1. Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine
- Author
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Medical School, The University of Michigan, Ann Arbor, Michigan, College of Pharmacy, The University of Michigan, USA; Pharmacy Services, University Hospital, Ann Arbor, Michigan, 48109, Office of Research Resources, CDER, FDA, Rockville, Maryland, 20852, Yamanouchi Pharmaceutical Co. Ltd., Shizuoka, Japan, Sookmyung Women' University, Seoul, 140-742, Korea, School of Pharmacy, Uppsala University, Uppsala, Sweden, Office of Clinical Pharmacology and Biopharmaceutics, CDER, FDA, Rockville, Maryland, 20852, Nagoya City University, Aichi, Japan, Jordan University of Science and Technology, Irbid, Jordan, Ono Pharmaceutical Co. Ltd., c, Osaka, Japan, 618, Pfizer Global R & D, Ann Arbor, Michigan, 48105, Ann Arbor, Lennern??s, Hans, Yamamoto, Ryuzo, Hussain, Ajaz S., Takamatsu, Narushi, Barnett, Jeffrey L., Kim, Ok-Nam, Lipka, Elke, Hayashi, Yayoi, Welage, Lynda S., Lesko, Lawrence J., Amidon, Gordon L., Idkaidek, Nasir M., Medical School, The University of Michigan, Ann Arbor, Michigan, College of Pharmacy, The University of Michigan, USA; Pharmacy Services, University Hospital, Ann Arbor, Michigan, 48109, Office of Research Resources, CDER, FDA, Rockville, Maryland, 20852, Yamanouchi Pharmaceutical Co. Ltd., Shizuoka, Japan, Sookmyung Women' University, Seoul, 140-742, Korea, School of Pharmacy, Uppsala University, Uppsala, Sweden, Office of Clinical Pharmacology and Biopharmaceutics, CDER, FDA, Rockville, Maryland, 20852, Nagoya City University, Aichi, Japan, Jordan University of Science and Technology, Irbid, Jordan, Ono Pharmaceutical Co. Ltd., c, Osaka, Japan, 618, Pfizer Global R & D, Ann Arbor, Michigan, 48105, Ann Arbor, Lennern??s, Hans, Yamamoto, Ryuzo, Hussain, Ajaz S., Takamatsu, Narushi, Barnett, Jeffrey L., Kim, Ok-Nam, Lipka, Elke, Hayashi, Yayoi, Welage, Lynda S., Lesko, Lawrence J., Amidon, Gordon L., and Idkaidek, Nasir M.
- Abstract
Purpose . To determine the human jejunal permeability of cimetidine and ranitidine using a regional jejunal perfusion approach, and to integrate such determinations with previous efforts to establish a baseline correlation between permeability and fraction dose absorbed in humans for soluble drugs.
- Published
- 2006