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45 results on '"Leemans, C. R."'

1. The impact of the COVID-19 pandemic on health-related quality of life in head and neck cancer survivors:An observational cohort studs

Author

Lissenberg-Witte, B. I., Jansen, F., Baatenburg de Jong, R. J., Lamers, F., Leemans, C. R., Oosting, S. F., Takes, R. P., Verdonck-de Leeuw, I. M., Lissenberg-Witte, B. I., Jansen, F., Baatenburg de Jong, R. J., Lamers, F., Leemans, C. R., Oosting, S. F., Takes, R. P., and Verdonck-de Leeuw, I. M.

Abstract

Objective: To investigate the impact of the COVID-19 pandemic on physical, psychological, and social aspects of health-related quality of life (HRQOL) among head and neck cancer (HNC) survivors. Materials and methods: Prospectively collected data from the NETherlands QUality of life and BIomedical Cohort study in HNC were used. All patients were diagnosed and treated before the COVID-19 pandemic. Patient reported outcome measures (PROMs) collected 24 and 36 months after treatment (M24 and M36) were compared between survivors who completed both assessments before the COVID-19 pandemic and those who completed M24 before but M36 during the pandemic. Personal, clinical, physical, psychological, social, and lifestyle characteristics of the survivors assessed at baseline or M24 were investigated as potential effect modifiers. Results: In total, 318 HNC survivors were included, of which 199 completed both M24 and M36 before the COVID-19 pandemic and 119 completed M24 before but M36 during the pandemic. Changes in HRQOL between 24 and 36 months follow-up did not differ between the two groups for any of the PROMs. Nevertheless, in some subgroups of HNC survivors the COVID-19 pandemic negatively affected the course of HRQOL for several PROMs while it positively affected the course of HRQOL for other PROMs. Conclusions: The COVID-19 pandemic did not affect HRQOL in HNC survivors in general, but some subgroups were affected in a positive and others in a negative way.

Published
2023

2. Phase III study assessing the best of radiotherapy compared to the best of surgery (trans-oral surgery (TOS)) in patients with T1-T2, N0-N1 oropharyngeal, supraglottic carcinoma and with T1, N0 hypopharyngeal carcinoma

Author

Simon, C., Lefevre, C. Fortpied, Govaerts, A-S., Raveloarivahy, T., Bourhis, J., Evans, M., Klussmann, J. P., Leemans, C. R., Hunter, K. D., Singer, S., Nuyts, S., Willemse, E., Ansarin, M., Spriano, G., Golusinski, W., Giger, R., Boehm, A., Lopez, F., Gregoire, V., Simon, C., Lefevre, C. Fortpied, Govaerts, A-S., Raveloarivahy, T., Bourhis, J., Evans, M., Klussmann, J. P., Leemans, C. R., Hunter, K. D., Singer, S., Nuyts, S., Willemse, E., Ansarin, M., Spriano, G., Golusinski, W., Giger, R., Boehm, A., Lopez, F., and Gregoire, V.

Published
2022

4. The eHealth self-management application ‘Oncokompas’ that supports cancer survivors to improve health-related quality of life and reduce symptoms:which groups benefit most?

Author

van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., van Uden-Kraan, C. F., Nieuwenhuijzen, G. A.P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J.E., Bosscha, K., van den Brekel, M. W.M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, I., van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E.J., Leemans, C. R., Zijlstra, J. M., Cuijpers, P., van de Poll-Franse, L. V., Verdonck-de Leeuw, I. M., van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., van Uden-Kraan, C. F., Nieuwenhuijzen, G. A.P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J.E., Bosscha, K., van den Brekel, M. W.M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, I., van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E.J., Leemans, C. R., Zijlstra, J. M., Cuijpers, P., van de Poll-Franse, L. V., and Verdonck-de Leeuw, I. M.

