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Image restoration in adverse weather conditions is a difficult task in computer vision. In this paper, we propose a novel transformer-based framework called GridFormer which serves as a backbone for image restoration under adverse weather conditions. GridFormer is designed in a grid structure using a residual dense transformer block, and it introduces two core designs. First, it uses an enhanced attention mechanism in the transformer layer. The mechanism includes stages of the sampler and compact self-attention to improve efficiency, and a local enhancement stage to strengthen local information. Second, we introduce a residual dense transformer block (RDTB) as the final GridFormer layer. This design further improves the network’s ability to learn effective features from both preceding and current local features. The GridFormer framework achieves state-of-the-art results on five diverse image restoration tasks in adverse weather conditions, including image deraining, dehazing, deraining & dehazing, desnowing, and multi-weather restoration. The source code and pre-trained models will be released. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

Image restoration under hazy weather condition, which is called single image dehazing, has been of significant interest for various computer vision applications. In recent years, deep learning-based methods have achieved success. However, existing image dehazing methods typically neglect the hierarchy of features in the neural network and fail to exploit their relationships fully. To this end, we propose an effective image dehazing method named Hierarchical Contrastive Dehazing (HCD), which is based on feature fusion and contrastive learning strategies. HCD consists of a hierarchical dehazing network (HDN) and a novel hierarchical contrastive loss (HCL). Specifically, the core design in the HDN is a hierarchical interaction module, which utilizes multi-scale activation to revise the feature responses hierarchically. To cooperate with the training of HDN, we propose HCL which performs contrastive learning on hierarchically paired exemplars, facilitating haze removal. Extensive experiments on public datasets, RESIDE, HazeRD, and DENSE-HAZE, demonstrate that HCD quantitatively outperforms the state-of-the-art methods in terms of PSNR, SSIM and achieves better visual quality. © 2023 Elsevier Ltd

Yanyi Wang,1,2,* Juan Wen,1– 3,* Tong Lu,1,2 Wei Han,2,4 Kai Jiao,5 Huang Li1,2 1Department of Orthodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, People’s Republic of China; 2Medical School of Nanjing University, Nanjing, People’s Republic of China; 3Centre for Orofacial Regeneration, Reconstruction and Rehabilitation (COR3), School of Dentistry, The University of Queensland, Brisbane, Queensland, 4006, Australia; 4Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, People’s Republic of China; 5Department of Stomatology, Tangdu Hospital & State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Han, Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, 30 Central Road, Nanjing, 210008, People’s Republic of China, Email doctorhanwei@hotmail.com Huang Li, Department of Orthodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, 30 Central Road, Nanjing, 210008, People’s Republic of China, Tel +86-25-83620173, Fax +86-25-83620200, Email lihuang76@nju.edu.cnAbstract: Extracellular vesicles (EVs) can deliver various bioactive molecules among cells, making them promising diagnostic and therapeutic alternatives in diseases. Mesenchymal stem cell-derived EVs (MSC-EVs) have shown therapeutic potential similar to MSCs bu

Understanding videos is one of the fundamental directions in computer vision research, with extensive efforts dedicated to exploring various architectures such as RNN, 3D CNN, and Transformers. The newly proposed architecture of state space model, e.g., Mamba, shows promising traits to extend its success in long sequence modeling to video modeling. To assess whether Mamba can be a viable alternative to Transformers in the video understanding domain, in this work, we conduct a comprehensive set of studies, probing different roles Mamba can play in modeling videos, while investigating diverse tasks where Mamba could exhibit superiority. We categorize Mamba into four roles for modeling videos, deriving a Video Mamba Suite composed of 14 models/modules, and evaluating them on 12 video understanding tasks. Our extensive experiments reveal the strong potential of Mamba on both video-only and video-language tasks while showing promising efficiency-performance trade-offs. We hope this work could provide valuable data points and insights for future research on video understanding. Code is public: https://github.com/OpenGVLab/video-mamba-suite., Comment: Technical Report

Background: The concerted regulation of placenta microbiota and the immune responses secures the occurrence and development of pregnancy, while few studies reported this correlation. This study aimed to explore the relationship between the placenta microbiota and immune regulation during pregnancy. Methods: Twenty-six healthy pregnant women scheduled for elective cesarean section in the First Affiliated Hospital of Jinan University who met the inclusion criteria were recruited. Placenta and peripheral venous blood samples were collected. Microbiota in placental tissue was detected using high-throughput sequencing. Flow cytometry was used to detect immune cells in placental tissue and peripheral venous blood. ELISA and Luminex liquid chip technology were used to detect the content of cytokines in placental tissue and peripheral venous blood, respectively. Results: The placental microbiota has stimulating effects on the local immunity of the placenta and mainly stimulates the placental balance ratio CD56 + CD16 + /CD56 + CD16 and the placental macrophages, that is, it plays the role of immune protection and supporting nutrition. The stimulating effect of placental microbiota on maternal systemic immunity mainly induces peripheral Treg cells and B lymphocytes. Conclusion: The placental microbiota may be an important factor mediating local immune regulation in the placenta, and placental microbiota participates in the regulatory function of the maternal immune system. © The Author(s) 2024.

Transformers have revolutionized computer vision and natural language processing, but their high computational complexity limits their application in high-resolution image processing and long-context analysis. This paper introduces Vision-RWKV (VRWKV), a model adapted from the RWKV model used in the NLP field with necessary modifications for vision tasks. Similar to the Vision Transformer (ViT), our model is designed to efficiently handle sparse inputs and demonstrate robust global processing capabilities, while also scaling up effectively, accommodating both large-scale parameters and extensive datasets. Its distinctive advantage lies in its reduced spatial aggregation complexity, which renders it exceptionally adept at processing high-resolution images seamlessly, eliminating the necessity for windowing operations. Our evaluations demonstrate that VRWKV surpasses ViT's performance in image classification and has significantly faster speeds and lower memory usage processing high-resolution inputs. In dense prediction tasks, it outperforms window-based models, maintaining comparable speeds. These results highlight VRWKV's potential as a more efficient alternative for visual perception tasks. Code is released at \url{https://github.com/OpenGVLab/Vision-RWKV}.

