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Your search keyword '"Lantier, Frederic"' showing total 3 results
Start Over Author "Lantier, Frederic" Publication Type Electronic Resources
3 results on '"Lantier, Frederic"'

1. Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains

Author

European Commission, Ministry of Agriculture, Nature and Food Quality (The Netherlands), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Economía y Competitividad (España), Nonno, Romolo [0000-0001-7556-1564], Marín-Moreno, Alba [0000-0002-4023-6398], Espinosa Martín, Juan Carlos [0000-0002-6719-9902], Fast, C. [0000-0002-7341-7873], Van Keulen, Lucien [0000-0002-8645-5190], Spiropoulos, J. [0000-0003-0119-8920], Lantier, Isabelle [0000-0003-1250-767X], Andréoletti, Olivier [0000-0002-7369-6016], Pirisinu, Laura [0000-0002-6548-8225], di Bari, Michele [0000-0003-0943-6823], Sklaviadis, T. [0000-0002-0246-3100], Acutis, Pier Luigi [0000-0003-4814-2924], Acin, Cristina [0000-0001-5105-6133], Bossers, A. [0000-0002-6586-717X], Vaccari, Gabriel [0000-0003-0215-3521], Chiappini, Barbara [0000-0002-5260-5285], Lantier, Frederic [0000-0001-5896-330X], Groschup, M. H. [0000-0003-0215-185X], Agrimi, Umberto [0000-0001-7828-0186], Torres, Juan María [0000-0003-0443-9232], Langeveld, J. [0000-0002-4165-3230], Nonno, Romolo, Marín-Moreno, Alba, Espinosa Martín, Juan Carlos, Fast, C., Van Keulen, Lucien, Spiropoulos, J., Lantier, Isabelle, Andréoletti, Olivier, Pirisinu, Laura, di Bari, Michele, Aguilar-Calvo, Patricia, Sklaviadis, T., Papasavva-Stylianou, Penelope, Acutis, Pier Luigi, Acin, Cristina, Bossers, A., Jacobs, Jorge G., Vaccari, Gabriel, D'Agostino, Claudia, Chiappini, Barbara, Lantier, Frederic, Groschup, M. H., Agrimi, Umberto, Torres, Juan María, Langeveld, J., European Commission, Ministry of Agriculture, Nature and Food Quality (The Netherlands), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Economía y Competitividad (España), Nonno, Romolo [0000-0001-7556-1564], Marín-Moreno, Alba [0000-0002-4023-6398], Espinosa Martín, Juan Carlos [0000-0002-6719-9902], Fast, C. [0000-0002-7341-7873], Van Keulen, Lucien [0000-0002-8645-5190], Spiropoulos, J. [0000-0003-0119-8920], Lantier, Isabelle [0000-0003-1250-767X], Andréoletti, Olivier [0000-0002-7369-6016], Pirisinu, Laura [0000-0002-6548-8225], di Bari, Michele [0000-0003-0943-6823], Sklaviadis, T. [0000-0002-0246-3100], Acutis, Pier Luigi [0000-0003-4814-2924], Acin, Cristina [0000-0001-5105-6133], Bossers, A. [0000-0002-6586-717X], Vaccari, Gabriel [0000-0003-0215-3521], Chiappini, Barbara [0000-0002-5260-5285], Lantier, Frederic [0000-0001-5896-330X], Groschup, M. H. [0000-0003-0215-185X], Agrimi, Umberto [0000-0001-7828-0186], Torres, Juan María [0000-0003-0443-9232], Langeveld, J. [0000-0002-4165-3230], Nonno, Romolo, Marín-Moreno, Alba, Espinosa Martín, Juan Carlos, Fast, C., Van Keulen, Lucien, Spiropoulos, J., Lantier, Isabelle, Andréoletti, Olivier, Pirisinu, Laura, di Bari, Michele, Aguilar-Calvo, Patricia, Sklaviadis, T., Papasavva-Stylianou, Penelope, Acutis, Pier Luigi, Acin, Cristina, Bossers, A., Jacobs, Jorge G., Vaccari, Gabriel, D'Agostino, Claudia, Chiappini, Barbara, Lantier, Frederic, Groschup, M. H., Agrimi, Umberto, Torres, Juan María, and Langeveld, J.

