1. Treatment and monitoring of children with chronic hepatitis C in the Pre-DAA era: A European survey of 38 paediatric specialists
- Author
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Indolfi, Giuseppe Bailey, Heather Serranti, Daniele and Giaquinto, Carlo Thorne, Claire Indolfi, Giuseppe Bailey, Heather Serranti, Daniele Giaquinto, Carlo Thorne, Claire and Jahnel, Joerg Sokal, Etienne Lamireau, Thierry Lacaille, Florence Debray, Dominique Girard, Muriel Feiterna-Sperling, Cornelia Wirth, Stefan Vassiliki, Papaevangelou Dezsofi, Antal Guidi, Roberto Verucchi, Gabriella D'Antiga, Lorenzo and Nicastro, Emanuele Maggiore, Giuseppe Trapani, Sandra and Ricci, Silvia Resti, Massimo Giacomet, Vania Benincaso, Anna Rita Nebbia, Gabriella Iorio, Raffaele Cananzi, Mara and Riva, Silvia Bossi, Grazia Dodi, Icilio Nobili, Valerio and Comparcola, Donatella Garazzino, Silvia Calvo, Pier Luigi and Pokorska-Spiewak, Maria Pawlowska, Malgorzata Goncalves, Cristina Goncalves, Isabel Tudor, Ana Maria Noguera-Julian, Antoni Hierro, Loreto Ramos, Jose T. Fischler, Bjorn and McLin, Valerie Kansu, Aydan Brown, Maxine Kelly, Deirdre and Davison, Suzanne Turkova, Anna Bamford, Alasdair PENTAHep Study Grp and Indolfi, Giuseppe Bailey, Heather Serranti, Daniele and Giaquinto, Carlo Thorne, Claire Indolfi, Giuseppe Bailey, Heather Serranti, Daniele Giaquinto, Carlo Thorne, Claire and Jahnel, Joerg Sokal, Etienne Lamireau, Thierry Lacaille, Florence Debray, Dominique Girard, Muriel Feiterna-Sperling, Cornelia Wirth, Stefan Vassiliki, Papaevangelou Dezsofi, Antal Guidi, Roberto Verucchi, Gabriella D'Antiga, Lorenzo and Nicastro, Emanuele Maggiore, Giuseppe Trapani, Sandra and Ricci, Silvia Resti, Massimo Giacomet, Vania Benincaso, Anna Rita Nebbia, Gabriella Iorio, Raffaele Cananzi, Mara and Riva, Silvia Bossi, Grazia Dodi, Icilio Nobili, Valerio and Comparcola, Donatella Garazzino, Silvia Calvo, Pier Luigi and Pokorska-Spiewak, Maria Pawlowska, Malgorzata Goncalves, Cristina Goncalves, Isabel Tudor, Ana Maria Noguera-Julian, Antoni Hierro, Loreto Ramos, Jose T. Fischler, Bjorn and McLin, Valerie Kansu, Aydan Brown, Maxine Kelly, Deirdre and Davison, Suzanne Turkova, Anna Bamford, Alasdair PENTAHep Study Grp
- Abstract
The burden of paediatric Hepatitis C virus (HCV) infection across Europe is unknown, as are current policies regarding monitoring and treatment. This collaborative study aimed to collect aggregate data to characterise the population of <= 18-year-olds with HCV infection in specialist follow up in a 12-month period (2016) across the PENTAHep European consortium, and investigate current policies around monitoring and treatment. A cross-sectional, web-based survey was distributed in April 2017 to 50 paediatricians in 19 European countries, covering patients’ profile, and monitoring and treatment practices. Responses were received from 38/50 clinicians collectively caring for 663 children with chronic HCV infection of whom three-quarters were aged >= 6 years and 90% vertically infected. HCV genotype 1 was the most common (n 380; 57.3%), followed by genotype 3, 4 and 2. Seventeen children (3%) with chronic HCV infection were diagnosed with cirrhosis, and six were reported to have received liver transplantation for HCV-related liver disease. The majority (n 425; 64.1%) of the European children with HCV infection remained treatment-naive in 2016. Age affected clinicians’ attitudes towards treatment; 94% reported being willing to use direct-acting antivirals, if available, in adolescents (aged >= 11 years), 78% in children aged 6-10 and 42% in those 3-5 years of age (Pearson correlation coefficient -0.98; P 0.0001). This survey provides the largest characterisation of the population of children in clinical follow-up for chronic HCV infection in Europe, alongside important contextual information on their management and treatment. Discussion is needed around strategies and criteria for use of direct-acting antivirals in these children.
- Published
- 2019