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Issue Online: 11 January 2018 Version of Record online: 23 November 2017 Manuscript accepted: 03 October 2017 Manuscript revised: 30 September 2017 Manuscript received: 02 August 2016, The use of orange essential oils (EOs) as a complementary treatment is very common in Brazilian popular culture. The levels of melatonin (MEL) and corticosterone (CORT) hormones were investigated simultaneously, by the Luminex™ immunoassay system in mice plasma, after Citrus aurantium and Citrus sinensis EOs inhalation for 30 min. The plasma was analyzed by headspace through gas chromatography coupled to mass spectrometry for investigation of the EO components. Mice were submitted to behavioral testing to research anxiolytic-like, sedative, and antidepressant-like effects. The inhalation of atmosphere obtained from vaporization of 10% solution of this Citrus EO separately did not affect MEL or CORT plasma levels; that is, the MEL and CORT levels did not present variation in function of the EO in the schedule used. On the other hand, the imipramine positive control used altered the level of MEL as expected. The EO constituents were detected in plasma at different ratios that is present in inhaled EO. Behavioral tests showed that the inhalation of 10% C. sinensis EO presents an anxiolytic-like and sedative effect. Thus, C. sinensis EO can be a valuable tool for treatment of the anxiety disturbs, apparently without interference with MEL and CORT physiological levels., Consejo Nacional de Desarrollo Científico y Tecnológico (CNPq) (Brasil), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) (Brasil), Depto. de Bioquímica y Biología Molecular, Fac. de Medicina, TRUE, pub