Abstract

Bovine Spongiform Encephalopathy (BSE) is the only animal prion which has been recognized as a zoonotic agent so far. The identification of BSE in two goats raised the need to reliably identify BSE in small ruminants. However, our understanding of scrapie strain diversity in small ruminants remains ill-defined, thus limiting the accuracy of BSE surveillance and spreading fear that BSE might lurk unrecognized in goats. We investigated prion strain diversity in a large panel of European goats by a novel experimental approach that, instead of assessing the neuropathological profile after serial transmissions in a single animal model, was based on the direct interaction of prion isolates with several recipient rodent models expressing small ruminants or heterologous prion proteins. The findings show that the biological properties of scrapie isolates display different patterns of geographical distribution in Europe and suggest that goat BSE could be reliably discriminated from a wide range of biologically and geographically diverse goat prion isolates. Finally, most field prion isolates showed composite strain features, with discrete strain components or sub-strains being present in different proportions in individual goats or tissues. This has important implications for understanding the nature and evolution of scrapie strains and their transmissibility to other species, including humans.

Published
2020

2. Evidence for zoonotic potential of ovine scrapie prions

Author

Cassard, Hervé [0000-0001-8651-6179], Douet, Jean-Yves [0000-0002-0426-4957], Lantier, Isabelle [0000-0003-1250-767X], Lantier, Frederic [0000-0001-5896-330X], Cassard, Hervé, Torres, J. M., Lacroux, C., Douet, Jean-Yves, Benestad, Sylvie L., Lantier, Frederic, Lugan, Séverine, Lantier, Isabelle, Costes, Pierrete, Aron, Naima, Reine, F., Herzog, L., Espinosa Martín, Juan Carlos, Béringue, V., Andréoletti, Olivier, Cassard, Hervé [0000-0001-8651-6179], Douet, Jean-Yves [0000-0002-0426-4957], Lantier, Isabelle [0000-0003-1250-767X], Lantier, Frederic [0000-0001-5896-330X], Cassard, Hervé, Torres, J. M., Lacroux, C., Douet, Jean-Yves, Benestad, Sylvie L., Lantier, Frederic, Lugan, Séverine, Lantier, Isabelle, Costes, Pierrete, Aron, Naima, Reine, F., Herzog, L., Espinosa Martín, Juan Carlos, Béringue, V., and Andréoletti, Olivier

Abstract

Although Bovine Spongiform Encephalopathy (BSE) is the cause of variant Creutzfeldt Jakob disease (vCJD) in humans, the zoonotic potential of scrapie prions remains unknown. Mice genetically engineered to overexpress the human prion protein (tgHu) have emerged as highly relevant models for gauging the capacity of prions to transmit to humans. These models can propagate human prions without any apparent transmission barrier and have been used used to confirm the zoonotic ability of BSE. Here we show that a panel of sheep scrapie prions transmit to several tgHu mice models with an efficiency comparable to that of cattle BSE. The serial transmission of different scrapie isolates in these mice led to the propagation of prions that are phenotypically identical to those causing sporadic CJD (sCJD) in humans. These results demonstrate that scrapie prions have a zoonotic potential and raise new questions about the possible link between animal and human prions. © 2014 Macmillan Publishers Limited. All rights reserved.

Published
2014

3. Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep

Author

Lantier, Frederic [0000-0001-5896-330X], Andréoletti, Olivier, Morel, N., Lacroux, C., Rouillon, V., Barc, C., Tabouret, G., Sarradin, P., Berthon, P., Bernardet, P., Mathey, J., Lugan, Séverine, Costes, Pierrete, Corbière, F., Espinosa Martín, Juan Carlos, Torres, J. M., Grassi, J., Schelcher, F., Lantier, Frederic, Lantier, Frederic [0000-0001-5896-330X], Andréoletti, Olivier, Morel, N., Lacroux, C., Rouillon, V., Barc, C., Tabouret, G., Sarradin, P., Berthon, P., Bernardet, P., Mathey, J., Lugan, Séverine, Costes, Pierrete, Corbière, F., Espinosa Martín, Juan Carlos, Torres, J. M., Grassi, J., Schelcher, F., and Lantier, Frederic

Abstract

Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrPSc in the spleen. © 2006 SGM.

Published
2006

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