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5 results on '"Kirsanow, Karola"'

1. Population genomic analysis of elongated skulls reveals extensive female-biased immigration in Early Medieval Bavaria

Author

Veeramah, Krishna R., Rott, Andreas, Groß, Melanie, Dorp, Lucy van, López, Saioa, Kirsanow, Karola, Sell, Christian, Blöcher, Jens, Wegmann, Daniel, Link, Vivian, Hofmanová, Zuzana, Peters, Joris, Trautmann, Bernd, Gairhos, Anja, Haberstroh, Jochen, Päffgen, Bernd, Hellenthal, Garrett, Haas-Gebhard, Brigitte, Harbeck, Michaela, Burger, Joachim, Veeramah, Krishna R., Rott, Andreas, Groß, Melanie, Dorp, Lucy van, López, Saioa, Kirsanow, Karola, Sell, Christian, Blöcher, Jens, Wegmann, Daniel, Link, Vivian, Hofmanová, Zuzana, Peters, Joris, Trautmann, Bernd, Gairhos, Anja, Haberstroh, Jochen, Päffgen, Bernd, Hellenthal, Garrett, Haas-Gebhard, Brigitte, Harbeck, Michaela, and Burger, Joachim

Abstract

Modern European genetic structure demonstrates strong correlations with geography, while genetic analysis of prehistoric humans has indicated at least two major waves of immigration from outside the continent during periods of cultural change. However, population-level genome data that could shed light on the demographic processes occurring during the intervening periods have been absent. Therefore, we generated genomic data from 41 individuals dating mostly to the late 5th/early 6th century AD from present-day Bavaria in southern Germany, including 11 whole genomes (mean depth 5.56×). In addition we developed a capture array to sequence neutral regions spanning a total of 5 Mb and 486 functional polymorphic sites to high depth (mean 72×) in all individuals. Our data indicate that while men generally had ancestry that closely resembles modern northern and central Europeans, women exhibit a very high genetic heterogeneity; this includes signals of genetic ancestry ranging from western Europe to East Asia. Particularly striking are women with artificial skull deformations; the analysis of their collective genetic ancestry suggests an origin in southeastern Europe. In addition, functional variants indicate that they also differed in visible characteristics. This example of female-biased migration indicates that complex demographic processes during the Early Medieval period may have contributed in an unexpected way to shape the modern European genetic landscape. Examination of the panel of functional loci also revealed that many alleles associated with recent positive selection were already at modern-like frequencies in European populations ∼1,500 years ago.

Published
2018

2. Early farmers from across Europe directly descended from Neolithic Aegeans

Author

Hofmanová, Zuzana, Kreutzer, Susanne, Hellenthal, Garrett, Sell, Christian, Diekmann, Yoan, Díez-del-Molino, David, Dorp, Lucy van, López, Saioa, Kousathanas, Athanasios, Link, Vivian, Kirsanow, Karola, Cassidy, Lara M., Martiniano, Rui, Strobel, Melanie, Scheu, Amelie, Kotsakis, Kostas, Halstead, Paul, Triantaphyllou, Sevi, Kyparissi-Apostolika, Nina, Urem-Kotsou, Dushka, Ziota, Christina, Adaktylou, Fotini, Gopalan, Shyamalika, Bobo, Dean M., Winkelbach, Laura, Blöcher, Jens, Unterländer, Martina, Leuenberger, Christoph, Çilingiroğlu, Çiler, Horejs, Barbara, Gerritsen, Fokke, Shennan, Stephen J., Bradley, Daniel G., Currat, Mathias, Veeramah, Krishna R., Wegmann, Daniel, Thomas, Mark G., Papageorgopoulou, Christina, Burger, Joachim, Hofmanová, Zuzana, Kreutzer, Susanne, Hellenthal, Garrett, Sell, Christian, Diekmann, Yoan, Díez-del-Molino, David, Dorp, Lucy van, López, Saioa, Kousathanas, Athanasios, Link, Vivian, Kirsanow, Karola, Cassidy, Lara M., Martiniano, Rui, Strobel, Melanie, Scheu, Amelie, Kotsakis, Kostas, Halstead, Paul, Triantaphyllou, Sevi, Kyparissi-Apostolika, Nina, Urem-Kotsou, Dushka, Ziota, Christina, Adaktylou, Fotini, Gopalan, Shyamalika, Bobo, Dean M., Winkelbach, Laura, Blöcher, Jens, Unterländer, Martina, Leuenberger, Christoph, Çilingiroğlu, Çiler, Horejs, Barbara, Gerritsen, Fokke, Shennan, Stephen J., Bradley, Daniel G., Currat, Mathias, Veeramah, Krishna R., Wegmann, Daniel, Thomas, Mark G., Papageorgopoulou, Christina, and Burger, Joachim

