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19 results on '"Kostic J"'

1. Longitudinal profile of the genotoxic potential of the River Danube on erythrocytes of wild common bleak (Alburnus alburnus) assessed using the comet and micronucleus assay

Author

Deutschmann, B., Kolarevic, S., Brack, Werner, Kaisarevic, S., Kostic, J., Kracun-Kolarevic, M., Liska, I., Paunovic, M., Seiler, T.-B., Shao, Y., Sipos, S., Slobodnik, J., Teodorovic, I., Vukovic-Gacic, B., Hollert, H., Deutschmann, B., Kolarevic, S., Brack, Werner, Kaisarevic, S., Kostic, J., Kracun-Kolarevic, M., Liska, I., Paunovic, M., Seiler, T.-B., Shao, Y., Sipos, S., Slobodnik, J., Teodorovic, I., Vukovic-Gacic, B., and Hollert, H.

Abstract

The Joint Danube Survey 3 (JDS3; the biggest river expedition in 2013) had offered the unique opportunity for a large-scale monitoring approach for biomarker response in feral fish collected along a Danube stretch from Kehlheim (DE) to Sulina (RO). The advantage of genotoxicity as a marker for pollution exposure in fish is the early detection of possible long-term effects such as cancer. Therefore, genotoxicity was in the focus of the biomarker investigations in fish during the expedition. Blood samples of common bleak (Alburnus alburnus) for the investigation of the micronucleus frequency and comet tail intensity of fragmented DNA material in erythrocytes were collected at 18 and 12 sampling sites, respectively. For 9 sampling sites same samples were used to compare the in-situ data for the comparable genotoxic endpoint in the micronucleus (MN) and comet assay (CM). The data of both in-situ assays showed a significant correlation, indicating the strength and comparability of the data sets. Significant variation in DNA damage in fish along the longitudinal profile of the Danube was demonstrated for both assays compared to reference sites. The results suggest that DNA damage in erythrocytes of fish was mainly affected by wastewater of highly populated regions. No linkage between the results and the general health/dietary status of the fish were revealed, whereas correlation with some genotoxicity drivers in the water phase, suspended particulate matter and sediments could be demonstrated.

Published
2016

2. A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

Author

Kiemeney, L.A.L.M., Sulem, P., Besenbacher, S., Vermeulen, S., Sigurdsson, A., Thorleifsson, G., Gudbjartsson, D.F., Stacey, S.N., Gudmundsson, J., Zanon, C., Kostic, J., Masson, G., Bjarnason, H., Palsson, S., Skarphedinsson, O.B., Gudjonsson, S.A., Witjes, J.A., Grotenhuis, A.J., Verhaegh, G.W.C.T., Bishop, D.T., Sak, S.C., Choudhury, A., Elliott, F., Barrett, J.H., Hurst, C.D., Verdier, P. de, Ryk, C., Rudnai, P., Gurzau, E, Koppova, K., Vineis, P., Polidoro, S., Guarrera, S., Sacerdote, C., Campagna, M., Placidi, D., Arici, C., Zeegers, M.P., Kellen, E., Gutierrez, B.S., Sanz-Velez, J.I., Sanchez-Zalabardo, M., Valdivia, G., Garcia-Prats, M.D., Hengstler, J.G., Blaszkewicz, M., Dietrich, H., Ophoff, R.A., Berg, L.H. van den, Alexiusdottir, K., Kristjansson, K., Geirsson, G., Nikulasson, S., Petursdottir, V., Kong, A., Thorgeirsson, T.E., Mungan, N.A., Lindblom, A., Es, M.A. van, Porru, S., Buntinx, F., Golka, K., Mayordomo, J.I., Kumar, R., Matullo, G., Steineck, G., Kiltie, A.E., Aben, K.K.H., Jonsson, E., Thorsteinsdottir, U., Knowles, M.A., Rafnar, T., Stefansson, K., Kiemeney, L.A.L.M., Sulem, P., Besenbacher, S., Vermeulen, S., Sigurdsson, A., Thorleifsson, G., Gudbjartsson, D.F., Stacey, S.N., Gudmundsson, J., Zanon, C., Kostic, J., Masson, G., Bjarnason, H., Palsson, S., Skarphedinsson, O.B., Gudjonsson, S.A., Witjes, J.A., Grotenhuis, A.J., Verhaegh, G.W.C.T., Bishop, D.T., Sak, S.C., Choudhury, A., Elliott, F., Barrett, J.H., Hurst, C.D., Verdier, P. de, Ryk, C., Rudnai, P., Gurzau, E, Koppova, K., Vineis, P., Polidoro, S., Guarrera, S., Sacerdote, C., Campagna, M., Placidi, D., Arici, C., Zeegers, M.P., Kellen, E., Gutierrez, B.S., Sanz-Velez, J.I., Sanchez-Zalabardo, M., Valdivia, G., Garcia-Prats, M.D., Hengstler, J.G., Blaszkewicz, M., Dietrich, H., Ophoff, R.A., Berg, L.H. van den, Alexiusdottir, K., Kristjansson, K., Geirsson, G., Nikulasson, S., Petursdottir, V., Kong, A., Thorgeirsson, T.E., Mungan, N.A., Lindblom, A., Es, M.A. van, Porru, S., Buntinx, F., Golka, K., Mayordomo, J.I., Kumar, R., Matullo, G., Steineck, G., Kiltie, A.E., Aben, K.K.H., Jonsson, E., Thorsteinsdottir, U., Knowles, M.A., Rafnar, T., and Stefansson, K.

Abstract

Contains fulltext : 87396.pdf (publisher's version ) (Closed access)

