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2. CCR2- and Flt3-Dependent Inflammatory Conventional Type 2 Dendritic Cells Are Necessary for the Induction of Adaptive Immunity by the Human Vaccine Adjuvant System AS01

Author

Bosteels, C. (Cedric), Fierens, K. (Kaat), Prijck, S. (Sofie) de, Van Moorleghem, J. (Justine), Heerswynghels, M. (Manon) van, De Wolf, C. (Caroline), Chalon, A. (Aurélie), Collignon, C. (Catherine), Hammad, H. (Hamida), Didierlaurent, A. (Arnaud), Lambrecht, B.N.M. (Bart), Bosteels, C. (Cedric), Fierens, K. (Kaat), Prijck, S. (Sofie) de, Van Moorleghem, J. (Justine), Heerswynghels, M. (Manon) van, De Wolf, C. (Caroline), Chalon, A. (Aurélie), Collignon, C. (Catherine), Hammad, H. (Hamida), Didierlaurent, A. (Arnaud), and Lambrecht, B.N.M. (Bart)

Abstract

The Adjuvant System AS01 contains monophosphoryl lipid A (MPL) and the saponin QS-21 in a liposomal formulation. AS01 is included in recently developed vaccines against malaria and varicella zoster virus. Like for many other adjuvants, induction of adaptive immunity by AS01 is highly dependent on the ability to recruit and activate dendritic cells (DCs) that migrate to the draining lymph node for T and B cell stimulation. The objective of this study was to more precisely address the contribution of the different conventional (cDC) and monocyte-derived DC (MC) subsets in the orchestration of the adaptive immune response after immunization with AS01 adjuvanted vaccine. The combination of MPL and QS-21 in AS01 induced strong recruitment of CD26+XCR1+ cDC1s, CD26+CD172+ cDC2s and a recently defined CCR2-dependent CD64-expressing inflammatory cDC2 (inf-cDC2) subset to the draining lymph node compared to antigen alone, while CD26-CD64+CD88+ MCs were barely detectable. At 24 h post-vaccination, cDC2s and inf-cDC2s were superior amongst the different subsets in priming antigen-specific CD4+ T cells, while simultaneously presenting antigen to CD8+ T cells. Diphtheria toxin (DT) mediated depletion of all DCs prior to vaccination completely abolished adaptive immune responses, while depletion 24 h after vaccination mainly affected CD8+ T cell responses. Vaccinated mice lacking Flt3 or the chemokine receptor CCR2 showed a marked deficit in inf-cDC2 recruitment and failed to raise proper antibody and T cell responses. Thus, the adjuvant activity of AS01 is associated with the potent activation of subsets of cDC2s, including the newly described inf-cDC2s.

Published
2020
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3. European guidelines for quality assurance in breast cancer screening and diagnosis

Author

Perry, N, Broeders, M, de Wolf, C, Törnberg, S, Holland, R, von Karsa, L, Perry, N ( N ), Broeders, M ( M ), de Wolf, C ( C ), Törnberg, S ( S ), Holland, R ( R ), von Karsa, L ( L ), Amendoeira, I, et al, Perry, N, Broeders, M, de Wolf, C, Törnberg, S, Holland, R, von Karsa, L, Perry, N ( N ), Broeders, M ( M ), de Wolf, C ( C ), Törnberg, S ( S ), Holland, R ( R ), von Karsa, L ( L ), Amendoeira, I, and et al

Abstract

The fourth edition of the European guidelines for quality assurance in breast cancer screening and diagnosis was published by the European Commission in 2006. The present supplements to the fourth edition have been produced by the same groups of experts originally established under the Europe Against Cancer programme that have developed and updated the guidelines since the early 1990s. Over the years, the scope and the depth of the multidisciplinary guidelines have expanded, and recommendations and protocols have been updated to keep pace with developments in the field. The present supplements lay a cornerstone for a new, completely revised fifth edition of the guidelines

