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Yang Li,1,* Huihui Fan,2,* Wei Wei,3 Hanyu Zhu,4 Haifeng Wang,4 Dayao Lyu,1 Zengrui Zhang,1 Ying Tan1 1Department of Neurology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, People’s Republic of China; 2Department of Ultrasound, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, People’s Republic of China; 3Department of Key Laboratory of Basic Research and Clinical Translation, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, People’s Republic of China; 4Department of Neurology, Medical School of Huzhou University, Huzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Tan, Email zzftyzhy@126.comIntroduction: The primary clinical manifestation of venous thrombosis is discomfort in the lower extremities. Some early Parkinson’s disease (PD) patients feel discomfort in the lower limbs. Venous thrombosis can risk lives by causing pulmonary embolism. This study examines the incidence of DVT in early PD patients and its correlation with different clinical and lab features.Methods: A cross-sectional study was conducted on 117 patients with early-stage PD. Ultrasonography was employed to detect the presence of DVT. Factors such as age, gender, body mass index, lifestyle habits (smoking and drinking), medical history (hypertension, diabetes, atrial fibrillation, and tumor), and other lab tests linked to thrombosis were analyzed.Results: In 117 patients, 11 (9.4%) had DVT, while 106 (90.6%) did not. There were no significant differences in gender, BMI, habits, medical history, or other thrombosis-related tests between both groups. However, DVT patients were older with higher d-dimer levels. They also showed an increased right substantia nigra ultrasound echo area, higher HY grades, higher UPDRS 3 scores, less im

Climate-sensitive northern cryosphere inland waters emit greenhouse gases (GHGs) into the atmosphere, yet their total emissions remain poorly constrained. We present a data-driven synthesis of GHG emissions from northern cryosphere inland waters considering water body types, cryosphere zones, and seasonality. We find that annual GHG emissions are dominated by carbon dioxide ([Formula: see text] teragrams of CO2; [Formula: see text]) and methane ([Formula: see text] teragrams of CH4), while the nitrous oxide emission ([Formula: see text] gigagrams of N2O) is minor. The annual CO2-equivalent (CO2e) GHG emissions from northern cryosphere inland waters total [Formula: see text] or [Formula: see text] petagrams of CO2e using the 100- or 20-year global warming potentials, respectively. Rivers emit 64% more CO2e GHGs than lakes, despite having only one-fifth of their surface area. The continuous permafrost zone contributed half of the inland water GHG emissions. Annual CO2e emissions from northern cryosphere inland waters exceed the region's terrestrial net ecosystem exchange, highlighting the important role of inland waters in the cryospheric land-aquatic continuum under a warming climate.

Keyang Li,1,* Debao Li,2,* Hongliang Dong,1 Dongmei Ren,2 Dandan Gong,1 Shubo Wang,1 Yang Li,1 Yuanyuan Wu,1 Jikang Yang,3 Wenjuan Yan,4 Yi Li4 1Department of Clinical Pharmacy, Jiaozuo People’s Hospital, Jiaozuo, Henan, People’s Republic of China; 2Department of Clinical Laboratory, Jiaozuo People’s Hospital, Jiaozuo, Henan, People’s Republic of China; 3Infectious Diseases Department, Jiaozuo People’s Hospital, Jiaozuo, Henan, People’s Republic of China; 4Department of Clinical Laboratory, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenjuan Yan; Yi Li, Department of Clinical Laboratory, Henan Provincial People’s Hospital, Weiwu Road 7#, Jinshui District, Zhengzhou, Henan, 450003, People’s Republic of China, Tel +86 15225061830 ; +86 15939039006, Email yanwenjuan2008@126.com; liyilabmed@henu.edu.cnPurpose: Since the introduction of ceftazidime–avibactam (CZA) in the Chinese market, accumulating clinical evidence has substantiated its efficacy in the treatment of infections caused by carbapenem-resistant gram-negative bacteria (CR-GNB). Nevertheless, an ongoing debate persists concerning the choice between monotherapy and combination therapy when devising clinical anti-infection protocols.Patients and Methods: This retrospective, single-center observational study enrolled patients with CR-GNB infections who received CZA treatment between December 2019 and August 2023. The primary outcome assessed was 30-day mortality, and the secondary outcome measured was 14-day bacterial clearance. A multivariate Cox regression model was used to identify variables that were independently associated with 30-day mortality rate.Results: Eighty-three patients were enrolled in the study; of which, 45 received CZA monotherapy, whereas 38 received combination therapy. The overall 30-day mortality rate was 31.3%, and no significant differe

