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Erratum

B cells are known to play a dominant pathogenic role in autoimmune conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. In recent times, the chemokine receptor CCR6 and its cognate ligand CCL20 have been shown to play a role in the fundamental kinetics of germinal centres and B cell responses. As CCR6 is found on B cells and is upregulated after activation, we investigated the expression of CCR6 on naive, pre-germinal centre (GC), GC/plasma cell and memory B cells in peripheral B cells of SLE patients and healthy controls using flow cytometry. Pre-germinal centre B cells are found in lower proportions and the expression of CCR6 is increased on B cells of SLE patients, suggesting a role for the chemokine pair in the pathogenesis of the disease. Further studies are needed to explore these preliminary results.

Erratum

B cells are known to play a dominant pathogenic role in autoimmune conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. In recent times, the chemokine receptor CCR6 and its cognate ligand CCL20 have been shown to play a role in the fundamental kinetics of germinal centres and B cell responses. As CCR6 is found on B cells and is upregulated after activation, we investigated the expression of CCR6 on naive, pre-germinal centre (GC), GC/plasma cell and memory B cells in peripheral B cells of SLE patients and healthy controls using flow cytometry. Pre-germinal centre B cells are found in lower proportions and the expression of CCR6 is increased on B cells of SLE patients, suggesting a role for the chemokine pair in the pathogenesis of the disease. Further studies are needed to explore these preliminary results.

Terahertz emission spectroscopy (TES) of ultrathin multilayers of magnetic and heavy metals has recently attracted much interest. This method not only provides fundamental insights into photoinduced spin transport and spin–orbit interaction at highest frequencies, but has also paved the way for applications such as efficient and ultrabroadband emitters of terahertz (THz) electromagnetic radiation. So far, predominantly standard ferromagnetic materials have been exploited. Here, by introducing a suitable figure of merit, we systematically compare the strength of THz emission from X/Pt bilayers with X being a complex ferro-, ferri- and antiferromagnetic metal, that is, dysprosium cobalt (DyCo5), gadolinium iron (Gd24Fe76), magnetite (Fe3O4) and iron rhodium (FeRh). We find that the performance in terms of spin-current generation not only depends on the spin polarization of the magnet's conduction electrons, but also on the specific interface conditions, thereby suggesting TES to be a highly interface-sensitive technique. In general, our results are relevant for all applications that rely on the optical generation of ultrafast spin currents in spintronic metallic multilayers.

© 2014 The Guilford Press. In Australia, unlike much of the rest of the world, HIV transmission through heterosexual contact remains a relatively rare occurrence. In consequence, HIV-prevention efforts have been frmly focused on male-to-male sex as the most frequent source of HIV transmission. There are emerging signs that this epidemiological landscape may be shifting, which raises questions about current and future HIV prevention strategies. Over the past decade, national surveillance data have shown an increase in HIV notifca-tions for which exposure to HIV was attributed to heterosexual contact. This paper offers an epidemiological and sociocultural picture of heterosexual HIV transmission in Australia. We outline recent trends in hetero-sexually acquired HIV and discuss specifc factors that shape transmission and prevention among people at risk of HIV infection through heterosexual contact. To illustrate the contextual dynamics surrounding HIV in this diverse population, we detail two key examples: HIV among people from minority ethnic backgrounds in New South Wales; and overseas-acquired HIV among men in Western Australia. We argue that, despite their differences, there are signifcant commonalities across groups at risk of HIV infection through heterosexual contact, which not only provide opportunities for HIV prevention, but also call for a rethink of the dominant HIV response in Australia.

©2011 American Institute of Physics. Work supported by Spanish MCINN Grant No. FIS2008- 06249, Consolider CSD2007-00010, CM Grant No. S2009/ MAT-1726, and Santander-UCM Grant No. GR35/10-A- 910571. Research at UCSD was funded by the US-NSF and at UC-Davis by US NSF (DMR-1008791). CAR gratefully acknowledges support from the Singapore-MIT Alliance and the assistance of Moyukh Chatterjee in modeling. We thank Y. Rosen for a critical reading of the manuscript., Strong superconducting pinning effects are observed from magnetic landscapes produced by arrays of circular rings with varying magnetic remanent states. The collective and the background pinning of superconducting Nb films is strongly enhanced by the stray magnetic field produced by an array of circular Ni rings magnetized to form “onion” (bidomain) states. On the other hand, when the same rings are magnetized into vortex (flux-closed) states, or are randomly magnetized, the superconducting pinning is much smaller. The greatest pinning is produced when the superconducting vortex lattice motion is along a direction in which there is a strong magnetic field variation., Ministerio de Ciencia e Innovación (MICINN), Comunidad de Madrid, Consolider, Universidad Complutense de Madrid/Banco de Santander, US-NSF, Depto. de Física de Materiales, Fac. de Ciencias Físicas, TRUE, pub

©2011 American Institute of Physics. Work supported by Spanish MCINN Grant No. FIS2008- 06249, Consolider CSD2007-00010, CM Grant No. S2009/ MAT-1726, and Santander-UCM Grant No. GR35/10-A- 910571. Research at UCSD was funded by the US-NSF and at UC-Davis by US NSF (DMR-1008791). CAR gratefully acknowledges support from the Singapore-MIT Alliance and the assistance of Moyukh Chatterjee in modeling. We thank Y. Rosen for a critical reading of the manuscript., Strong superconducting pinning effects are observed from magnetic landscapes produced by arrays of circular rings with varying magnetic remanent states. The collective and the background pinning of superconducting Nb films is strongly enhanced by the stray magnetic field produced by an array of circular Ni rings magnetized to form “onion” (bidomain) states. On the other hand, when the same rings are magnetized into vortex (flux-closed) states, or are randomly magnetized, the superconducting pinning is much smaller. The greatest pinning is produced when the superconducting vortex lattice motion is along a direction in which there is a strong magnetic field variation., Ministerio de Ciencia e Innovación (MICINN), Comunidad de Madrid, Consolider, Universidad Complutense de Madrid/Banco de Santander, US-NSF, Depto. de Física de Materiales, Fac. de Ciencias Físicas, TRUE, pub