Existing single image reflection removal (SIRR) methods using deep learning tend to miss key low-frequency (LF) and high-frequency (HF) differences in images, affecting their effectiveness in removing reflections. To address this problem, this paper proposes a novel prompt-guided reflection removal (PromptRR) framework that uses frequency information as new visual prompts for better reflection performance. Specifically, the proposed framework decouples the reflection removal process into the prompt generation and subsequent prompt-guided restoration. For the prompt generation, we first propose a prompt pre-training strategy to train a frequency prompt encoder that encodes the ground-truth image into LF and HF prompts. Then, we adopt diffusion models (DMs) as prompt generators to generate the LF and HF prompts estimated by the pre-trained frequency prompt encoder. For the prompt-guided restoration, we integrate specially generated prompts into the PromptFormer network, employing a novel Transformer-based prompt block to effectively steer the model toward enhanced reflection removal. The results on commonly used benchmarks show that our method outperforms state-of-the-art approaches. The codes and models are available at https://github.com/TaoWangzj/PromptRR., Comment: 10 pages, 10 figures

Developing generative models for interleaved image-text data has both research and practical value. It requires models to understand the interleaved sequences and subsequently generate images and text. However, existing attempts are limited by the issue that the fixed number of visual tokens cannot efficiently capture image details, which is particularly problematic in the multi-image scenarios. To address this, this paper presents MM-Interleaved, an end-to-end generative model for interleaved image-text data. It introduces a multi-scale and multi-image feature synchronizer module, allowing direct access to fine-grained image features in the previous context during the generation process. MM-Interleaved is end-to-end pre-trained on both paired and interleaved image-text corpora. It is further enhanced through a supervised fine-tuning phase, wherein the model improves its ability to follow complex multi-modal instructions. Experiments demonstrate the versatility of MM-Interleaved in recognizing visual details following multi-modal instructions and generating consistent images following both textual and visual conditions. Code and models are available at \url{https://github.com/OpenGVLab/MM-Interleaved}., Comment: 20 pages, 9 figures, 17 tables

We introduce Deformable Convolution v4 (DCNv4), a highly efficient and effective operator designed for a broad spectrum of vision applications. DCNv4 addresses the limitations of its predecessor, DCNv3, with two key enhancements: 1. removing softmax normalization in spatial aggregation to enhance its dynamic property and expressive power and 2. optimizing memory access to minimize redundant operations for speedup. These improvements result in a significantly faster convergence compared to DCNv3 and a substantial increase in processing speed, with DCNv4 achieving more than three times the forward speed. DCNv4 demonstrates exceptional performance across various tasks, including image classification, instance and semantic segmentation, and notably, image generation. When integrated into generative models like U-Net in the latent diffusion model, DCNv4 outperforms its baseline, underscoring its possibility to enhance generative models. In practical applications, replacing DCNv3 with DCNv4 in the InternImage model to create FlashInternImage results in up to 80% speed increase and further performance improvement without further modifications. The advancements in speed and efficiency of DCNv4, combined with its robust performance across diverse vision tasks, show its potential as a foundational building block for future vision models., Comment: Tech report; Code: https://github.com/OpenGVLab/DCNv4

Point cloud completion is an indispensable task for recovering complete point clouds due to incompleteness caused by occlusion, limited sensor resolution, etc. The family of coarse-to-fine generation architectures has recently exhibited great success in point cloud completion and gradually became mainstream. In this work, we unveil one of the key ingredients behind these methods: meticulously devised feature extraction operations with explicit cross-resolution aggregation. We present Cross-Resolution Transformer that efficiently performs cross-resolution aggregation with local attention mechanisms. With the help of our recursive designs, the proposed operation can capture more scales of features than common aggregation operations, which is beneficial for capturing fine geometric characteristics. While prior methodologies have ventured into various manifestations of inter-level cross-resolution aggregation, the effectiveness of intra-level one and their combination has not been analyzed. With unified designs, Cross-Resolution Transformer can perform intra- or inter-level cross-resolution aggregation by switching inputs. We integrate two forms of Cross-Resolution Transformers into one up-sampling block for point generation, and following the coarse-to-fine manner, we construct CRA-PCN to incrementally predict complete shapes with stacked up-sampling blocks. Extensive experiments demonstrate that our method outperforms state-of-the-art methods by a large margin on several widely used benchmarks. Codes are available at https://github.com/EasyRy/CRA-PCN., Comment: Accepted to AAAI 2024

In this report, we introduce InternVL 1.5, an open-source multimodal large language model (MLLM) to bridge the capability gap between open-source and proprietary commercial models in multimodal understanding. We introduce three simple improvements: (1) Strong Vision Encoder: we explored a continuous learning strategy for the large-scale vision foundation model -- InternViT-6B, boosting its visual understanding capabilities, and making it can be transferred and reused in different LLMs. (2) Dynamic High-Resolution: we divide images into tiles ranging from 1 to 40 of 448$\times$448 pixels according to the aspect ratio and resolution of the input images, which supports up to 4K resolution input. (3) High-Quality Bilingual Dataset: we carefully collected a high-quality bilingual dataset that covers common scenes, document images, and annotated them with English and Chinese question-answer pairs, significantly enhancing performance in OCR- and Chinese-related tasks. We evaluate InternVL 1.5 through a series of benchmarks and comparative studies. Compared to both open-source and proprietary models, InternVL 1.5 shows competitive performance, achieving state-of-the-art results in 8 of 18 benchmarks. Code has been released at https://github.com/OpenGVLab/InternVL., Comment: Technical report

As the quality of optical sensors improves, there is a need for processing large-scale images. In particular, the ability of devices to capture ultra-high definition (UHD) images and video places new demands on the image processing pipeline. In this paper, we consider the task of low-light image enhancement (LLIE) and introduce a large-scale database consisting of images at 4K and 8K resolution.We conduct systematic benchmarking studies and provide a comparison of current LLIE algorithms. As a second contribution, we introduce LLFormer, a transformer-based low-light enhancement method. The core components of LLFormer are the axis-based multi-head selfattention and cross-layer attention fusion block, which significantly reduces the linear complexity. Extensive experiments on the new dataset and existing public datasets show that LLFormer outperforms state-of-the-art methods. We also show that employing existing LLIE methods trained on our benchmark as a pre-processing step significantly improves the performance of downstream tasks, e.g., face detection in low-light conditions. The source code and pre-trained models are available at https://github.com/TaoWangzj/LLFormer. © 2023, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved.

This dissertation contains three projects that collectively tackle statistical challenges in the field of high-dimensional brain connectome data analysis and enhance our understanding of the intricate workings of the human brain. Project 1 proposes a novel network method for detecting brain-disease-related alterations in voxel-pair-level brain functional connectivity with spatial constraints, thus improving spatial specificity and sensitivity. Its effectiveness is validated through extensive simulations and real data applications in nicotine addiction and schizophrenia studies. Project 2 introduces a multivariate multiple imputation method specifically designed for voxel-level neuroimaging data in high dimensions based on Bayesian models and Markov chain Monte Carlo processes. According to both synthetic data and real neurovascular water exchange data extracted from a neuroimaging dataset in a schizophrenia study, our method indicates high imputation accuracy and computational efficiency. Project 3 develops a multi-level network model based on graph combinatorics that captures vector-to-matrix associations between brain structural imaging measures and functional connectomic networks. The validity of the proposed model is justified through extensive simulations and a real structure-function imaging dataset from UK Biobank. These three projects contribute innovative methodologies and insights that advance neuroimaging data analysis, including improvements in spatial specificity, statistical power, imputation accuracy, and computational efficiency when revealing the brain’s complex neurological patterns.

