1. Platelet-to-Lymphocyte Ratio Improves the Predictive Ability of the Risk Score for Atrial Fibrillation Recurrence After Radiofrequency Ablation
- Author
-
Huang,Wenchao, Sun,Huaxin, Tang,Yan, Luo,Yan, Liu,Hanxiong, Huang,Wenchao, Sun,Huaxin, Tang,Yan, Luo,Yan, and Liu,Hanxiong
- Abstract
Wenchao Huang,* Huaxin Sun,* Yan Tang,* Yan Luo, Hanxiong Liu Department of Cardiology, The Third Peopleâs Hospital of Chengdu, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Hanxiong Liu, Affiliated Hospital of Southwest Jiaotong University, The Third Peopleâs Hospital of Chengdu, Chengdu Cardiovascular Disease Research Institute, 82 Qinglong St. Chengdu, Sichuan, Peopleâs Republic of China, Tel +86 18897966045, Email clin999@163.comPurpose: To investigate the effect and comprehensive predictive value of the platelet-to-lymphocyte ratio (PLR) for long-term recurrence in patients with atrial fibrillation (AF) post ablation.Patients and Methods: We retrospectively analysed 638 consecutive AF patients who underwent ablation, including 302 (47.3%) with paroxysmal AF and 336 (52.7%) with nonparoxysmal AF. Patients were grouped into the recurrence and nonrecurrence groups.Results: After a mean follow-up of 15.1± 9.3 months, 175 patients (27.4%) with AF had long-term recurrence, including 114 patients (33.9%) with nonparoxysmal AF and 61 patients (20.2%) with paroxysmal AF. In the entire cohort and in patients with nonparoxysmal AF, but not in those with paroxysmal AF, the PLR was significantly higher in the recurrence group than in the nonrecurrence group (P< 0.05). After adjusting for the APPLE score, the PLR as a continuous variable independently predicted AF recurrence (hazard ratio [HR], 1.003; 95% confidence interval [CI], 1.001â 1.005; P< 0.01). The addition of the PLR to the APPLE score improved its predictive ability for recurrence (the C-statistic value increased from 0.645 to 0.675, P=0.02; the net reclassification improvement was 0.221, 95% CI 0.049â 0.394, P=0.01; and the integrated discrimination improvement was 0.029, 95% CI 0.013â 0.045, P< 0.01). For nonparoxysmal AF, the PLR
- Published
- 2023