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Aluminium / vanadyl 3,10,17,24-tetra-tert-butyl-1,8,15,22-tetrakis(dimethylamino)− 29 H,31 H-phthalocyanine (VTP) / Aluminium, (Al/VTP/Al) has been successfully studied for capacitive humidity sensing. The metal-containing vanadium central atom in the metal phthalocyanine has contributed towards excellent capacitance response at low humidity conditions as low as 10RH. In addition, high surface roughness revealed by atomic force microscopy (AFM) images has also given insight into the low hysteresis lag. The film's large surface area helped prevent the water molecules from accumulating in the VTP pores and capillaries. Grazing-incidence wide and small-angle X-ray scattering (GIWAXS-GISAXS) indicates some face-on crystallite orientation produced by the partially ordered film, impacting the transient performance of the sensor. © 2024 Elsevier Ltd

Aluminium / vanadyl 3,10,17,24-tetra-tert-butyl-1,8,15,22-tetrakis(dimethylamino)− 29 H,31 H-phthalocyanine (VTP) / Aluminium, (Al/VTP/Al) has been successfully studied for capacitive humidity sensing. The metal-containing vanadium central atom in the metal phthalocyanine has contributed towards excellent capacitance response at low humidity conditions as low as 10RH. In addition, high surface roughness revealed by atomic force microscopy (AFM) images has also given insight into the low hysteresis lag. The film's large surface area helped prevent the water molecules from accumulating in the VTP pores and capillaries. Grazing-incidence wide and small-angle X-ray scattering (GIWAXS-GISAXS) indicates some face-on crystallite orientation produced by the partially ordered film, impacting the transient performance of the sensor. © 2024 Elsevier Ltd

Kaempferia galanga L. rhizomes contain ethyl trans-p-methoxycinnamate as a major secondary metabolite compound and biomarker. Various extraction methods with different solvents can isolate ethyl trans-p-methoxycinnamate with potential bioactivities. This paper reported the isolation of ethyl trans-p-methoxycinnamate from two varieties of K. galanga L. rhizomes by maceration in n-hexane. The small and large varieties of K. galanga samples produced ethyl trans-p-methoxycinnamate in 1.43% and 1.84% yields, higher than other methods and polar solvents of previous research. Structural elucidation of the obtained ethyl trans-p-methoxycinnamate was performed by FTIR, MS, and 1H NMR spectroscopies.

Kaempferia galanga L. rhizomes contain ethyl trans-p-methoxycinnamate as a major secondary metabolite compound and biomarker. Various extraction methods with different solvents can isolate ethyl trans-p-methoxycinnamate with potential bioactivities. This paper reported the isolation of ethyl trans-p-methoxycinnamate from two varieties of K. galanga L. rhizomes by maceration in n-hexane. The small and large varieties of K. galanga samples produced ethyl trans-p-methoxycinnamate in 1.43% and 1.84% yields, higher than other methods and polar solvents of previous research. Structural elucidation of the obtained ethyl trans-p-methoxycinnamate was performed by FTIR, MS, and 1H NMR spectroscopies.

Multicomponent reactions involving three or more reactants are commonly used to prepare dihydropyrimidinone with various bioactivities. This study reports the different routes for the synthesis of benzaldehyde-based dihydropyrimidinone via the Biginelli reaction and investigates the yield of the obtained products. The synthesis was performed via routes A, B, C, D, and E based on the formation of iminium, enamine, and Knoevenagel intermediates between urea, benzaldehyde, and ethyl acetoacetate. Route A, through a one-pot reaction via iminium, produced dihydropyrimidinone with a yield of 58%. The product from route B via iminium was obtained in 62% yield. Route C and D occurred via enamine at room temperature, and reflux gave the product 31% and 40% yield, respectively. Route E involving Knoevenagel intermediate provided the product in a 38% yield. 1H NMR, FTIR, and MS spectroscopic techniques were used for structure elucidation.

Multicomponent reactions involving three or more reactants are commonly used to prepare dihydropyrimidinone with various bioactivities. This study reports the different routes for the synthesis of benzaldehyde-based dihydropyrimidinone via the Biginelli reaction and investigates the yield of the obtained products. The synthesis was performed via routes A, B, C, D, and E based on the formation of iminium, enamine, and Knoevenagel intermediates between urea, benzaldehyde, and ethyl acetoacetate. Route A, through a one-pot reaction via iminium, produced dihydropyrimidinone with a yield of 58%. The product from route B via iminium was obtained in 62% yield. Route C and D occurred via enamine at room temperature, and reflux gave the product 31% and 40% yield, respectively. Route E involving Knoevenagel intermediate provided the product in a 38% yield. 1H NMR, FTIR, and MS spectroscopic techniques were used for structure elucidation.