In this report, we present our champion solution to the WSDM2023 Toloka Visual Question Answering (VQA) Challenge. Different from the common VQA and visual grounding (VG) tasks, this challenge involves a more complex scenario, i.e. inferring and locating the object implicitly specified by the given interrogative question. For this task, we leverage ViT-Adapter, a pre-training-free adapter network, to adapt multi-modal pre-trained Uni-Perceiver for better cross-modal localization. Our method ranks first on the leaderboard, achieving 77.5 and 76.347 IoU on public and private test sets, respectively. It shows that ViT-Adapter is also an effective paradigm for adapting the unified perception model to vision-language downstream tasks. Code and models will be released at https://github.com/czczup/ViT-Adapter/tree/main/wsdm2023., Comment: Technical report in WSDM Cup 2023

Image restoration in adverse weather conditions is a difficult task in computer vision. In this paper, we propose a novel transformer-based framework called GridFormer which serves as a backbone for image restoration under adverse weather conditions. GridFormer is designed in a grid structure using a residual dense transformer block, and it introduces two core designs. First, it uses an enhanced attention mechanism in the transformer layer. The mechanism includes stages of the sampler and compact self-attention to improve efficiency, and a local enhancement stage to strengthen local information. Second, we introduce a residual dense transformer block (RDTB) as the final GridFormer layer. This design further improves the network's ability to learn effective features from both preceding and current local features. The GridFormer framework achieves state-of-the-art results on five diverse image restoration tasks in adverse weather conditions, including image deraining, dehazing, deraining & dehazing, desnowing, and multi-weather restoration. The source code and pre-trained models will be released., Comment: 17 pages, 12 figures

With the exponential growth of video data, there is an urgent need for automated technology to analyze and comprehend video content. However, existing video understanding models are often task-specific and lack a comprehensive capability of handling diverse tasks. The success of large language models (LLMs) like GPT has demonstrated their impressive abilities in sequence causal reasoning. Building upon this insight, we propose a novel framework called VideoLLM that leverages the sequence reasoning capabilities of pre-trained LLMs from natural language processing (NLP) for video sequence understanding. VideoLLM incorporates a carefully designed Modality Encoder and Semantic Translator, which convert inputs from various modalities into a unified token sequence. This token sequence is then fed into a decoder-only LLM. Subsequently, with the aid of a simple task head, our VideoLLM yields an effective unified framework for different kinds of video understanding tasks. To evaluate the efficacy of VideoLLM, we conduct extensive experiments using multiple LLMs and fine-tuning methods. We evaluate our VideoLLM on eight tasks sourced from four different datasets. The experimental results demonstrate that the understanding and reasoning capabilities of LLMs can be effectively transferred to video understanding tasks. We release the code at https://github.com/cg1177/VideoLLM., Comment: Technical Report

This paper presents a novel transformer architecture for graph representation learning. The core insight of our method is to fully consider the information propagation among nodes and edges in a graph when building the attention module in the transformer blocks. Specifically, we propose a new attention mechanism called Graph Propagation Attention (GPA). It explicitly passes the information among nodes and edges in three ways, i.e. node-to-node, node-to-edge, and edge-to-node, which is essential for learning graph-structured data. On this basis, we design an effective transformer architecture named Graph Propagation Transformer (GPTrans) to further help learn graph data. We verify the performance of GPTrans in a wide range of graph learning experiments on several benchmark datasets. These results show that our method outperforms many state-of-the-art transformer-based graph models with better performance. The code will be released at https://github.com/czczup/GPTrans., Comment: Accepted to IJCAI 2023

Large language models (LLMs) have notably accelerated progress towards artificial general intelligence (AGI), with their impressive zero-shot capacity for user-tailored tasks, endowing them with immense potential across a range of applications. However, in the field of computer vision, despite the availability of numerous powerful vision foundation models (VFMs), they are still restricted to tasks in a pre-defined form, struggling to match the open-ended task capabilities of LLMs. In this work, we present an LLM-based framework for vision-centric tasks, termed VisionLLM. This framework provides a unified perspective for vision and language tasks by treating images as a foreign language and aligning vision-centric tasks with language tasks that can be flexibly defined and managed using language instructions. An LLM-based decoder can then make appropriate predictions based on these instructions for open-ended tasks. Extensive experiments show that the proposed VisionLLM can achieve different levels of task customization through language instructions, from fine-grained object-level to coarse-grained task-level customization, all with good results. It's noteworthy that, with a generalist LLM-based framework, our model can achieve over 60\% mAP on COCO, on par with detection-specific models. We hope this model can set a new baseline for generalist vision and language models. The demo shall be released based on https://github.com/OpenGVLab/InternGPT. The code shall be released at https://github.com/OpenGVLab/VisionLLM., Comment: Technical Report

Action detection is a challenging video understanding task, requiring modeling spatio-temporal and interaction relations. Current methods usually model actor-actor and actor-context relations separately, ignoring their complementarity and mutual support. To solve this problem, we propose a novel network called Multi-Relation Support Network (MRSN). In MRSN, Actor-Context Relation Encoder (ACRE) and Actor-Actor Relation Encoder (AARE) model the actor-context and actor-actor relation separately. Then Relation Support Encoder (RSE) computes the supports between the two relations and performs relation-level interactions. Finally, Relation Consensus Module (RCM) enhances two relations with the long-term relations from the Long-term Relation Bank (LRB) and yields a consensus. Our experiments demonstrate that modeling relations separately and performing relation-level interactions can achieve and outperformer state-of-the-art results on two challenging video datasets: AVA and UCF101-24., Comment: 6 pages

We propose a simple, efficient, yet powerful framework for dense visual predictions based on the conditional diffusion pipeline. Our approach follows a "noise-to-map" generative paradigm for prediction by progressively removing noise from a random Gaussian distribution, guided by the image. The method, called DDP, efficiently extends the denoising diffusion process into the modern perception pipeline. Without task-specific design and architecture customization, DDP is easy to generalize to most dense prediction tasks, e.g., semantic segmentation and depth estimation. In addition, DDP shows attractive properties such as dynamic inference and uncertainty awareness, in contrast to previous single-step discriminative methods. We show top results on three representative tasks with six diverse benchmarks, without tricks, DDP achieves state-of-the-art or competitive performance on each task compared to the specialist counterparts. For example, semantic segmentation (83.9 mIoU on Cityscapes), BEV map segmentation (70.6 mIoU on nuScenes), and depth estimation (0.05 REL on KITTI). We hope that our approach will serve as a solid baseline and facilitate future research, Comment: Added controlnet exp