Jiewei Cui,1,* Yang Li,2,* Qingyan Du,3,* Yuanhui Wei,1 Jinxia Liu,1 Zhixin Liang1 1College of Pulmonary & Critical Care Medicine, 8th Medical Center of Chinese PLA General Hospital, Beijing, 100091, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, The First Hospital of Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 3Jiamei Dental Hospital, Beijing, 100143, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhixin Liang, Email liangzhixin301@163.comObjective: Bloodstream infection (BSI) is characterized by high mortality, especially among these increasing super-elderly patients (≥ 85 years), and this study was conducted to understand the species distribution, typical clinical features and risk factors for poor prognosis of super-elderly patients with BSI.Methods: Based on previous work, this retrospective study was performed by reviewing an ongoing prospective medical database in a comprehensive tertiary center in China, and all super-elderly patients with BSI in the past 6 years were enrolled in this study.Results: Out of 5944 adult-patients with BSI, there were totally 431 super-elderly patients (≥ 85 years old) enrolled in this study and age ≥ 90 years accounted for 31.1% (134/431). Among these 431 super-elderly patients with BSI, 40 patients (9.3%) were diagnosed with BSI and the remained 401 super-elderly patients (90.7%) were defined as hospital-acquired BSI. The typical feature of these super-elderly patients with BSI was the high proportion of patients with various comorbidities, such as cardiovascular disease (83.8%), ischemic cerebrovascular disease (63.3%) and pulmonary infection (61.0%). The other typical feature was that most (60.1%) of these patients had been hospitalized for long time (≥ 28 days) prior to the onset of BSI, and most patients had received various invasive treatments, such as indwelling central

Yan Liu, Yang Li, Song Yuan, Wei Ma, Si Chen, Li-Yi Wang Department of Infection Control, the Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of ChinaCorrespondence: Li-Yi Wang, Department of Infection Control, the Second Hospital of Hebei Medical University, No. 215 of Heping West Road; Xinhua District, Shijiazhuang, Hebei, 050000, People’s Republic of China, Tel +86 13673160996, Fax +86 0311 83179721, Email wangliyi66@163.comObjective: To examine the risk factors linked with occupational blood exposure (OBE) among nursing staff (NS), we pinpoint deficiencies in the compliance with policies of infection prevention and control, and assess the expenditures associated with infection prevention and control.Methods: Healthcare workers that completed an “Occupational Blood Exposure Report Form” were divided into NS (observation) group and non-NS (control) group. Univariate and multivariable analyses were conducted to compare both groups in various aspects. We also explored design patents intended to minimize occupational exposure.Results: The highest incidence of OBE was observed in the department of neurosurgery. Among NS, OBE incidence was found to be influenced by independent risk factors, such as gender, age, occupational title, work location, and incidence of sharps injuries. Protective factors against OBEs included the use of arterial blood gas needles and suture needles. Personal protective equipment (PPE) usage rates were low in both groups prior to OBEs (0.74% vs 0.00%, P > 0.05). Correct emergency management could be improved promptly by both groups following an OBE (P > 0.05). However, the observation group exhibited a higher proportion of blood expression after a sharps injury and a higher re-evaluation rate at 6 months post-exposure compared to the control group (P < 0.05). In 2018, the per capita costs of infection prevention and control for NS were the Chinese Yuan (RMB) 339.43 per individual. In response to th

Zijuan Ma,1,&ast; Yunge Fan,1,&ast; Zhijun Yu,1 Wenxuan Wu,1 Xiangting Zhang,1 Huolian Li,1 Shaochen Zhao,2 Yang Li,3 Yuanyuan Li,4 Dongfang Wang,1 Fang Fan1 1Center for Studies of Psychological Application, School of Psychology, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, People’s Republic of China; 2Research Center for Guangdong-Hong Kong-Macao Policing Model Innovation, China People’s Police University, Guangzhou, People’s Republic of China; 3Department of Educational Psychology, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 4Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dongfang Wang; Fang Fan, School of Psychology, South China Normal University, Shipai Road, Guangzhou, 510631, People’s Republic of China, Email wdfpsyc@126.com; fangfan@scnu.edu.cnPurpose: Although experimental psychopathology using PET, EEG, and fMRI is at the forefront of understanding the underlying mechanisms of sleep inertia, many questions concerning causality remain unanswerable due to ethical constraints and the use of small and heterogeneous samples in experimental methods. There is a pressing need for a novel perspective in a large and relatively homogeneous population to fully capture and elucidate longitudinal processes and dynamic causality that culminate in episodes of sleep inertia over time. Therefore, this study aimed to reveal the causal relationships between symptoms of sleep inertia across its distinct patterns.Patients and Methods: A total of 1636 intern nurses participated in the first survey (94.1% validity rate), then 1277 intern nurses were followed up (82.9% tracing rate). Symptoms of sleep inertia were self-reported using the Sleep Inertia Question

