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Your search keyword '"Krop, E. J. M."' showing total 18 results
Start Over Author "Krop, E. J. M." Publication Type Electronic Resources
18 results on '"Krop, E. J. M."'

1. Effectiveness of pulmonary rehabilitation at high-altitude compared to sea-level in adults with severe refractory asthma

Author

Onderzoek Longziekten, MS MDL 1, Longziekten, Infection & Immunity, de Nijs, S B, Krop, E J M, Portengen, L, Rijssenbeek-Nouwens, L H, de Vries, D, Weersink, E J M, Heijerman, H G M, Heederik, D J J, Lammers, J W J, Onderzoek Longziekten, MS MDL 1, Longziekten, Infection & Immunity, de Nijs, S B, Krop, E J M, Portengen, L, Rijssenbeek-Nouwens, L H, de Vries, D, Weersink, E J M, Heijerman, H G M, Heederik, D J J, and Lammers, J W J

Published
2020

3. Stability of individual LPS-induced ex vivo cytokine release in a whole blood assay over a five-year interval

Author

LS IRAS VPH VV (veterinaire volksgezh.), One Health Chemisch, One Health Microbieel, dIRAS RA-I&I RA, dIRAS RA-2, Dep IRAS, Sub Medicinal Chemistry & Chemical biol., Spierenburg, E A J, Portengen, L, Smit, L A M, Krop, E J M, Hylkema, M N, Rijkers, G T, Heederik, D, Wouters, I M, LS IRAS VPH VV (veterinaire volksgezh.), One Health Chemisch, One Health Microbieel, dIRAS RA-I&I RA, dIRAS RA-2, Dep IRAS, Sub Medicinal Chemistry & Chemical biol., Spierenburg, E A J, Portengen, L, Smit, L A M, Krop, E J M, Hylkema, M N, Rijkers, G T, Heederik, D, and Wouters, I M

Published
2018

4. Stability of individual LPS-induced ex vivo cytokine release in a whole blood assay over a five-year interval

Author

LS IRAS VPH VV (veterinaire volksgezh.), One Health Chemisch, One Health Microbieel, dIRAS RA-I&I RA, dIRAS RA-2, Dep IRAS, Sub Medicinal Chemistry & Chemical biol., Spierenburg, E A J, Portengen, L, Smit, L A M, Krop, E J M, Hylkema, M N, Rijkers, G T, Heederik, D, Wouters, I M, LS IRAS VPH VV (veterinaire volksgezh.), One Health Chemisch, One Health Microbieel, dIRAS RA-I&I RA, dIRAS RA-2, Dep IRAS, Sub Medicinal Chemistry & Chemical biol., Spierenburg, E A J, Portengen, L, Smit, L A M, Krop, E J M, Hylkema, M N, Rijkers, G T, Heederik, D, and Wouters, I M

Published
2018

5. Stability of individual LPS-induced ex vivo cytokine release in a whole blood assay over a five-year interval

Author

LS IRAS VPH VV (veterinaire volksgezh.), One Health Chemisch, One Health Microbieel, dIRAS RA-I&I RA, dIRAS RA-2, Dep IRAS, Sub Medicinal Chemistry & Chemical biol., Spierenburg, E A J, Portengen, L, Smit, L A M, Krop, E J M, Hylkema, M N, Rijkers, G T, Heederik, D, Wouters, I M, LS IRAS VPH VV (veterinaire volksgezh.), One Health Chemisch, One Health Microbieel, dIRAS RA-I&I RA, dIRAS RA-2, Dep IRAS, Sub Medicinal Chemistry & Chemical biol., Spierenburg, E A J, Portengen, L, Smit, L A M, Krop, E J M, Hylkema, M N, Rijkers, G T, Heederik, D, and Wouters, I M

Published
2018

6. Occupational endotoxin exposure in association with atopic sensitization and respiratory health in adults: Results of a 5-year follow-up

Author

Spierenburg, E A J, Smit, L A M, Krop, E J M, Heederik, D, Hylkema, M N, Wouters, I M, Spierenburg, E A J, Smit, L A M, Krop, E J M, Heederik, D, Hylkema, M N, and Wouters, I M