To respond to the rapid growth of shipping container throughput, terminals urgently need to improve the efficiency of thier operations and reduce operational costs through automation and intellectualization upgrades, thereby improving service levels and enhancing market competitiveness. Due to the advantages of reliable transportation, efficient operation, and environmental friendliness, AGV-based automated container terminal (ACT) has become the development trend of container terminals. To help ACT improve its operational management capabilities, plenty of scholars have explored the transportation system of ACT. Through the analysis of operational management issues, the paper defines the four main research topics in vehicle transportation of the ACT including equipment scheduling, path planning, exception handling, and vehicle management. Then, in each topic, the works in the recent 25 years are summarized and several research opportunities for possible follow-up research directions in different fields are proposed. We expect our survey could not only provide references for more scholars on the research of operation and management of terminals, but also provide guidance for system evaluation and improvement for terminal system engineers and operation managers. IEEE

The exponential growth of large language models (LLMs) has opened up numerous possibilities for multimodal AGI systems. However, the progress in vision and vision-language foundation models, which are also critical elements of multi-modal AGI, has not kept pace with LLMs. In this work, we design a large-scale vision-language foundation model (InternVL), which scales up the vision foundation model to 6 billion parameters and progressively aligns it with the LLM, using web-scale image-text data from various sources. This model can be broadly applied to and achieve state-of-the-art performance on 32 generic visual-linguistic benchmarks including visual perception tasks such as image-level or pixel-level recognition, vision-language tasks such as zero-shot image/video classification, zero-shot image/video-text retrieval, and link with LLMs to create multi-modal dialogue systems. It has powerful visual capabilities and can be a good alternative to the ViT-22B. We hope that our research could contribute to the development of multi-modal large models. Code and models are available at https://github.com/OpenGVLab/InternVL., Comment: 25 pages, 5 figures, 28 tables

End-to-end autonomous driving recently emerged as a promising research direction to target autonomy from a full-stack perspective. Along this line, many of the latest works follow an open-loop evaluation setting on nuScenes to study the planning behavior. In this paper, we delve deeper into the problem by conducting thorough analyses and demystifying more devils in the details. We initially observed that the nuScenes dataset, characterized by relatively simple driving scenarios, leads to an under-utilization of perception information in end-to-end models incorporating ego status, such as the ego vehicle's velocity. These models tend to rely predominantly on the ego vehicle's status for future path planning. Beyond the limitations of the dataset, we also note that current metrics do not comprehensively assess the planning quality, leading to potentially biased conclusions drawn from existing benchmarks. To address this issue, we introduce a new metric to evaluate whether the predicted trajectories adhere to the road. We further propose a simple baseline able to achieve competitive results without relying on perception annotations. Given the current limitations on the benchmark and metrics, we suggest the community reassess relevant prevailing research and be cautious whether the continued pursuit of state-of-the-art would yield convincing and universal conclusions. Code and models are available at \url{https://github.com/NVlabs/BEV-Planner}, Comment: Accept to cvpr 2024

Images or videos captured by the Under-Display Camera (UDC) suffer from severe degradation, such as saturation degeneration and color shift. While restoration for UDC has been a critical task, existing works of UDC restoration focus only on images. UDC video restoration (UDC-VR) has not been explored in the community. In this work, we first propose a GAN-based generation pipeline to simulate the realistic UDC degradation process. With the pipeline, we build the first large-scale UDC video restoration dataset called PexelsUDC, which includes two subsets named PexelsUDC-T and PexelsUDC-P corresponding to different displays for UDC. Using the proposed dataset, we conduct extensive benchmark studies on existing video restoration methods and observe their limitations on the UDC-VR task. To this end, we propose a novel transformer-based baseline method that adaptively enhances degraded videos. The key components of the method are a spatial branch with local-aware transformers, a temporal branch embedded temporal transformers, and a spatial-temporal fusion module. These components drive the model to fully exploit spatial and temporal information for UDC-VR. Extensive experiments show that our method achieves state-of-the-art performance on PexelsUDC. The benchmark and the baseline method are expected to promote the progress of UDC-VR in the community, which will be made public.

Most existing forecasting systems are memory-based methods, which attempt to mimic human forecasting ability by employing various memory mechanisms and have progressed in temporal modeling for memory dependency. Nevertheless, an obvious weakness of this paradigm is that it can only model limited historical dependence and can not transcend the past. In this paper, we rethink the temporal dependence of event evolution and propose a novel memory-anticipation-based paradigm to model an entire temporal structure, including the past, present, and future. Based on this idea, we present Memory-and-Anticipation Transformer (MAT), a memory-anticipation-based approach, to address the online action detection and anticipation tasks. In addition, owing to the inherent superiority of MAT, it can process online action detection and anticipation tasks in a unified manner. The proposed MAT model is tested on four challenging benchmarks TVSeries, THUMOS'14, HDD, and EPIC-Kitchens-100, for online action detection and anticipation tasks, and it significantly outperforms all existing methods. Code is available at https://github.com/Echo0125/Memory-and-Anticipation-Transformer., Comment: ICCV 2023 Camera Ready

View Transformation Module (VTM), where transformations happen between multi-view image features and Bird-Eye-View (BEV) representation, is a crucial step in camera-based BEV perception systems. Currently, the two most prominent VTM paradigms are forward projection and backward projection. Forward projection, represented by Lift-Splat-Shoot, leads to sparsely projected BEV features without post-processing. Backward projection, with BEVFormer being an example, tends to generate false-positive BEV features from incorrect projections due to the lack of utilization on depth. To address the above limitations, we propose a novel forward-backward view transformation module. Our approach compensates for the deficiencies in both existing methods, allowing them to enhance each other to obtain higher quality BEV representations mutually. We instantiate the proposed module with FB-BEV, which achieves a new state-of-the-art result of 62.4% NDS on the nuScenes test set. Code and models are available at https://github.com/NVlabs/FB-BEV., Comment: Accept to ICCV 2023, camera-ready version

We present the All-Seeing (AS) project: a large-scale data and model for recognizing and understanding everything in the open world. Using a scalable data engine that incorporates human feedback and efficient models in the loop, we create a new dataset (AS-1B) with over 1 billion regions annotated with semantic tags, question-answering pairs, and detailed captions. It covers a wide range of 3.5 million common and rare concepts in the real world, and has 132.2 billion tokens that describe the concepts and their attributes. Leveraging this new dataset, we develop the All-Seeing model (ASM), a unified framework for panoptic visual recognition and understanding. The model is trained with open-ended language prompts and locations, which allows it to generalize to various vision and language tasks with remarkable zero-shot performance, including region-text retrieval, region recognition, captioning, and question-answering. We hope that this project can serve as a foundation for vision-language artificial general intelligence research. Models and the dataset shall be released at https://github.com/OpenGVLab/All-Seeing, and demo can be seen at https://huggingface.co/spaces/OpenGVLab/all-seeing., Comment: Technical Report

