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Differential cross sections of the elastic pion-proton scattering are investigated at very small momentum transfer in a holographic QCD model, considering both the strong and Coulomb interaction in the Regge regime. The strong interaction is described by the Pomeron and Reggeon exchange, and the Coulomb interaction is characterized by the one photon exchange. The two interactions are linked through an interference term and we only need to determine a single adjustable parameter involved in this term. As to the parameters for the strong interaction, we can utilize the values determined in the previous studies. The differential cross sections can be predicted without any additional parameters, and it is shown that our predictions are consistent with the experimental data. We explicitly show the momentum transfer dependence for the interference effect. The energy dependence of the contribution ratios for each component is also discussed., Comment: 24 pages, 5 figures, version accepted for publication in Phys. Rev. D

The differential cross sections of elastic proton-proton (pp) and proton-antiproton (pp\bar) scattering are studied in a holographic QCD model, considering the strong and Coulomb interaction in the Regge regime. Based on previous studies of strong interactions described in terms of Pomeron and Reggeon exchange, we add the contribution of Coulomb interaction described by photon exchange. We present the momentum transfer dependence of the contribution rates for each component, especially for the Coulomb-nuclear interference, which refers to the cross term between both interactions. For the adjustable parameters for the strong interaction, we can adopt the values determined in previous studies, and there are no extra adjustable parameters that need to be determined for the Coulomb interaction. It is presented that the resulting differential cross sections are consistent with the data for pp and pp\bar scattering., Comment: 19 pages, 6 figures

Using gauge/gravity duality, we first study the string breaking and melting of doubly heavy baryon at a finite chemical potential and temperature in this paper. The decay mode $\rm{Q Q q \rightarrow Q q q+Q \bar{q}}$ is investigated with the presence of temperature and chemical potential in this paper. With the increase of temperature and chemical potential, string breaking takes place at a smaller potential energy and the string-breaking distance will increase slightly. It is also found that the $\rm{QQq}$ melts at small separate distance with the increase of temperature and chemical potential. Then, we compare the screening distance of $\rm{QQq}$ with $\rm{Q \bar{Q}}$ under the same conditions. Finally, we draw the melting diagram of $\rm{QQq}$ and $\rm{Q \bar{Q}}$ in the $T-\mu$ plane., Comment: 24pages, 18 figures

We consider the effect of gluon condensation on the holographic entanglement entropy, which can be regarded as an order parameter of deconfinement phase transition, in a holographic model at zero and finite temperature. At zero temperature, it is found that phase transition can occur at critical length for small gluon condensation. With the increase of gluon condensation, the critical length becomes small which means the phase transition is easy to occur. The difference of entanglement entropy between the connected and disconnected surfaces is always negative at large gluon condensation, which indicates no phase transition can occur in the deconfined phase as the subsystem size varies. These results show that the gluon condensation is related to the phase transition and contributes to deconfinement. At finite temperature, we can see that the difference of the entanglement entropy is also always negative and the system is always deconfined for vanishing and non-vanishing gluon condensation in this model. These results confirm that the difference of entanglement entropy is a useful probe to detect whether a system is in the confinement or deconfinement phase.

Using the gauge/gravity duality, we investigate the string breaking and dissolution of two heavy quarks coupled to a light quark at finite temperature. It is found that there exist three configurations of QQq with the increase of separate distance for heavy quarks in the confined phase. Besides, the string breaking occurs at the distance $L_{\rm{QQq}} = 1.27 \rm{fm}$($T = 0.1 \rm{GeV}$) for the decay mode $\rm{Q Q q \rightarrow Q q q+Q \bar{q}}$. In the deconfined phase, QQq will melt at a certain distance then becomes free quarks. At last, we compare the potential of QQq with that of $\rm{Q\bar{Q}}$ and find $\rm{Q\bar{Q}}$ is more stable than QQq at high temperature., Comment: 23 pages, 24 figures