Published
2013

4. Management of women with ductal carcinoma in situ of the breast: a population-based study

Author

Verkooijen, H. M., Fioretta, G., de Wolf, C., Vlastos, G., Kurtz, J., Borisch, B., Schäfer, P., Spiliopoulos, A., Sappino, A. P., Renella, R., Pittet, B., Schmid de Gruneck, J., Wespi, Y., Neyroud-Caspar, I., Bouchardy, C., Verkooijen, H. M., Fioretta, G., de Wolf, C., Vlastos, G., Kurtz, J., Borisch, B., Schäfer, P., Spiliopoulos, A., Sappino, A. P., Renella, R., Pittet, B., Schmid de Gruneck, J., Wespi, Y., Neyroud-Caspar, I., and Bouchardy, C.

Abstract

Background: Increasing incidence of ductal carcinoma in situ (DCIS) confronts patients and clinicians with optimal treatment decisions. This multidisciplinary study investigates therapeutic modalities of DCIS in daily practice and provides recommendations on how to increase quality of care. Patients and methods: All women (n = 116) with unilateral DCIS recorded in the Geneva Cancer Registry from 1995 to 1999 were considered. Information concerned patient and tumor characteristics, treatment and outcome. Factors linked to therapy were determined using a case-control approach. Cases were women with treatment of interest and controls other women on the study. Results: Most DCIS cases (62%) were discovered by mammography screening. Ninety (78%) women had breast-conserving surgery (BCS), 18 (16%) mastectomy and seven (6%) bilateral mastectomy. Eight (7%) patients had tumor-positive margins, 18 (16%) lymph node dissection and two (1.7%) chemotherapy. Twenty-five per cent of women with BCS had no radiotherapy, three had radiotherapy after mastectomy. Less than 50% underwent breast reconstruction after mastectomy. Method of discovery, multifocality, tumor localization, size and differentiation were linked to the use of BCS or lymph node dissection. Conclusions: Because of important disparities in DCIS management, recommendations are made to increase quality of care, in particular to prevent axillary dissection or bilateral mastectomy and to increase the use of radiotherapy after BCS

Published
2017

5. Mammographic screening programmes in Europe:organization, coverage and participation

Author

Giordano, Livia, von Karsa, Lawrence, Tomatis, Mariano, Majek, Ondrej, de Wolf, Chris, Lancucki, Lesz, Hofvind, Solveig, Nyström, Lennarth, Segnan, Nereo, Ponti, Antonio, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, My Catarina, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick J, J, Lancucki, L, Giordano, Livia, von Karsa, Lawrence, Tomatis, Mariano, Majek, Ondrej, de Wolf, Chris, Lancucki, Lesz, Hofvind, Solveig, Nyström, Lennarth, Segnan, Nereo, Ponti, Antonio, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, My Catarina, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick J, J, and Lancucki, L

Abstract

To summarize participation and coverage rates in population mammographic screening programmes for breast cancer in Europe.

Published
2012

6. False-positive results in mammographic screening for breast cancer in Europe:a literature review and survey of service screening programmes

Author

Hofvind, Solveig, Ponti, Antonio, Patnick, Julietta, Ascunce, Nieves, Njor, Sisse Helle, Broeders, Mireille, Giordano, Livia, Frigerio, Alfonso, Törnberg, Sven, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, M, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick, J, Lancucki, L, Ducarroz, S, Hofvind, Solveig, Ponti, Antonio, Patnick, Julietta, Ascunce, Nieves, Njor, Sisse Helle, Broeders, Mireille, Giordano, Livia, Frigerio, Alfonso, Törnberg, Sven, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, M, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick, J, Lancucki, L, and Ducarroz, S

Abstract

To estimate the cumulative risk of a false-positive screening result in European mammographic screening programmes, and examine the rates and procedures of further assessment.

