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10 results on '"Hamm CW"'

1. Relationship between cardiovascular risk factors and biomarkers with necrotic core and atheroma size: a serial intravascular ultrasound radiofrequency data analysis

Author

Garcia Garcia, Hector, Klauss, V, Gonzalo, N, Garg, Scot, Onuma, Yoshinobu, Hamm, CW, Wijns, W (William), Shannon, J, Serruys, PWJC (Patrick), Garcia Garcia, Hector, Klauss, V, Gonzalo, N, Garg, Scot, Onuma, Yoshinobu, Hamm, CW, Wijns, W (William), Shannon, J, and Serruys, PWJC (Patrick)

Abstract

We explored the impact of patient demographics, anthropometric measurements, cardiovascular risk factors, and soluble biomarkers on necrotic core and atheroma size in patients with coronary disease. The IBIS-2 trial enrolled 330 patients. In the multivariate analysis, at baseline, creatinine had a positive, whereas baseline mean lumen diameter and myeloperoxidase had a negative, independent association with percentage of necrotic core (PNC); while age, glomerular filtration rate < 60, HbA1c, previous PCI or CABG and baseline % diameter stenosis were positively, and acute coronary syndromes (ACS) were negatively associated with baseline percentage atheroma volume (PAV). The variables associated with a decrease in PNC from baseline were darapladib, ACS and a large content of NC at baseline, while variables associated with an increase in PNC were previous stroke and % diameter stenosis at baseline. Those variables associated with a decrease in PAV from baseline were waist circumference, statin use, CD40L and baseline PAV, while the only variable associated with an increase in PAV was baseline diastolic blood pressure. Treatment with darapladib was associated with a decrease in necrotic core, but was not associated with a decrease in percentage atheroma volume. On the contrary, statin use was only associated with a decrease in percentage atheroma volume.

Published
2012

2. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)

Author

Hamm, Cw, Bassand, J, Agewall, S, Bax, J, Boersma, E, Bueno, H, Caso, P, Dudek, D, Gielen, S, Huber, K, Ohman, M, Petrie, Mc, Sonntag, F, Uva, M, Storey, Rf, Wijns, W, Zahger, D, Bax, Jj, Auricchio, A, Baumgartner, H, Ceconi, C, Dean, V, Deaton, C, Fagard, R, Funck Brentano, C, Hasdai, D, Hoes, A, Knuuti, J, Kolh, P, Mcdonagh, T, Moulin, C, Poldermans, D, Popescu, Ba, Reiner, Z, Sechtem, U, Sirnes, Pa, Torbicki, A, Vahanian, A, Windecker, S, Achenbach, S, Badimon, L, Bertrand, M, Bøtker, He, Collet, J, Crea, Filippo, Danchin, N, Falk, E, Goudevenos, J, Gulba, D, Hambrecht, R, Herrmann, J, Kastrati, A, Kjeldsen, K, Kristensen, Sd, Lancellotti, P, Mehilli, J, Merkely, B, Montalescot, G, Neumann, F, Neyses, L, Perk, J, Roffi, M, Romeo, Fabio, Ruda, M, Swahn, E, Valgimigli, M, Vrints, Cj, Widimsky, P., Crea, Filippo (ORCID:0000-0001-9404-8846), Hamm, Cw, Bassand, J, Agewall, S, Bax, J, Boersma, E, Bueno, H, Caso, P, Dudek, D, Gielen, S, Huber, K, Ohman, M, Petrie, Mc, Sonntag, F, Uva, M, Storey, Rf, Wijns, W, Zahger, D, Bax, Jj, Auricchio, A, Baumgartner, H, Ceconi, C, Dean, V, Deaton, C, Fagard, R, Funck Brentano, C, Hasdai, D, Hoes, A, Knuuti, J, Kolh, P, Mcdonagh, T, Moulin, C, Poldermans, D, Popescu, Ba, Reiner, Z, Sechtem, U, Sirnes, Pa, Torbicki, A, Vahanian, A, Windecker, S, Achenbach, S, Badimon, L, Bertrand, M, Bøtker, He, Collet, J, Crea, Filippo, Danchin, N, Falk, E, Goudevenos, J, Gulba, D, Hambrecht, R, Herrmann, J, Kastrati, A, Kjeldsen, K, Kristensen, Sd, Lancellotti, P, Mehilli, J, Merkely, B, Montalescot, G, Neumann, F, Neyses, L, Perk, J, Roffi, M, Romeo, Fabio, Ruda, M, Swahn, E, Valgimigli, M, Vrints, Cj, Widimsky, P., and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

