Search

Contains fulltext : 305843.pdf (Publisher’s version ) (Open Access), Background: Although clinical guidelines prioritize the treatment of depression and anxiety in young persons, there is accumulating evidence that the presence of symptoms of borderline personality disorder (BPD) is associated with the limited effectiveness of these standard treatments. These findings stress the need for interventions addressing early-stage BPD in young people with presenting symptoms of anxiety and depressive disorders. The aim of this study is to investigate the (cost-)effectiveness of an early intervention programme for BPD (MBT-early) compared to first-choice psychological treatment for depression and anxiety according to Dutch treatment guidelines (CBT), in adolescents with either depression, anxiety, or both, in combination with early-stage BPD. Methods: This study is a multi-centre randomized controlled trial. A total of 132 adolescents, presenting with either depression, anxiety, or both and significant BPD features will be randomized to either MBT-early or CBT. The severity of BPD, symptoms of depression and anxiety, personality, social and academic functioning, and quality of life will be assessed at baseline, end of treatment, and at 12-, 18-, and 24-month follow-up, along with medical costs and costs of productivity losses for cost-effectiveness analyses. Discussion: This study will provide an empirical evaluation of the potential surplus value of early intervention in young people for whom treatment oriented at common mental disorders like anxiety and depression may be insufficient given their underlying personality problems. Trial registration: Netherlands Trial Register, NL9569. Registered on June 15, 2021., 16 p.

Background Although clinical guidelines prioritize the treatment of depression and anxiety in young persons, there is accumulating evidence that the presence of symptoms of borderline personality disorder (BPD) is associated with the limited effectiveness of these standard treatments. These findings stress the need for interventions addressing early-stage BPD in young people with presenting symptoms of anxiety and depressive disorders. The aim of this study is to investigate the (cost-)effectiveness of an early intervention programme for BPD (MBT-early) compared to first-choice psychological treatment for depression and anxiety according to Dutch treatment guidelines (CBT), in adolescents with either depression, anxiety, or both, in combination with early-stage BPD. Methods This study is a multi-centre randomized controlled trial. A total of 132 adolescents, presenting with either depression, anxiety, or both and significant BPD features will be randomized to either MBT-early or CBT. The severity of BPD, symptoms of depression and anxiety, personality, social and academic functioning, and quality of life will be assessed at baseline, end of treatment, and at 12-, 18-, and 24-month follow-up, along with medical costs and costs of productivity losses for cost-effectiveness analyses. Discussion This study will provide an empirical evaluation of the potential surplus value of early intervention in young people for whom treatment oriented at common mental disorders like anxiety and depression may be insufficient given their underlying personality problems. Trial registration Netherlands Trial Register, NL9569. Registered on June 15, 2021.

Simulating trial trenches for archaeological prospec- tion: assessing the variability in intersection rates. In this study we draw attention to the inherent variability in the results of trial trenching, when taking into account the countless variations in orientation and positioning of trenches. Grids of trial trenches were simulated time and again on the excavation plans of 16 archaeological sites from Flanders, Belgium. Orientation and positioning of the grid layout was shifted randomly, whilst the area cov- erage varied from 2,5 % to 80 %. The intersection rates of the archaeological features allow to gain more insight in trends and variability that are inherent to the chosen design of trial trenches. It is assessed how robust a cho- sen grid layout performs on (multi-period) archaeological sites and how variable these results might be. The most effective layout appears to be a grid with short, parallel and discontinuous trenches or a standard grid, closely followed by 2m wide continuous trenches. Implement- ing 4m wide trenches reduces the effectiveness of the lat- ter method substantially. When the area coverage of the trenches is below 10 %, the results of the archaeological prospection become unreliable and can potentially lead to a substantial over- or underestimation of the actual feature density on the site.

Simulating trial trenches for archaeological prospec- tion: assessing the variability in intersection rates. In this study we draw attention to the inherent variability in the results of trial trenching, when taking into account the countless variations in orientation and positioning of trenches. Grids of trial trenches were simulated time and again on the excavation plans of 16 archaeological sites from Flanders, Belgium. Orientation and positioning of the grid layout was shifted randomly, whilst the area cov- erage varied from 2,5 % to 80 %. The intersection rates of the archaeological features allow to gain more insight in trends and variability that are inherent to the chosen design of trial trenches. It is assessed how robust a cho- sen grid layout performs on (multi-period) archaeological sites and how variable these results might be. The most effective layout appears to be a grid with short, parallel and discontinuous trenches or a standard grid, closely followed by 2m wide continuous trenches. Implement- ing 4m wide trenches reduces the effectiveness of the lat- ter method substantially. When the area coverage of the trenches is below 10 %, the results of the archaeological prospection become unreliable and can potentially lead to a substantial over- or underestimation of the actual feature density on the site.

In this study we draw attention to the inherent variability in the results of trial trenching, when taking into account the countless variations in orientation and positioning of trenches. Grids of trial trenches were simulated time and again on the excavation plans of 16 archaeological sites from Flanders, Belgium. Orientation and positioning of the grid layout was shifted randomly, whilst the area coverage varied from 2.5% to 80%. The intersection rates of the archaeological features allow to gain more insight in trends and variability that are inherent to the chosen design of trial trenches. It is assessed how robust a chosen grid layout performs on (multi-period) archaeological sites and how variable these results might be. The most effective layout appears to be a grid with short, parallel and discontinuous trenches or a standard grid, closely followed by 2m wide continuous trenches. Implementing 4m wide trenches reduces the effectiveness of the latter method substantially. When the area coverage of the trenches is below 10%, the results of the archaeological prospection become unreliable and can potentially lead to a substantial over-or underestimation of the actual feature density on the site.