Tumor-specific T cell receptor (TCR) gene transfer enables specific and potent immune targeting of tumor antigens. Due to the prevalence of the HLA-A2 MHC class I supertype in most human populations, the majority of TCR gene therapy trials targeting public antigens have employed HLA-A2-restricted TCRs, limiting this approach to those patients expressing this allele. For these patients, TCR gene therapy trials have resulted in both tantalizing successes and lethal adverse events, underscoring the need for careful selection of antigenic targets. Broad and safe application of public antigen-targeted TCR gene therapies will require (i) selecting public antigens that are highly tumor-specific and (ii) targeting multiple epitopes derived from these antigens by obtaining an assortment of TCRs restricted by multiple common MHC alleles. The canonical cancer-testis antigen, NY-ESO-1, is not expressed in normal tissues but is aberrantly expressed across a broad array of cancer types. It has also been targeted with A2-restricted TCR gene therapy without adverse events or notable side effects. To enable the targeting of NY-ESO-1 in a broader array of HLA haplotypes, we isolated TCRs specific for NY-ESO-1 epitopes presented by four MHC molecules: HLA-A2, -B07, -B18, and -C03. Using these TCRs, we pilot an approach to extend TCR gene therapies targeting NY-ESO-1 to patient populations beyond those expressing HLA-A2.

Tumor-specific T cell receptor (TCR) gene transfer enables specific and potent immune targeting of tumor antigens. Due to the prevalence of the HLA-A2 MHC class I supertype in most human populations, the majority of TCR gene therapy trials targeting public antigens have employed HLA-A2-restricted TCRs, limiting this approach to those patients expressing this allele. For these patients, TCR gene therapy trials have resulted in both tantalizing successes and lethal adverse events, underscoring the need for careful selection of antigenic targets. Broad and safe application of public antigen-targeted TCR gene therapies will require (i) selecting public antigens that are highly tumor-specific and (ii) targeting multiple epitopes derived from these antigens by obtaining an assortment of TCRs restricted by multiple common MHC alleles. The canonical cancer-testis antigen, NY-ESO-1, is not expressed in normal tissues but is aberrantly expressed across a broad array of cancer types. It has also been targeted with A2-restricted TCR gene therapy without adverse events or notable side effects. To enable the targeting of NY-ESO-1 in a broader array of HLA haplotypes, we isolated TCRs specific for NY-ESO-1 epitopes presented by four MHC molecules: HLA-A2, -B07, -B18, and -C03. Using these TCRs, we pilot an approach to extend TCR gene therapies targeting NY-ESO-1 to patient populations beyond those expressing HLA-A2.

In this talk, we first briefly review the isospin dependence of the total nucleon effective mass $M^{\ast}_{J}$ inferred from analyzing nucleon-nucleus scattering data within an isospin dependent non-relativistic optical potential model, and the isospin dependence of the nucleon E-mass $M^{\ast,\rm{E}}_{J}$ obtained from applying the Migdal-Luttinger theorem to a phenomenological single-nucleon momentum distribution in nuclei constrained by recent electron-nucleus scattering experiments. Combining information about the isospin dependence of both the nucleon total effective mass and E-mass, we then infer the isospin dependence of nucleon k-mass using the well-known relation $M^{\ast}_{J}=M^{\ast,\rm{E}}_{J}\cdot M^{\ast,\rm{k}}_{J}$. Implications of the results on the nucleon mean free path (MFP) in neutron-rich matter are discussed., Comment: An invited talk given at the 5th International Workshop on Nuclear Dynamics in Heavy-Ion Reactions (IWND2016), Xinxiang, China, May 15-20, 2016

In this talk, we first briefly review the isospin dependence of the total nucleon effective mass $M^{\ast}_{J}$ inferred from analyzing nucleon-nucleus scattering data within an isospin dependent non-relativistic optical potential model, and the isospin dependence of the nucleon E-mass $M^{\ast,\rm{E}}_{J}$ obtained from applying the Migdal-Luttinger theorem to a phenomenological single-nucleon momentum distribution in nuclei constrained by recent electron-nucleus scattering experiments. Combining information about the isospin dependence of both the nucleon total effective mass and E-mass, we then infer the isospin dependence of nucleon k-mass using the well-known relation $M^{\ast}_{J}=M^{\ast,\rm{E}}_{J}\cdot M^{\ast,\rm{k}}_{J}$. Implications of the results on the nucleon mean free path (MFP) in neutron-rich matter are discussed., Comment: An invited talk given at the 5th International Workshop on Nuclear Dynamics in Heavy-Ion Reactions (IWND2016), Xinxiang, China, May 15-20, 2016

The microstructure and hardness of the stir zone (SZ) with different welding heat inputs were investigated for friction stir-welded 2024-T3 aluminum by transmission electron microscopy, differential scanning calorimeter and Vickers micro-hardness test. The results show that welding heat input has a significant effect on the hardness of the SZ. Under high welding heat input condition, a higher welding speed is beneficial for improving the hardness of the SZ. However, when the welding heat input is low, the hardness of the SZ elevates with increasing the rotation speed. The hardness of the SZ decreases after post-welded heat treatment due to overaging. The joints welded at 500 r/min and 100 mm/min show a high resistance to overaging. The reduction of hardness in the SZ is only 3.8%, while in other joints, the reduction is more than 10%. The morphology of strengthening precipitates plays important roles for the improvement of hardness.