N/A

Published
2011

3. Use of platelet glycoprotein IIb/IIIa inhibitors in diabetics undergoing PCI for non-ST-segment elevation acute coronary syndromes: impact of clinical status and procedural characteristics

Author

Bauer, T, Mollmann, H, Weidinger, F, Zeymer, U, Seabra-Gomes, R, Eberli, F, Serruys, PWJC (Patrick), Vahanian, A, Silber, S, Wijns, W (William), Hochadel, M, Nef, HM, Hamm, CW, Marco, J, Gitt, AK, Bauer, T, Mollmann, H, Weidinger, F, Zeymer, U, Seabra-Gomes, R, Eberli, F, Serruys, PWJC (Patrick), Vahanian, A, Silber, S, Wijns, W (William), Hochadel, M, Nef, HM, Hamm, CW, Marco, J, and Gitt, AK

Abstract

The most recent ESC guidelines for percutaneous coronary intervention (PCI) recommend the use of glycoprotein IIb/IIIa inhibitors (GPI) in high risk patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), particularly in diabetics. Little is known about the adherence to these guidelines within Europe. Between May 2005 and April 2008 a total of 47,407 consecutive patients undergoing PCI were prospectively enrolled into the PCI-Registry of the Euro Heart Survey Programme. In the present analysis we examined the use of GPI in 2,922 diabetics who underwent PCI for NSTE-ACS. In this high risk population only 22.2% received a GPI; 8.9% upstream and 13.4% during PCI. The strategy of the individual institution had a major impact on the usage of GPI. In the multiple regression analysis clinical instability and complex lesion characteristics were strong independent determinants for the use of GPI, whereas renal insufficiency was negatively associated with its use. After adjustment for confounding variables no significant differences in hospital mortality could be observed between the cohorts, but a significantly higher rate of non-fatal postprocedural myocardial infarction was observed among patients receiving GPI upstream. Despite the recommendation for its use in the current ESC guidelines, only a minority of the diabetics in Europe undergoing PCI for NSTE-ACS received a GPI. The use of GPI was mainly triggered by high-risk interventional scenarios.

Published
2010

6. Soluble CD40 ligand in acute coronary syndromes

Author

Heeschen, C, Dimmeler, S, Hamm, CW, van den Brand, MJBM (Marcel), Boersma, Eric, Zeiher, AM, Simoons, Maarten, Heeschen, C, Dimmeler, S, Hamm, CW, van den Brand, MJBM (Marcel), Boersma, Eric, Zeiher, AM, and Simoons, Maarten

Published
2003

10. Recanalization of total Coronary Occlusions Using a Laser Guidewire (The European TOTAL Surveillance Study)

Author

Hamburger, JN, Serruys, PWJC (Patrick), Scabra-Gomes, R, Simon, R, Koolen, JJ, Fleck, E, Mathey, D, Sievert, H, Rutsch, W, Buchwald, A, Marco, J, Al-Kasab, SM, Pizulli, L, Hamm, CW, Corcos, T, Reifart, N, Hanrath, P, Taeymans, Y, Hamburger, JN, Serruys, PWJC (Patrick), Scabra-Gomes, R, Simon, R, Koolen, JJ, Fleck, E, Mathey, D, Sievert, H, Rutsch, W, Buchwald, A, Marco, J, Al-Kasab, SM, Pizulli, L, Hamm, CW, Corcos, T, Reifart, N, Hanrath, P, and Taeymans, Y

Published
1997

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