Published
2010

3. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Author

Gretarsdottir, S., Baas, A.F., Thorleifsson, G., Holm, H., Heijer, M. den, Vries, J.P. de, Kranendonk, S.E., Zeebregts, C.J.A., Sterkenburg, S.M. van, Geelkerken, R.H., Rij, A.M. van, Williams, M.J., Boll, A.P.M., Kostic, J., Jonasdottir, A., Walters, G.B., Masson, G., Sulem, P., Saemundsdottir, J., Mouy, M., Magnusson, K.P., Tromp, G., Elmore, J.B., Sakalihasan, N., Limet, R., Defraigne, J.O., Ferrell, R.E., Ronkainen, A., Ruigrok, Y.M., Wijmenga, C., Grobbee, D.E., Shah, S.H., Granger, C.B., Quyyumi, A.A., Vaccarino, V., Patel, R., Zafari, A.M., Levey, A.I., Austin, H., Girelli, D., Pignatti, P.F., Olivieri, O., Martinelli, N., Malerba, G., Trabetti, E., Becker, L.C., Becker, D.M., Reilly, M.P., Rader, D.J., Mueller, T., Dieplinger, B., Haltmayer, M., Urbonavicius, S., Lindblad, B., Gottsäter, A., Gaetani, E., Pola, R., Wells, P., Rodger, M., Forgie, M., Langlois, N., Corral, J., Vicente, V., Fontcuberta, J., España, F., Grarup, N., Jørgensen, T., Witte, D.R., Hansen, T., Pedersen, O., Aben, K.K.H., Graaf, J. de, Holewijn, S., Folkersen, L., Franco-Cereceda, A., Eriksson, P., Collier, D.A., Stefansson, H., Steinthorsdottir, V., Rafnar, T., Valdimarsson, E.M., Magnadottir, H.B., Sveinbjornsdottir, S., Olafsson, I., Magnusson, M.K., Palmason, R., Haraldsdottir, V., Andersen, K., Onundarson, P.T., Thorgeirsson, G., Kiemeney, L.A.L.M., Powell, J.T., Carey, D.J., Kuivaniemi, H., Lindholt, J.S., Jones, G.T., Blankensteijn, J.D., Gretarsdottir, S., Baas, A.F., Thorleifsson, G., Holm, H., Heijer, M. den, Vries, J.P. de, Kranendonk, S.E., Zeebregts, C.J.A., Sterkenburg, S.M. van, Geelkerken, R.H., Rij, A.M. van, Williams, M.J., Boll, A.P.M., Kostic, J., Jonasdottir, A., Walters, G.B., Masson, G., Sulem, P., Saemundsdottir, J., Mouy, M., Magnusson, K.P., Tromp, G., Elmore, J.B., Sakalihasan, N., Limet, R., Defraigne, J.O., Ferrell, R.E., Ronkainen, A., Ruigrok, Y.M., Wijmenga, C., Grobbee, D.E., Shah, S.H., Granger, C.B., Quyyumi, A.A., Vaccarino, V., Patel, R., Zafari, A.M., Levey, A.I., Austin, H., Girelli, D., Pignatti, P.F., Olivieri, O., Martinelli, N., Malerba, G., Trabetti, E., Becker, L.C., Becker, D.M., Reilly, M.P., Rader, D.J., Mueller, T., Dieplinger, B., Haltmayer, M., Urbonavicius, S., Lindblad, B., Gottsäter, A., Gaetani, E., Pola, R., Wells, P., Rodger, M., Forgie, M., Langlois, N., Corral, J., Vicente, V., Fontcuberta, J., España, F., Grarup, N., Jørgensen, T., Witte, D.R., Hansen, T., Pedersen, O., Aben, K.K.H., Graaf, J. de, Holewijn, S., Folkersen, L., Franco-Cereceda, A., Eriksson, P., Collier, D.A., Stefansson, H., Steinthorsdottir, V., Rafnar, T., Valdimarsson, E.M., Magnadottir, H.B., Sveinbjornsdottir, S., Olafsson, I., Magnusson, M.K., Palmason, R., Haraldsdottir, V., Andersen, K., Onundarson, P.T., Thorgeirsson, G., Kiemeney, L.A.L.M., Powell, J.T., Carey, D.J., Kuivaniemi, H., Lindholt, J.S., Jones, G.T., and Blankensteijn, J.D.

Abstract

Contains fulltext : 88507.pdf (publisher's version ) (Closed access)

Published
2010

4. A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

Author

Kiemeney, L.A.L.M., Sulem, P., Besenbacher, S., Vermeulen, S., Sigurdsson, A., Thorleifsson, G., Gudbjartsson, D.F., Stacey, S.N., Gudmundsson, J., Zanon, C., Kostic, J., Masson, G., Bjarnason, H., Palsson, S., Skarphedinsson, O.B., Gudjonsson, S.A., Witjes, J.A., Grotenhuis, A.J., Verhaegh, G.W.C.T., Bishop, D.T., Sak, S.C., Choudhury, A., Elliott, F., Barrett, J.H., Hurst, C.D., Verdier, P. de, Ryk, C., Rudnai, P., Gurzau, E, Koppova, K., Vineis, P., Polidoro, S., Guarrera, S., Sacerdote, C., Campagna, M., Placidi, D., Arici, C., Zeegers, M.P., Kellen, E., Gutierrez, B.S., Sanz-Velez, J.I., Sanchez-Zalabardo, M., Valdivia, G., Garcia-Prats, M.D., Hengstler, J.G., Blaszkewicz, M., Dietrich, H., Ophoff, R.A., Berg, L.H. van den, Alexiusdottir, K., Kristjansson, K., Geirsson, G., Nikulasson, S., Petursdottir, V., Kong, A., Thorgeirsson, T.E., Mungan, N.A., Lindblom, A., Es, M.A. van, Porru, S., Buntinx, F., Golka, K., Mayordomo, J.I., Kumar, R., Matullo, G., Steineck, G., Kiltie, A.E., Aben, K.K.H., Jonsson, E., Thorsteinsdottir, U., Knowles, M.A., Rafnar, T., Stefansson, K., Kiemeney, L.A.L.M., Sulem, P., Besenbacher, S., Vermeulen, S., Sigurdsson, A., Thorleifsson, G., Gudbjartsson, D.F., Stacey, S.N., Gudmundsson, J., Zanon, C., Kostic, J., Masson, G., Bjarnason, H., Palsson, S., Skarphedinsson, O.B., Gudjonsson, S.A., Witjes, J.A., Grotenhuis, A.J., Verhaegh, G.W.C.T., Bishop, D.T., Sak, S.C., Choudhury, A., Elliott, F., Barrett, J.H., Hurst, C.D., Verdier, P. de, Ryk, C., Rudnai, P., Gurzau, E, Koppova, K., Vineis, P., Polidoro, S., Guarrera, S., Sacerdote, C., Campagna, M., Placidi, D., Arici, C., Zeegers, M.P., Kellen, E., Gutierrez, B.S., Sanz-Velez, J.I., Sanchez-Zalabardo, M., Valdivia, G., Garcia-Prats, M.D., Hengstler, J.G., Blaszkewicz, M., Dietrich, H., Ophoff, R.A., Berg, L.H. van den, Alexiusdottir, K., Kristjansson, K., Geirsson, G., Nikulasson, S., Petursdottir, V., Kong, A., Thorgeirsson, T.E., Mungan, N.A., Lindblom, A., Es, M.A. van, Porru, S., Buntinx, F., Golka, K., Mayordomo, J.I., Kumar, R., Matullo, G., Steineck, G., Kiltie, A.E., Aben, K.K.H., Jonsson, E., Thorsteinsdottir, U., Knowles, M.A., Rafnar, T., and Stefansson, K.