Abstract

Farming and sedentism first appeared in southwestern Asia during the early Holocene and later spread to neighboring regions, including Europe, along multiple dispersal routes. Conspicuous uncertainties remain about the relative roles of migration, cultural diffusion, and admixture with local foragers in the early Neolithization of Europe. Here we present paleogenomic data for five Neolithic individuals from northern Greece and northwestern Turkey spanning the time and region of the earliest spread of farming into Europe. We use a novel approach to recalibrate raw reads and call genotypes from ancient DNA and observe striking genetic similarity both among Aegean early farmers and with those from across Europe. Our study demonstrates a direct genetic link between Mediterranean and Central European early farmers and those of Greece and Anatolia, extending the European Neolithic migratory chain all the way back to southwestern Asia.

Published
2016

3. Ancient human genomes suggest three ancestral populations for present-day Europeans

Author

Lazaridis, Iosif, Patterson, Nick, Mittnik, Alissa, Renaud, Gabriel, Mallick, Swapan, Kirsanow, Karola, Sudmant, Peter H., Schraiber, Joshua G., Castellano, Sergi, Lipson, Mark, Berger, Bonnie, Economou, Christos, Bollongino, Ruth, Fu, Qiaomei, Bos, Kirsten I., Nordenfelt, Susanne, Li, Heng, de Filippo, Cesare, Pruefer, Kay, Sawyer, Susanna, Posth, Cosimo, Haak, Wolfgang, Hallgren, Fredrik, Fornander, Elin, Rohland, Nadin, Delsate, Dominique, Francken, Michael, Guinet, Jean-Michel, Wahl, Joachim, Ayodo, George, Babiker, Hamza A., Bailliet, Graciela, Balanovska, Elena, Balanovsky, Oleg, Barrantes, Ramiro, Bedoya, Gabriel, Ben-Ami, Haim, Bene, Judit, Berrada, Fouad, Bravi, Claudio M., Brisighelli, Francesca, Busby, George B. J., Cali, Francesco, Churnosov, Mikhail, Cole, David E. C., Corach, Daniel, Damba, Larissa, van Driem, George, Dryomov, Stanislav, Dugoujon, Jean-Michel, Fedorova, Sardana A., Romero, Irene Gallego, Gubina, Marina, Hammer, Michael, Henn, Brenna M., Hervig, Tor, Hodoglugil, Ugur, Jha, Aashish R., Karachanak-Yankova, Sena, Khusainova, Rita, Khusnutdinova, Elza, Kittles, Rick, Kivisild, Toomas, Klitz, William, Kucinskas, Vaidutis, Kushniarevich, Alena, Laredj, Leila, Litvinov, Sergey, Loukidis, Theologos, Mahley, Robert W., Melegh, Bela, Metspalu, Ene, Molina, Julio, Mountain, Joanna, Nakkalajarvi, Klemetti, Nesheva, Desislava, Nyambo, Thomas, Osipova, Ludmila, Parik, Jueri, Platonov, Fedor, Posukh, Olga, Romano, Valentino, Rothhammer, Francisco, Rudan, Igor, Ruizbakiev, Ruslan, Sahakyan, Hovhannes, Sajantila, Antti, Salas, Antonio, Starikovskaya, Elena B., Tarekegn, Ayele, Toncheva, Draga, Turdikulova, Shahlo, Uktveryte, Ingrida, Utevska, Olga, Vasquez, Rene, Villena, Mercedes, Voevoda, Mikhail, Winkler, Cheryl A., Yepiskoposyan, Levon, Zalloua, Pierre, Zemunik, Tatijana, Cooper, Alan, Capelli, Cristian, Thomas, Mark G., Ruiz-Linares, Andres, Tishkoff, Sarah A., Singh, Lalji, Thangaraj, Kumarasamy, Villems, Richard, Comas, David, Sukernik, Rem, Metspalu, Mait, Meyer, Matthias, Eichler, Evan E., Burger, Joachim, Slatkin, Montgomery, Paeaebo, Svante, Kelso, Janet, Reich, David, Krause, Johannes, Lazaridis, Iosif, Patterson, Nick, Mittnik, Alissa, Renaud, Gabriel, Mallick, Swapan, Kirsanow, Karola, Sudmant, Peter H., Schraiber, Joshua G., Castellano, Sergi, Lipson, Mark, Berger, Bonnie, Economou, Christos, Bollongino, Ruth, Fu, Qiaomei, Bos, Kirsten I., Nordenfelt, Susanne, Li, Heng, de Filippo, Cesare, Pruefer, Kay, Sawyer, Susanna, Posth, Cosimo, Haak, Wolfgang, Hallgren, Fredrik, Fornander, Elin, Rohland, Nadin, Delsate, Dominique, Francken, Michael, Guinet, Jean-Michel, Wahl, Joachim, Ayodo, George, Babiker, Hamza A., Bailliet, Graciela, Balanovska, Elena, Balanovsky, Oleg, Barrantes, Ramiro, Bedoya, Gabriel, Ben-Ami, Haim, Bene, Judit, Berrada, Fouad, Bravi, Claudio M., Brisighelli, Francesca, Busby, George B. J., Cali, Francesco, Churnosov, Mikhail, Cole, David E. C., Corach, Daniel, Damba, Larissa, van Driem, George, Dryomov, Stanislav, Dugoujon, Jean-Michel, Fedorova, Sardana A., Romero, Irene Gallego, Gubina, Marina, Hammer, Michael, Henn, Brenna M., Hervig, Tor, Hodoglugil, Ugur, Jha, Aashish R., Karachanak-Yankova, Sena, Khusainova, Rita, Khusnutdinova, Elza, Kittles, Rick, Kivisild, Toomas, Klitz, William, Kucinskas, Vaidutis, Kushniarevich, Alena, Laredj, Leila, Litvinov, Sergey, Loukidis, Theologos, Mahley, Robert W., Melegh, Bela, Metspalu, Ene, Molina, Julio, Mountain, Joanna, Nakkalajarvi, Klemetti, Nesheva, Desislava, Nyambo, Thomas, Osipova, Ludmila, Parik, Jueri, Platonov, Fedor, Posukh, Olga, Romano, Valentino, Rothhammer, Francisco, Rudan, Igor, Ruizbakiev, Ruslan, Sahakyan, Hovhannes, Sajantila, Antti, Salas, Antonio, Starikovskaya, Elena B., Tarekegn, Ayele, Toncheva, Draga, Turdikulova, Shahlo, Uktveryte, Ingrida, Utevska, Olga, Vasquez, Rene, Villena, Mercedes, Voevoda, Mikhail, Winkler, Cheryl A., Yepiskoposyan, Levon, Zalloua, Pierre, Zemunik, Tatijana, Cooper, Alan, Capelli, Cristian, Thomas, Mark G., Ruiz-Linares, Andres, Tishkoff, Sarah A., Singh, Lalji, Thangaraj, Kumarasamy, Villems, Richard, Comas, David, Sukernik, Rem, Metspalu, Mait, Meyer, Matthias, Eichler, Evan E., Burger, Joachim, Slatkin, Montgomery, Paeaebo, Svante, Kelso, Janet, Reich, David, and Krause, Johannes