Abstract

The objective of the present longitudinal study was to investigate the effects of occupational endotoxin exposure on respiratory health and atopic sensitization in adults. Health outcomes and personal endotoxin exposure estimates were determined for 234 farmers and agricultural workers both at baseline and 5 years later. A questionnaire was used to assess respiratory symptoms, spirometry tests were performed and total and specific IgE levels were measured in serum. A twofold increase in personal endotoxin exposure was associated with less hay fever (OR 0.68, 95%CI 0.54-0.87) and grass IgE positivity (OR 0.81, 95%CI 0.68-0.97) at both time points ("persistent" versus "never"). Although not statistically significant, a consistent protective pattern was observed for an increased loss of hay fever symptoms (OR 2.19, 95%CI 0.96-4.99) and grass IgE positivity (OR 1.24, 95%CI 0.76-2.02), and for less new-onset of hay fever (OR 0.87, 95%CI 0.65-1.17), grass IgE positivity (OR 0.83, 95%CI 0.61-1.12) and atopic sensitization (OR 0.75, 95%CI 0.55-1.02). Endotoxin exposure was not associated with changes in lung function. We showed that occupational endotoxin exposure is associated with a long-term protective effect on hay fever and grass IgE positivity. Results on longitudinal changes in hay fever, atopy and grass IgE positivity in adulthood were consistent with a protective effect of endotoxin exposure, but results need to be confirmed in larger cohorts. An effect of endotoxin exposure on lung function decline was not found.

Published
2017

7. School attendance and daily respiratory symptoms in children: influence of moisture damage

Author

Casas, L, Espinosa, A, Pekkanen, J, Asikainen, A, Borràs-Santos, A, Jacobs, J., Krop, E J M, Täubel, M, Hyvärinen, A, Heederik, D, Zock, J-P, Casas, L, Espinosa, A, Pekkanen, J, Asikainen, A, Borràs-Santos, A, Jacobs, J., Krop, E J M, Täubel, M, Hyvärinen, A, Heederik, D, and Zock, J-P

Abstract

We investigated the effect of weekends and school holidays on the daily frequency and severity of respiratory and other symptoms among children attending schools with (index) or without (reference) moisture damage in Spain, the Netherlands, and Finland. Throughout 1 year, parents of 419 children with a respiratory condition attending index (n=15) or reference (n=10) primary schools completed three symptom diaries. We assessed associations between lower respiratory tract, upper respiratory tract or allergy, and other symptom scores and school day, weekend, or summer holiday using mixed regression models stratified by country and moisture damage. We evaluated interactions between moisture damage and type of day. We combined country-specific estimates (incidence rate ratios [IRRs] and 95% confidence interval [CI]) in meta-analyses. Symptom scores were lower during weekends and holiday. Lower respiratory tract symptoms were statistically significantly less common during holiday with strongest effect in index schools (IRR=0.7; CI=0.6-0.8). Reporting of other symptoms was more reduced during holiday in index (IRR=0.6; CI=0.4-0.9) than in reference (IRR=0.95; CI=0.8-1.2) schools (interaction P<.01). In conclusion, symptoms were less frequent and/or severe during summer holiday and weekends. This pattern was stronger among children attending moisture-damaged schools, suggesting potential improvement in moisture damage-related symptoms during school breaks.

Published
2017

9. School attendance and daily respiratory symptoms in children: influence of moisture damage

Author

dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Casas, L, Espinosa, A, Pekkanen, J, Asikainen, A, Borràs-Santos, A, Jacobs, J., Krop, E J M, Täubel, M, Hyvärinen, A, Heederik, D, Zock, J-P, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Casas, L, Espinosa, A, Pekkanen, J, Asikainen, A, Borràs-Santos, A, Jacobs, J., Krop, E J M, Täubel, M, Hyvärinen, A, Heederik, D, and Zock, J-P

Published
2017

10. Occupational endotoxin exposure in association with atopic sensitization and respiratory health in adults: Results of a 5-year follow-up

Author

LS IRAS VPH VV (veterinaire volksgezh.), LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Spierenburg, E A J, Smit, L A M, Krop, E J M, Heederik, D, Hylkema, M N, Wouters, I M, LS IRAS VPH VV (veterinaire volksgezh.), LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Spierenburg, E A J, Smit, L A M, Krop, E J M, Heederik, D, Hylkema, M N, and Wouters, I M

Published
2017

11. Occupational endotoxin exposure in association with atopic sensitization and respiratory health in adults: Results of a 5-year follow-up

Author

LS IRAS VPH VV (veterinaire volksgezh.), LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Spierenburg, E A J, Smit, L A M, Krop, E J M, Heederik, D, Hylkema, M N, Wouters, I M, LS IRAS VPH VV (veterinaire volksgezh.), LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Spierenburg, E A J, Smit, L A M, Krop, E J M, Heederik, D, Hylkema, M N, and Wouters, I M

