n=32 (median score 5.5, range: 0.0-11, p=0.337)). Similarly, DT scores were not significantly different between survivors with or without ototoxicity (p=0.441). Compared to the 599 non-platinum treated survivors, median HADS and DT scores of platinum-treated survivors were not significantly different. Conclusion: Based on this first, small study, we didn't find differences between CCS who suffer from platinum-related ototoxicity and survivors without hearing impairment, suggesting that CCS with ototoxicity do not necessarily encounter more socio-demographic challenges and psych

Published
2017

20. Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors

Author

Clemens, Eva, de Vries, Andrica C H, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J.E., Loonen, Jacqueline J, Pluijm, Saskia F.M., Van Dulmen-Den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C M, van der Pal, Helena J., Neggers, Sebastian J C M M, van Grotel, Martine, M van den Heuvel-Eibrink, Marry, Clemens, Eva, de Vries, Andrica C H, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J.E., Loonen, Jacqueline J, Pluijm, Saskia F.M., Van Dulmen-Den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C M, van der Pal, Helena J., Neggers, Sebastian J C M M, van Grotel, Martine, and M van den Heuvel-Eibrink, Marry

Published
2017

21. Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors

Author

Clemens, Eva, de Vries, Andrica C H, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J.E., Loonen, Jacqueline J, Pluijm, Saskia F.M., Van Dulmen-Den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C M, van der Pal, Helena J., Neggers, Sebastian J C M M, van Grotel, Martine, M van den Heuvel-Eibrink, Marry, Clemens, Eva, de Vries, Andrica C H, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J.E., Loonen, Jacqueline J, Pluijm, Saskia F.M., Van Dulmen-Den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C M, van der Pal, Helena J., Neggers, Sebastian J C M M, van Grotel, Martine, and M van den Heuvel-Eibrink, Marry

Published
2017

22. Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors

Author

Clemens, Eva, de Vries, Andrica C H, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J.E., Loonen, Jacqueline J, Pluijm, Saskia F.M., Van Dulmen-Den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C M, van der Pal, Helena J., Neggers, Sebastian J C M M, van Grotel, Martine, M van den Heuvel-Eibrink, Marry, Clemens, Eva, de Vries, Andrica C H, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J.E., Loonen, Jacqueline J, Pluijm, Saskia F.M., Van Dulmen-Den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C M, van der Pal, Helena J., Neggers, Sebastian J C M M, van Grotel, Martine, and M van den Heuvel-Eibrink, Marry

Published
2017

23. Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors

Author

PMC Research, Haematologie patientenzorg, Child Health, PMC Medisch specialisten, Clemens, Eva, de Vries, Andrica C H, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J.E., Loonen, Jacqueline J, Pluijm, Saskia F.M., Van Dulmen-Den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C M, van der Pal, Helena J., Neggers, Sebastian J C M M, van Grotel, Martine, M van den Heuvel-Eibrink, Marry, PMC Research, Haematologie patientenzorg, Child Health, PMC Medisch specialisten, Clemens, Eva, de Vries, Andrica C H, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J.E., Loonen, Jacqueline J, Pluijm, Saskia F.M., Van Dulmen-Den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C M, van der Pal, Helena J., Neggers, Sebastian J C M M, van Grotel, Martine, and M van den Heuvel-Eibrink, Marry

Published
2017

24. Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors

Author

Clemens, Eva, de Vries, A.C.H., Zehnhoff-Dinnesen, AA, Tissing, WJE, Loonen, JJ, Pluijm, Saskia, van Dulmen-den Broeder, E, Bresters, D, Versluys, B, Kremer, LCM (Leontien), van der Pal, HJ, Neggers, S.J.C.M.M., van Grotel, M, Van den Heuvel - Eibrink, Marry, Clemens, Eva, de Vries, A.C.H., Zehnhoff-Dinnesen, AA, Tissing, WJE, Loonen, JJ, Pluijm, Saskia, van Dulmen-den Broeder, E, Bresters, D, Versluys, B, Kremer, LCM (Leontien), van der Pal, HJ, Neggers, S.J.C.M.M., van Grotel, M, and Van den Heuvel - Eibrink, Marry

Published
2017

25. Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer : A DCOG late-effects study

Author

Clemens, Eva, de Vries, Andrica C, Pluijm, Saskia F, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C, van der Pal, Heleen J, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, DCOG-LATER, The Netherlands, Clemens, Eva, de Vries, Andrica C, Pluijm, Saskia F, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C, van der Pal, Heleen J, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, and DCOG-LATER, The Netherlands

Published
2016

26. Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer : A DCOG late-effects study

Author

Clemens, Eva, de Vries, Andrica C, Pluijm, Saskia F, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C, van der Pal, Heleen J, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, DCOG-LATER, The Netherlands, Clemens, Eva, de Vries, Andrica C, Pluijm, Saskia F, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C, van der Pal, Heleen J, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, and DCOG-LATER, The Netherlands

Published
2016

27. Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer : A DCOG late-effects study

Author

Clemens, Eva, de Vries, Andrica C, Pluijm, Saskia F, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C, van der Pal, Heleen J, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, DCOG-LATER, The Netherlands, Clemens, Eva, de Vries, Andrica C, Pluijm, Saskia F, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C, van der Pal, Heleen J, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, and DCOG-LATER, The Netherlands

Published
2016

28. Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer: A DCOG late-effects study

Author

PMC Research, Haematologie patientenzorg, Child Health, PMC Medisch specialisten, Zorg en O&O, Clemens, Eva, de Vries, Andrica C, Pluijm, Saskia F, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C, van der Pal, Heleen J, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, DCOG-LATER, The Netherlands, PMC Research, Haematologie patientenzorg, Child Health, PMC Medisch specialisten, Zorg en O&O, Clemens, Eva, de Vries, Andrica C, Pluijm, Saskia F, Am Zehnhoff-Dinnesen, Antoinette, Tissing, Wim J, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, Bresters, Dorine, Versluys, Birgitta, Kremer, Leontien C, van der Pal, Heleen J, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, and DCOG-LATER, The Netherlands

Published
2016

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