Spin selective catalysis is an emerging approach for improving the thermodynamics and kinetics of reactions. The role of electron spins has been scarcely studied in catalytic reactions. One exception is the oxygen evolution reaction (OER) where strongly correlated metals and oxides are used as catalysts. In OER, spin alignment facilitates the transition of singlet state of the reactant to the triplet state of O2. However, the influence of strong correlations on spin exchange mechanism and spin selective thermodynamics of most catalytic reactions remain unclear. Here we decouple the strongly correlated catalyst from the electrolyte to study spin exchange in two-dimensional (2D) magnetic iron germanium telluride (FGT) heterostructure. We demonstrate that transmission of spin and electrochemical information between the catalyst and the reactant can occur through quantum exchange interaction despite the catalyst of FGT being completely encapsulated by graphene or hexagonal boron nitride (hBN). The strong correlations in FGT that lead to enhanced spin exchange in OER are observed in graphene or hBN layers with thicknesses of up to 6 nm. We demonstrate that spin alignment in FGT leads to a lowering of thermodynamic barrier for adsorption of hydroxide ion and electron transfer to the catalyst. This results in up to fivefold enhancement in OER performance and improved kinetics. Our results provide clear evidence that transmission of both quantum mechanical and electrochemical information through quantum spin exchange interaction in FGT leads to an enhancement in catalytic performance.

Chaetoceros Ehrenberg is one of the most diverse genera of planktonic diatoms. The species in section Chaetoceros are characterized by cells and setae having numerous chloroplasts and being widely distributed. However, the delimitations of some species are problematic because of limited morphological information in the classical descriptions. Monoclonal strains of the section Chaetoceros were established, morphological features were studied using light and electron microscopy, and the hypervariable D1–D3 region of the nuclear ribosomal large subunit gene was sequenced to address phylogenetic relationships. Fifteen species belonging to the section Chaetoceros were recorded, including two new species, C. hainanensis sp. nov. and C. tridiscus sp. nov. Chaetoceros hainanensis was characterized by straight chains, narrowly lanceolate to hexagonal apertures, sibling setae diverging in nearly right angles, stipule-shaped spines on terminal setae and arrowhead-shaped spines on intercalary setae. C. tridiscus had short straight chains, narrowly lanceolate apertures, arrowhead-shaped spines and circular poroids arranged in a grid pattern on terminal and intercalary setae. The phylogenetic analyses revealed six groups formed by 19 species within the section Chaetoceros, which was found to be monophyletic. The subdivision of the section is still not well understood. The morphological characters within each group varied considerably and molecular information on more species are needed to enrich the phylogenetic profiling.

Pseudo-nitzschia is a group of widely distributed planktonic diatoms. Some species produce the neurotoxin domoic acid. Herein, two new Pseudo-nitzschia species were described from Chinese coastal waters and the South China Sea after combining morphological and molecular data, together with biogeographical traits. Pseudo-nitzschia punctionis sp. nov. was similar to Pseudo-nitzschia bipertita morphologically, but differed in poroid structure, which was undivided in P. punctionis but divided in two sectors in P. bipertita. This difference corresponded to the presence of two hemicompensatory base changes (HCBCs) in the secondary structure of internal transcribed spacer 2. Pseudo-nitzschia polymorpha sp. nov. was sister to Pseudo-nitzschia limii phylogenetically, but distinct by the various shapes of perforations on the valve and copula, which was supported by four HCBCs. In a metabarcoding analysis, multiple new ribotypes were identified within the two new species, and intraspecific genetic divergences were analyzed. Metabarcoding data revealed that P. punctionis had a broader temperature range (12.9–30.5 °C) than P. polymorpha (22.3–30.5 °C). Within the two new species, different traits were found among the amplicon sequence variants regarding temperature and biogeography, representing different microevolutionary directions under environmental selection. The two new species had different biogeographical traits when compared to their closely related species. Domoic acid was detected in strains of P. punctionis at a concentration of 13.5–17.7 fg/cell, but the toxin was not found in strains of P. polymorpha. A combination of characters based on laboratory strains and field metabarcoding data provided more data for delimiting Pseudo-nitzschia species and gave new insights into their diversity and biogeography.

Applications of large-scale knowledge graphs in the e-commerce platforms can improve shopping experience for their customers. While existing e-commerce knowledge graphs (KGs) integrate a large volume of concepts or product attributes, they fail to discover user intentions, leaving the gap with how people think, behave, and interact with the surrounding world. In this work, we present COSMO, a scalable system to mine user-centric commonsense knowledge from massive behaviors and construct industry-scale knowledge graphs to empower diverse online services. In particular, we describe a pipeline for collecting high-quality seed knowledge assertions that are distilled from large language models (LLMs) and further refined by critic classifiers trained over human-in-the-loop annotated data.Since those generations may not always align with human preferences and contain noises, we then describe how we adopt instruction tuning to finetune an efficient language model∼(COSMO-LM) for faithful e-commerce commonsense knowledge generation at scale. COSMO-LM effectively expands our knowledge graph to 18 major categories at Amazon, producing millions of high-quality knowledge with only 30k annotated instructions. Finally COSMO has been deployed in Amazon search applications such as search navigation. Both offline and online A/B experiments demonstrate our proposed system achieves significant improvement. Furthermore, these experiments highlight the immense potential of commonsense knowledge extracted from instruction-finetuned large language models. © 2024 ACM.