Abstract

Background: Oncokompas is a web-based self-management application that supports cancer survivors to monitor their health-related quality of life (HRQOL) and symptoms, and to obtain personalised feedback and tailored options for supportive care. In a large randomised controlled trial among survivors of head and neck cancer, colorectal cancer, and breast cancer and (non-)Hodgkin lymphoma, Oncokompas proved to improve HRQOL, and to reduce several tumour-specific symptoms. Effect sizes were however small, and no effect was observed on the primary outcome patient activation. Therefore, this study aims to explore which subgroups of cancer survivors may especially benefit from Oncokompas. Materials and methods: Cancer survivors (n = 625) were randomly assigned to the intervention group (access to Oncokompas, n = 320) or control group (6 months waiting list, n = 305). Outcome measures were HRQOL, tumour-specific symptoms, and patient activation. Potential moderators included socio-demographic (sex, age, marital status, education, employment), clinical (tumour type, stage, time since diagnosis, treatment modality, comorbidities), and personal factors (self-efficacy, personal control, health literacy, Internet use), and patient activation, mental adjustment to cancer, HRQOL, symptoms, and need for supportive care, measured at baseline. Linear mixed models were performed to investigate potential moderators. Results: The intervention effect on HRQOL was the largest among cancer survivors with low to moderate self-efficacy, and among those with high personal control and those with high health literacy scores. Cancer survivors with higher baseline symptom scores benefitted more on head and neck (pain in the mouth, social eating, swallowing, coughing, trismus), and colorectal cancer (weight) specific symptoms. Discussion: Oncokompas seems most effective in reducing symptoms in head and neck cancer and colorectal cancer survivors who report a higher burden of tumour-specific sym

Published
2021

5. Reasons for not reaching or using web-based self-management applications, and the use and evaluation of Oncokompas among cancer survivors, in the context of a randomised controlled trial

Author

Hout, A. van der, van Uden-Kraan, C. F., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., Nieuwenhuijzen, G. A. P., Hardillo, J. A., Jong, R. J. Baatenburg de, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., Brekel, M. W. M. van den, Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbosq, I., Broek, W. T. van den, de Brees, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstrab, J. M., Cuijpers, P., Poll-Franse, L. V. van de, Leeuw, I. M. Verdonck-de, Hout, A. van der, van Uden-Kraan, C. F., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., Nieuwenhuijzen, G. A. P., Hardillo, J. A., Jong, R. J. Baatenburg de, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., Brekel, M. W. M. van den, Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbosq, I., Broek, W. T. van den, de Brees, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstrab, J. M., Cuijpers, P., Poll-Franse, L. V. van de, and Leeuw, I. M. Verdonck-de

Abstract

Introduction: The web-based self-management application Oncokompas was developed to support cancer survi-vors to monitor health-related quality of life and symptoms (Measure) and to provide tailored information (Learn) and supportive care options (Act). In a previously reported randomised controlled trial (RCT), 68% of 655 recruited survivors were eligible, and of those 45% participated in the RCT. Among participants of the RCT that were randomised to the intervention group, 52% used Oncokompas as intended. The aim of this study was to explore reasons for not participating in the RCT, and reasons for not using Oncokompas among non-users, and the use and evaluation of Oncokompas among users.

Published
2021

6. Reasons for not reaching or using web-based self-management applications, and the use and evaluation of Oncokompas among cancer survivors, in the context of a randomised controlled trial

Author

Hout, A. van der, van Uden-Kraan, C. F., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., Nieuwenhuijzen, G. A. P., Hardillo, J. A., Jong, R. J. Baatenburg de, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., Brekel, M. W. M. van den, Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbosq, I., Broek, W. T. van den, de Brees, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstrab, J. M., Cuijpers, P., Poll-Franse, L. V. van de, Leeuw, I. M. Verdonck-de, Hout, A. van der, van Uden-Kraan, C. F., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., Nieuwenhuijzen, G. A. P., Hardillo, J. A., Jong, R. J. Baatenburg de, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., Brekel, M. W. M. van den, Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbosq, I., Broek, W. T. van den, de Brees, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstrab, J. M., Cuijpers, P., Poll-Franse, L. V. van de, and Leeuw, I. M. Verdonck-de