Published
2012

7. Mammographic screening programmes in Europe:organization, coverage and participation

Author

Giordano, Livia, von Karsa, Lawrence, Tomatis, Mariano, Majek, Ondrej, de Wolf, Chris, Lancucki, Lesz, Hofvind, Solveig, Nyström, Lennarth, Segnan, Nereo, Ponti, Antonio, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, My Catarina, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick J, J, Lancucki, L, Giordano, Livia, von Karsa, Lawrence, Tomatis, Mariano, Majek, Ondrej, de Wolf, Chris, Lancucki, Lesz, Hofvind, Solveig, Nyström, Lennarth, Segnan, Nereo, Ponti, Antonio, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, My Catarina, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick J, J, and Lancucki, L

Abstract

To summarize participation and coverage rates in population mammographic screening programmes for breast cancer in Europe.

Published
2012

8. False-positive results in mammographic screening for breast cancer in Europe:a literature review and survey of service screening programmes

Author

Hofvind, Solveig, Ponti, Antonio, Patnick, Julietta, Ascunce, Nieves, Njor, Sisse Helle, Broeders, Mireille, Giordano, Livia, Frigerio, Alfonso, Törnberg, Sven, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, M, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick, J, Lancucki, L, Ducarroz, S, Hofvind, Solveig, Ponti, Antonio, Patnick, Julietta, Ascunce, Nieves, Njor, Sisse Helle, Broeders, Mireille, Giordano, Livia, Frigerio, Alfonso, Törnberg, Sven, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, M, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick, J, Lancucki, L, and Ducarroz, S

Abstract

To estimate the cumulative risk of a false-positive screening result in European mammographic screening programmes, and examine the rates and procedures of further assessment.

Published
2012

11. Stellungnahme zur Wirksamkeit des Mammographiescreenings in der Schweiz

Author

Bouchardy, C, Raymond, L, de Wolf, C, Abel, T, Ackermann-Liebrich, Ursula, Goldhirsch, A, Gutzwiller, Felix, Haefliger, J M, Levi, F, Noseda, G, Obrist, R, Paccaud, Fred, Probst-Hensch, Nicole, Rougemont, A, Stahel, R, Tubiana, M, Weber, W, Bouchardy, C, Raymond, L, de Wolf, C, Abel, T, Ackermann-Liebrich, Ursula, Goldhirsch, A, Gutzwiller, Felix, Haefliger, J M, Levi, F, Noseda, G, Obrist, R, Paccaud, Fred, Probst-Hensch, Nicole, Rougemont, A, Stahel, R, Tubiana, M, and Weber, W

Published
2001

12. Prise de position en faveur du dépistage mammographique du cancer du sein en Suisse

Author

Bouchardy, C, Raymond, L, de Wolf, C, Abel, T, Ackermann-Liebrich, Ursula, Goldhirsch, A, Gutzwiller, Felix, Haefliger, J M, Levi, F, Noseda, G, Obrist, R, Paccaud, Fred, Probst-Hensch, Nicole, Rougemont, A, Stahel, R, Tubiana, M, Weber, W, Bouchardy, C, Raymond, L, de Wolf, C, Abel, T, Ackermann-Liebrich, Ursula, Goldhirsch, A, Gutzwiller, Felix, Haefliger, J M, Levi, F, Noseda, G, Obrist, R, Paccaud, Fred, Probst-Hensch, Nicole, Rougemont, A, Stahel, R, Tubiana, M, and Weber, W

Published
2001

13. European guidelines for quality assurance in the surgical management of mammographically detected lesions.

Author

O'Higgins, N, Linos, DA, Blichert-Toft, M, Cataliotti, L, de Wolf, C, Rochard, F, Rutgers, EJT, Roberts, P, Mattheiem, W, da Silva, MA, Holmberg, L, Schulz, KD, Smola, MG, Mansel, RE, O'Higgins, N, Linos, DA, Blichert-Toft, M, Cataliotti, L, de Wolf, C, Rochard, F, Rutgers, EJT, Roberts, P, Mattheiem, W, da Silva, MA, Holmberg, L, Schulz, KD, Smola, MG, and Mansel, RE