Alzheimer's Disease (AD) and related dementia are a growing global health challenge due to the aging population. In this paper, we present ADMarker, the first end-to-end system that integrates multi-modal sensors and new federated learning algorithms for detecting multidimensional AD digital biomarkers in natural living environments. ADMarker features a novel three-stage multi-modal federated learning architecture that can accurately detect digital biomarkers in a privacy-preserving manner. Our approach collectively addresses several major real-world challenges, such as limited data labels, data heterogeneity, and limited computing resources. We built a compact multi-modality hardware system and deployed it in a four-week clinical trial involving 91 elderly participants. The results indicate that ADMarker can accurately detect a comprehensive set of digital biomarkers with up to 93.8% accuracy and identify early AD with an average of 88.9% accuracy. ADMarker offers a new platform that can allow AD clinicians to characterize and track the complex correlation between multidimensional interpretable digital biomarkers, demographic factors of patients, and AD diagnosis in a longitudinal manner.

The spontaneous conversion of muonium to antimuonium is one of the interesting charged lepton flavor violation phenomena, offering a sensitive probe of potential new physics and serving as a tool to constrain the parameter space beyond the Standard Model. Utilizing a high-intensity muon beam, a Michel electron magnetic spectrometer and a positron transport solenoid together with a positron detection system, MACE aims to discover or constrain this rare process at the conversion probability beyond the level of $10^{-13}$. This report provides an overview of the theoretical framework and detailed experimental design in the search for the muonium-to-antimuonium conversion., Comment: 115 pages, 59 figures

We continue our investigation of the stress within a strongly coupled scalar nucleon, and now dissect the gravitational form factors into contributions from its constituents, the (mock) nucleon and the (mock) pion. The computation is based on a non-perturbative solution of the scalar Yukawa model in the light-front Hamiltonian formalism with a Fock sector expansion including up to one nucleon and two pions. By employing the ``good currents" $T^{++}_i$, $T^{+-}_i$ and $T^{12}_i$, we extract the full set of gravitational form factors $A_i$, $D_i$, $\bar c_i$ without the contamination of the spurious form factors, and free of uncanceled UV divergences. With these results, we decompose the mass of the system into its constituents and compute the matter and mechanical radii, gaining insights into the strongly coupled system., Comment: 11 pages, 4 figures

We solve the nucleon's wave functions from the eigenstates of the light-front quantum chromodynamics Hamiltonian for the first time, using a fully relativistic and nonperturbative approach based on light-front quantization, without an explicit confining potential. These eigenstates are determined for the three-quark, three-quark-gluon, and three-quark-quark-antiquark Fock representations, making them suitable for low-resolution probes. From this, we calculate the nucleon's quark and gluon matter densities, helicity, and transversity distributions, which show qualitative consistency with experimental extractions. We also compute the contributions of quark and gluon helicity to the proton spin and the tensor charges. The obtained light-front wave functions represent a significant advancement towards a unified description of various hadron distribution functions in both longitudinal and transverse momentum space.

Based on our recent analysis of the hadronic matrix element of the stress-energy tensor in covariant light front dynamics, we extract the charmonium gravitational form factor $D(Q^2)$ from shear stress $T^{12}$. This is in contrast to our recent work using the (light-front) energy density $T^{+-}$. Indeed, by comparing these two currents, we identify terms that are responsible for the violation of the current conservation. Numerical results based on basis light-front quantization show that the violation effects are small and the $D$-term extracted from the two currents are close to each other, hence validating our previous work using $T^{+-}$., Comment: 9 pages, 4 figures

We present the first systematic study of the relativistic axial-vector four-current distributions inside a nucleon. We show in particular that the slope of the axial form factor $G_A(Q^2)$ in the forward limit -- conventionally denoted as $R^2_A$ in the literature -- does not represent the three-dimensional mean-square axial radius in the Breit frame, but corresponds instead to a contribution to the mean-square spin radius. We derive explicit expressions for the latter in different frames and find in general additional contributions that depend on both the nucleon mass and the forward values of the axial-vector form factors $G_A(0)$ and $G_P(0)$. This provides an additional key motivation for ongoing lattice quantum chromodynamics (QCD) calculations and future experimental measurements of the induced pseudoscalar form factor $G_P(Q^2)$., Comment: 7 pages, 3 figures

In this paper, we evaluate the electromagnetic and gravitational form factors as well as the corresponding generalized parton distributions of the electron using the Basis Light-front Quantization approach to QED. We compare our results with those from light-front perturbation theory. We adopt a novel basis with its scale depending on the constituents' longitudinal momentum fraction. We show that this basis improves convergence of the form factors with increasing basis dimension, compared to that calculated in the original basis with fixed scale. These results both validate the BLFQ approach and provide guidance for its efficient implementation in solving light-front Hamiltonian mass eigenstates for more complex systems in QED and QCD.