Abstract

Contains fulltext : 87396.pdf (publisher's version ) (Closed access)

Published
2010

5. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Author

Gretarsdottir, S., Baas, A.F., Thorleifsson, G., Holm, H., Heijer, M. den, Vries, J.P. de, Kranendonk, S.E., Zeebregts, C.J.A., Sterkenburg, S.M. van, Geelkerken, R.H., Rij, A.M. van, Williams, M.J., Boll, A.P.M., Kostic, J., Jonasdottir, A., Walters, G.B., Masson, G., Sulem, P., Saemundsdottir, J., Mouy, M., Magnusson, K.P., Tromp, G., Elmore, J.B., Sakalihasan, N., Limet, R., Defraigne, J.O., Ferrell, R.E., Ronkainen, A., Ruigrok, Y.M., Wijmenga, C., Grobbee, D.E., Shah, S.H., Granger, C.B., Quyyumi, A.A., Vaccarino, V., Patel, R., Zafari, A.M., Levey, A.I., Austin, H., Girelli, D., Pignatti, P.F., Olivieri, O., Martinelli, N., Malerba, G., Trabetti, E., Becker, L.C., Becker, D.M., Reilly, M.P., Rader, D.J., Mueller, T., Dieplinger, B., Haltmayer, M., Urbonavicius, S., Lindblad, B., Gottsäter, A., Gaetani, E., Pola, R., Wells, P., Rodger, M., Forgie, M., Langlois, N., Corral, J., Vicente, V., Fontcuberta, J., España, F., Grarup, N., Jørgensen, T., Witte, D.R., Hansen, T., Pedersen, O., Aben, K.K.H., Graaf, J. de, Holewijn, S., Folkersen, L., Franco-Cereceda, A., Eriksson, P., Collier, D.A., Stefansson, H., Steinthorsdottir, V., Rafnar, T., Valdimarsson, E.M., Magnadottir, H.B., Sveinbjornsdottir, S., Olafsson, I., Magnusson, M.K., Palmason, R., Haraldsdottir, V., Andersen, K., Onundarson, P.T., Thorgeirsson, G., Kiemeney, L.A.L.M., Powell, J.T., Carey, D.J., Kuivaniemi, H., Lindholt, J.S., Jones, G.T., Blankensteijn, J.D., Gretarsdottir, S., Baas, A.F., Thorleifsson, G., Holm, H., Heijer, M. den, Vries, J.P. de, Kranendonk, S.E., Zeebregts, C.J.A., Sterkenburg, S.M. van, Geelkerken, R.H., Rij, A.M. van, Williams, M.J., Boll, A.P.M., Kostic, J., Jonasdottir, A., Walters, G.B., Masson, G., Sulem, P., Saemundsdottir, J., Mouy, M., Magnusson, K.P., Tromp, G., Elmore, J.B., Sakalihasan, N., Limet, R., Defraigne, J.O., Ferrell, R.E., Ronkainen, A., Ruigrok, Y.M., Wijmenga, C., Grobbee, D.E., Shah, S.H., Granger, C.B., Quyyumi, A.A., Vaccarino, V., Patel, R., Zafari, A.M., Levey, A.I., Austin, H., Girelli, D., Pignatti, P.F., Olivieri, O., Martinelli, N., Malerba, G., Trabetti, E., Becker, L.C., Becker, D.M., Reilly, M.P., Rader, D.J., Mueller, T., Dieplinger, B., Haltmayer, M., Urbonavicius, S., Lindblad, B., Gottsäter, A., Gaetani, E., Pola, R., Wells, P., Rodger, M., Forgie, M., Langlois, N., Corral, J., Vicente, V., Fontcuberta, J., España, F., Grarup, N., Jørgensen, T., Witte, D.R., Hansen, T., Pedersen, O., Aben, K.K.H., Graaf, J. de, Holewijn, S., Folkersen, L., Franco-Cereceda, A., Eriksson, P., Collier, D.A., Stefansson, H., Steinthorsdottir, V., Rafnar, T., Valdimarsson, E.M., Magnadottir, H.B., Sveinbjornsdottir, S., Olafsson, I., Magnusson, M.K., Palmason, R., Haraldsdottir, V., Andersen, K., Onundarson, P.T., Thorgeirsson, G., Kiemeney, L.A.L.M., Powell, J.T., Carey, D.J., Kuivaniemi, H., Lindholt, J.S., Jones, G.T., and Blankensteijn, J.D.

Abstract

Contains fulltext : 88507.pdf (publisher's version ) (Closed access)

Published
2010

6. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Author

Gretarsdottir, S., Baas, A.F., Thorleifsson, G., Holm, H., Heijer, M. den, Vries, J.P. de, Kranendonk, S.E., Zeebregts, C.J.A., Sterkenburg, S.M. van, Geelkerken, R.H., Rij, A.M. van, Williams, M.J., Boll, A.P.M., Kostic, J., Jonasdottir, A., Walters, G.B., Masson, G., Sulem, P., Saemundsdottir, J., Mouy, M., Magnusson, K.P., Tromp, G., Elmore, J.B., Sakalihasan, N., Limet, R., Defraigne, J.O., Ferrell, R.E., Ronkainen, A., Ruigrok, Y.M., Wijmenga, C., Grobbee, D.E., Shah, S.H., Granger, C.B., Quyyumi, A.A., Vaccarino, V., Patel, R., Zafari, A.M., Levey, A.I., Austin, H., Girelli, D., Pignatti, P.F., Olivieri, O., Martinelli, N., Malerba, G., Trabetti, E., Becker, L.C., Becker, D.M., Reilly, M.P., Rader, D.J., Mueller, T., Dieplinger, B., Haltmayer, M., Urbonavicius, S., Lindblad, B., Gottsäter, A., Gaetani, E., Pola, R., Wells, P., Rodger, M., Forgie, M., Langlois, N., Corral, J., Vicente, V., Fontcuberta, J., España, F., Grarup, N., Jørgensen, T., Witte, D.R., Hansen, T., Pedersen, O., Aben, K.K.H., Graaf, J. de, Holewijn, S., Folkersen, L., Franco-Cereceda, A., Eriksson, P., Collier, D.A., Stefansson, H., Steinthorsdottir, V., Rafnar, T., Valdimarsson, E.M., Magnadottir, H.B., Sveinbjornsdottir, S., Olafsson, I., Magnusson, M.K., Palmason, R., Haraldsdottir, V., Andersen, K., Onundarson, P.T., Thorgeirsson, G., Kiemeney, L.A.L.M., Powell, J.T., Carey, D.J., Kuivaniemi, H., Lindholt, J.S., Jones, G.T., Blankensteijn, J.D., Gretarsdottir, S., Baas, A.F., Thorleifsson, G., Holm, H., Heijer, M. den, Vries, J.P. de, Kranendonk, S.E., Zeebregts, C.J.A., Sterkenburg, S.M. van, Geelkerken, R.H., Rij, A.M. van, Williams, M.J., Boll, A.P.M., Kostic, J., Jonasdottir, A., Walters, G.B., Masson, G., Sulem, P., Saemundsdottir, J., Mouy, M., Magnusson, K.P., Tromp, G., Elmore, J.B., Sakalihasan, N., Limet, R., Defraigne, J.O., Ferrell, R.E., Ronkainen, A., Ruigrok, Y.M., Wijmenga, C., Grobbee, D.E., Shah, S.H., Granger, C.B., Quyyumi, A.A., Vaccarino, V., Patel, R., Zafari, A.M., Levey, A.I., Austin, H., Girelli, D., Pignatti, P.F., Olivieri, O., Martinelli, N., Malerba, G., Trabetti, E., Becker, L.C., Becker, D.M., Reilly, M.P., Rader, D.J., Mueller, T., Dieplinger, B., Haltmayer, M., Urbonavicius, S., Lindblad, B., Gottsäter, A., Gaetani, E., Pola, R., Wells, P., Rodger, M., Forgie, M., Langlois, N., Corral, J., Vicente, V., Fontcuberta, J., España, F., Grarup, N., Jørgensen, T., Witte, D.R., Hansen, T., Pedersen, O., Aben, K.K.H., Graaf, J. de, Holewijn, S., Folkersen, L., Franco-Cereceda, A., Eriksson, P., Collier, D.A., Stefansson, H., Steinthorsdottir, V., Rafnar, T., Valdimarsson, E.M., Magnadottir, H.B., Sveinbjornsdottir, S., Olafsson, I., Magnusson, M.K., Palmason, R., Haraldsdottir, V., Andersen, K., Onundarson, P.T., Thorgeirsson, G., Kiemeney, L.A.L.M., Powell, J.T., Carey, D.J., Kuivaniemi, H., Lindholt, J.S., Jones, G.T., and Blankensteijn, J.D.

