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1. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

Author

The Genetics of DNA Methylation Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Daniel L. McCartney, Josine L. Min, RC (Rebecca) Richmond, Ake T. Lu, Maria K. Sobczyk, Gail Davies, L. (Linda) Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Seyma Katrinli, Pei Lun Kuo, Pamela R. Matias-Garcia, Pashupati P. Mishra, Marianne Nygaard, Teemu Palviainen, Amit Patki, Laura M. Raffield, Scott M. Ratliff, Tom G. Richardson, Oliver Robinson, Mette Soerensen, Dianjianyi Sun, Pei Chien Tsai, Matthijs D. van der Zee, Rosie M. Walker, Xiaochuan Wang, Yunzhang Wang, Rui Xia, Zongli Xu, Jie Yao, W. (Wei) Zhao, Adolfo Correa, Eric Boerwinkle, Pierre Antoine Dugué, Peter Durda, Hannah R. Elliott, Christian Gieger, Eco J.C. de Geus, Sarah E. Harris, Gibran Hemani, Medea Imboden, Mika Kähönen, Sharon L.R. Kardia, Jacob K. Kresovich, Shengxu Li, A.G. (André) Uitterlinden, JT (Jordana) Bell, J.B.J. (Joyce) van Meurs, The Genetics of DNA Methylation Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Daniel L. McCartney, Josine L. Min, RC (Rebecca) Richmond, Ake T. Lu, Maria K. Sobczyk, Gail Davies, L. (Linda) Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Seyma Katrinli, Pei Lun Kuo, Pamela R. Matias-Garcia, Pashupati P. Mishra, Marianne Nygaard, Teemu Palviainen, Amit Patki, Laura M. Raffield, Scott M. Ratliff, Tom G. Richardson, Oliver Robinson, Mette Soerensen, Dianjianyi Sun, Pei Chien Tsai, Matthijs D. van der Zee, Rosie M. Walker, Xiaochuan Wang, Yunzhang Wang, Rui Xia, Zongli Xu, Jie Yao, W. (Wei) Zhao, Adolfo Correa, Eric Boerwinkle, Pierre Antoine Dugué, Peter Durda, Hannah R. Elliott, Christian Gieger, Eco J.C. de Geus, Sarah E. Harris, Gibran Hemani, Medea Imboden, Mika Kähönen, Sharon L.R. Kardia, Jacob K. Kresovich, Shengxu Li, A.G. (André) Uitterlinden, JT (Jordana) Bell, and J.B.J. (Joyce) van Meurs

Abstract

Background: Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results: Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci

Published
2021
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2. [George C. Richardson and Co.]

Author

Gregory, Franklin E.; Guild, George K.; Lambert, William G.; Richardson, George C.; Smith, Charles S., Black, James Wallace, 1825-1896, photographer., Gregory, Franklin E.; Guild, George K.; Lambert, William G.; Richardson, George C.; Smith, Charles S., and Black, James Wallace, 1825-1896, photographer.

Abstract

Identified is Geo.C. Richardson and Co. owned by George C. Richardson, William G. Lambert, Charles S. Smith, George K. Guild, and Franklin E. Gregory. Part of Black's series showing the devastation of the Great Boston Fire of 1872. Title devised by curator. Etched in black in the lower right portion of the photograph is number 38 and in white on the left middle edge appears "Black Photo." In graphite on mount below photograph is "96 Devonshire St. G.C. Richardson and Co."; above is number 29 and in the upper right corner the page number 25. Retrospective conversion record.

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