The microstructure and hardness of the stir zone (SZ) with different welding heat inputs were investigated for friction stir-welded 2024-T3 aluminum by transmission electron microscopy, differential scanning calorimeter and Vickers micro-hardness test. The results show that welding heat input has a significant effect on the hardness of the SZ. Under high welding heat input condition, a higher welding speed is beneficial for improving the hardness of the SZ. However, when the welding heat input is low, the hardness of the SZ elevates with increasing the rotation speed. The hardness of the SZ decreases after post-welded heat treatment due to overaging. The joints welded at 500 r/min and 100 mm/min show a high resistance to overaging. The reduction of hardness in the SZ is only 3.8%, while in other joints, the reduction is more than 10%. The morphology of strengthening precipitates plays important roles for the improvement of hardness.

The microstructure and hardness of the stir zone (SZ) with different welding heat inputs were investigated for friction stir-welded 2024-T3 aluminum by transmission electron microscopy, differential scanning calorimeter and Vickers micro-hardness test. The results show that welding heat input has a significant effect on the hardness of the SZ. Under high welding heat input condition, a higher welding speed is beneficial for improving the hardness of the SZ. However, when the welding heat input is low, the hardness of the SZ elevates with increasing the rotation speed. The hardness of the SZ decreases after post-welded heat treatment due to overaging. The joints welded at 500 r/min and 100 mm/min show a high resistance to overaging. The reduction of hardness in the SZ is only 3.8%, while in other joints, the reduction is more than 10%. The morphology of strengthening precipitates plays important roles for the improvement of hardness.

The microstructure and hardness of the stir zone (SZ) with different welding heat inputs were investigated for friction stir-welded 2024-T3 aluminum by transmission electron microscopy, differential scanning calorimeter and Vickers micro-hardness test. The results show that welding heat input has a significant effect on the hardness of the SZ. Under high welding heat input condition, a higher welding speed is beneficial for improving the hardness of the SZ. However, when the welding heat input is low, the hardness of the SZ elevates with increasing the rotation speed. The hardness of the SZ decreases after post-welded heat treatment due to overaging. The joints welded at 500 r/min and 100 mm/min show a high resistance to overaging. The reduction of hardness in the SZ is only 3.8%, while in other joints, the reduction is more than 10%. The morphology of strengthening precipitates plays important roles for the improvement of hardness.

According to the Hugenholtz-Van Hove theorem, the symmetry energy and its density slope can be decomposed uniquely in terms of the single-nucleon potential in asymmetric nuclear matter which, at normal density, can be constrained by the nucleon optical model potential extracted from analyzing the nucleon-nucleus scattering data. To more accurately extract information on the symmetry energy and its density slope at normal density from neutron-nucleus scattering data, going beyond the well-known Lane potential, we include consistently the second order terms in isospin asymmetry in both the optical model potential and the symmetry energy decomposition. We find that the strength of the second-order symmetry potential $U_{sym,2}$ in asymmetric nuclear matter is significant compared to the first-order one U_{sym,1}$, especially at high nucleon momentum. While the $U_{sym,1}$ at normal density decreases with nucleon momentum, the $U_{sym,2}$ is found to have the opposite behavior. Moreover, we discuss effects of the $U_{sym,1}$ and $U_{sym,2}$ on determining the density dependence of the symmetry energy, and we find that the available neutron-nucleus scattering data favor a softer density dependence of the symmetry energy at normal density with a negligible contribution from the $U_{sym,2}$., Comment: 7 pages, 4 figures, 2 tables. Discussions and 1 table added. Accepted version to appear in PLB