Abstract

Contains fulltext : 88507.pdf (publisher's version ) (Closed access)

Published
2010

7. A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

Author

Kiemeney, L.A.L.M., Sulem, P., Besenbacher, S., Vermeulen, S., Sigurdsson, A., Thorleifsson, G., Gudbjartsson, D.F., Stacey, S.N., Gudmundsson, J., Zanon, C., Kostic, J., Masson, G., Bjarnason, H., Palsson, S., Skarphedinsson, O.B., Gudjonsson, S.A., Witjes, J.A., Grotenhuis, A.J., Verhaegh, G.W.C.T., Bishop, D.T., Sak, S.C., Choudhury, A., Elliott, F., Barrett, J.H., Hurst, C.D., Verdier, P. de, Ryk, C., Rudnai, P., Gurzau, E, Koppova, K., Vineis, P., Polidoro, S., Guarrera, S., Sacerdote, C., Campagna, M., Placidi, D., Arici, C., Zeegers, M.P., Kellen, E., Gutierrez, B.S., Sanz-Velez, J.I., Sanchez-Zalabardo, M., Valdivia, G., Garcia-Prats, M.D., Hengstler, J.G., Blaszkewicz, M., Dietrich, H., Ophoff, R.A., Berg, L.H. van den, Alexiusdottir, K., Kristjansson, K., Geirsson, G., Nikulasson, S., Petursdottir, V., Kong, A., Thorgeirsson, T.E., Mungan, N.A., Lindblom, A., Es, M.A. van, Porru, S., Buntinx, F., Golka, K., Mayordomo, J.I., Kumar, R., Matullo, G., Steineck, G., Kiltie, A.E., Aben, K.K.H., Jonsson, E., Thorsteinsdottir, U., Knowles, M.A., Rafnar, T., Stefansson, K., Kiemeney, L.A.L.M., Sulem, P., Besenbacher, S., Vermeulen, S., Sigurdsson, A., Thorleifsson, G., Gudbjartsson, D.F., Stacey, S.N., Gudmundsson, J., Zanon, C., Kostic, J., Masson, G., Bjarnason, H., Palsson, S., Skarphedinsson, O.B., Gudjonsson, S.A., Witjes, J.A., Grotenhuis, A.J., Verhaegh, G.W.C.T., Bishop, D.T., Sak, S.C., Choudhury, A., Elliott, F., Barrett, J.H., Hurst, C.D., Verdier, P. de, Ryk, C., Rudnai, P., Gurzau, E, Koppova, K., Vineis, P., Polidoro, S., Guarrera, S., Sacerdote, C., Campagna, M., Placidi, D., Arici, C., Zeegers, M.P., Kellen, E., Gutierrez, B.S., Sanz-Velez, J.I., Sanchez-Zalabardo, M., Valdivia, G., Garcia-Prats, M.D., Hengstler, J.G., Blaszkewicz, M., Dietrich, H., Ophoff, R.A., Berg, L.H. van den, Alexiusdottir, K., Kristjansson, K., Geirsson, G., Nikulasson, S., Petursdottir, V., Kong, A., Thorgeirsson, T.E., Mungan, N.A., Lindblom, A., Es, M.A. van, Porru, S., Buntinx, F., Golka, K., Mayordomo, J.I., Kumar, R., Matullo, G., Steineck, G., Kiltie, A.E., Aben, K.K.H., Jonsson, E., Thorsteinsdottir, U., Knowles, M.A., Rafnar, T., and Stefansson, K.

Abstract

Contains fulltext : 87396.pdf (publisher's version ) (Closed access)

Published
2010

8. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.

Author

Gudmundsson, J., Sulem, P., Rafnar, T., Bergthorsson, J.T., Manolescu, A., Gudbjartsson, D.F., Agnarsson, B.A., Sigurdsson, A., Benediktsdottir, K.R., Blondal, T., Jakobsdottir, M., Stacey, S.N., Kostic, J., Kristinsson, K.T., Birgisdottir, B., Ghosh, S., Magnusdottir, D., Thorlacius, S., Thorleifsson, G., Zheng, S.L., Sun, J., Chang, B.L., Elmore, J.B., Breyer, J.P., McReynolds, K.M., Bradley, K.M., Yaspan, B.L., Wiklund, F., Stattin, P, Lindstrom, S., Adami, H.O., McDonnell, S.K., Schaid, D.J., Cunningham, J.M., Wang, L., Cerhan, J.R., Sauver, J.L. St, Isaacs, S.D., Wiley, K.E., Partin, A.W., Walsh, P.C., Polo, S., Ruiz-Echarri, M., Navarrete, S., Fuertes, F., Saez, B., Godino, J., Weijerman, P.C., Swinkels, D.W., Aben, K.K.H., Witjes, J.A., Suarez, B.K., Helfand, B.T., Frigge, M.L., Kristjansson, K., Ober, C., Jonsson, E., Einarsson, G.V., Xu, J., Gronberg, H., Smith, J.R., Thibodeau, S.N., Isaacs, W.B., Catalona, W.J., Mayordomo, J.I., Kiemeney, L.A.L.M., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., Stefansson, K., Gudmundsson, J., Sulem, P., Rafnar, T., Bergthorsson, J.T., Manolescu, A., Gudbjartsson, D.F., Agnarsson, B.A., Sigurdsson, A., Benediktsdottir, K.R., Blondal, T., Jakobsdottir, M., Stacey, S.N., Kostic, J., Kristinsson, K.T., Birgisdottir, B., Ghosh, S., Magnusdottir, D., Thorlacius, S., Thorleifsson, G., Zheng, S.L., Sun, J., Chang, B.L., Elmore, J.B., Breyer, J.P., McReynolds, K.M., Bradley, K.M., Yaspan, B.L., Wiklund, F., Stattin, P, Lindstrom, S., Adami, H.O., McDonnell, S.K., Schaid, D.J., Cunningham, J.M., Wang, L., Cerhan, J.R., Sauver, J.L. St, Isaacs, S.D., Wiley, K.E., Partin, A.W., Walsh, P.C., Polo, S., Ruiz-Echarri, M., Navarrete, S., Fuertes, F., Saez, B., Godino, J., Weijerman, P.C., Swinkels, D.W., Aben, K.K.H., Witjes, J.A., Suarez, B.K., Helfand, B.T., Frigge, M.L., Kristjansson, K., Ober, C., Jonsson, E., Einarsson, G.V., Xu, J., Gronberg, H., Smith, J.R., Thibodeau, S.N., Isaacs, W.B., Catalona, W.J., Mayordomo, J.I., Kiemeney, L.A.L.M., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 70723.pdf (publisher's version ) (Closed access), We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

Published
2008

9. Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer.