Published
2017

12. School attendance and daily respiratory symptoms in children: influence of moisture damage

Author

dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Casas, L, Espinosa, A, Pekkanen, J, Asikainen, A, Borràs-Santos, A, Jacobs, J., Krop, E J M, Täubel, M, Hyvärinen, A, Heederik, D, Zock, J-P, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Casas, L, Espinosa, A, Pekkanen, J, Asikainen, A, Borràs-Santos, A, Jacobs, J., Krop, E J M, Täubel, M, Hyvärinen, A, Heederik, D, and Zock, J-P

Published
2017

13. Occupational endotoxin exposure in association with atopic sensitization and respiratory health in adults: Results of a 5-year follow-up

Author

LS IRAS VPH VV (veterinaire volksgezh.), LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Spierenburg, E A J, Smit, L A M, Krop, E J M, Heederik, D, Hylkema, M N, Wouters, I M, LS IRAS VPH VV (veterinaire volksgezh.), LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Spierenburg, E A J, Smit, L A M, Krop, E J M, Heederik, D, Hylkema, M N, and Wouters, I M

Published
2017

14. School attendance and daily respiratory symptoms in children: influence of moisture damage

Author

dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Casas, L, Espinosa, A, Pekkanen, J, Asikainen, A, Borràs-Santos, A, Jacobs, J., Krop, E J M, Täubel, M, Hyvärinen, A, Heederik, D, Zock, J-P, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Casas, L, Espinosa, A, Pekkanen, J, Asikainen, A, Borràs-Santos, A, Jacobs, J., Krop, E J M, Täubel, M, Hyvärinen, A, Heederik, D, and Zock, J-P

Published
2017

15. Endotoxin levels in settled airborne dust in European schools: The HITEA school study

Author

Jacobs, J. H., Krop, E. J M, Borras-Santos, A., Zock, J. P., Taubel, M., Hyvarinnen, A., Pekkanen, J., Doekes, G., Heederik, D. J J, Jacobs, J. H., Krop, E. J M, Borras-Santos, A., Zock, J. P., Taubel, M., Hyvarinnen, A., Pekkanen, J., Doekes, G., and Heederik, D. J J

Abstract

Indoor exposure to microbial agents is known to influence respiratory health. Besides home exposure, exposure in schools can affect respiratory health. In this study, we measured endotoxin in settled dust in primary schools in three European countries from three different geographical regions with different climates. Our aim was to characterize endotoxin levels in primary schools and evaluate associations with potential determinants. Endotoxin levels were repeatedly assessed in 23 schools in Spain (n = 7), the Netherlands (n = 10), and Finland (n = 6) using electrostatic dustfall collectors. In total, 645 measurements were taken in 237 classrooms. Endotoxin levels differed significantly between countries; Dutch schools had the highest levels, while Finnish schools showed the lowest levels. In each country, differences in endotoxin levels were observed between schools and over the sampling periods. Estimates improved after adjustment for sampling period. Factors affecting endotoxin levels in a school differed per country. In general, endotoxin levels were higher in lower grades and in classrooms with higher occupancy. School endotoxin levels may contribute significantly to total endotoxin exposure in children and teachers. As the correlation between the repeated measurements is reasonable, single endotoxin measurements form a reasonable basis for estimating annual endotoxin levels in schools.

Published
2014

16. Endotoxin levels in settled airborne dust in European schools: The HITEA school study

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Jacobs, J. H., Krop, E. J M, Borras-Santos, A., Zock, J. P., Taubel, M., Hyvarinnen, A., Pekkanen, J., Doekes, G., Heederik, D. J J, LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Jacobs, J. H., Krop, E. J M, Borras-Santos, A., Zock, J. P., Taubel, M., Hyvarinnen, A., Pekkanen, J., Doekes, G., and Heederik, D. J J

Published
2014

17. Endotoxin levels in settled airborne dust in European schools: The HITEA school study

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Jacobs, J. H., Krop, E. J M, Borras-Santos, A., Zock, J. P., Taubel, M., Hyvarinnen, A., Pekkanen, J., Doekes, G., Heederik, D. J J, LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Jacobs, J. H., Krop, E. J M, Borras-Santos, A., Zock, J. P., Taubel, M., Hyvarinnen, A., Pekkanen, J., Doekes, G., and Heederik, D. J J

Published
2014

18. Endotoxin levels in settled airborne dust in European schools: The HITEA school study

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Jacobs, J. H., Krop, E. J M, Borras-Santos, A., Zock, J. P., Taubel, M., Hyvarinnen, A., Pekkanen, J., Doekes, G., Heederik, D. J J, LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Jacobs, J. H., Krop, E. J M, Borras-Santos, A., Zock, J. P., Taubel, M., Hyvarinnen, A., Pekkanen, J., Doekes, G., and Heederik, D. J J

Published
2014

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