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This article describes four fluorescent membrane tension probes that have been designed, synthesized, evaluated, commercialized and applied to current biology challenges in the context of the NCCR Chemical Biology. Their names are Flipper-TR®, ER Flipper-TR®, Lyso Flipper-TR®, and Mito Flipper-TR®. They are available from Spirochrome.

Water soluble 2D crystalline monolayers of fullerenes grow on planar assemblies of engineered consensus tetratricopeptide repeat proteins. Designed fullerene-coordinating tyrosine clamps on the protein introduce specific fullerene binding sites, which facilitate fullerene nucleation. Through reciprocal interactions between the components, the hybrid material assembles into two-dimensional 2 nm thick structures with crystalline order, that conduct photo-generated charges. Thus, the protein-fullerene hybrid material is a demonstration of the developments toward functional materials with protein-based precision control of functional elements.

The precise control over the organization of photoactive components at the nanoscale is one of the main challenges for the generation of new and sophisticated macroscopically ordered materials with enhanced properties. In this work we present a novel bioinspired approach using protein-based building blocks for the arrangement of photo and electroactive porphyrin derivatives. We used a designed repeat protein scaffold with demonstrated unique features that allow for the control of their structure, functionality, and assembly. Our designed domains act as exact biomolecular templates to organize porphyrin molecules at the required distance. The hybrid conjugates retain the structure and assembly properties of the protein scaffold and display the spectroscopic features of orderly aggregated porphyrins along the protein structure. Finally,we achieved a solid ordered bio-organic hybrid thin film with anisotropic photoconductivity., Unión Europea. FP7, Ministerio de Economía y Competitividad (MINECO), European Research Council, Depto. de Química Orgánica, Fac. de Ciencias Químicas, TRUE, pub

La nanotecnología, referida a la manipulación de la materia a nivel molecular y supramolecular, es un área emergente con prometedores beneficios para la humanidad.1 En particular, las nanoestructuras de carbono han captado gran atención debido a sus atractivas propiedades electrónicas y mecánicas. Imitar la naturaleza mediante el desarrollo de procedimientos bioinspirados puede ser una interesante estrategia para organizar nanomateriales ricos en carbono con el fin de maximizar sus propiedades optoelectrónicas..., Nanotechnology, referring as the manipulation of matter at the molecular and supramolecular scale, is an emerging area with promising benefits for humanity.1 In particular, carbon nanostructures have received a great attention due to their exciting electronic and mechanical properties. Mimicking nature, that is, developing bioinspired procedures, could be one of the most intelligent strategies to organize matter, in particular carbon-rich nanostructures, with the aim of maximizing their fabulous optoelectronic properties...

La nanotecnología, referida a la manipulación de la materia a nivel molecular y supramolecular, es un área emergente con prometedores beneficios para la humanidad.1 En particular, las nanoestructuras de carbono han captado gran atención debido a sus atractivas propiedades electrónicas y mecánicas. Imitar la naturaleza mediante el desarrollo de procedimientos bioinspirados puede ser una interesante estrategia para organizar nanomateriales ricos en carbono con el fin de maximizar sus propiedades optoelectrónicas..., Nanotechnology, referring as the manipulation of matter at the molecular and supramolecular scale, is an emerging area with promising benefits for humanity.1 In particular, carbon nanostructures have received a great attention due to their exciting electronic and mechanical properties. Mimicking nature, that is, developing bioinspired procedures, could be one of the most intelligent strategies to organize matter, in particular carbon-rich nanostructures, with the aim of maximizing their fabulous optoelectronic properties...

Fullerenes of increasing electron deficiency are designed, synthesized and evaluated in multicomponent surface architectures to ultimately build gradients in LUMO levels with nine components over 350 mV down to -4.22 eV., Ministerio de Economía y Competitividad (MINECO), European Research Council, Comunidad de Madrid, Depto. de Química Orgánica, Fac. de Ciencias Químicas, TRUE, pub

La nanotecnología, referida a la manipulación de la materia a nivel molecular y supramolecular, es un área emergente con prometedores beneficios para la humanidad.1 En particular, las nanoestructuras de carbono han captado gran atención debido a sus atractivas propiedades electrónicas y mecánicas. Imitar la naturaleza mediante el desarrollo de procedimientos bioinspirados puede ser una interesante estrategia para organizar nanomateriales ricos en carbono con el fin de maximizar sus propiedades optoelectrónicas...

La nanotecnología, referida a la manipulación de la materia a nivel molecular y supramolecular, es un área emergente con prometedores beneficios para la humanidad.1 En particular, las nanoestructuras de carbono han captado gran atención debido a sus atractivas propiedades electrónicas y mecánicas. Imitar la naturaleza mediante el desarrollo de procedimientos bioinspirados puede ser una interesante estrategia para organizar nanomateriales ricos en carbono con el fin de maximizar sus propiedades optoelectrónicas...