We compute the gravitational form factors $A_i$, $D_i$ and $\bar c_i$ of the scalar Yukawa theory using both the light-cone and covariant perturbation theory at the one-loop level. The light-cone formalism provides a potential approach to access these form factors beyond the perturbative regime. However, unlike the covariant formulation, the Poincar\'e symmetry on the light cone is not manifest. In this work, we use perturbation theory as a benchmark to extract the gravitational form factors from the light-front energy-momentum tensor. By comparing results on and off the light cone, we identify $T^{++}, T^{+a}, T^{+-}, T^{12}$ as the "good currents" that are properly renormalized and can be used to extract the gravitational form factors., Comment: 13 pages, 2 figures. Published in JHEP

We investigate the gravitational form factors of charmonium. Our method is based on a Hamiltonian formalism on the light front known as basis light-front quantization. The charmonium mass spectrum and light-front wave functions were obtained from diagonalizing an effective Hamiltonian that incorporates confinement from holographic QCD and one-gluon exchange interaction from light-front QCD. We proposed a quantum many-body approach to construct the hadronic matrix elements of the energy momentum tensor $T^{++}$ and $T^{+-}$, which are used to extract the gravitational form factors $A(Q^2)$ and $D(Q^2)$. The obtained form factors satisfy the known constraints, e.g. von Laue condition. From these quantities, we also extract the energy, pressure and light-front energy distributions of the system. We find that hadrons are multi-layer systems., Comment: 19 pages, 9 figures; published in PRD under the title: Gravitational form factors of charmonia; Corrected a few typos in Table I

Everything gravitates and they do so through the energy-momentum tensor (EMT). However, there is no consensus on how to define the EMT of a hadron, e.g. the proton, the fundamental building blocks of the visible world. In this work, we show that the hadronic EMT can be cast into the form of relativistic continua with spin. The fluid-like form allows a clear identification of the proper hadronic energy density, pressure and shear. A spin tensor contribution is also identified without the reference to the total angular momentum operator, in alignment with the recent development in relativistic spin hydrodynamics. The hadronic EMT is related to the quantum expectation value of the EMT operator through the convolution with the hadronic wavepacket. To factorize out the hadronic EMT, different multipole expansion schemes are explored. We show that the popular Breit-frame densities and light-front densities emerge as the monopole momentum densities from different factorization schemes., Comment: 6 pages, no figure

We demonstrate, in the context of a scalar version of the chiral effective field theory, that the multi-sea quark contribution to the nucleon is significant and highly non-trivial in sharp contrast to the prediction of perturbation theory. The non-perturbative calculation is performed in the Fock sector dependent renormalization scheme on the light front, in which the non-perturbative renormalization is incorporated. The calculation suggests that a fully non-perturbative calculation of the chiral EFT is needed to obtain a robust result to be compared with the recent experimental measurement of flavor asymmetry in the proton., Comment: 7 pages, 5 figures

Yang Li,1 Yuhan Zhang,1 Na Feng,2 Fan Yu,1 Bin Liu3 1Department of Gastroenterology and Hepatology, China-Japan Union Hospital of Jilin University, Changchun, 130033, People’s Republic of China; 2Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic of China; 3Department of Urology, China-Japan Union Hospital of Jilin University, Changchun, 130033, People’s Republic of ChinaCorrespondence: Fan Yu; Bin Liu, Email yufan2017@jlu.edu.cn; liub18@mails.jlu.edu.cnPurpose: Bladder cancer is a common malignancy of the urinary system and the development of noninvasive therapeutic methods is imperative to avoid radical cystectomy, which results in a poor quality of life for patients.Methods: In this study, ultrasmall copper–palladium nanozymes decorated with cysteamine (CPC) nanoparticles (NPs) were synthesized to enhance the efficacy of radiotherapy (RT) in treating bladder cancer. CPC NPs react with intracellular overexpressed H2O2 in the tumor microenvironment to produce large quantities of reactive oxygen species (ROS) and induce tumor cell apoptosis. Furthermore, the CPC nanozymes can generate ample oxygen within tumors by utilizing H2O2, addressing hypoxia conditions, and mitigating radioresistance. Additionally, CPC facilitates the oxidation of glutathione (GSH) into oxidized glutathione disulfide (GSSG), blocking the self-repair mechanisms of tumor cells post-treatment. Simultaneously, CPC enhances the ionization energy deposition effect on tumor cells.Results: The results demonstrate an increased level of ROS and an elevation in oxygen content at the tumor site. Importantly, tumor growth was restrained without apparent systemic toxicity during the combined treatment.Conclusion: In summary, this study highlights the potential of CPC nanozyme-mediated radiotherapy as a promising avenue for the effective treatment of bladder cancer and demonstrates its potential for future clinical applications in t