We report on the utilization of 1′-1′-diethyl-4,4′-dicarbocyanine iodide (DDCI-4) as a photoactive material for organic photodiodes (OPDs). A device was fabricated using a ternary blended ratio in the conventional stack order of ITO/PEDOT:PSS/P3HT:DDCI-4:OXCBA/Al to improve stability and enhance light absorption. An investigation was carried out into the optical and morphological characteristics of the device along with its electrical performance using different concentrations of DDCI-4 in a blended ratio of P3HT:DDCI-4:OXCBA in the photoactive layer. The mechanism of the OPD device and its performance with a gradual increase in DDCI-4 concentration is explained throughout this work, in which the increase in DDCI-4 concentration caused the dislocation defect and a decrease in charge carriers. The appropriate concentration of DDCl-4 resulted in improved light broadening, especially in near-infrared (NIR) regions.

We report on the utilization of 1′-1′-diethyl-4,4′-dicarbocyanine iodide (DDCI-4) as a photoactive material for organic photodiodes (OPDs). A device was fabricated using a ternary blended ratio in the conventional stack order of ITO/PEDOT:PSS/P3HT:DDCI-4:OXCBA/Al to improve stability and enhance light absorption. An investigation was carried out into the optical and morphological characteristics of the device along with its electrical performance using different concentrations of DDCI-4 in a blended ratio of P3HT:DDCI-4:OXCBA in the photoactive layer. The mechanism of the OPD device and its performance with a gradual increase in DDCI-4 concentration is explained throughout this work, in which the increase in DDCI-4 concentration caused the dislocation defect and a decrease in charge carriers. The appropriate concentration of DDCl-4 resulted in improved light broadening, especially in near-infrared (NIR) regions.

Meciadanol merupakan flavanol katekin termetilasi pada posisi C3 yang mampu menghambat pembentukan histamin oleh histidin dekarboksilase. Senyawa ini merupakan target menarik dalam pengembangan agen antikanker karena histamin diketahui terlibat dalam perkembangan kanker. Histamin juga dilaporkan dapat berkaitan dengan death associated protein kinase 1 (DAPK1) yang berhubungan dengan apoptosis. Penelitian ini mempelajari potensi aktivitas antikanker meciadanol terhadap DAPK1 secara in silico. Penambatan molekul terhadap protein DAPK1 (kode 5AUX dan 5AV3) dilakukan dengan Autodock Vina yang dilanjutkan dengan evaluasi sifat fisikokimia dan profil ADMET menggunakan SwissADME dan pkCSM. Nilai afinitas ikatan meciadanol terhadap 5AUX dan 5AV3 masing-masing sebesar -7,4 kkal/mol dan -7,0 kkal/mol. Meciadanol selanjutnya tidak melanggar aturan Lipinski, Ghose, Veber, Egan dan Muegge, dan memiliki profil ADMET yang baik berdasarkan deskriptor evaluasi.

Meciadanol merupakan flavanol katekin termetilasi pada posisi C3 yang mampu menghambat pembentukan histamin oleh histidin dekarboksilase. Senyawa ini merupakan target menarik dalam pengembangan agen antikanker karena histamin diketahui terlibat dalam perkembangan kanker. Histamin juga dilaporkan dapat berkaitan dengan death associated protein kinase 1 (DAPK1) yang berhubungan dengan apoptosis. Penelitian ini mempelajari potensi aktivitas antikanker meciadanol terhadap DAPK1 secara in silico. Penambatan molekul terhadap protein DAPK1 (kode 5AUX dan 5AV3) dilakukan dengan Autodock Vina yang dilanjutkan dengan evaluasi sifat fisikokimia dan profil ADMET menggunakan SwissADME dan pkCSM. Nilai afinitas ikatan meciadanol terhadap 5AUX dan 5AV3 masing-masing sebesar -7,4 kkal/mol dan -7,0 kkal/mol. Meciadanol selanjutnya tidak melanggar aturan Lipinski, Ghose, Veber, Egan dan Muegge, dan memiliki profil ADMET yang baik berdasarkan deskriptor evaluasi.