Abstract

We sequenced the genomes of a similar to 7,000-year-old farmer from Germany and eight similar to 8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes(1-4) with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians(3), who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had similar to 44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages., AuthorCount:120

Published
2014
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4. Population genomic analysis of elongated skulls reveals extensive female-biased immigration in Early Medieval Bavaria

Author

Veeramah, Krishna R., Rott, Andreas, Groß, Melanie, Dorp, Lucy van, López, Saioa, Kirsanow, Karola, Sell, Christian, Blöcher, Jens, Wegmann, Daniel, Link, Vivian, Hofmanová, Zuzana, Peters, Joris, Trautmann, Bernd, Gairhos, Anja, Haberstroh, Jochen, Päffgen, Bernd, Hellenthal, Garrett, Haas-Gebhard, Brigitte, Harbeck, Michaela, Burger, Joachim, Veeramah, Krishna R., Rott, Andreas, Groß, Melanie, Dorp, Lucy van, López, Saioa, Kirsanow, Karola, Sell, Christian, Blöcher, Jens, Wegmann, Daniel, Link, Vivian, Hofmanová, Zuzana, Peters, Joris, Trautmann, Bernd, Gairhos, Anja, Haberstroh, Jochen, Päffgen, Bernd, Hellenthal, Garrett, Haas-Gebhard, Brigitte, Harbeck, Michaela, and Burger, Joachim