The Triple Dominance Measure (choosing between prosocial, individualistic, and competitive options) and the Slider Measure (“sliding” between various orientations, for example, from individualistic to prosocial) are two widely used techniques to measure social value orientation, that is, the weight individuals assign to own and others’ outcomes in interdependent situations. Surprisingly, there is only moderate correspondence between these measures, but it is unclear why and what the implications are for identifying individual differences in social value orientation. Using a dataset of 8021 participants from 31 countries and regions, this study revealed that the Slider Measure identified fewer competitors than the Triple Dominance Measure, accounting for approximately one-third of the non-correspondence between the two measures. This is (partially) because many of the Slider items do not afford a competitive option. In items where competition is combined with individualism, competitors tended to make the same choices as individualists. Futhermore, we demonstrated the uniqueness of competitors. Compared to prosocials and individualists, competitors exhibited lower levels of both social mindfulness and trust. Overall, the present work highlights the importance of situational affordances in measuring personality, the benefits of distinguishing between individualists and competitors, and the importance of utilizing a measure that distinguishes between these two proself orientations.

Rui Tang,1,2 Dongping Wan,3 Chuan Leng,2 Xiaohong Fan,2 Yang Li,1 Jianbing Ma,1 Yuanchi Huang,1 Chao Xu1 1Department of Knee Joint Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shanxi Province, People’s Republic of China; 2The Clinical Medical College, Chengdu University of Chinese Traditional Medicine, Chengdu, Sichuan Province, People’s Republic of China; 3The First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaCorrespondence: Chao Xu; Yuanchi Huang, Department of Knee Joint Surgery, Honghui Hospital, Xi’an, Shanxi Province, People’s Republic of China, Email honghuixuchao@163.com; huangychell@163.comPurpose: This research aims to develop and validate the Chinese version of the Central Sensitization Inventory (CSI-CV) for patients suffering from chronic non-specific low back pain (CNSLBP). The study evaluates both the validity and reliability of the CSI-CV.Patients and Methods: The cross-cultural adaptation of the scale strictly adhered to the principles of Bombardier and Beaton. Initially, two professors of Chinese-English translation independently translated the original CSI scale into the target language, and then collaborated with an expert in cross-cultural adaptation to merge into a single version. This version was back-translated into English by two professors whose native language is English. Following this, the scale underwent preliminary review by bilingual experts and the research team, and was preliminarily tested, ultimately culminating in the formation of the CSI-CV version. A total of 310 patients with CNSLBP completed the CSI-CV, while 50 of them repeated the survey one week later to test the stability of the scale. The CSI-CV’s reliability, validity, and internal consistency were assessed through exploratory factor analysis (EFA), correlation coefficients, and Cronbach’s α.Results: EFA revealed five distinct factors from the 25

Intestinal organoids are valuable tools for investigating intestinal physiology and pathology ex vivo. In previous studies, intestinal organoids of commercial pigs have been developed. Here, we established intestinal organoids derived from Wuzhishan miniature pigs (WZS pigs), a unique kind of pig in the Hainan province of China. Three-dimensional (3D) intestinal organoids and organoid monolayers were developed and assessed. Furthermore, the susceptibility of organoid monolayers of WZS pigs to transmissible gastroenteritis virus (TGEV) was demonstrated. An RNA-seq analysis revealed that the TGEV infection stimulated antiviral and inflammatory immune responses in organoid monolayer models. The study implied the transmission risk of swine enteric coronavirus on WZS pigs and provided useful tools for further research on WZS pigs as laboratory miniature pig models.

Human genetics has emerged as one of the most dynamic areas of biology, with a broadening societal impact. In this review, we discuss recent achievements, ongoing efforts, and future challenges in the field. Advances in technology, statistical methods, and the growing scale of research efforts have all provided many insights into the processes that have given rise to the current patterns of genetic variation. Vast maps of genetic associations with human traits and diseases have allowed characterization of their genetic architecture. Finally, studies of molecular and cellular effects of genetic variants have provided insights into biological processes underlying disease. Many outstanding questions remain, but the field is well poised for groundbreaking discoveries as it increases the use of genetic data to understand both the history of our species and its applications to improve human health., QC 20240307