Abstract

Introduction The web-based self-management application Oncokompas was developed to support cancer survivors to monitor health-related quality of life and symptoms (Measure) and to provide tailored information (Learn) and supportive care options (Act). In a previously reported randomised controlled trial (RCT), 68% of 655 recruited survivors were eligible, and of those 45% participated in the RCT. Among participants of the RCT that were randomised to the intervention group, 52% used Oncokompas as intended. The aim of this study was to explore reasons for not participating in the RCT, and reasons for not using Oncokompas among non-users, and the use and evaluation of Oncokompas among users. Methods Reasons for not participating were assessed with a study-specific questionnaire among 243 survivors who declined participation. Usage was investigated among 320 participants randomised to the intervention group of the RCT via system data and a study-specific questionnaire that was assessed during the 1 week follow-up (T1) assessment. Results Main reasons for not participating were not interested in participation in scientific research (40%) and not interested in scientific research and Oncokompas (28%). Main reasons for not being interested in Oncokompas were wanting to leave the period of being ill behind (29%), no symptom burden (23%), or lacking internet skills (18%). Out of the 320 participants in the intervention group 167 (52%) used Oncokompas as intended. Among 72 non-users, main reasons for not using Oncokompas were no symptom burden (32%) or lack of time (26%). Among 248 survivors that activated their account, satisfaction and user-friendliness were rated with a 7 (scale 0–10). Within 3 (IQR 1–4) sessions, users selected 32 (IQR 6–37) topics. Main reasons for not using healthcare options in Act were that the information in Learn was already sufficient (44%) or no supportive care needs (32%). Discussion Main reasons for not

Published
2021

7. The eHealth self-management application 'Oncokompas' that supports cancer survivors to improve health-related quality of life and reduce symptoms: Which groups benefit most?

Author

van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B., Van Uden-Kraan, C. F., Nieuwenhuijzen, G. A. P., Hardillo, J. A., de Jong, R. J. Baatenburg, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., van den Brekel, M. W. M., Petersen, F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, null, van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstra, J. M., Cuijpersa, P., Van De Poll-Franse, L. V., Verdonck-de Leeuw, I. M., van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B., Van Uden-Kraan, C. F., Nieuwenhuijzen, G. A. P., Hardillo, J. A., de Jong, R. J. Baatenburg, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., van den Brekel, M. W. M., Petersen, F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, null, van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstra, J. M., Cuijpersa, P., Van De Poll-Franse, L. V., and Verdonck-de Leeuw, I. M.

Abstract

BackgroundOncokompas is a web-based self-management application that supports cancer survivors to monitor their health-related quality of life (HRQOL) and symptoms, and to obtain personalised feedback and tailored options for supportive care. In a large randomised controlled trial among survivors of head and neck cancer, colorectal cancer, and breast cancer and (non-)Hodgkin lymphoma, Oncokompas proved to improve HRQOL, and to reduce several tumour-specific symptoms. Effect sizes were however small, and no effect was observed on the primary outcome patient activation. Therefore, this study aims to explore which subgroups of cancer survivors may especially benefit from Oncokompas.Materials and methodsCancer survivors (n = 625) were randomly assigned to the intervention group (access to Oncokompas, n = 320) or control group (6 months waiting list, n = 305). Outcome measures were HRQOL, tumour-specific symptoms, and patient activation. Potential moderators included socio-demographic (sex, age, marital status, education, employment), clinical (tumour type, stage, time since diagnosis, treatment modality, comorbidities), and personal factors (self-efficacy, personal control, health literacy, Internet use), and patient activation, mental adjustment to cancer, HRQOL, symptoms, and need for supportive care, measured at baseline. Linear mixed models were performed to investigate potential moderators.ResultsThe intervention effect on HRQOL was the largest among cancer survivors with low to moderate self-efficacy, and among those with high personal control and those with high health literacy scores. Cancer survivors with higher baseline symptom scores benefitted more on head and neck (pain in the mouth, social eating, swallowing, coughing, trismus), and colorectal cancer (weight) specific symptoms.DiscussionOncokompas seems most effective in reducing symptoms in head and neck cancer and colorectal cancer survivors who report

Published
2021

8. The eHealth self-management application ‘Oncokompas’ that supports cancer survivors to improve health-related quality of life and reduce symptoms: which groups benefit most?