The combination of audio and vision has long been a topic of interest in the multi-modal community. Recently, a new audio-visual segmentation (AVS) task has been introduced, aiming to locate and segment the sounding objects in a given video. This task demands audio-driven pixel-level scene understanding for the first time, posing significant challenges. In this paper, we propose AVSegFormer, a novel framework for AVS tasks that leverages the transformer architecture. Specifically, we introduce audio queries and learnable queries into the transformer decoder, enabling the network to selectively attend to interested visual features. Besides, we present an audio-visual mixer, which can dynamically adjust visual features by amplifying relevant and suppressing irrelevant spatial channels. Additionally, we devise an intermediate mask loss to enhance the supervision of the decoder, encouraging the network to produce more accurate intermediate predictions. Extensive experiments demonstrate that AVSegFormer achieves state-of-the-art results on the AVS benchmark. The code is available at https://github.com/vvvb-github/AVSegFormer., Comment: 7 pages, 6 figures

Panoptic segmentation involves a combination of joint semantic segmentation and instance segmentation, where image contents are divided into two types: things and stuff. We present Panoptic SegFormer, a general framework for panoptic segmentation with transformers. It contains three innovative components: an efficient deeply-supervised mask decoder, a query decoupling strategy, and an improved postprocessing method. We also use Deformable DETR to efficiently process multiscale features, which is a fast and efficient version of DETR. Specifically, we supervise the attention modules in the mask decoder in a layer-wise manner. This deep supervision strategy lets the attention modules quickly focus on meaningful semantic regions. It improves performance and reduces the number of required training epochs by half compared to Deformable DETR. Our query decoupling strategy decouples the responsibilities of the query set and avoids mutual interference between things and stuff. In addition, our post-processing strategy improves performance without additional costs by jointly considering classification and segmentation qualities to resolve conflicting mask overlaps. Our approach increases the accuracy 6.2% PQ over the baseline DETR model. Panoptic SegFormer achieves state-of-the-art results on COCO testdev with 56.2% PQ. It also shows stronger zero-shot robustness over existing methods.

The MURANO trial (A Study to Evaluate the Benefit of Venetoclax Plus Rituximab Compared With Bendamustine Plus Rituximab in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia [CLL]; ClinicalTrials.gov identifier #NCT02005471) reported superior progression-free survival (PFS) and overall survival (OS) with venetoclax-rituximab (VenR) vs bendamustine-rituximab (BR) in relapsed/refractory (R/R) CLL. Patients were randomized to 2 years of VenR (n = 194; rituximab for the first 6 months) or 6 months of BR (n = 195). Although undetectable minimal residual disease (uMRD) was achieved more often with VenR, the long-term implications of uMRD with this fixed-duration, chemotherapy-free regimen have not been explored. We report MRD kinetics and updated outcomes with 5 years' follow-up. Survival benefits with VenR vs BR were sustained (median PFS [95% confidence interval]: 53.6 [48.4, 57.0] vs 17.0 [15.5, 21.7] months, respectively, P < .0001; 5-year OS [95% confidence interval]: 82.1% [76.4, 87.8] vs 62.2% [54.8, 69.6], P < .0001). VenR was superior to BR, regardless of cytogenetic category. VenR-treated patients with uMRD at end of treatment (EOT; n = 83) had superior OS vs those with high-MRD+ (n = 12): 3-year post-EOT survival rates were 95.3% vs 72.9% (P = .039). In those with uMRD at EOT, median time to MRD conversion was 19.4 months. Of 47 patients with documented MRD conversion, 19 developed progressive disease (PD); median time from conversion to PD was 25.2 months. A population-based logistic growth model indicated slower MRD median doubling time post-EOT with VenR (93 days) vs BR (53 days; P = 1.2 x 10(-7)). No new safety signals were identified. Sustained survival, uMRD benefits, and durable responses support 2-year fixed-duration VenR treatment in R/R CLL.

Image restoration under hazy weather condition, which is called single image dehazing, has been of significant interest for various computer vision applications. In recent years, deep learning-based methods have achieved success. However, existing image dehazing methods typically neglect the hierarchy of features in the neural network and fail to exploit their relationships fully. To this end, we propose an effective image dehazing method named Hierarchical Contrastive Dehazing (HCD), which is based on feature fusion and contrastive learning strategies. HCD consists of a hierarchical dehazing network (HDN) and a novel hierarchical contrastive loss (HCL). Specifically, the core design in the HDN is a hierarchical interaction module, which utilizes multi-scale activation to revise the feature responses hierarchically. To cooperate with the training of HDN, we propose HCL which performs contrastive learning on hierarchically paired exemplars, facilitating haze removal. Extensive experiments on public datasets, RESIDE, HazeRD, and DENSE-HAZE, demonstrate that HCD quantitatively outperforms the state-of-the-art methods in terms of PSNR, SSIM and achieves better visual quality., Comment: 30 pages, 10 figures

As the quality of optical sensors improves, there is a need for processing large-scale images. In particular, the ability of devices to capture ultra-high definition (UHD) images and video places new demands on the image processing pipeline. In this paper, we consider the task of low-light image enhancement (LLIE) and introduce a large-scale database consisting of images at 4K and 8K resolution. We conduct systematic benchmarking studies and provide a comparison of current LLIE algorithms. As a second contribution, we introduce LLFormer, a transformer-based low-light enhancement method. The core components of LLFormer are the axis-based multi-head self-attention and cross-layer attention fusion block, which significantly reduces the linear complexity. Extensive experiments on the new dataset and existing public datasets show that LLFormer outperforms state-of-the-art methods. We also show that employing existing LLIE methods trained on our benchmark as a pre-processing step significantly improves the performance of downstream tasks, e.g., face detection in low-light conditions. The source code and pre-trained models are available at https://github.com/TaoWangzj/LLFormer., Comment: Accepted at AAAI 2023. #AAAI2023

In this report, we present our champion solutions to five tracks at Ego4D challenge. We leverage our developed InternVideo, a video foundation model, for five Ego4D tasks, including Moment Queries, Natural Language Queries, Future Hand Prediction, State Change Object Detection, and Short-term Object Interaction Anticipation. InternVideo-Ego4D is an effective paradigm to adapt the strong foundation model to the downstream ego-centric video understanding tasks with simple head designs. In these five tasks, the performance of InternVideo-Ego4D comprehensively surpasses the baseline methods and the champions of CVPR2022, demonstrating the powerful representation ability of InternVideo as a video foundation model. Our code will be released at https://github.com/OpenGVLab/ego4d-eccv2022-solutions, Comment: Technical report in 2nd International Ego4D Workshop@ECCV 2022. Code will be released at https://github.com/OpenGVLab/ego4d-eccv2022-solutions