According to the Hugenholtz-Van Hove theorem, the symmetry energy and its density slope can be decomposed uniquely in terms of the single-nucleon potential in asymmetric nuclear matter which, at normal density, can be constrained by the nucleon optical model potential extracted from analyzing the nucleon-nucleus scattering data. To more accurately extract information on the symmetry energy and its density slope at normal density from neutron-nucleus scattering data, going beyond the well-known Lane potential, we include consistently the second order terms in isospin asymmetry in both the optical model potential and the symmetry energy decomposition. We find that the strength of the second-order symmetry potential $U_{sym,2}$ in asymmetric nuclear matter is significant compared to the first-order one U_{sym,1}$, especially at high nucleon momentum. While the $U_{sym,1}$ at normal density decreases with nucleon momentum, the $U_{sym,2}$ is found to have the opposite behavior. Moreover, we discuss effects of the $U_{sym,1}$ and $U_{sym,2}$ on determining the density dependence of the symmetry energy, and we find that the available neutron-nucleus scattering data favor a softer density dependence of the symmetry energy at normal density with a negligible contribution from the $U_{sym,2}$., Comment: 7 pages, 4 figures, 2 tables. Discussions and 1 table added. Accepted version to appear in PLB

The nuclear symmetry energy $E_{sym}(\rho)$ and its density slope $L(\rho)$ can be decomposed analytically in terms of the single-nucleon potential in isospin asymmetric nuclear matter. Using three popular nuclear effective interaction models which have been extensively used in nuclear structure and reaction studies, namely, the isospin and momentum dependent MDI interaction model, the Skyrme Hartree-Fock approach and the Gogny Hartree-Fock approach, we analyze the contribution of different terms in the single-nucleon potential to the $E_{sym}(\rho)$ and $L(\rho)$. Our results show that the observed different density behaviors of $E_{sym}(\rho)$ for different interactions are essentially due to the variation of the symmetry potential $U_{sym,1}(\rho,k)$. Furthermore, we find that the contribution of the second-order symmetry potential $U_{sym,2}(\rho,k)$ to the $L(\rho)$ generally cannot be neglected. Moreover, our results demonstrate that the magnitude of the $U_{sym,2}(\rho,k)$ is generally comparable with that of $U_{sym,1}(\rho,k)$, indicating the second-order symmetry potential $U_{sym,2}(\rho,k)$ may have significant corrections to the widely used Lane approximation to the single-nucleon potential in extremely neutron(proton)-rich nuclear matter., Comment: 16 pages, 13 figures, 1 big table. Results of BSk14-17, Rsigma-fit, and Gsigma-fit in the big table updated, typos fixed. Published version in PRC

In this paper, we construct a new phenomenological isospin dependent global neutron-nucleus optical model potential. Based on the existing experimental data of elastic scattering angular distributions for neutron as projectile, we obtain a set of the isospin dependent global neutron-nucleus optical model potential parameters, which can basically reproduce the experimental data for target nuclei from $^{24}$Mg to $^{242}$Pu with the energy region up to 200 MeV., Comment: 35 pages, 12 figures, 3 tables. Discussions and 1 table added, 24 figures removed. Accepted version to appear in NPA

The nuclear symmetry energy $E_{sym}(\rho)$ and its density slope $L(\rho)$ can be decomposed analytically in terms of the single-nucleon potential in isospin asymmetric nuclear matter. Using three popular nuclear effective interaction models which have been extensively used in nuclear structure and reaction studies, namely, the isospin and momentum dependent MDI interaction model, the Skyrme Hartree-Fock approach and the Gogny Hartree-Fock approach, we analyze the contribution of different terms in the single-nucleon potential to the $E_{sym}(\rho)$ and $L(\rho)$. Our results show that the observed different density behaviors of $E_{sym}(\rho)$ for different interactions are essentially due to the variation of the symmetry potential $U_{sym,1}(\rho,k)$. Furthermore, we find that the contribution of the second-order symmetry potential $U_{sym,2}(\rho,k)$ to the $L(\rho)$ generally cannot be neglected. Moreover, our results demonstrate that the magnitude of the $U_{sym,2}(\rho,k)$ is generally comparable with that of $U_{sym,1}(\rho,k)$, indicating the second-order symmetry potential $U_{sym,2}(\rho,k)$ may have significant corrections to the widely used Lane approximation to the single-nucleon potential in extremely neutron(proton)-rich nuclear matter., Comment: 16 pages, 13 figures, 1 big table. Results of BSk14-17, Rsigma-fit, and Gsigma-fit in the big table updated, typos fixed. Published version in PRC

In this paper, we construct a new phenomenological isospin dependent global neutron-nucleus optical model potential. Based on the existing experimental data of elastic scattering angular distributions for neutron as projectile, we obtain a set of the isospin dependent global neutron-nucleus optical model potential parameters, which can basically reproduce the experimental data for target nuclei from $^{24}$Mg to $^{242}$Pu with the energy region up to 200 MeV., Comment: 35 pages, 12 figures, 3 tables. Discussions and 1 table added, 24 figures removed. Accepted version to appear in NPA