The invariant mass spectrum of e^+ e^- pairs produced in ^{12}C+^{12}C collisions at 2 GeV per nucleon incident energy has been measured for the first time with the HADES spectrometer at GSI. The measured pair production probabilities span over five orders of magnitude within the \pi^0\to e^+e^-\gamma to \rho/\omega\to e^+e^- invariant mass region. A thermal model of the dielectron sources underestimates the measured probabilities by a factor of roughly two at intermediate masses (0.2 -- 0.6 GeV/c^2) whereas it overshoots data at the \rho/\omega pole. Transport model calculations assuming vacuum spectral functions of the vector mesons fail to describe the entire invariant mass spectrum, as well.

The human condition autoimmune lymphoproliferative syndrome and the murine mutation generalized lymphoproliferative disorder (gld/gld) are both caused by mutations of Fas or Fas ligand and are characterized by severe splenomegaly and lymphadenopathy. in the mouse, the additional absence of TNF attenuates the gld/gld syndrome through an unknown mechanism. We hypothesized that this unexpected outcome was not mediated by increased apoptosis but changes of T cell localization. We demonstrated that the homeostatic chemokine CCL21 is strongly up-regulated in the spleen of C57BL/6 (B6).gld/gld and B6.gld-/-gld.TRAIL-/- mice. in contrast, a distinct consequence of TNF deficiency in B6.gld/gld mice was the substantially reduced splenic production of CCL21. An analysis of the cognate chemokine receptor CCR7 showed a complete, age-dependent down-regulation of this receptor on B6.gld/gld conventional peripheral T cells that are therefore unable to react to this chemokine. These results demonstrate a new role for the pro-inflammatory cytokine TNF and the TNF-regulated chemokine CCL21 in the complex etiology of the autoimmune syndrome in B6.gld/gld mice. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

The human condition autoimmune lymphoproliferative syndrome and the murine mutation generalized lymphoproliferative disorder (gld/gld) are both caused by mutations of Fas or Fas ligand and are characterized by severe splenomegaly and lymphadenopathy. in the mouse, the additional absence of TNF attenuates the gld/gld syndrome through an unknown mechanism. We hypothesized that this unexpected outcome was not mediated by increased apoptosis but changes of T cell localization. We demonstrated that the homeostatic chemokine CCL21 is strongly up-regulated in the spleen of C57BL/6 (B6).gld/gld and B6.gld-/-gld.TRAIL-/- mice. in contrast, a distinct consequence of TNF deficiency in B6.gld/gld mice was the substantially reduced splenic production of CCL21. An analysis of the cognate chemokine receptor CCR7 showed a complete, age-dependent down-regulation of this receptor on B6.gld/gld conventional peripheral T cells that are therefore unable to react to this chemokine. These results demonstrate a new role for the pro-inflammatory cytokine TNF and the TNF-regulated chemokine CCL21 in the complex etiology of the autoimmune syndrome in B6.gld/gld mice. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Secondary lymphoid tissue organogenesis requires tumor necrosis factor (TNF) and lymphotoxin alpha (LTalpha). The role of TNF in B cell positioning and formation of follicular structure was studied by comparing the location of newly produced naive recirculating and antigen-stimulated B cells in TNF-/- and TNF/LTalpha-/- mice. By creating radiation bone marrow chimeras from wild-type and TNF-/- mice, formation of normal splenic B cell follicles was shown to depend on TNF production by radiation-sensitive cells of hemopoietic origin. Reciprocal adoptive transfers of mature B cells between wild-type and knockout mice indicated that normal follicular tropism of recirculating naive B cells occurs independently of TNF derived from the recipient spleen. Moreover, soluble TNF receptor-IgG fusion protein administered in vivo failed to prevent B cell localization to the follicle or the germinal center reaction. Normal T zone tropism was observed when antigen-stimulated B cells were transferred into TNF-/- recipients, but not into TNF/LTalpha-/- recipients. This result appeared to account for the defect in isotype switching observed in intact TNF/LTalpha-/- mice because TNF/LTalpha-/- B cells, when stimulated in vitro, switched isotypes normally. Thus, TNF is necessary for creating the permissive environment for B cell movement and function, but is not itself responsible for these processes.

To evaluate the risk of abortion after genetic amniocentesis in twin pregnancies, a retrospective study of 15 centers was performed. The spontaneous abortion rate up to 20 completed weeks of gestation was 2.3%; the abortion rate up to 28 completed weeks, as defined by WHO, was 3.7%. The abortion rate could not be correlated either with the number of needle insertions or with the type of marker dye used. There was also no correlation between the abortion rate and the gestational age at which amniocentesis was performed. A significant association was shown between congenital intestinal obstructions and the application of methylene blue intra‐amniotically as a marker dye. Considering the increased natural loss rate in multiple gestations, amniocentesis in twin pregnancies seems to be a safe and reliable technique. Copyright