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., van Uden-Kraan, C. F., Nieuwenhuijzen, G. A.P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J.E., Bosscha, K., van den Brekel, M. W.M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, I., van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E.J., Leemans, C. R., Zijlstra, J. M., Cuijpers, P., van de Poll-Franse, L. V., Verdonck-de Leeuw, I. M., MS Hoofd-Hals Chirurgische Oncologie, Cancer, van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., van Uden-Kraan, C. F., Nieuwenhuijzen, G. A.P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J.E., Bosscha, K., van den Brekel, M. W.M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, I., van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E.J., Leemans, C. R., Zijlstra, J. M., Cuijpers, P., van de Poll-Franse, L. V., and Verdonck-de Leeuw, I. M.

Published
2021

9. Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management: results of a randomised controlled trial

Author

CDL Patiëntenzorg KC, Anatomie, ZL Neuromusculaire Ziekten Zorg, MS Hoofd-Hals Chirurgische Oncologie, Cancer, van der Hout, A, Jansen, F, van Uden-Kraan, C F, Coupé, V M, Holtmaat, K, Nieuwenhuijzen, G A, Hardillo, J A, de Jong, R J Baatenburg, Tiren-Verbeet, N L, Sommeijer, D W, de Heer, K, Schaar, C G, Sedee, R J E, Bosscha, K, van den Brekel, M W M, Petersen, J F, Westerman, M, Honings, J, Takes, R P, Houtenbos, I, van den Broek, W T, de Bree, R, Jansen, P, Eerenstein, S E J, Leemans, C R, Zijlstra, J M, Cuijpers, P, van de Poll-Franse, L V, Verdonck-de Leeuw, I M, CDL Patiëntenzorg KC, Anatomie, ZL Neuromusculaire Ziekten Zorg, MS Hoofd-Hals Chirurgische Oncologie, Cancer, van der Hout, A, Jansen, F, van Uden-Kraan, C F, Coupé, V M, Holtmaat, K, Nieuwenhuijzen, G A, Hardillo, J A, de Jong, R J Baatenburg, Tiren-Verbeet, N L, Sommeijer, D W, de Heer, K, Schaar, C G, Sedee, R J E, Bosscha, K, van den Brekel, M W M, Petersen, J F, Westerman, M, Honings, J, Takes, R P, Houtenbos, I, van den Broek, W T, de Bree, R, Jansen, P, Eerenstein, S E J, Leemans, C R, Zijlstra, J M, Cuijpers, P, van de Poll-Franse, L V, and Verdonck-de Leeuw, I M

Published
2021

10. Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

Author

MS Radiotherapie, Cancer, Douma, J A J, Verdonck-de Leeuw, I M, Leemans, C R, Jansen, F, Langendijk, J A, Baatenburg de Jong, R J, Terhaard, C H J, Takes, R P, Chinapaw, M J, Altenburg, T M, Buffart, L M, MS Radiotherapie, Cancer, Douma, J A J, Verdonck-de Leeuw, I M, Leemans, C R, Jansen, F, Langendijk, J A, Baatenburg de Jong, R J, Terhaard, C H J, Takes, R P, Chinapaw, M J, Altenburg, T M, and Buffart, L M

Published
2020

11. Correction to : Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: The NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank(BMC Cancer (2019) 19 (765) DOI: 10.1186/s12885-019-5866-z)

Author

Verdonck-De Leeuw, I. M., Jansen, F., Brakenhoff, R. H., Langendijk, J. A., Takes, R., Terhaard, C. H.J., Baatenburg De Jong, R. J., Smit, J. H., Leemans, C. R., Verdonck-De Leeuw, I. M., Jansen, F., Brakenhoff, R. H., Langendijk, J. A., Takes, R., Terhaard, C. H.J., Baatenburg De Jong, R. J., Smit, J. H., and Leemans, C. R.