Abstract

Modern European genetic structure demonstrates strong correlations with geography, while genetic analysis of prehistoric humans has indicated at least two major waves of immigration from outside the continent during periods of cultural change. However, population-level genome data that could shed light on the demographic processes occurring during the intervening periods have been absent. Therefore, we generated genomic data from 41 individuals dating mostly to the late 5th/early 6th century AD from present-day Bavaria in southern Germany, including 11 whole genomes (mean depth 5.56×). In addition we developed a capture array to sequence neutral regions spanning a total of 5 Mb and 486 functional polymorphic sites to high depth (mean 72×) in all individuals. Our data indicate that while men generally had ancestry that closely resembles modern northern and central Europeans, women exhibit a very high genetic heterogeneity; this includes signals of genetic ancestry ranging from western Europe to East Asia. Particularly striking are women with artificial skull deformations; the analysis of their collective genetic ancestry suggests an origin in southeastern Europe. In addition, functional variants indicate that they also differed in visible characteristics. This example of female-biased migration indicates that complex demographic processes during the Early Medieval period may have contributed in an unexpected way to shape the modern European genetic landscape. Examination of the panel of functional loci also revealed that many alleles associated with recent positive selection were already at modern-like frequencies in European populations ∼1,500 years ago.

5. Early farmers from across Europe directly descended from Neolithic Aegeans

Author

Hofmanová, Zuzana, Kreutzer, Susanne, Hellenthal, Garrett, Sell, Christian, Diekmann, Yoan, Díez-del-Molino, David, Dorp, Lucy van, López, Saioa, Kousathanas, Athanasios, Link, Vivian, Kirsanow, Karola, Cassidy, Lara M., Martiniano, Rui, Strobel, Melanie, Scheu, Amelie, Kotsakis, Kostas, Halstead, Paul, Triantaphyllou, Sevi, Kyparissi-Apostolika, Nina, Urem-Kotsou, Dushka, Ziota, Christina, Adaktylou, Fotini, Gopalan, Shyamalika, Bobo, Dean M., Winkelbach, Laura, Blöcher, Jens, Unterländer, Martina, Leuenberger, Christoph, Çilingiroğlu, Çiler, Horejs, Barbara, Gerritsen, Fokke, Shennan, Stephen J., Bradley, Daniel G., Currat, Mathias, Veeramah, Krishna R., Wegmann, Daniel, Thomas, Mark G., Papageorgopoulou, Christina, Burger, Joachim, Hofmanová, Zuzana, Kreutzer, Susanne, Hellenthal, Garrett, Sell, Christian, Diekmann, Yoan, Díez-del-Molino, David, Dorp, Lucy van, López, Saioa, Kousathanas, Athanasios, Link, Vivian, Kirsanow, Karola, Cassidy, Lara M., Martiniano, Rui, Strobel, Melanie, Scheu, Amelie, Kotsakis, Kostas, Halstead, Paul, Triantaphyllou, Sevi, Kyparissi-Apostolika, Nina, Urem-Kotsou, Dushka, Ziota, Christina, Adaktylou, Fotini, Gopalan, Shyamalika, Bobo, Dean M., Winkelbach, Laura, Blöcher, Jens, Unterländer, Martina, Leuenberger, Christoph, Çilingiroğlu, Çiler, Horejs, Barbara, Gerritsen, Fokke, Shennan, Stephen J., Bradley, Daniel G., Currat, Mathias, Veeramah, Krishna R., Wegmann, Daniel, Thomas, Mark G., Papageorgopoulou, Christina, and Burger, Joachim

Abstract

Farming and sedentism first appeared in southwestern Asia during the early Holocene and later spread to neighboring regions, including Europe, along multiple dispersal routes. Conspicuous uncertainties remain about the relative roles of migration, cultural diffusion, and admixture with local foragers in the early Neolithization of Europe. Here we present paleogenomic data for five Neolithic individuals from northern Greece and northwestern Turkey spanning the time and region of the earliest spread of farming into Europe. We use a novel approach to recalibrate raw reads and call genotypes from ancient DNA and observe striking genetic similarity both among Aegean early farmers and with those from across Europe. Our study demonstrates a direct genetic link between Mediterranean and Central European early farmers and those of Greece and Anatolia, extending the European Neolithic migratory chain all the way back to southwestern Asia.

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