1. Niclosamide is active in vitro against mycetoma pathogens
- Author
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Abdelhalim B. Mahmoud, Shereen Abd Algaffar, W.W.J. (Wendy) Laureijssen - van de Sande, Sami Khalid, Marcel Kaiser, Pascal Mäser, Abdelhalim B. Mahmoud, Shereen Abd Algaffar, W.W.J. (Wendy) Laureijssen - van de Sande, Sami Khalid, Marcel Kaiser, and Pascal Mäser
- Abstract
Redox-active drugs are the mainstay of parasite chemotherapy. To assess their repurposing potential for eumycetoma, we have tested a set of nitroheterocycles and peroxides in vitro against two isolates of Madurella mycetomatis, the main causative agent of eumycetoma in Sudan. All the tested compounds were inactive except for niclosamide, which had minimal inhibitory concentrations of around 1 µg/mL. Further tests with niclosamide and niclosamide ethanolamine demonstrated in vitro activity not only against M. mycetomatis but also against Actinomadura spp., causative agents of actinomycetoma, with minimal inhibitory concentrations
- Published
- 2021
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