Author

Stacey, S.N., Manolescu, A., Sulem, P., Thorlacius, S., Gudjonsson, S.A., Jonsson, G.F., Jakobsdottir, M., Bergthorsson, J.T., Gudmundsson, J., Aben, K.K.H., Strobbe, L.J., Swinkels, D.W., Engelenburg, K.C.A. van, Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Saez, B., Lambea, J., Godino, J., Polo, E., Tres, A., Picelli, S., Rantala, J., Margolin, S., Jonsson, T., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Sveinsdottir, S.G., Alexiusdottir, K., Saemundsdottir, J., Sigurdsson, A., Kostic, J., Gudmundsson, L., Kristjansson, K., Masson, G., Fackenthal, J.D., Adebamowo, C., Ogundiran, T., Olopade, O.I., Haiman, C.A., Lindblom, A., Mayordomo, J.I., Kiemeney, L.A.L.M., Gulcher, J.R., Rafnar, T., Thorsteinsdottir, U., Johannsson, O.T., Kong, A., Stefansson, K., Stacey, S.N., Manolescu, A., Sulem, P., Thorlacius, S., Gudjonsson, S.A., Jonsson, G.F., Jakobsdottir, M., Bergthorsson, J.T., Gudmundsson, J., Aben, K.K.H., Strobbe, L.J., Swinkels, D.W., Engelenburg, K.C.A. van, Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Saez, B., Lambea, J., Godino, J., Polo, E., Tres, A., Picelli, S., Rantala, J., Margolin, S., Jonsson, T., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Sveinsdottir, S.G., Alexiusdottir, K., Saemundsdottir, J., Sigurdsson, A., Kostic, J., Gudmundsson, L., Kristjansson, K., Masson, G., Fackenthal, J.D., Adebamowo, C., Ogundiran, T., Olopade, O.I., Haiman, C.A., Lindblom, A., Mayordomo, J.I., Kiemeney, L.A.L.M., Gulcher, J.R., Rafnar, T., Thorsteinsdottir, U., Johannsson, O.T., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 70749.pdf (publisher's version ) (Closed access), We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer.

Published
2008

10. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.

Author

Gudmundsson, J., Sulem, P., Rafnar, T., Bergthorsson, J.T., Manolescu, A., Gudbjartsson, D.F., Agnarsson, B.A., Sigurdsson, A., Benediktsdottir, K.R., Blondal, T., Jakobsdottir, M., Stacey, S.N., Kostic, J., Kristinsson, K.T., Birgisdottir, B., Ghosh, S., Magnusdottir, D., Thorlacius, S., Thorleifsson, G., Zheng, S.L., Sun, J., Chang, B.L., Elmore, J.B., Breyer, J.P., McReynolds, K.M., Bradley, K.M., Yaspan, B.L., Wiklund, F., Stattin, P, Lindstrom, S., Adami, H.O., McDonnell, S.K., Schaid, D.J., Cunningham, J.M., Wang, L., Cerhan, J.R., Sauver, J.L. St, Isaacs, S.D., Wiley, K.E., Partin, A.W., Walsh, P.C., Polo, S., Ruiz-Echarri, M., Navarrete, S., Fuertes, F., Saez, B., Godino, J., Weijerman, P.C., Swinkels, D.W., Aben, K.K.H., Witjes, J.A., Suarez, B.K., Helfand, B.T., Frigge, M.L., Kristjansson, K., Ober, C., Jonsson, E., Einarsson, G.V., Xu, J., Gronberg, H., Smith, J.R., Thibodeau, S.N., Isaacs, W.B., Catalona, W.J., Mayordomo, J.I., Kiemeney, L.A.L.M., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., Stefansson, K., Gudmundsson, J., Sulem, P., Rafnar, T., Bergthorsson, J.T., Manolescu, A., Gudbjartsson, D.F., Agnarsson, B.A., Sigurdsson, A., Benediktsdottir, K.R., Blondal, T., Jakobsdottir, M., Stacey, S.N., Kostic, J., Kristinsson, K.T., Birgisdottir, B., Ghosh, S., Magnusdottir, D., Thorlacius, S., Thorleifsson, G., Zheng, S.L., Sun, J., Chang, B.L., Elmore, J.B., Breyer, J.P., McReynolds, K.M., Bradley, K.M., Yaspan, B.L., Wiklund, F., Stattin, P, Lindstrom, S., Adami, H.O., McDonnell, S.K., Schaid, D.J., Cunningham, J.M., Wang, L., Cerhan, J.R., Sauver, J.L. St, Isaacs, S.D., Wiley, K.E., Partin, A.W., Walsh, P.C., Polo, S., Ruiz-Echarri, M., Navarrete, S., Fuertes, F., Saez, B., Godino, J., Weijerman, P.C., Swinkels, D.W., Aben, K.K.H., Witjes, J.A., Suarez, B.K., Helfand, B.T., Frigge, M.L., Kristjansson, K., Ober, C., Jonsson, E., Einarsson, G.V., Xu, J., Gronberg, H., Smith, J.R., Thibodeau, S.N., Isaacs, W.B., Catalona, W.J., Mayordomo, J.I., Kiemeney, L.A.L.M., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 70723.pdf (publisher's version ) (Closed access), We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

Published
2008

11. Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer.

Author

Stacey, S.N., Manolescu, A., Sulem, P., Thorlacius, S., Gudjonsson, S.A., Jonsson, G.F., Jakobsdottir, M., Bergthorsson, J.T., Gudmundsson, J., Aben, K.K.H., Strobbe, L.J., Swinkels, D.W., Engelenburg, K.C.A. van, Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Saez, B., Lambea, J., Godino, J., Polo, E., Tres, A., Picelli, S., Rantala, J., Margolin, S., Jonsson, T., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Sveinsdottir, S.G., Alexiusdottir, K., Saemundsdottir, J., Sigurdsson, A., Kostic, J., Gudmundsson, L., Kristjansson, K., Masson, G., Fackenthal, J.D., Adebamowo, C., Ogundiran, T., Olopade, O.I., Haiman, C.A., Lindblom, A., Mayordomo, J.I., Kiemeney, L.A.L.M., Gulcher, J.R., Rafnar, T., Thorsteinsdottir, U., Johannsson, O.T., Kong, A., Stefansson, K., Stacey, S.N., Manolescu, A., Sulem, P., Thorlacius, S., Gudjonsson, S.A., Jonsson, G.F., Jakobsdottir, M., Bergthorsson, J.T., Gudmundsson, J., Aben, K.K.H., Strobbe, L.J., Swinkels, D.W., Engelenburg, K.C.A. van, Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Saez, B., Lambea, J., Godino, J., Polo, E., Tres, A., Picelli, S., Rantala, J., Margolin, S., Jonsson, T., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Sveinsdottir, S.G., Alexiusdottir, K., Saemundsdottir, J., Sigurdsson, A., Kostic, J., Gudmundsson, L., Kristjansson, K., Masson, G., Fackenthal, J.D., Adebamowo, C., Ogundiran, T., Olopade, O.I., Haiman, C.A., Lindblom, A., Mayordomo, J.I., Kiemeney, L.A.L.M., Gulcher, J.R., Rafnar, T., Thorsteinsdottir, U., Johannsson, O.T., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 70749.pdf (publisher's version ) (Closed access), We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer.