Published
1998

14. European guidelines for quality assurance in the surgical management of mammographically detected lesions.

Author

O'Higgins, N, Linos, DA, Blichert-Toft, M, Cataliotti, L, de Wolf, C, Rochard, F, Rutgers, EJT, Roberts, P, Mattheiem, W, da Silva, MA, Holmberg, L, Schulz, KD, Smola, MG, Mansel, RE, O'Higgins, N, Linos, DA, Blichert-Toft, M, Cataliotti, L, de Wolf, C, Rochard, F, Rutgers, EJT, Roberts, P, Mattheiem, W, da Silva, MA, Holmberg, L, Schulz, KD, Smola, MG, and Mansel, RE

Published
1998

15. Significant differences in incubation times in sheep infected with bovine spongiform encephalopathy result from variation at codon 141 in the PRNP gene

Author

Tan, B. C., Blanco, A. R. A., Houston, E. F., Stewart, P., Goldmann, W., Gill, Andrew, de Wolf, C., Manson, J. C., McCutcheon, S., Tan, B. C., Blanco, A. R. A., Houston, E. F., Stewart, P., Goldmann, W., Gill, Andrew, de Wolf, C., Manson, J. C., and McCutcheon, S.

Abstract

The susceptibility of sheep to prion infection is linked to variation in the PRNP gene, which encodes the prion protein. Common polymorphisms occur at codons 136, 154 and 171. Sheep which are homozygous for the A136R154Q171 allele are the most susceptible to bovine spongiform encephalopathy (BSE). The effect of other polymorphisms on BSE susceptibility is unknown. We orally infected ARQ/ARQ Cheviot sheep with equal amounts of BSE brain homogenate and a range of incubation periods was observed. When we segregated sheep according to the amino acid (L or F) encoded at codon 141 of the PRNP gene, the shortest incubation period was observed in LL141 sheep, whilst incubation periods in FF141 and LF141 sheep were significantly longer. No statistically significant differences existed in the expression of total prion protein or the disease-associated isoform in BSE-infected sheep within each genotype subgroup. This suggested that the amino acid encoded at codon 141 probably affects incubation times through direct effects on protein misfolding rates.

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16. Management of women with ductal carcinoma in situ of the breast: a population-based study

Author

Verkooijen, H. M., Fioretta, G., de Wolf, C., Vlastos, G., Kurtz, J., Borisch, B., Schäfer, P., Spiliopoulos, A., Sappino, A. P., Renella, R., Pittet, B., Schmid de Gruneck, J., Wespi, Y., Neyroud-Caspar, I., Bouchardy, C., Verkooijen, H. M., Fioretta, G., de Wolf, C., Vlastos, G., Kurtz, J., Borisch, B., Schäfer, P., Spiliopoulos, A., Sappino, A. P., Renella, R., Pittet, B., Schmid de Gruneck, J., Wespi, Y., Neyroud-Caspar, I., and Bouchardy, C.

Abstract

Background: Increasing incidence of ductal carcinoma in situ (DCIS) confronts patients and clinicians with optimal treatment decisions. This multidisciplinary study investigates therapeutic modalities of DCIS in daily practice and provides recommendations on how to increase quality of care. Patients and methods: All women (n = 116) with unilateral DCIS recorded in the Geneva Cancer Registry from 1995 to 1999 were considered. Information concerned patient and tumor characteristics, treatment and outcome. Factors linked to therapy were determined using a case-control approach. Cases were women with treatment of interest and controls other women on the study. Results: Most DCIS cases (62%) were discovered by mammography screening. Ninety (78%) women had breast-conserving surgery (BCS), 18 (16%) mastectomy and seven (6%) bilateral mastectomy. Eight (7%) patients had tumor-positive margins, 18 (16%) lymph node dissection and two (1.7%) chemotherapy. Twenty-five per cent of women with BCS had no radiotherapy, three had radiotherapy after mastectomy. Less than 50% underwent breast reconstruction after mastectomy. Method of discovery, multifocality, tumor localization, size and differentiation were linked to the use of BCS or lymph node dissection. Conclusions: Because of important disparities in DCIS management, recommendations are made to increase quality of care, in particular to prevent axillary dissection or bilateral mastectomy and to increase the use of radiotherapy after BCS

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