Published
2019

12. Correction to : Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: The NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank(BMC Cancer (2019) 19 (765) DOI: 10.1186/s12885-019-5866-z)

Author

Verdonck-De Leeuw, I. M., Jansen, F., Brakenhoff, R. H., Langendijk, J. A., Takes, R., Terhaard, C. H.J., Baatenburg De Jong, R. J., Smit, J. H., Leemans, C. R., Verdonck-De Leeuw, I. M., Jansen, F., Brakenhoff, R. H., Langendijk, J. A., Takes, R., Terhaard, C. H.J., Baatenburg De Jong, R. J., Smit, J. H., and Leemans, C. R.

Published
2019

13. Correction to : Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: The NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank(BMC Cancer (2019) 19 (765) DOI: 10.1186/s12885-019-5866-z)

Author

Verdonck-De Leeuw, I. M., Jansen, F., Brakenhoff, R. H., Langendijk, J. A., Takes, R., Terhaard, C. H.J., Baatenburg De Jong, R. J., Smit, J. H., Leemans, C. R., Verdonck-De Leeuw, I. M., Jansen, F., Brakenhoff, R. H., Langendijk, J. A., Takes, R., Terhaard, C. H.J., Baatenburg De Jong, R. J., Smit, J. H., and Leemans, C. R.

Published
2019

14. Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank

Author

Anatomie, MS Radiotherapie, Cancer, CTI Nierkens, Verdonck-de Leeuw, I M, Jansen, F, Brakenhoff, R H, Langendijk, J A, Takes, R, Terhaard, C H J, Baatenburg de Jong, R J, Smit, J H, Leemans, C R, Anatomie, MS Radiotherapie, Cancer, CTI Nierkens, Verdonck-de Leeuw, I M, Jansen, F, Brakenhoff, R H, Langendijk, J A, Takes, R, Terhaard, C H J, Baatenburg de Jong, R J, Smit, J H, and Leemans, C R

Published
2019

16. Multidisciplinary treatment of the neck

Author

Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., Leemans, C. R., Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., and Leemans, C. R.

Published
2016

17. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients : a randomized, controlled trial

Author

Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, Verdonck-de Leeuw, I M, Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, and Verdonck-de Leeuw, I M

Published
2016

18. Multidisciplinary treatment of the neck

Author

Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., Leemans, C. R., Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., and Leemans, C. R.

Published
2016

19. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients : a randomized, controlled trial

Author

Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, Verdonck-de Leeuw, I M, Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, and Verdonck-de Leeuw, I M

Published
2016

21. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients : a randomized, controlled trial

Author

Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, Verdonck-de Leeuw, I M, Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, and Verdonck-de Leeuw, I M

Published
2016

22. Multidisciplinary treatment of the neck

Author

Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., Leemans, C. R., Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., and Leemans, C. R.

Published
2016

23. Feasibility of an eHealth application 'OncoKompas' to improve personalized survivorship cancer care

Author

Duman-Lubberding, S, van Uden-Kraan, C F, Jansen, F, Witte, B I, van der Velden, L A, Lacko, M, Cuijpers, P, Leemans, C R, Verdonck-de Leeuw, I M, Duman-Lubberding, S, van Uden-Kraan, C F, Jansen, F, Witte, B I, van der Velden, L A, Lacko, M, Cuijpers, P, Leemans, C R, and Verdonck-de Leeuw, I M