Published
2008

12. Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer.

Author

Stacey, S.N., Manolescu, A., Sulem, P., Thorlacius, S., Gudjonsson, S.A., Jonsson, G.F., Jakobsdottir, M., Bergthorsson, J.T., Gudmundsson, J., Aben, K.K.H., Strobbe, L.J., Swinkels, D.W., Engelenburg, K.C.A. van, Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Saez, B., Lambea, J., Godino, J., Polo, E., Tres, A., Picelli, S., Rantala, J., Margolin, S., Jonsson, T., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Sveinsdottir, S.G., Alexiusdottir, K., Saemundsdottir, J., Sigurdsson, A., Kostic, J., Gudmundsson, L., Kristjansson, K., Masson, G., Fackenthal, J.D., Adebamowo, C., Ogundiran, T., Olopade, O.I., Haiman, C.A., Lindblom, A., Mayordomo, J.I., Kiemeney, L.A.L.M., Gulcher, J.R., Rafnar, T., Thorsteinsdottir, U., Johannsson, O.T., Kong, A., Stefansson, K., Stacey, S.N., Manolescu, A., Sulem, P., Thorlacius, S., Gudjonsson, S.A., Jonsson, G.F., Jakobsdottir, M., Bergthorsson, J.T., Gudmundsson, J., Aben, K.K.H., Strobbe, L.J., Swinkels, D.W., Engelenburg, K.C.A. van, Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Saez, B., Lambea, J., Godino, J., Polo, E., Tres, A., Picelli, S., Rantala, J., Margolin, S., Jonsson, T., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Sveinsdottir, S.G., Alexiusdottir, K., Saemundsdottir, J., Sigurdsson, A., Kostic, J., Gudmundsson, L., Kristjansson, K., Masson, G., Fackenthal, J.D., Adebamowo, C., Ogundiran, T., Olopade, O.I., Haiman, C.A., Lindblom, A., Mayordomo, J.I., Kiemeney, L.A.L.M., Gulcher, J.R., Rafnar, T., Thorsteinsdottir, U., Johannsson, O.T., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 70749.pdf (publisher's version ) (Closed access), We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer.

Published
2008

13. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.

Author

Gudmundsson, J., Sulem, P., Rafnar, T., Bergthorsson, J.T., Manolescu, A., Gudbjartsson, D.F., Agnarsson, B.A., Sigurdsson, A., Benediktsdottir, K.R., Blondal, T., Jakobsdottir, M., Stacey, S.N., Kostic, J., Kristinsson, K.T., Birgisdottir, B., Ghosh, S., Magnusdottir, D., Thorlacius, S., Thorleifsson, G., Zheng, S.L., Sun, J., Chang, B.L., Elmore, J.B., Breyer, J.P., McReynolds, K.M., Bradley, K.M., Yaspan, B.L., Wiklund, F., Stattin, P, Lindstrom, S., Adami, H.O., McDonnell, S.K., Schaid, D.J., Cunningham, J.M., Wang, L., Cerhan, J.R., Sauver, J.L. St, Isaacs, S.D., Wiley, K.E., Partin, A.W., Walsh, P.C., Polo, S., Ruiz-Echarri, M., Navarrete, S., Fuertes, F., Saez, B., Godino, J., Weijerman, P.C., Swinkels, D.W., Aben, K.K.H., Witjes, J.A., Suarez, B.K., Helfand, B.T., Frigge, M.L., Kristjansson, K., Ober, C., Jonsson, E., Einarsson, G.V., Xu, J., Gronberg, H., Smith, J.R., Thibodeau, S.N., Isaacs, W.B., Catalona, W.J., Mayordomo, J.I., Kiemeney, L.A.L.M., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., Stefansson, K., Gudmundsson, J., Sulem, P., Rafnar, T., Bergthorsson, J.T., Manolescu, A., Gudbjartsson, D.F., Agnarsson, B.A., Sigurdsson, A., Benediktsdottir, K.R., Blondal, T., Jakobsdottir, M., Stacey, S.N., Kostic, J., Kristinsson, K.T., Birgisdottir, B., Ghosh, S., Magnusdottir, D., Thorlacius, S., Thorleifsson, G., Zheng, S.L., Sun, J., Chang, B.L., Elmore, J.B., Breyer, J.P., McReynolds, K.M., Bradley, K.M., Yaspan, B.L., Wiklund, F., Stattin, P, Lindstrom, S., Adami, H.O., McDonnell, S.K., Schaid, D.J., Cunningham, J.M., Wang, L., Cerhan, J.R., Sauver, J.L. St, Isaacs, S.D., Wiley, K.E., Partin, A.W., Walsh, P.C., Polo, S., Ruiz-Echarri, M., Navarrete, S., Fuertes, F., Saez, B., Godino, J., Weijerman, P.C., Swinkels, D.W., Aben, K.K.H., Witjes, J.A., Suarez, B.K., Helfand, B.T., Frigge, M.L., Kristjansson, K., Ober, C., Jonsson, E., Einarsson, G.V., Xu, J., Gronberg, H., Smith, J.R., Thibodeau, S.N., Isaacs, W.B., Catalona, W.J., Mayordomo, J.I., Kiemeney, L.A.L.M., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 70723.pdf (publisher's version ) (Closed access), We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

Published
2008

14. Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.

