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1. Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections

Author

Tober-Lau, Pinkus, Gruell, Henning, Vanshylla, Kanika, Koch, Willi M., Hillus, David, Schommers, Philipp, Suarez, Isabelle, Suttorp, Norbert, Sander, Leif Erik, Klein, Florian, Kurth, Florian, Tober-Lau, Pinkus, Gruell, Henning, Vanshylla, Kanika, Koch, Willi M., Hillus, David, Schommers, Philipp, Suarez, Isabelle, Suttorp, Norbert, Sander, Leif Erik, Klein, Florian, and Kurth, Florian

Abstract

To determine neutralizing activity against the severe acute respiratory syndrome coronavirus 2 ancestral strain and 4 variants of concern, we tested serum from 30 persons with breakthrough infection after 2-dose vaccination. Cross-variant neutralizing activity was comparable to that after 3-dose vaccination. Shorter intervals between vaccination and breakthrough infection correlated with lower neutralizing titers.

Published
2022

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