Abstract

PURPOSE: The purpose of this study was to investigate the feasibility of an online self-management application (OncoKompas) among cancer survivors. In OncoKompas, cancer survivors can monitor their quality of life (QOL) via participant reported outcomes (PROs) ("Measure"), which is followed by automatically generated individually tailored feedback ("Learn") and personalized advice on supportive care services ("Act").METHODS: A pretest-posttest design was used, conducting a survey before providing access to OncoKompas, and 2 weeks after, followed by an interview by a nurse. Adoption was defined as the percentage of cancer survivors that agreed to participate in the study and returned the T0 questionnaire. Implementation was defined as the percentage of participants that actually used OncoKompas as intended (T1). General satisfaction was assessed based on the mean score of three study-specific questions: (1) general impression of OncoKompas, (2) the user-friendliness, and (3) the ability to use OncoKompas without assistance (10-point Likert scales). Furthermore, satisfaction was measured with the Net Promotor Scale (NPS).RESULTS: OncoKompas was feasible with an adoption grade of 64 %, an implementation grade of 75-91 %, a mean satisfaction score of 7.3, and a positive NPS (1.9). Sociodemographic and clinical factors and QOL were not associated with satisfaction. Several facilitators and barriers related to the feasibility of OncoKompas were identified.CONCLUSION: OncoKompas is considered feasible, but has to be further improved. In order to enhance feasibility and increase satisfaction, we have to balance the time it takes to use OncoKompas, measurement precision, and tailoring towards personalized advices.

Published
2016
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24. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients : a randomized, controlled trial

Author

Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, Verdonck-de Leeuw, I M, Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, and Verdonck-de Leeuw, I M

Published
2016

25. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients : a randomized, controlled trial

Author

Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, Verdonck-de Leeuw, I M, Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, and Verdonck-de Leeuw, I M

Published
2016

26. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients : a randomized, controlled trial

Author

Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, Verdonck-de Leeuw, I M, Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, and Verdonck-de Leeuw, I M

Published
2016

28. Multidisciplinary treatment of the neck

Author

Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., Leemans, C. R., Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., and Leemans, C. R.

Published
2016

30. Multidisciplinary treatment of the neck

Author

Verpleegafdeling Mondz/Kaakchir. D5 Oost, Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., Leemans, C. R., Verpleegafdeling Mondz/Kaakchir. D5 Oost, Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., and Leemans, C. R.

Published
2016

31. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients : a randomized, controlled trial

Author

Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, Verdonck-de Leeuw, I M, Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, and Verdonck-de Leeuw, I M

Published
2016

32. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients: a randomized, controlled trial

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, Verdonck-de Leeuw, I M, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Krebber, A M H, Jansen, F, Witte, B I, Cuijpers, P, de Bree, R, Becker-Commissaris, A, Smit, E. F, van Straten, A, Eeckhout, A M, Beekman, A T F, Leemans, C R, and Verdonck-de Leeuw, I M

Published
2016

33. Multidisciplinary treatment of the neck

Author

Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., Leemans, C. R., Bernier, Jacques, de Bree, Remco, Langendijk, Johannes A., and Leemans, C. R.

Abstract

Since lymph node metastases are one of the most important prognostic factors, treatment of the neck is challenging. In clinically N0 neck, (super)selective neck dissection is indicated, whereas a more extensive neck dissection with preservation of important structures is performed in N2-N3 disease. Adjuvant treatment consists of radiotherapy with or without chemotherapy in patients with an intermediate or high risk of recurrence in the neck. Primary radiotherapy alone is effective in non-bulky disease. In more extensive neck disease, a combination of radiotherapy and chemotherapy with or without planned neck dissection is indicated. Advances in imaging and treatment as well as risk assessment have further modified the paradigm of planned neck dissection. Primary chemoradiation is effective for sterilising occult disease, and, therefore, post-treatment (super)selective neck dissection seems to be sufficient.

Published
2016

34. Feasibility of an eHealth application 'OncoKompas' to improve personalized survivorship cancer care

Author

Duman-Lubberding, S, van Uden-Kraan, C F, Jansen, F, Witte, B I, van der Velden, L A, Lacko, M, Cuijpers, P, Leemans, C R, Verdonck-de Leeuw, I M, Duman-Lubberding, S, van Uden-Kraan, C F, Jansen, F, Witte, B I, van der Velden, L A, Lacko, M, Cuijpers, P, Leemans, C R, and Verdonck-de Leeuw, I M

