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The slowing-down of Moore’s law is shifting the computing paradigm towards solutions based on quantum and neuromorphic computing elements. Unlike conventional digital computing, neuromorphic computing is based on analog devices. In this work, we propose a three-terminal neuromorphic organic device (NODe) capable of providing both analog computing and memory in a single device by tuning its conductance. The availability of three-terminal devices enables the independent tuning of the NODes, preventing write sneak path issues typical of the two-terminal memristor crossbar array. The NODe conductance relaxes exponentially with a measured time constant of 2.9 h, furthermore, it can be operated at 51 MHz, corresponding to an estimated energy efficiency of 0.1 pJ per multiply-accumulate (MAC) operation. To demonstrate the NODe’s computing capabilities, a 3×3 crossbar array has been successfully used to perform edge detection and blurring on an image with 128×64 pixels.

Recent developments in organic neuromorphic devices and biohybrid interfaces are promising examples that show potential to improve implantable devices toward organic adaptive brain-machine interfaces. However, fully integrated neuromorphic arrays still require relatively complex circuitry that includes multiple access devices to ensure synaptic weight stability and prevent sneak paths. Here, it is shown that polydopamine (PDA), the byproduct of dopamine autoxidation, promotes proton conductivity and can serve as a solid-state electrolyte. Slow kinetics and high energy barriers of the PDA solid electrolyte prevent loss of conductance state for the device with a three-terminal configuration without an access device, while partial dedoping of the conductive polymer channel by PDA simultaneously increases its stability in ambient environments. Fabricating the neuromorphic device on a flexible poly(styrene-block-isobutylene-block-styrene) substrate and the inherent biocompatibility of PDA demonstrates its potential toward more sophisticated implantable neuromorphic circuits for advanced neuroprosthetics.

Brain-inspired computing paradigms have led to substantial advances in the automation of visual and linguistic tasks by emulating the distributed information processing of biological systems1. The similarity between artificial neural networks (ANNs) and biological systems has inspired ANN implementation in biomedical interfaces including prosthetics2 and brain-machine interfaces3. While promising, these implementations rely on software to run ANN algorithms. Ultimately, it is desirable to build hardware ANNs4,5 that can both directly interface with living tissue and adapt based on biofeedback6,7. The first essential step towards biologically integrated neuromorphic systems is to achieve synaptic conditioning based on biochemical signalling activity. Here, we directly couple an organic neuromorphic device with dopaminergic cells to constitute a biohybrid synapse with neurotransmitter-mediated synaptic plasticity. By mimicking the dopamine recycling machinery of the synaptic cleft, we demonstrate both long-term conditioning and recovery of the synaptic weight, paving the way towards combining artificial neuromorphic systems with biological neural networks.

Functional emulation of biological synapses using electronic devices is regarded as the first step toward neuromorphic engineering and artificial neural networks (ANNs). Electrolyte-gated transistors (EGTs) are mixed ionic-electronic conductivity devices capable of efficient gate-channel capacitance coupling, biocompatibility, and flexible architectures. Electrolyte gating offers significant advantages for the realization of neuromorphic devices/architectures, including ultralow-voltage operation and the ability to form parallel-interconnected networks with minimal hardwired connectivity. In this review, the most recent developments in EGT-based electronics are introduced with their synaptic behaviors and detailed mechanisms, including short-/long-term plasticity, global regulation phenomena, lateral coupling between device terminals, and spatiotemporal correlated functions. Analog memory phenomena allow for the implementation of perceptron-based ANNs. Due to their mixed-conductivity phenomena, neuromorphic circuits based on EGTs allow for facile interfacing with biological environments. We also discuss the future challenges in implementing low power, high speed, and reliable neuromorphic computing for large-scale ANNs with these neuromorphic devices. The advancement of neuromorphic devices that rely on EGTs highlights the importance of this field for neuromorphic computing and for novel healthcare technologies in the form of adaptable or trainable biointerfacing.

Functional emulation of biological synapses using electronic devices is regarded as the first step toward neuromorphic engineering and artificial neural networks (ANNs). Electrolyte-gated transistors (EGTs) are mixed ionic-electronic conductivity devices capable of efficient gate-channel capacitance coupling, biocompatibility, and flexible architectures. Electrolyte gating offers significant advantages for the realization of neuromorphic devices/architectures, including ultralow-voltage operation and the ability to form parallel-interconnected networks with minimal hardwired connectivity. In this review, the most recent developments in EGT-based electronics are introduced with their synaptic behaviors and detailed mechanisms, including short-/long-term plasticity, global regulation phenomena, lateral coupling between device terminals, and spatiotemporal correlated functions. Analog memory phenomena allow for the implementation of perceptron-based ANNs. Due to their mixed-conductivity phenomena, neuromorphic circuits based on EGTs allow for facile interfacing with biological environments. We also discuss the future challenges in implementing low power, high speed, and reliable neuromorphic computing for large-scale ANNs with these neuromorphic devices. The advancement of neuromorphic devices that rely on EGTs highlights the importance of this field for neuromorphic computing and for novel healthcare technologies in the form of adaptable or trainable biointerfacing.

Brain-inspired computing paradigms have led to substantial advances in the automation of visual and linguistic tasks by emulating the distributed information processing of biological systems1. The similarity between artificial neural networks (ANNs) and biological systems has inspired ANN implementation in biomedical interfaces including prosthetics2 and brain-machine interfaces3. While promising, these implementations rely on software to run ANN algorithms. Ultimately, it is desirable to build hardware ANNs4,5 that can both directly interface with living tissue and adapt based on biofeedback6,7. The first essential step towards biologically integrated neuromorphic systems is to achieve synaptic conditioning based on biochemical signalling activity. Here, we directly couple an organic neuromorphic device with dopaminergic cells to constitute a biohybrid synapse with neurotransmitter-mediated synaptic plasticity. By mimicking the dopamine recycling machinery of the synaptic cleft, we demonstrate both long-term conditioning and recovery of the synaptic weight, paving the way towards combining artificial neuromorphic systems with biological neural networks.