Capturing the state changes of interacting objects is a key technology for understanding human-object interactions. This technical report describes our method using heterogeneous backbones for the Ego4D Object State Change Classification and PNR Temporal Localization Challenge. In the challenge, we used the heterogeneous video understanding backbones, namely CSN with 3D convolution as operator and VideoMAE with Transformer as operator. Our method achieves an accuracy of 0.796 on OSCC while achieving an absolute temporal localization error of 0.516 on PNR. These excellent results rank 1st on the leaderboard of Ego4D OSCC & PNR-TL Challenge 2022., Comment: 5 pages, 3 figures

We provide the technical report for Ego4D audio-only diarization challenge in ECCV 2022. Speaker diarization takes the audio streams as input and outputs the homogeneous segments according to the speaker's identity. It aims to solve the problem of "Who spoke when." In this paper, we explore a Detection-based method to tackle the audio-only speaker diarization task. Our method first extracts audio features by audio backbone and then feeds the feature to a detection-generate network to get the speaker proposals. Finally, after postprocessing, we can get the diarization results. The validation dataset validates this method, and our method achieves 53.85 DER on the test dataset. These results rank 3rd on the leaderboard of Ego4D audio-only diarization challenge 2022., Comment: 2 pages

Compared to the great progress of large-scale vision transformers (ViTs) in recent years, large-scale models based on convolutional neural networks (CNNs) are still in an early state. This work presents a new large-scale CNN-based foundation model, termed InternImage, which can obtain the gain from increasing parameters and training data like ViTs. Different from the recent CNNs that focus on large dense kernels, InternImage takes deformable convolution as the core operator, so that our model not only has the large effective receptive field required for downstream tasks such as detection and segmentation, but also has the adaptive spatial aggregation conditioned by input and task information. As a result, the proposed InternImage reduces the strict inductive bias of traditional CNNs and makes it possible to learn stronger and more robust patterns with large-scale parameters from massive data like ViTs. The effectiveness of our model is proven on challenging benchmarks including ImageNet, COCO, and ADE20K. It is worth mentioning that InternImage-H achieved a new record 65.4 mAP on COCO test-dev and 62.9 mIoU on ADE20K, outperforming current leading CNNs and ViTs. The code will be released at https://github.com/OpenGVLab/InternImage., Comment: Accepted to CVPR 2023

Face Restoration (FR) aims to restore High-Quality (HQ) faces from Low-Quality (LQ) input images, which is a domain-specific image restoration problem in the low-level computer vision area. The early face restoration methods mainly use statistic priors and degradation models, which are difficult to meet the requirements of real-world applications in practice. In recent years, face restoration has witnessed great progress after stepping into the deep learning era. However, there are few works to study deep learning-based face restoration methods systematically. Thus, this paper comprehensively surveys recent advances in deep learning techniques for face restoration. Specifically, we first summarize different problem formulations and analyze the characteristic of the face image. Second, we discuss the challenges of face restoration. Concerning these challenges, we present a comprehensive review of existing FR methods, including prior based methods and deep learning-based methods. Then, we explore developed techniques in the task of FR covering network architectures, loss functions, and benchmark datasets. We also conduct a systematic benchmark evaluation on representative methods. Finally, we discuss future directions, including network designs, metrics, benchmark datasets, applications,etc. We also provide an open-source repository for all the discussed methods, which is available at https://github.com/TaoWangzj/Awesome-Face-Restoration., Comment: 21 pages, 19 figures

StarCraft II (SC2) poses a grand challenge for reinforcement learning (RL), of which the main difficulties include huge state space, varying action space, and a long time horizon. In this work, we investigate a set of RL techniques for the full-length game of StarCraft II. We investigate a hierarchical RL approach involving extracted macro-actions and a hierarchical architecture of neural networks. We investigate a curriculum transfer training procedure and train the agent on a single machine with 4 GPUs and 48 CPU threads. On a 64x64 map and using restrictive units, we achieve a win rate of 99% against the level-1 built-in AI. Through the curriculum transfer learning algorithm and a mixture of combat models, we achieve a 93% win rate against the most difficult non-cheating level built-in AI (level-7). In this extended version of the paper, we improve our architecture to train the agent against the cheating level AIs and achieve the win rate against the level-8, level-9, and level-10 AIs as 96%, 97%, and 94%, respectively. Our codes are at https://github.com/liuruoze/HierNet-SC2. To provide a baseline referring the AlphaStar for our work as well as the research and open-source community, we reproduce a scaled-down version of it, mini-AlphaStar (mAS). The latest version of mAS is 1.07, which can be trained on the raw action space which has 564 actions. It is designed to run training on a single common machine, by making the hyper-parameters adjustable. We then compare our work with mAS using the same resources and show that our method is more effective. The codes of mini-AlphaStar are at https://github.com/liuruoze/mini-AlphaStar. We hope our study could shed some light on the future research of efficient reinforcement learning on SC2 and other large-scale games., Comment: 48 pages,21 figures

Incremental few-shot semantic segmentation (IFSS) targets at incrementally expanding model's capacity to segment new class of images supervised by only a few samples. However, features learned on old classes could significantly drift, causing catastrophic forgetting. Moreover, few samples for pixel-level segmentation on new classes lead to notorious overfitting issues in each learning session. In this paper, we explicitly represent class-based knowledge for semantic segmentation as a category embedding and a hyper-class embedding, where the former describes exclusive semantical properties, and the latter expresses hyper-class knowledge as class-shared semantic properties. Aiming to solve IFSS problems, we present EHNet, i.e., Embedding adaptive-update and Hyper-class representation Network from two aspects. First, we propose an embedding adaptive-update strategy to avoid feature drift, which maintains old knowledge by hyper-class representation, and adaptively update category embeddings with a class-attention scheme to involve new classes learned in individual sessions. Second, to resist overfitting issues caused by few training samples, a hyper-class embedding is learned by clustering all category embeddings for initialization and aligned with category embedding of the new class for enhancement, where learned knowledge assists to learn new knowledge, thus alleviating performance dependence on training data scale. Significantly, these two designs provide representation capability for classes with sufficient semantics and limited biases, enabling to perform segmentation tasks requiring high semantic dependence. Experiments on PASCAL-5i and COCO datasets show that EHNet achieves new state-of-the-art performance with remarkable advantages.