Abstract

PURPOSE: The purpose of this study was to investigate the feasibility of an online self-management application (OncoKompas) among cancer survivors. In OncoKompas, cancer survivors can monitor their quality of life (QOL) via participant reported outcomes (PROs) ("Measure"), which is followed by automatically generated individually tailored feedback ("Learn") and personalized advice on supportive care services ("Act").METHODS: A pretest-posttest design was used, conducting a survey before providing access to OncoKompas, and 2 weeks after, followed by an interview by a nurse. Adoption was defined as the percentage of cancer survivors that agreed to participate in the study and returned the T0 questionnaire. Implementation was defined as the percentage of participants that actually used OncoKompas as intended (T1). General satisfaction was assessed based on the mean score of three study-specific questions: (1) general impression of OncoKompas, (2) the user-friendliness, and (3) the ability to use OncoKompas without assistance (10-point Likert scales). Furthermore, satisfaction was measured with the Net Promotor Scale (NPS).RESULTS: OncoKompas was feasible with an adoption grade of 64 %, an implementation grade of 75-91 %, a mean satisfaction score of 7.3, and a positive NPS (1.9). Sociodemographic and clinical factors and QOL were not associated with satisfaction. Several facilitators and barriers related to the feasibility of OncoKompas were identified.CONCLUSION: OncoKompas is considered feasible, but has to be further improved. In order to enhance feasibility and increase satisfaction, we have to balance the time it takes to use OncoKompas, measurement precision, and tailoring towards personalized advices.

Published
2016
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42. Salvage Chirurgia di salvataggio nel carcinoma della laringe o dell’ipofaringe post-chemioradioterapia: Risultati e revisione della letteratura

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, van der Putten, L., de Bree, R., Doornaert, P. A., Buter, J., Eerenstein, S. E J, Rietveld, D. H F, Kuik, D. J., Leemans, C. R., MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, van der Putten, L., de Bree, R., Doornaert, P. A., Buter, J., Eerenstein, S. E J, Rietveld, D. H F, Kuik, D. J., and Leemans, C. R.

Published
2015

43. Quality assurance in head and neck surgical oncology: EORTC 24954 trial on larynx preservation

Author

UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Leemans, C R, Tijink, B M, Langendijk, J A, Andry, G, Hamoir, Marc, Lefebvre, J L, Subcommittee of Surgery of the EORTC Head and Neck Cooperative Group, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Leemans, C R, Tijink, B M, Langendijk, J A, Andry, G, Hamoir, Marc, Lefebvre, J L, and Subcommittee of Surgery of the EORTC Head and Neck Cooperative Group

Abstract

Background The Head and Neck Cancer Group (HNCG) of the EORTC conducted a quality assurance program in the EORTC 24954 trial on larynx preservation. In this multicentre study, patients with resectable advanced squamous cell carcinoma of the larynx or hypopharynx were randomly assigned for treatment with sequential or alternating chemoradiation. The need for a quality assurance program is the evaluation and prevention of differences in treatments between centres in this multidisciplinary study. Method The surgical subcommittee of the HNCG prepared a questionnaire, and clinical records of all patients were verified during audits of independent teams. Data relating institutional practices were collected during a face to face interview with members of the local team. Results 271 clinical records from the nine main contributing centres were reviewed. The main difference between centres was the time interval between first consultation and treatment initiation, with a mean of 45 days. On the pathology report the nodal involvement was described by level in 36% of the cases according to the American Academy of Otolaryngology - Head and Neck Surgery classification. Extranodal spread was not always described in neck dissection specimens. Conclusion The EORTC 24954 trial on larynx preservation was the first prospective trial with a quality assurance program in head and neck surgical oncology. The analysis shows similarities in practices, but also points out some important differences between centres. Operation reports were fairly complete, but uniformity in pathology reports should be improved.

