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BackgroundIn 2017, a prospective multicenter, multinational, investigational pilot study was conducted examining outcomes using a novel surgical technique, the Mini-Jupette sling, for the management of erectile dysfunction (ED) patients with climacturia and/or minimal stress urinary incontinence (SUI) after prostate procedures. Climacturia has been reported in up to 64% of patients following radical prostatectomy (RP). We sought to report the 5-year outcomes from this original cohort to assess long-term safety and effectivity of the mini-jupette sling in the treatment of ED and concomitant mild SUI and/or climacturia.MethodsThis is a single-arm, multicenter, retrospective, observational study. We identified patients who were enrolled in the previous multicenter study with post-RP ED and climacturia and/or mild SUI- 2 PADS PER DAY (PPD) and underwent inflatable penile prosthesis (IPP) insertion with simultaneous placement of a mini-jupette sling. Data were collected including current PPD, subjective improvement in climacturia/SUI, complications, need for revision of IPP or additional urinary incontinence surgery, and date of most recent follow-up. SPSS was used for statistical analysis.ResultsOf the original 38 patients, 5 have since died and 10 were lost to follow-up with 23/38 (61%) patients available for evaluation of long-term outcomes. The average follow-up time was 59 months (SD =8.8) with a mean age of 69 years (SD =6.8). Most patients (n=21, 91%) had subjective improvement of SUI and climacturia. One patient with persistent bothersome incontinence underwent artificial urinary sphincter (AUS) placement in 2018 with no complications, while the other is still considering a repeat procedure due to minor but persistent SUI. The mean PPD decreased from 1.4 preoperatively to 0.4 at a mean of 5 years of follow-up. Most patients reported satisfaction in their urinary symptoms with 91% and 73% reporting improvement in SUI and climacturia respectively, compared to 86% a

It is well known that in a firm real time system with a renewal arrival process, exponential service times and independent and identically distributed deadlines till the end of service of a job, the earliest deadline first (EDF) scheduling policy has smaller loss ratio (expected fraction of jobs, not completed) than any other service time independent scheduling policy, including the first come first served (FCFS). Various modifications to the EDF and FCFS policies have been proposed in the literature, with a view to improving performance. In this article, we compare the loss ratios of these two policies along with some of the said modifications, as well as their counterparts with deterministic deadlines. The results include some formal inequalities and some counter-examples to establish non-existence of an order. A few relations involving loss ratios are posed as conjectures, and simulation results in support of these are reported. These results lead to a complete picture of dominance and non-dominance relations between pairs of scheduling policies, in terms of loss ratios., Comment: 8 pages, 10 figures

The history of the toxicology programs of the military services is an appropriate consideration when addressing the application policy, and practice to chemical risk assessment in the Department of Defense. Assessment of risk implies evaluating the probability of adverse effects caused by a chemical--under specific conditions--as opposed to a more straightforward description of the toxicity (potential for harm) of that chemical, This article is from 'Proceedings of The Conference on Chemical Risk Assessment in the DoD: Science, Policy and Practice, Held in Dayton, OH on April 8 - 11, 1991. AD-A268 643, p197 - 201.