Search

Gym, Dining Hall, Ferris School

Woodshaven-Kruse School, barn

Woodshaven-Kruse School exterior, Dorothy Banten Building

Woodshaven-Kruse School, garage

Woodshaven-Kruse School exterior, Maintenance quarters

Woodshaven-Kruse School, Mahaffey Cottage

Woodshaven-Kruse School, Marks Cottage

Woodshaven-Kruse School exterior, Phoebe Curtis School

Woodshaven-Kruse School exterior, Mary R. Bancroft Cottage

Sowden Cottage, Ferris School

Administration Building, Ferris School

Dumbar Cottage, Ferris School

Infirmary, Ferris School

Auto repair shop, Ferris School

Murphy Cottage, Ferris School

Old Jug, Boiler Room, Ferris School

Mowlds Cottage, Ferris School

Director's House, Ferris School

Gym, Dining Hall, Ferris School

Washington Cottage, Ferris School

Ball Cottage, Ferris School

School building, Ferris School

Garage, Ferris School

Grace Cottage, Ferris School

Stable, Ferris School

Gym, Dining Hall, Ferris School

Oxidative damage has been documented in the peripheral tissues of autism patients. In this study, we sought evidence of oxidative injury in autistic brain. Carboxyethyl pyrrole (CEP) and iso[4]levuglandin (iso[4]LG)E2-protein adducts, that are uniquely generated through peroxidation of docosahexaenoate and arachidonate-containing lipids respectively, and heme oxygenase-1 were detected immunocytochemically in cortical brain tissues and by ELISA in blood plasma. Significant immunoreactivity toward all three of these markers of oxidative damage in the white matter and often extending well into the grey matter of axons was found in every case of autism examined. This striking threadlike pattern appears to be a hallmark of the autistic brain as it was not seen in any control brain, young or aged, used as controls for the oxidative assays. Western blot and immunoprecipitation analysis confirmed neurofilament heavy chain to be a major target of CEP-modification. In contrast, in plasma from 27 autism spectrum disorder patients and 11 age-matched healthy controls we found similar levels of plasma CEP (124.5 ± 57.9 versus 110.4 ± 30.3 pmol/mL), iso[4]LGE2 protein adducts (16.7 ± 5.8 versus 13.4 ± 3.4 nmol/mL), anti-CEP (1.2 ± 0.7 versus 1.2 ± 0.3) and anti-iso[4]LGE2 autoantibody titre (1.3 ± 1.6 versus 1.0 ± 0.9), and no differences between the ratio of NO2Tyr/Tyr (7.81 E-06 ± 3.29 E-06 versus 7.87 E-06 ± 1.62 E-06). These findings provide the first direct evidence of increased oxidative stress in the autistic brain. It seems likely that oxidative injury of proteins in the brain would be associated with neurological abnormalities and provide a cellular basis at the root of autism spectrum disorders.

The mechanism(s) responsible for the loss of neurons that characterizes Alzheimer disease is incompletely understood. Nonetheless, there is considerable evidence suggestive of immune abnormalities coupled to alterations in blood-brain barrier permeability that likely play a key role in both the etiology and progression of the disease. To examine these issues further, this study was designed to examine the presence of human antibodies within hippocampal regions of both diseased and normal brains. Specifically, using antibodies directed against either human lambda (λ) or kappa (κ) subunits of human IgG, we examined the amount and localization of endogenous human antibodies within the brain. In cases of Alzheimer disease, but not in age-matched controls, we found human antibodies associated with pyramidal neurons and dystrophic neurites surrounding amyloid plaques - pathological structures that characterize the disease. Since such human immunoglobulins likely originate in the vasculature, we also examined cases of cerebral amyloid angiopathy to further explore the importance of blood-brain barrier breaches and found high levels of antibodies associated with many blood vessels as well as pyramidal neurons. Taken together, these findings strengthen the notion that alterations in blood brain barrier permeability in both Alzheimer disease and cerebral amyloid angiopathy leads to the accumulation of antibodies that then may contribute to the inflammatory cascade within the brain.

The increasing use of concrete building blocks employing lightweight volcanic aggregates has presented many problems. Questions are constantly arising regarding locations of suitable lightweight aggregates, properties of the various materials, properties of blocks with different proportions of cement, and methods of manufacturing.

The increasing use of concrete building blocks employing lightweight volcanic aggregates has presented many problems. Questions are constantly arising regarding locations of suitable lightweight aggregates, properties of the various materials, properties of blocks with different proportions of cement, and methods of manufacturing.

理学研究科所蔵, 理学部中央図書室:6-I/338, 4 p., 61 colored plates ; 43 cm, At the title page,"containing a new arrangement of the genera and species, illustrated by coloured engravings executed from the natural specimens, and including the latest discoveries", 京都大学理学研究科 Graduate School of Science, Kyoto University || https://rmda.kulib.kyoto-u.ac.jp/reuse