Published
2013

44. Joint practice guidelines for radionuclide lymphoscintigraphy for sentinel node localization in oral/oropharyngeal squamous cell carcinoma

Author

Alkureishi, L W T, Burak, Z, Alvarez, J A, Ballinger, J, Bilde, A, Britten, A J, Calabrese, L, Chiesa, C, Chiti, A, de Bree, R, Gray, H W, Hunter, K, Kovacs, A F, Lassmann, M, Leemans, C R, Mamelle, G, McGurk, M, Mortensen, J, Poli, T, Shoaib, T, Sloan, P, Sorensen, J A, Stoeckli, S J, Thomsen, J B, Trifiro, G, Werner, J, Ross, G L, Alkureishi, L W T, Burak, Z, Alvarez, J A, Ballinger, J, Bilde, A, Britten, A J, Calabrese, L, Chiesa, C, Chiti, A, de Bree, R, Gray, H W, Hunter, K, Kovacs, A F, Lassmann, M, Leemans, C R, Mamelle, G, McGurk, M, Mortensen, J, Poli, T, Shoaib, T, Sloan, P, Sorensen, J A, Stoeckli, S J, Thomsen, J B, Trifiro, G, Werner, J, and Ross, G L

Abstract

Udgivelsesdato: 2009-Nov, Involvement of the cervical lymph nodes is the most important prognostic factor for patients with oral/oropharyngeal squamous cell carcinoma (OSCC), and the decision of whether to electively treat patients with clinically negative necks remains a controversial topic. Sentinel node biopsy (SNB) provides a minimally invasive method for determining the disease status of the cervical node basin, without the need for a formal neck dissection. This technique potentially improves the accuracy of histologic nodal staging and avoids overtreating three-quarters of this patient population, minimizing associated morbidity. The technique has been validated for patients with OSCC, and larger-scale studies are in progress to determine its exact role in the management of this patient population. This document is designed to outline the current best practice guidelines for the provision of SNB in patients with early-stage OSCC, and to provide a framework for the currently evolving recommendations for its use. Preparation of this guideline was carried out by a multidisciplinary surgical/nuclear medicine/pathology expert panel under the joint auspices of the European Association of Nuclear Medicine (EANM) Oncology Committee and the Sentinel European Node Trial (SENT) Committee.

Published
2009

45. Joint practice guidelines for radionuclide lymphoscintigraphy for sentinel node localization in oral/oropharyngeal squamous cell carcinoma

Author

Alkureishi, L W T, Burak, Z, Alvarez, J A, Ballinger, J, Bilde, A, Britten, A J, Calabrese, L, Chiesa, C, Chiti, A, de Bree, R, Gray, H W, Hunter, K, Kovacs, A F, Lassmann, M, Leemans, C R, Mamelle, G, McGurk, M, Mortensen, J, Poli, T, Shoaib, T, Sloan, P, Sorensen, J A, Stoeckli, S J, Thomsen, J B, Trifiro, G, Werner, J, Ross, G L, Alkureishi, L W T, Burak, Z, Alvarez, J A, Ballinger, J, Bilde, A, Britten, A J, Calabrese, L, Chiesa, C, Chiti, A, de Bree, R, Gray, H W, Hunter, K, Kovacs, A F, Lassmann, M, Leemans, C R, Mamelle, G, McGurk, M, Mortensen, J, Poli, T, Shoaib, T, Sloan, P, Sorensen, J A, Stoeckli, S J, Thomsen, J B, Trifiro, G, Werner, J, and Ross, G L

Abstract

Udgivelsesdato: 2009-Nov, Involvement of the cervical lymph nodes is the most important prognostic factor for patients with oral/oropharyngeal squamous cell carcinoma (OSCC), and the decision of whether to electively treat patients with clinically negative necks remains a controversial topic. Sentinel node biopsy (SNB) provides a minimally invasive method for determining the disease status of the cervical node basin, without the need for a formal neck dissection. This technique potentially improves the accuracy of histologic nodal staging and avoids overtreating three-quarters of this patient population, minimizing associated morbidity. The technique has been validated for patients with OSCC, and larger-scale studies are in progress to determine its exact role in the management of this patient population. This document is designed to outline the current best practice guidelines for the provision of SNB in patients with early-stage OSCC, and to provide a framework for the currently evolving recommendations for its use. Preparation of this guideline was carried out by a multidisciplinary surgical/nuclear medicine/pathology expert panel under the joint auspices of the European Association of Nuclear Medicine (EANM) Oncology Committee and the Sentinel European Node Trial (SENT) Committee.

Published
2009

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