Yang Li,1 Xue Yan,2 Zhen Luo,1 Xianxian Fu,1 Zhongju Li,1 Qiuzhu Xu,3 Juanjuan Chen,1 Jingmin Yang,2,4,5 Daru Lu4,5 1Department of Nephropathy, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Hainan, People’s Republic of China; 2Department of Medicine, Shanghai WeHealth Biomedical Technology Co., Ltd., Shanghai, People’s Republic of China; 3Department of Central Supply Service Department, Haikou Orthopedic and Diabetes Hospital, Hainan, People’s Republic of China; 4NHC Key Laboratory of Birth Defects and Reproductive Health (Chongqing Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning, Science and Technology Research Institute), Chongqing, People’s Republic of China; 5State Key Laboratory of Genetic Engineering and MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Jingmin Yang; Daru Lu, Email jingmin.yang@we-health.vip; Email drlu@fudan.edu.cnIntroduction: X-linked Alport syndrome (XLAS) is caused by pathogenic variants in COL4A5 which lead to abnormalities of the glomerular basement membrane (GBM) structural and is characterized by progressive kidney disease, hearing loss, and ocular abnormalities. The aim of this study was to identify gene mutations in a Chinese family with XLAS by whole-exome sequencing (WES) and verified the pathogenicity of the mutation in vitro experiments.Case Presentation: A five-generation pedigree with a total of 49 family members originating from Hainan province of China was investigated in this study. The proband was a 23-year-old male who developed microscopic hematuria, proteinuria and end-stage kidney disease (ESKD) at age 17. WES identified a novel splicing mutation c.321+5G>A of COL4A5, which cause exon skip. Further co-segregation analysis confirmed that this mutation exists in relatives who had renal abnormalities using Sanger sequencing. Accor

Juying Zhang,1 Xia Luo,1 Xin Yang,1 Hanmei Li,1 Qiong Jiang,1 You Yang,1 Menglin Luo,1 Zijun Ma,1 Ping He,1 Linli Feng,1 Ling Li,1 Maochun Zhang,1 Yang Li,2,3 Jinhong Yu1,3 1Department of Ultrasound, Affiliated Hospital of North Sichuan Medical College, Innovation Centre for Science and Technology of North Sichuan Medical College, Nanchong, Sichuan, 637000, People’s Republic of China; 2Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, People’s Republic of China; 3Department of Ultrasound, Yuechi People’s Hospital, Guangan, Sichuan, 638300, People’s Republic of ChinaCorrespondence: Jinhong Yu, Email yujinhong@nsmc.edu.cnPurpose: The incidence of hepatocellular carcinoma (HCC) is continuously increasing, and the mortality rate remains high. Thus, more effective strategies are needed to improve the treatment of HCC.Methods: In this study, we report the use of a visualized glypican-3 (GPC3)-targeting nanodelivery system (named GC-NBs) in combination with sonodynamic therapy (SDT) to enhance the therapeutic efficacy for treating HCC. The obtained nanodelivery system could actively target hepatocellular carcinoma cells and achieve ultrasound imaging through phase changes into nanobubbles under low-intensity ultrasound irradiation. Meanwhile, the released chlorine e6 (Ce6) after the nanobubbles collapse could lead to the generation of reactive oxygen species (ROS) under ultrasound irradiation to induce SDT.Results: Both in vitro and in vivo experiments have shown that GC-NBs can accumulate in tumour areas and achieve sonodynamic antitumour therapy under the navigation action of glypican-3-antibody (GPC3-Ab). Furthermore, in vitro and in vivo experiments did not show significant biological toxicity of the nanodelivery system. Moreover, GC-NBs can be imaged with ultrasound, providing personalized treatment monitoring.Conclusion: GC-NBs enable a visualized antitumour strategy from a targeted sonodynamic perspecti

California faces several serious direct and indirect climate exposures that can adversely affect public health, some of which are already occurring. The public health burden now and in the future will depend on atmospheric greenhouse gas concentrations, underlying population vulnerabilities, and adaptation efforts. Here, we present a structured review of recent literature to examine the leading climate risks to public health in California, including extreme heat, extreme precipitation, wildfires, air pollution, and infectious diseases. Comparisons among different climate-health pathways are difficult due to inconsistencies in study design regarding spatial and temporal scales and health outcomes examined. We find, however, that the current public health burden likely affects thousands of Californians each year, depending on the exposure pathway and health outcome. Further, while more evidence exists for direct and indirect proximal health effects that are the focus of this review, distal pathways (e.g., impacts of drought on nutrition) are more uncertain but could add to this burden. We find that climate adaptation measures can provide significant health benefits, particularly in disadvantaged communities. We conclude with priority recommendations for future analyses and solution-driven policy actions.

Bingcong Zhao,1,2 Zhigang Li,3 Chuan Shi,4 Yan Liu,5 Yang Sun,3 Bin Li,1,2 Jie Zhang,6 Zhizhong Gong,7 Yuanzheng Wang,8 Xuehong Ma,9 Xinjing Yang,10 Huili Jiang,3 Yuanbo Fu,1,2 Xin Wang,1,2 Yang Li,6 Hengchia Liu,6 Tuya Bao,3 Yutong Fei11– 13 1Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, People’s Republic of China; 3School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 4Psychological Assessment Center, Peking University Sixth Hospital, Beijing, People’s Republic of China; 5Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 6Department of Psychosomatic Medicine, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 7Division of Medical Affairs, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 8Department of Integrative TCM and Western Medicine, Peking University First Hospital, Beijing, People’s Republic of China; 9Department of Acupuncture & Moxibustion, Dongfang Hospital, the Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 10Department of Traditional Chinese Medicine, South China Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 11Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 12Institute of Excellence in Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 13Beijing GRADE Centre, Beijing, People’s Republic of ChinaCorrespondence: Tuya Bao, School of Acupuncture-Moxibustion and Tuina, Beijing University of Ch

