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Shuang Liang,1 Yan-Jun Liang,1 Zhao Li,2 Yong Wang,1 Xin-Ru Guo,1 Chao-yang Zhang,1 Chun Zhang,1 Jie Wu,1 Xiao-Long Wang,1 Yi-Sha Li,1 Guang-Yan Cai,1 Xiang-Mei Chen1 1Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, People’s Republic of China; 2Haikou People’s Hospital Affiliated to Xiangya School of Medicine, Haikou, People’s Republic of ChinaCorrespondence: Guang-Yan Cai, Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, People’s Republic of China, Tel +86 13601062936, Fax +86 010-68130297, Email caiguangyan@sina.comPurpose: Tacrolimus is recommended by KDIGO Clinical Practice Guidelines as an initial therapy for the treatment of membranous nephropathy (MN). However, little is known about the factors that influence response and recurrence of the disease after tacrolimus therapy, and there are limited data regarding the duration of tacrolimus treatment. Here, we present a real-world retrospective cohort study of 182 MN patients treated with tacrolimus, aiming to assess the efficacy and safety of tacrolimus in the treatment of MN.Patients and Methods: The clinical data of 182 patients with MN treated with tacrolimus and followed up for at least one year were analyzed retrospectively for the efficacy and safety of tacrolimus.Results: The mean follow-up period was 27.3 (19.3– 41.6) months. A total of 154 patients (84.6%) achieved complete or partial remission, and 28 patients (15.4%) did not. Multivariate Cox regression analysis showed that male and higher baseline

Zhao-Yin Ma,1,* Yong-Ya Wu,2,* Hong-Yin-Long Cui,3 Guang-Yan Yao,3 Hong Bian3,4 1Department of Diagnostic, Medical Integration and Practice Center, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Emergency Critical Care Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 3Department of Neurology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China; 4Department of Neurology, Jinan Central Hospital, Shandong University, Jinan, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Bian, Department of Neurology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China, Tel +86-15318816109, Fax +86-053188382085, Email jnbianh@163.comObjective: Type 2 diabetes mellitus (T2DM) and ischemic stroke, which are common diseases among older people, are closely related to cognitive impairment. This study aims to investigate the influencing factors of post-stroke cognitive impairment (PSCI) in patients with T2DM.Methods: We enrolled 161 patients with T2DM who experienced acute ischemic stroke and were hospitalized in the Department of Neurology, Jinan Central Hospital, Shandong, China. Cognitive function was evaluated with the Montreal Cognitive Assessment scale. According to the results, patients were divided into three groups—the cognitively normal group, mild cognitive impairment group, and severe cognitive impairment group. We analyzed general demographic data, laboratory information, imaging data, the results of neuropsychological evaluation, and clinical features as well as influencing factors of PSCI in these patients and established a prediction model.Results: The three groups of patients were significantly different in terms of age, education level, course of diabe

Qiu-Xia Han,1–3,* Dong Zhang,1,* Ya-Li Zhao,4 Liang Liu,5 Jing Li,5 Fu Zhang,5 Fu-Xin Luan,5 Dong-Wei Liu,3 Zhang-Suo Liu,3 Guang-Yan Cai,1,2 Xiang-Mei Chen,1,2 Han-Yu Zhu1 1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases，Beijing Key Laboratory of Kidney Diseases, Beijing 100853, People’s Republic of China; 2Medical College, Nankai University, Tianjin 300000, People’s Republic of China; 3Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology of Zhengzhou University, Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou 450052, People’s Republic of China; 4Central Laboratory, Hainan Branch of Chinese PLA General Hospital, Sanya 572000, People’s Republic of China; 5Management Department, Hainan Branch of Chinese PLA General Hospital, Sanya 572000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Han-Yu Zhu; Xiang-Mei ChenDepartment of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, 28 Fuxing Road, Haidian District, Beijing 100853, People’s Republic of ChinaTel +86 10 6693 7763; +86 10 6693 7748Email hanyuzhu301@126.com; xiangmeichen301@126.comPurpose: Hyperuricemia is an important potential pathogenic factor for hypertension, cardiovascular disease and stroke. The current study aimed to investigate the prevalence of hyperuricemia and its relationship to lifestyle characteristics and dietary habits in centenarians and near-centenarians.Patients and methods: In total, 966 centenarians and 788 near-centenarians were included. Community-based surv