Point cloud completion has become increasingly popular among generation tasks of 3D point clouds, as it is a challenging yet indispensable problem to recover the complete shape of a 3D object from its partial observation. In this paper, we propose a novel SeedFormer to improve the ability of detail preservation and recovery in point cloud completion. Unlike previous methods based on a global feature vector, we introduce a new shape representation, namely Patch Seeds, which not only captures general structures from partial inputs but also preserves regional information of local patterns. Then, by integrating seed features into the generation process, we can recover faithful details for complete point clouds in a coarse-to-fine manner. Moreover, we devise an Upsample Transformer by extending the transformer structure into basic operations of point generators, which effectively incorporates spatial and semantic relationships between neighboring points. Qualitative and quantitative evaluations demonstrate that our method outperforms state-of-the-art completion networks on several benchmark datasets. Our code is available at https://github.com/hrzhou2/seedformer., Comment: Camera-ready, to be published in ECCV 2022, with supplementary material

This work investigates a simple yet powerful dense prediction task adapter for Vision Transformer (ViT). Unlike recently advanced variants that incorporate vision-specific inductive biases into their architectures, the plain ViT suffers inferior performance on dense predictions due to weak prior assumptions. To address this issue, we propose the ViT-Adapter, which allows plain ViT to achieve comparable performance to vision-specific transformers. Specifically, the backbone in our framework is a plain ViT that can learn powerful representations from large-scale multi-modal data. When transferring to downstream tasks, a pre-training-free adapter is used to introduce the image-related inductive biases into the model, making it suitable for these tasks. We verify ViT-Adapter on multiple dense prediction tasks, including object detection, instance segmentation, and semantic segmentation. Notably, without using extra detection data, our ViT-Adapter-L yields state-of-the-art 60.9 box AP and 53.0 mask AP on COCO test-dev. We hope that the ViT-Adapter could serve as an alternative for vision-specific transformers and facilitate future research. The code and models will be released at https://github.com/czczup/ViT-Adapter., Comment: Accepted to ICLR 2023

The transductive inference is an effective technique in the few-shot learning task, where query sets update prototypes to improve themselves. However, these methods optimize the model by considering only the classification scores of the query instances as confidence while ignoring the uncertainty of these classification scores. In this paper, we propose a novel method called Uncertainty-Based Network, which models the uncertainty of classification results with the help of mutual information. Specifically, we first data augment and classify the query instance and calculate the mutual information of these classification scores. Then, mutual information is used as uncertainty to assign weights to classification scores, and the iterative update strategy based on classification scores and uncertainties assigns the optimal weights to query instances in prototype optimization. Extensive results on four benchmarks show that Uncertainty-Based Network achieves comparable performance in classification accuracy compared to state-of-the-art method., Comment: Few-shot learning, Uncertainty, Mutual information

Temporal action detection (TAD) is extensively studied in the video understanding community by generally following the object detection pipeline in images. However, complex designs are not uncommon in TAD, such as two-stream feature extraction, multi-stage training, complex temporal modeling, and global context fusion. In this paper, we do not aim to introduce any novel technique for TAD. Instead, we study a simple, straightforward, yet must-known baseline given the current status of complex design and low detection efficiency in TAD. In our simple baseline (termed BasicTAD), we decompose the TAD pipeline into several essential components: data sampling, backbone design, neck construction, and detection head. We extensively investigate the existing techniques in each component for this baseline, and more importantly, perform end-to-end training over the entire pipeline thanks to the simplicity of design. As a result, this simple BasicTAD yields an astounding and real-time RGB-Only baseline very close to the state-of-the-art methods with two-stream inputs. In addition, we further improve the BasicTAD by preserving more temporal and spatial information in network representation (termed as PlusTAD). Empirical results demonstrate that our PlusTAD is very efficient and significantly outperforms the previous methods on the datasets of THUMOS14 and FineAction. Meanwhile, we also perform in-depth visualization and error analysis on our proposed method and try to provide more insights on the TAD problem. Our approach can serve as a strong baseline for future TAD research. The code and model will be released at https://github.com/MCG-NJU/BasicTAD., Comment: Accepted by CVIU

3D visual perception tasks, including 3D detection and map segmentation based on multi-camera images, are essential for autonomous driving systems. In this work, we present a new framework termed BEVFormer, which learns unified BEV representations with spatiotemporal transformers to support multiple autonomous driving perception tasks. In a nutshell, BEVFormer exploits both spatial and temporal information by interacting with spatial and temporal space through predefined grid-shaped BEV queries. To aggregate spatial information, we design spatial cross-attention that each BEV query extracts the spatial features from the regions of interest across camera views. For temporal information, we propose temporal self-attention to recurrently fuse the history BEV information. Our approach achieves the new state-of-the-art 56.9\% in terms of NDS metric on the nuScenes \texttt{test} set, which is 9.0 points higher than previous best arts and on par with the performance of LiDAR-based baselines. We further show that BEVFormer remarkably improves the accuracy of velocity estimation and recall of objects under low visibility conditions. The code is available at \url{https://github.com/zhiqi-li/BEVFormer}., Comment: Accepted to ECCV 2022

Point normal, as an intrinsic geometric property of 3D objects, not only serves conventional geometric tasks such as surface consolidation and reconstruction, but also facilitates cutting-edge learning-based techniques for shape analysis and generation. In this paper, we propose a normal refinement network, called Refine-Net, to predict accurate normals for noisy point clouds. Traditional normal estimation wisdom heavily depends on priors such as surface shapes or noise distributions, while learning-based solutions settle for single types of hand-crafted features. Differently, our network is designed to refine the initial normal of each point by extracting additional information from multiple feature representations. To this end, several feature modules are developed and incorporated into Refine-Net by a novel connection module. Besides the overall network architecture of Refine-Net, we propose a new multi-scale fitting patch selection scheme for the initial normal estimation, by absorbing geometry domain knowledge. Also, Refine-Net is a generic normal estimation framework: 1) point normals obtained from other methods can be further refined, and 2) any feature module related to the surface geometric structures can be potentially integrated into the framework. Qualitative and quantitative evaluations demonstrate the clear superiority of Refine-Net over the state-of-the-arts on both synthetic and real-scanned datasets. Our code is available at https://github.com/hrzhou2/refinenet., Comment: Accepted by TPAMI