The detached raft automatic frequency isolation system is a complicated system with high exceptionally nonlinear, high electromagnetic, and multi-source vibration modes. However, it generates a statistical method and it is hard to operate the organization. The fuzzy control algorithm, as an astute control method, can give a keen path to the active management of a complicated system of floating rafts. This study uses a system identification approach to construct mathematical models for a floating raft active vibration isolation system with discrete transfer work. The fuzzy model is used in tests and simulations controller is built using two contributions of acceleration and its variation, as well as a single result of control voltage. The control isolation system is a complicated system with many moving parts. A lot of moving parts profoundly nonlinear, high electromagnetic and multi-source vibration modes, generating a statistical method and it is hard to operate the organization. The fuzzy control algorithm, as a smart control method, can give a keen path to the active management of a sophisticated floating raft system. This research uses an identification strategy to construct a floating raft active vibration isolation technology discrete transfer work mathematical models. The fuzzy controller is then put together using two contributions: acceleration and variation, as well as a single outcome of control voltage for simulations and experiments research.

Swine enteric coronaviruses (SeCoVs) pose a significant threat to the global pig industry, but no effective drugs are available for treatment. Previous research has demonstrated that thapsigargin (TG), an ER stress inducer, has broad-spectrum antiviral effects on human coronaviruses. In this study, we investigated the impact of TG on transmissible gastroenteritis virus (TGEV) infection using cell lines, porcine intestinal organoid models, and piglets. The results showed that TG effectively inhibited TGEV replication both in vitro and ex vivo. Furthermore, animal experiments demonstrated that oral administration of TG inhibited TGEV infection in neonatal piglets and relieved TGEV-associated tissue injury. Transcriptome analyses revealed that TG improved the expression of the ER-associated protein degradation (ERAD) component and influenced the biological processes related to secretion, nutrient responses, and epithelial cell differentiation in the intestinal epithelium. Collectively, these results suggest that TG is a potential novel oral antiviral drug for the clinical treatment of TGEV infection, even for infections caused by other SeCoVs.

In response to pressing environmental challenges, the power system is gradually developing towards a more efficient, clean, and sustainable direction. Carbon capture power plants (CCPPs) and wind power generation will play a significant role in this eco-friendly transformation. However, the high energy consumption of CCPPs and the anti-peak regulation characteristics of wind power lead to contradictions in their coordinated operation during peak shaving, restricting the system's low-carbon economic development. Aiming at the above challenges, an interval optimization method is proposed to coordinate wind power and CCPPs. Firstly, a flexible operation model of CCPPs is established, and the coordinated scheduling mechanism of wind power joint carbon capture operation and load-side demand response is introduced to optimize the system carbon emission through low carbon scheduling on both sides of the source and load. Secondly, interval numbers are used to manage the uncertainty of wind power output, and the interval-optimized scheduling model of wind power combined CCPPs is established. To solve the proposed model, the improved interval possibility method is adopted to transform the uncertain model into a deterministic one, which is solved by the CPLEX solver. Finally, the simulation outcomes using the IEEE 30-bus system framework reveal that the proposed approach significantly enhances the coordination between CCPPs and wind power. Notably, when compared to scenarios that solely focus on CCPPs, the proposed method achieves a substantial reduction in total costs by 16.67 % and decreases carbon emissions by 26.53 %. This sets a significant reference for low-carbon economic dispatch within power systems, providing key insights and foundational guidelines for future implementations, as well as novel strategies and technological support for the sustainable transformation of the power system towards lower carbon emissions. © 2024 Elsevier Ltd

The integration of multi-energy sources in microgrids offers a promising approach to address the challenges of energy efficiency and bolster environmental stewardship. This paper presents a novel optimization scheduling model for multi-energy microgrids (MEMG) with carbon capture and storage (CCS) technology in various renewable energy scenarios. The model effectively coordinates integrated demand response (IDR) and the flexible operation of waste heat utilization, enhancing energy utilization efficiency while ensuring user satisfaction. Furthermore, introducing flexible operation combined with ladder-type carbon trading minimizes operating costs and carbon emissions. The improved particle swarm optimization (PSO) algorithm is employed to solve the eco-economic economic scheduling model. Simulation analysis shows that integrating CCS into MEMG can reduce carbon emissions by 74.4%, while lowering the overall cost by 37.9%. These findings not only improve MEMG's low-carbon and economic efficiency but also pave the way for environmentally responsible energy management practices. © 2024 Elsevier Ltd