Search

In the original article, there were errors. In the section In Vitro Cellular Evaluation of Composite Scaffold, “Cell Culture”, page 3, an acronym was not given in full at the first mention. The corrected sentence is as follows: “The scaffold (2 mm height and 8 mm diameter) were placed into the 48-well plates, sterilized by immersing in 75% ethanol overnight and washed with phosphate-buffered saline (PBS) for three times by 30 min interval.” Consequently, in the next section “Cell attachment”, the first sentence is corrected as follows: “For cell attachment testing, the scaffolds were harvested at 3 days and washed with PBS for twice, fixed with 2.5% glutaraldehyde at 4°C for 4 h” In Conclusions, page 9, there was a typo in which “was” was used instead of “were,” The corrected sentence is as follows: “The mechanical property and pore diameter of PLGA-MNBG scaffold were significantly improved due to the incorporation of MNBG particles.” In the next sentence, the word “cell” was used incorrectly in “the in vitro cell experiments.” The corrected sentence is as follows: “In addition, the in vitro experiments demonstrated that PLGA-MNBG scaffolds significantly enhanced the mBMSCs attachment, proliferation and osteogenic differentiation at a low MNBG concentration.”.

Constructing the interconnected porous biomaterials scaffolds with osteogenesis and angiogenesis capacity is extremely important for efficient bone tissue engineering. Herein, we fabricated a bioactive micro-nano composite scaffolds with excellent in vitro osteogenesis and angiogenesis capacity, based on poly (lactic-co-glycolic acid) (PLGA) incorporated with micro-nano bioactive glass (MNBG). The results showed that the addition of MNBG enlarged the pore size, increased the compressive modulus (4 times improvement), enhanced the physiological stability and apatite-forming ability of porous PLGA scaffolds. The in vitro studies indicated that the PLGA-MNBG porous scaffold could enhance the mouse bone mesenchymal stem cells (mBMSCs) attachment, proliferation, and promote the expression of osteogenesis marker (ALP). Additionally, PLGA-MNBG could also support the attachment and proliferation of human umbilical vein endothelial cells (HUVECs), and significantly enhanced the expression of angiogenesis marker (CD31) of HUVECs. The as-prepared bioactive PLGA-MNBG nanocomposites scaffolds with good osteogenesis and angiogenesis probably have a promising application for bone tissue regeneration.