Wen-Ling Wang,1,2 Shuang Liang,1 Fang-Lei Zhu,1 Jie-Qiong Liu,1 Si-Yang Wang,1 Xiang-Mei Chen,1 Guang-Yan Cai1 On behalf of the C-OPTION study group1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing, People’s Republic of China; 2General Internal Medicine Department, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of ChinaPurpose: The prevalence of depression and the relationship between depression and kidney function and health-related quality of life (HRQOL) are not well understood in elderly patients with predialysis chronic kidney disease (CKD). This study aimed to evaluate the prevalence of depression and the association between depression and kidney function and HRQOL.Patients and methods: In this cross-sectional study, 1079 elderly participants with CKD were recruited at 32 clinical centers located within 26 cities throughout 24 provinces in China. Demographic information and laboratory analyses were collected. Symptoms of depression were assessed using the 15-item Geriatric Depression Scale (GDS-15). HRQOL was evaluated using the Kidney Disease Quality of Life-36 (KDQOL-36) instrument.Results: The prevalence of depression was 23.0%. The estimated glomerular filtration rate (eGFR) was negatively correlated with the GDS score whether it was treated as a categorical variable (r=−0.097, P=0.001) or as a continuous variable (r=−0.100, P=0.001). Marital status, education level, history of CVD and diabetes, CKD stage and proteinuria confirmed to be independent and significant predictors of depression in patients with CKD. Compared with CKD 1–2 patients, we observed an increase of 0.541 and 4.171 in the odds for developing depression in patients CKD 4 (odds ratio [OR] =1.541; P=0.031) an

Jie-qiong Liu,1,2 Guang-yan Cai,1 Si-yang Wang,1 Yu-huan Song,1 Yuan-yuan Xia,1 Shuang Liang,1 Wen-ling Wang,1 Sa-sa Nie,1 Zhe Feng,1 Xiang-mei Chen1 1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Disease, Beijing, China; 2Department of Nephrology, Chinese PLA 401 Hospital, Qingdao, China Objectives: The most serious adverse reaction of cisplatin is acute kidney injury (AKI). Cisplatin-induced acute kidney injury (CIA) has no specific preventive measures. This study aims to explore the characteristics and risk factors for CIA in the elderly and to identify potential methods to reduce CIA. Materials and methods: Patients ≥18 years old, with primary tumors, who received initial cisplatin chemotherapy and whose serum creatinine (SCr) values were measured within 2 weeks pre- and postcisplatin treatment and who had complete medical records, were selected from a single center from January 1, 2013 to December 31, 2015. The exclusion criteria included radiotherapy or surgery, recurrent tumors, previous cisplatin treatment, lack of any SCr values before or after cisplatin therapy, and incomplete medical records. Results: Out of a total of 527 patients, 349 were elderly. Angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) use (9.2%) was more prevalent in the elderly than in younger patients (2.8%, p = 0.007). The dosage of cisplatin treatment was lower in the elderly, but the incidence of CIA (9.46%) was higher in the elderly than in younger patients (3.37%). There were significant differences in the SCr levels, estimated glomerular filtration rate, ACEI/ARB use, and whether a single application of cisplatin was administered, between the elderly AKI group and the non-AKI group. Multivariable analysis showed that administration of a single application of cisplatin (OR 2.853, 95% CI: 1.229, 6.621, p = 0.015) and

A novel mixed collector (BHOA) was prepared by mixing benzohydroxamic acid (BHA) and sodium oleate (NaOL) and applied to the flotation separation of smithsonite from dolomite. Flotation results showed that NaOL alone had good collecting performance on smithsonite and common gangue mineral dolomite but had poor selectivity. By using a BHA/NaOL mixed system with a molar ratio of 2:1, the recoveries of smithsonite and dolomite reached approximately 90% and 5%, respectively. Surface tension analysis showed that the surface activity of BHOA was a little higher than that of a single NaOL because of synergistic effects. Zeta potential and X-ray photoelectron spectroscopy measurements indicated that surfactants BHA and NaOL co-absorbed on the smithsonite surface and only NaOL was present on the dolomite surface in the presence of BHOA. (Authors.), A novel mixed collector (BHOA) was prepared by mixing benzohydroxamic acid (BHA) and sodium oleate (NaOL) and applied to the flotation separation of smithsonite from dolomite. Flotation results showed that NaOL alone had good collecting performance on smithsonite and common gangue mineral dolomite but had poor selectivity. By using a BHA/NaOL mixed system with a molar ratio of 2:1, the recoveries of smithsonite and dolomite reached approximately 90% and 5%, respectively. Surface tension analysis showed that the surface activity of BHOA was a little higher than that of a single NaOL because of synergistic effects. Zeta potential and X-ray photoelectron spectroscopy measurements indicated that surfactants BHA and NaOL co-absorbed on the smithsonite surface and only NaOL was present on the dolomite surface in the presence of BHOA. (Authors.)