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2 results on '"Di Cataldo, Antonio"'

1. Le disposizioni sui Comuni per il 2022: una rassegna normativa in un quadro di incertezza

Author

Massimo Allulli, Romano Astolfo, Gioacchino Benfante, Chiara Bergonzini, Paolo Biancone, Manuela Braione, Paolo Brambilla, Valerio Brescia, Vinicio Brigante, Noemi Ilaria Buonsante, Federico Caldura, Stefano Campostrini, Federico Chmet, Filippo D’Angelo, Simone D’Antonio, Marcello Degni, Elena Di Carpegna Brivio, Marco Di Cataldo, Antonio Di Stasio, Veronica Dini, Leonardo Draghetti, Simona Elmo, Elena Faccin, Fabrizio Fazioli, Giancarlo Ferrara, Andrea Ferri, Antonio Floridia, Giaime Gabrielli, Alessandro Giordano, Chiara Grasso, Rodolfo Lewanski, Eleonora Luciani, Vanessa Manzetti, Edoardo Meneghelli, Paolo Mezzanotte, Francesco Monaco, Andrea Morgia, Samuele Nannoni, Maria Teresa Nardo, Simone Ombuen, Carolina Pacchi, Alessandra Poggiani, Foscara Porchia, Stefania Porchia, Paola Pucci, Giuliano Resce, Giulia Romani, Luciano Sandel, Silvana Secinaro, Giulia Sonzogno, Stefano Sotgiu, Claudia Tubertini, Matteo Turrin, Maristella Zantedeschi., Degni, M, Luciani, E, Fabrizio, F, Luciani, E., Fabrizio, F., Massimo Allulli, Romano Astolfo, Gioacchino Benfante, Chiara Bergonzini, Paolo Biancone, Manuela Braione, Paolo Brambilla, Valerio Brescia, Vinicio Brigante, Noemi Ilaria Buonsante, Federico Caldura, Stefano Campostrini, Federico Chmet, Filippo D’Angelo, Simone D’Antonio, Marcello Degni, Elena Di Carpegna Brivio, Marco Di Cataldo, Antonio Di Stasio, Veronica Dini, Leonardo Draghetti, Simona Elmo, Elena Faccin, Fabrizio Fazioli, Giancarlo Ferrara, Andrea Ferri, Antonio Floridia, Giaime Gabrielli, Alessandro Giordano, Chiara Grasso, Rodolfo Lewanski, Eleonora Luciani, Vanessa Manzetti, Edoardo Meneghelli, Paolo Mezzanotte, Francesco Monaco, Andrea Morgia, Samuele Nannoni, Maria Teresa Nardo, Simone Ombuen, Carolina Pacchi, Alessandra Poggiani, Foscara Porchia, Stefania Porchia, Paola Pucci, Giuliano Resce, Giulia Romani, Luciano Sandel, Silvana Secinaro, Giulia Sonzogno, Stefano Sotgiu, Claudia Tubertini, Matteo Turrin, Maristella Zantedeschi., Degni, M, Luciani, E, Fabrizio, F, Luciani, E., and Fabrizio, F.

Published
2023

2. Cytotoxic and Immune-Sensitizing Properties of Nitric Oxide-Modified Saquinavir in iNOS-Positive Human Melanoma Cells

Author

Mijatović, Sanja, Maksimović-Ivanić, Danijela, Mojić, Marija, Timotijević, Gordana, Miljković, Djordje, Mangano, Katia, Donia, Marco, Di Cataldo, Antonio, Al-Abed, Yousef, Cheng, Kai Fan, Stošić-Grujičić, Stanislava, Nicoletti, Ferdinando, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Mojić, Marija, Timotijević, Gordana, Miljković, Djordje, Mangano, Katia, Donia, Marco, Di Cataldo, Antonio, Al-Abed, Yousef, Cheng, Kai Fan, Stošić-Grujičić, Stanislava, and Nicoletti, Ferdinando

Abstract

We have recently shown that covalent attachment of the NO moiety to the HIV protease inhibitor Saquinavir (Saq) produced a qualitatively new chemical entity, named Saquinavir-NO (Saq-NO), with enhanced anticancer properties and reduced toxicity. In this study we evaluated the impact of Saq-NO on the growth of A375 human melanoma cells, as a prototype of NO-dependent cancer model. The novel compound strongly affected the in vitro and in vivo progression of A375 melanoma cell growth. The mechanism of antimelanoma action comprised dual drug activity-induction of apoptotic cell death and acquisition of melanoma cell responsiveness to TRAIL. Saq-NO-triggered apoptosis was dependent on transient AKT up-regulation and reduced pERK and iNOS expression that were observed within the first 12 h of exposure to the drug. Thereafter, however, Saq-NO up-regulated both iNOS transcription and NO endogenous synthesis and sensitized A375 cells to TRAIL. Furthermore, reduced YY1 expression was observed after 24 h of Saq-NO exposure, which correlated with increased expression of DR5. The biological relevance of this complex and powerful action of Saq-NO was consistent with the marked drug-induced inhibition of the growth of A375 xenotransplants in nude mice. J. Cell. Physiol. 226: 1803-1812, 2011.

Published
2011

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