Author

Stacey, S.N., Manolescu, A., Sulem, P., Rafnar, T., Gudmundsson, J., Gudjonsson, S.A., Masson, G., Jakobsdottir, M., Thorlacius, S., Helgason, A., Aben, K.K.H., Strobbe, L.J., Albers-Akkers, M.T., Swinkels, D.W., Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Godino, J., Garcia-Prats, M.D., Polo, E., Tres, A., Mouy, M., Saemundsdottir, J., Backman, V.M., Gudmundsson, L., Kristjansson, K., Bergthorsson, J.T., Kostic, J., Frigge, M.L., Geller, F., Gudbjartsson, D.F., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Jonsson, T., Holst, S. von, Werelius, B., Margolin, S., Lindblom, A., Mayordomo, J.I., Haiman, C.A., Kiemeney, L.A.L.M., Johannsson, O.T., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., Stefansson, K., Stacey, S.N., Manolescu, A., Sulem, P., Rafnar, T., Gudmundsson, J., Gudjonsson, S.A., Masson, G., Jakobsdottir, M., Thorlacius, S., Helgason, A., Aben, K.K.H., Strobbe, L.J., Albers-Akkers, M.T., Swinkels, D.W., Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Godino, J., Garcia-Prats, M.D., Polo, E., Tres, A., Mouy, M., Saemundsdottir, J., Backman, V.M., Gudmundsson, L., Kristjansson, K., Bergthorsson, J.T., Kostic, J., Frigge, M.L., Geller, F., Gudbjartsson, D.F., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Jonsson, T., Holst, S. von, Werelius, B., Margolin, S., Lindblom, A., Mayordomo, J.I., Haiman, C.A., Kiemeney, L.A.L.M., Johannsson, O.T., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 52079.pdf (publisher's version ) (Closed access), Familial clustering studies indicate that breast cancer risk has a substantial genetic component. To identify new breast cancer risk variants, we genotyped approximately 300,000 SNPs in 1,600 Icelandic individuals with breast cancer and 11,563 controls using the Illumina Hap300 platform. We then tested selected SNPs in five replication sample sets. Overall, we studied 4,554 affected individuals and 17,577 controls. Two SNPs consistently associated with breast cancer: approximately 25% of individuals of European descent are homozygous for allele A of rs13387042 on chromosome 2q35 and have an estimated 1.44-fold greater risk than noncarriers, and for allele T of rs3803662 on 16q12, about 7% are homozygous and have a 1.64-fold greater risk. Risk from both alleles was confined to estrogen receptor-positive tumors. At present, no genes have been identified in the linkage disequilibrium block containing rs13387042. rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to bone.

Published
2007

15. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

Author

Gudmundsson, J., Sulem, P., Manolescu, A., Amundadottir, L.T., Gudbjartsson, D.F., Helgason, A., Rafnar, T., Bergthorsson, J.T., Agnarsson, B.A., Baker, A., Sigurdsson, A., Benediktsdottir, K.R., Jakobsdottir, M., Xu, J., Blondal, T., Kostic, J., Sun, J., Ghosh, S., Stacey, S.N., Mouy, M., Saemundsdottir, J., Backman, V.M., Kristjansson, K., Tres, A., Partin, A.W., Albers-Akkers, M.T., Marcos, J.G.I., Walsh, P.C., Swinkels, D.W., Navarrete, S., Isaacs, S.D., Aben, K.K.H., Graif, T., Cashy, J., Ruiz-Echarri, M., Wiley, K.E., Suarez, B.K., Witjes, J.A., Frigge, M., Ober, C., Jonsson, E., Einarsson, G.V., Mayordomo, J.I., Kiemeney, L.A.L.M., Isaacs, W.B., Catalona, W.J., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., Stefansson, K., Gudmundsson, J., Sulem, P., Manolescu, A., Amundadottir, L.T., Gudbjartsson, D.F., Helgason, A., Rafnar, T., Bergthorsson, J.T., Agnarsson, B.A., Baker, A., Sigurdsson, A., Benediktsdottir, K.R., Jakobsdottir, M., Xu, J., Blondal, T., Kostic, J., Sun, J., Ghosh, S., Stacey, S.N., Mouy, M., Saemundsdottir, J., Backman, V.M., Kristjansson, K., Tres, A., Partin, A.W., Albers-Akkers, M.T., Marcos, J.G.I., Walsh, P.C., Swinkels, D.W., Navarrete, S., Isaacs, S.D., Aben, K.K.H., Graif, T., Cashy, J., Ruiz-Echarri, M., Wiley, K.E., Suarez, B.K., Witjes, J.A., Frigge, M., Ober, C., Jonsson, E., Einarsson, G.V., Mayordomo, J.I., Kiemeney, L.A.L.M., Isaacs, W.B., Catalona, W.J., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 51723.pdf (publisher's version ) (Closed access), Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%-13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%-4%) susceptibility variant in individuals of European descent that happens to be very common (approximately 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis.

Published
2007

16. Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.

Author

Stacey, S.N., Manolescu, A., Sulem, P., Rafnar, T., Gudmundsson, J., Gudjonsson, S.A., Masson, G., Jakobsdottir, M., Thorlacius, S., Helgason, A., Aben, K.K.H., Strobbe, L.J., Albers-Akkers, M.T., Swinkels, D.W., Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Godino, J., Garcia-Prats, M.D., Polo, E., Tres, A., Mouy, M., Saemundsdottir, J., Backman, V.M., Gudmundsson, L., Kristjansson, K., Bergthorsson, J.T., Kostic, J., Frigge, M.L., Geller, F., Gudbjartsson, D.F., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Jonsson, T., Holst, S. von, Werelius, B., Margolin, S., Lindblom, A., Mayordomo, J.I., Haiman, C.A., Kiemeney, L.A.L.M., Johannsson, O.T., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., Stefansson, K., Stacey, S.N., Manolescu, A., Sulem, P., Rafnar, T., Gudmundsson, J., Gudjonsson, S.A., Masson, G., Jakobsdottir, M., Thorlacius, S., Helgason, A., Aben, K.K.H., Strobbe, L.J., Albers-Akkers, M.T., Swinkels, D.W., Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Godino, J., Garcia-Prats, M.D., Polo, E., Tres, A., Mouy, M., Saemundsdottir, J., Backman, V.M., Gudmundsson, L., Kristjansson, K., Bergthorsson, J.T., Kostic, J., Frigge, M.L., Geller, F., Gudbjartsson, D.F., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Jonsson, T., Holst, S. von, Werelius, B., Margolin, S., Lindblom, A., Mayordomo, J.I., Haiman, C.A., Kiemeney, L.A.L.M., Johannsson, O.T., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 52079.pdf (publisher's version ) (Closed access), Familial clustering studies indicate that breast cancer risk has a substantial genetic component. To identify new breast cancer risk variants, we genotyped approximately 300,000 SNPs in 1,600 Icelandic individuals with breast cancer and 11,563 controls using the Illumina Hap300 platform. We then tested selected SNPs in five replication sample sets. Overall, we studied 4,554 affected individuals and 17,577 controls. Two SNPs consistently associated with breast cancer: approximately 25% of individuals of European descent are homozygous for allele A of rs13387042 on chromosome 2q35 and have an estimated 1.44-fold greater risk than noncarriers, and for allele T of rs3803662 on 16q12, about 7% are homozygous and have a 1.64-fold greater risk. Risk from both alleles was confined to estrogen receptor-positive tumors. At present, no genes have been identified in the linkage disequilibrium block containing rs13387042. rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to bone.