PURPOSE The CLL14 study has established one-year fixed-duration treatment of venetoclax and obinutuzumab (Ven-Obi) for patients with previously untreated chronic lymphocytic leukemia. With all patients off treatment for least three years, we report a detailed analysis of minimal residual disease (MRD) kinetics and long-term outcome of patients treated in the CLL14 study. PATIENTS AND METHOD Patients were randomly assigned to receive six cycles of obinutuzumab with 12 cycles of venetoclax or 12 cycles of chlorambucil (CIb-Obi). Progression-free survival (PFS) was the primary end point. Key secondary end points included rates of undetectable MRD and overall survival. To analyze MRD kinetics, a population-based growth model with nonlinear mixed effects approach was developed. RESULTS Of 432 patients, 216 were assigned to Ven-Obi and 216 to CIb-Obi. Three months after treatment completion, 40% of patients in the Ven-Obi arm (7% in the CIb-Obi arm) had undetectable MRD levels < 10(-6) by next-generation sequencing in peripheral blood. Median MRD doubling time was longer after Ven-Obi than CIb-Obi therapy (median 80 v 69 days). At a median follow-up of 52.4 months, a sustained significant PFS improvement was observed in the Ven-Obi arm compared with CIb-Obi (median not reached v 36.4 months; hazard ratio 0.33; 95% CI, 0.25 to 0.45; P < .0001). The estimated 4-year PFS rate was 74.0% in the Ven-Obi and 35.4% in the CIb-Obi arm. No difference in overall survival was observed (hazard ratio 0.85; 95% CI, 0.54 to 1.35; P = .49). No new safety signals occurred. CONCLUSION Appearance of MRD after Ven-Obi is significantly slower than that after CIb-Obi with more effective MRD reduction. These findings translate into a superior long-term efficacy with the majority of Ven-Obi-treated patients remaining in remission. (C) 2021 by American Society of Clinical Oncology

Panoptic segmentation involves a combination of joint semantic segmentation and instance segmentation, where image contents are divided into two types: things and stuff. We present Panoptic SegFormer, a general framework for panoptic segmentation with transformers. It contains three innovative components: an efficient deeply-supervised mask decoder, a query decoupling strategy, and an improved post-processing method. We also use Deformable DETR to efficiently process multi-scale features, which is a fast and efficient version of DETR. Specifically, we supervise the attention modules in the mask decoder in a layer-wise manner. This deep supervision strategy lets the attention modules quickly focus on meaningful semantic regions. It improves performance and reduces the number of required training epochs by half compared to Deformable DETR. Our query decoupling strategy decouples the responsibilities of the query set and avoids mutual interference between things and stuff. In addition, our post-processing strategy improves performance without additional costs by jointly considering classification and segmentation qualities to resolve conflicting mask overlaps. Our approach increases the accuracy 6.2% PQ over the baseline DETR model. Panoptic SegFormer achieves state-of-the-art results on COCO test-dev with 56.2% PQ. It also shows stronger zero-shot robustness over existing methods. The code is released at {this https URL https://github.com/zhiqi-li/Panoptic-SegFormer}.

PURPOSE The CLL14 study has established one-year fixed-duration treatment of venetoclax and obinutuzumab (Ven-Obi) for patients with previously untreated chronic lymphocytic leukemia. With all patients off treatment for least three years, we report a detailed analysis of minimal residual disease (MRD) kinetics and long-term outcome of patients treated in the CLL14 study. PATIENTS AND METHOD Patients were randomly assigned to receive six cycles of obinutuzumab with 12 cycles of venetoclax or 12 cycles of chlorambucil (CIb-Obi). Progression-free survival (PFS) was the primary end point. Key secondary end points included rates of undetectable MRD and overall survival. To analyze MRD kinetics, a population-based growth model with nonlinear mixed effects approach was developed. RESULTS Of 432 patients, 216 were assigned to Ven-Obi and 216 to CIb-Obi. Three months after treatment completion, 40% of patients in the Ven-Obi arm (7% in the CIb-Obi arm) had undetectable MRD levels < 10(-6) by next-generation sequencing in peripheral blood. Median MRD doubling time was longer after Ven-Obi than CIb-Obi therapy (median 80 v 69 days). At a median follow-up of 52.4 months, a sustained significant PFS improvement was observed in the Ven-Obi arm compared with CIb-Obi (median not reached v 36.4 months; hazard ratio 0.33; 95% CI, 0.25 to 0.45; P < .0001). The estimated 4-year PFS rate was 74.0% in the Ven-Obi and 35.4% in the CIb-Obi arm. No difference in overall survival was observed (hazard ratio 0.85; 95% CI, 0.54 to 1.35; P = .49). No new safety signals occurred. CONCLUSION Appearance of MRD after Ven-Obi is significantly slower than that after CIb-Obi with more effective MRD reduction. These findings translate into a superior long-term efficacy with the majority of Ven-Obi-treated patients remaining in remission. (C) 2021 by American Society of Clinical Oncology

Temporal action detection aims to locate the boundaries of action in the video. The current method based on boundary matching enumerates and calculates all possible boundary matchings to generate proposals. However, these methods neglect the long-range context aggregation in boundary prediction. At the same time, due to the similar semantics of adjacent matchings, local semantic aggregation of densely-generated matchings cannot improve semantic richness and discrimination. In this paper, we propose the end-to-end proposal generation method named Dual Context Aggregation Network (DCAN) to aggregate context on two levels, namely, boundary level and proposal level, for generating high-quality action proposals, thereby improving the performance of temporal action detection. Specifically, we design the Multi-Path Temporal Context Aggregation (MTCA) to achieve smooth context aggregation on boundary level and precise evaluation of boundaries. For matching evaluation, Coarse-to-fine Matching (CFM) is designed to aggregate context on the proposal level and refine the matching map from coarse to fine. We conduct extensive experiments on ActivityNet v1.3 and THUMOS-14. DCAN obtains an average mAP of 35.39% on ActivityNet v1.3 and reaches mAP 54.14% at IoU@0.5 on THUMOS-14, which demonstrates DCAN can generate high-quality proposals and achieve state-of-the-art performance. We release the code at https://github.com/cg1177/DCAN., Comment: AAAI 2022 camera ready version

We propose an accurate and efficient scene text detection framework, termed FAST (i.e., faster arbitrarily-shaped text detector). Different from recent advanced text detectors that used complicated post-processing and hand-crafted network architectures, resulting in low inference speed, FAST has two new designs. (1) We design a minimalist kernel representation (only has 1-channel output) to model text with arbitrary shape, as well as a GPU-parallel post-processing to efficiently assemble text lines with a negligible time overhead. (2) We search the network architecture tailored for text detection, leading to more powerful features than most networks that are searched for image classification. Benefiting from these two designs, FAST achieves an excellent trade-off between accuracy and efficiency on several challenging datasets, including Total Text, CTW1500, ICDAR 2015, and MSRA-TD500. For example, FAST-T yields 81.6% F-measure at 152 FPS on Total-Text, outperforming the previous fastest method by 1.7 points and 70 FPS in terms of accuracy and speed. With TensorRT optimization, the inference speed can be further accelerated to over 600 FPS. Code and models will be released at https://github.com/czczup/FAST.