1. Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma
- Author
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Hedegaard, Jakob, Lamy, Philippe, Nordentoft, Iver, Algaba, Ferran, Hoyer, Soren, Ulhoi, Benedicte Parm, Vang, Soren, Reinert, Thomas, Hermann, Gregers G., Mogensen, Karin, Thomsen, Mathilde Borg Houlberg, Nielsen, Morten Muhlig, Marquez, Mirari, Segersten, Ulrika, Aine, Mattias, Hoglund, Mattias, Birkenkamp-Demtroder, Karin, Fristrup, Niels, Borre, Michael, Hartmann, Arndt, Stoehr, Robert, Wach, Sven, Keck, Bastian, Seitz, Anna Katharina, Nawroth, Roman, Maurer, Tobias, Tulic, Cane, Simic, Tatjana, Junker, Kerstin, Horstmann, Marcus, Harving, Niels, Petersen, Astrid Christine, Luz Calle, M., Steyerberg, Ewout W., Beukers, Willemien, van Kessel, Kim E. M., Jensen, Jorgen Bjerggaard, Pedersen, Jakob Skou, Malmström, Per-Uno, Malats, Nuria, Real, Francisco X., Zwarthoff, Ellen C., Orntoft, Torben Falck, Dyrskjot, Lars, Hedegaard, Jakob, Lamy, Philippe, Nordentoft, Iver, Algaba, Ferran, Hoyer, Soren, Ulhoi, Benedicte Parm, Vang, Soren, Reinert, Thomas, Hermann, Gregers G., Mogensen, Karin, Thomsen, Mathilde Borg Houlberg, Nielsen, Morten Muhlig, Marquez, Mirari, Segersten, Ulrika, Aine, Mattias, Hoglund, Mattias, Birkenkamp-Demtroder, Karin, Fristrup, Niels, Borre, Michael, Hartmann, Arndt, Stoehr, Robert, Wach, Sven, Keck, Bastian, Seitz, Anna Katharina, Nawroth, Roman, Maurer, Tobias, Tulic, Cane, Simic, Tatjana, Junker, Kerstin, Horstmann, Marcus, Harving, Niels, Petersen, Astrid Christine, Luz Calle, M., Steyerberg, Ewout W., Beukers, Willemien, van Kessel, Kim E. M., Jensen, Jorgen Bjerggaard, Pedersen, Jakob Skou, Malmström, Per-Uno, Malats, Nuria, Real, Francisco X., Zwarthoff, Ellen C., Orntoft, Torben Falck, and Dyrskjot, Lars
- Abstract
Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into three major classes with basal-and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions. Furthermore, mutations in well-known cancer driver genes (e.g., TP53 and ERBB2) were primarily found in high-risk tumors, together with APOBEC-related mutational signatures. The identification of subclasses in NMIBC may offer better prognostication and treatment selection based on subclass assignment.
- Published
- 2016
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