Published
2007

17. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

Author

Gudmundsson, J., Sulem, P., Manolescu, A., Amundadottir, L.T., Gudbjartsson, D.F., Helgason, A., Rafnar, T., Bergthorsson, J.T., Agnarsson, B.A., Baker, A., Sigurdsson, A., Benediktsdottir, K.R., Jakobsdottir, M., Xu, J., Blondal, T., Kostic, J., Sun, J., Ghosh, S., Stacey, S.N., Mouy, M., Saemundsdottir, J., Backman, V.M., Kristjansson, K., Tres, A., Partin, A.W., Albers-Akkers, M.T., Marcos, J.G.I., Walsh, P.C., Swinkels, D.W., Navarrete, S., Isaacs, S.D., Aben, K.K.H., Graif, T., Cashy, J., Ruiz-Echarri, M., Wiley, K.E., Suarez, B.K., Witjes, J.A., Frigge, M., Ober, C., Jonsson, E., Einarsson, G.V., Mayordomo, J.I., Kiemeney, L.A.L.M., Isaacs, W.B., Catalona, W.J., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., Stefansson, K., Gudmundsson, J., Sulem, P., Manolescu, A., Amundadottir, L.T., Gudbjartsson, D.F., Helgason, A., Rafnar, T., Bergthorsson, J.T., Agnarsson, B.A., Baker, A., Sigurdsson, A., Benediktsdottir, K.R., Jakobsdottir, M., Xu, J., Blondal, T., Kostic, J., Sun, J., Ghosh, S., Stacey, S.N., Mouy, M., Saemundsdottir, J., Backman, V.M., Kristjansson, K., Tres, A., Partin, A.W., Albers-Akkers, M.T., Marcos, J.G.I., Walsh, P.C., Swinkels, D.W., Navarrete, S., Isaacs, S.D., Aben, K.K.H., Graif, T., Cashy, J., Ruiz-Echarri, M., Wiley, K.E., Suarez, B.K., Witjes, J.A., Frigge, M., Ober, C., Jonsson, E., Einarsson, G.V., Mayordomo, J.I., Kiemeney, L.A.L.M., Isaacs, W.B., Catalona, W.J., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 51723.pdf (publisher's version ) (Closed access), Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%-13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%-4%) susceptibility variant in individuals of European descent that happens to be very common (approximately 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis.

Published
2007

18. Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.

Author

Stacey, S.N., Manolescu, A., Sulem, P., Rafnar, T., Gudmundsson, J., Gudjonsson, S.A., Masson, G., Jakobsdottir, M., Thorlacius, S., Helgason, A., Aben, K.K.H., Strobbe, L.J., Albers-Akkers, M.T., Swinkels, D.W., Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Godino, J., Garcia-Prats, M.D., Polo, E., Tres, A., Mouy, M., Saemundsdottir, J., Backman, V.M., Gudmundsson, L., Kristjansson, K., Bergthorsson, J.T., Kostic, J., Frigge, M.L., Geller, F., Gudbjartsson, D.F., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Jonsson, T., Holst, S. von, Werelius, B., Margolin, S., Lindblom, A., Mayordomo, J.I., Haiman, C.A., Kiemeney, L.A.L.M., Johannsson, O.T., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., Stefansson, K., Stacey, S.N., Manolescu, A., Sulem, P., Rafnar, T., Gudmundsson, J., Gudjonsson, S.A., Masson, G., Jakobsdottir, M., Thorlacius, S., Helgason, A., Aben, K.K.H., Strobbe, L.J., Albers-Akkers, M.T., Swinkels, D.W., Henderson, B.E., Kolonel, L.N., Marchand, L. le, Millastre, E., Andres, R., Godino, J., Garcia-Prats, M.D., Polo, E., Tres, A., Mouy, M., Saemundsdottir, J., Backman, V.M., Gudmundsson, L., Kristjansson, K., Bergthorsson, J.T., Kostic, J., Frigge, M.L., Geller, F., Gudbjartsson, D.F., Sigurdsson, H., Jonsdottir, T., Hrafnkelsson, J., Johannsson, J., Sveinsson, T., Myrdal, G., Grimsson, H.N., Jonsson, T., Holst, S. von, Werelius, B., Margolin, S., Lindblom, A., Mayordomo, J.I., Haiman, C.A., Kiemeney, L.A.L.M., Johannsson, O.T., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 52079.pdf (publisher's version ) (Closed access), Familial clustering studies indicate that breast cancer risk has a substantial genetic component. To identify new breast cancer risk variants, we genotyped approximately 300,000 SNPs in 1,600 Icelandic individuals with breast cancer and 11,563 controls using the Illumina Hap300 platform. We then tested selected SNPs in five replication sample sets. Overall, we studied 4,554 affected individuals and 17,577 controls. Two SNPs consistently associated with breast cancer: approximately 25% of individuals of European descent are homozygous for allele A of rs13387042 on chromosome 2q35 and have an estimated 1.44-fold greater risk than noncarriers, and for allele T of rs3803662 on 16q12, about 7% are homozygous and have a 1.64-fold greater risk. Risk from both alleles was confined to estrogen receptor-positive tumors. At present, no genes have been identified in the linkage disequilibrium block containing rs13387042. rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to bone.

Published
2007

19. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

Author

Gudmundsson, J., Sulem, P., Manolescu, A., Amundadottir, L.T., Gudbjartsson, D.F., Helgason, A., Rafnar, T., Bergthorsson, J.T., Agnarsson, B.A., Baker, A., Sigurdsson, A., Benediktsdottir, K.R., Jakobsdottir, M., Xu, J., Blondal, T., Kostic, J., Sun, J., Ghosh, S., Stacey, S.N., Mouy, M., Saemundsdottir, J., Backman, V.M., Kristjansson, K., Tres, A., Partin, A.W., Albers-Akkers, M.T., Marcos, J.G.I., Walsh, P.C., Swinkels, D.W., Navarrete, S., Isaacs, S.D., Aben, K.K.H., Graif, T., Cashy, J., Ruiz-Echarri, M., Wiley, K.E., Suarez, B.K., Witjes, J.A., Frigge, M., Ober, C., Jonsson, E., Einarsson, G.V., Mayordomo, J.I., Kiemeney, L.A.L.M., Isaacs, W.B., Catalona, W.J., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., Stefansson, K., Gudmundsson, J., Sulem, P., Manolescu, A., Amundadottir, L.T., Gudbjartsson, D.F., Helgason, A., Rafnar, T., Bergthorsson, J.T., Agnarsson, B.A., Baker, A., Sigurdsson, A., Benediktsdottir, K.R., Jakobsdottir, M., Xu, J., Blondal, T., Kostic, J., Sun, J., Ghosh, S., Stacey, S.N., Mouy, M., Saemundsdottir, J., Backman, V.M., Kristjansson, K., Tres, A., Partin, A.W., Albers-Akkers, M.T., Marcos, J.G.I., Walsh, P.C., Swinkels, D.W., Navarrete, S., Isaacs, S.D., Aben, K.K.H., Graif, T., Cashy, J., Ruiz-Echarri, M., Wiley, K.E., Suarez, B.K., Witjes, J.A., Frigge, M., Ober, C., Jonsson, E., Einarsson, G.V., Mayordomo, J.I., Kiemeney, L.A.L.M., Isaacs, W.B., Catalona, W.J., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A., and Stefansson, K.

Abstract

Contains fulltext : 51723.pdf (publisher's version ) (Closed access), Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%-13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%-4%) susceptibility variant in individuals of European descent that happens to be very common (approximately 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis.

Published
2007

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