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2 results on '"Masiria, Geraldine"'

1. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.

Author

Lee, Ahwon, Shannon, Casey P, Amenyogbe, Nelly, Bennike, Tue TB, Diray-Arce, Joann, Idoko, Olubukola OT, Gill, Erin E, Ben-Othman, Rym, Pomat, William WS, van Haren, Simon SD, Cao, Kim-Anh Lê, Cox, Momoudou, Darboe, Alansana, Falsafi, Reza, Ferrari, Davide, Harbeson, Daniel DJ, He, Daniel, Bing, Cai, Hinshaw, Samuel SJ, Ndure, Jorjoh, Njie-Jobe, Jainaba, Pettengill, Matthew MA, Richmond, Peter C, Ford, Rebecca, Saleu, Gerard, Masiria, Geraldine, Matlam, John Paul, Kirarock, Wendy, Roberts, Elishia, Malek, Mehrnoush, Sanchez-Schmitz, Guzmán, Singh, Amrit, Angelidou, Asimenia, Smolen, Kinga, EPIC Consortium, Brinkman, Ryan RR, Ozonoff, Al, Hancock, Robert REW, van den Biggelaar, Anita AHJ, Steen, Hanno, Tebbutt, Scott SJ, Kampmann, Beate, Levy, Ofer, Kollmann, Tobias R, Lee, Ahwon, Shannon, Casey P, Amenyogbe, Nelly, Bennike, Tue TB, Diray-Arce, Joann, Idoko, Olubukola OT, Gill, Erin E, Ben-Othman, Rym, Pomat, William WS, van Haren, Simon SD, Cao, Kim-Anh Lê, Cox, Momoudou, Darboe, Alansana, Falsafi, Reza, Ferrari, Davide, Harbeson, Daniel DJ, He, Daniel, Bing, Cai, Hinshaw, Samuel SJ, Ndure, Jorjoh, Njie-Jobe, Jainaba, Pettengill, Matthew MA, Richmond, Peter C, Ford, Rebecca, Saleu, Gerard, Masiria, Geraldine, Matlam, John Paul, Kirarock, Wendy, Roberts, Elishia, Malek, Mehrnoush, Sanchez-Schmitz, Guzmán, Singh, Amrit, Angelidou, Asimenia, Smolen, Kinga, EPIC Consortium, Brinkman, Ryan RR, Ozonoff, Al, Hancock, Robert REW, van den Biggelaar, Anita AHJ, Steen, Hanno, Tebbutt, Scott SJ, Kampmann, Beate, Levy, Ofer, and Kollmann, Tobias R

Abstract

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2019

2. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.

Author

Lee, Amy H., Shannon, Casey P., Amenyogbe, Nelly, Bennike, Tue B., Diray-Arce, Joann, Idoko, Olubukola T., Gill, Erin E., Ben-Othman, Rym, Pomat, William S., van Haren, Simon D., Cao, Kim-Anh Lê, Cox, Momoudou, Darboe, Alansana, Falsafi, Reza, Ferrari, Davide, Harbeson, Daniel J., He, Daniel, Bing, Cai, Hinshaw, Samuel J., Ndure, Jorjoh, Njie-Jobe, Jainaba, Pettengill, Matthew A., Richmond, Peter C., Ford, Rebecca, Saleu, Gerard, Masiria, Geraldine, Matlam, John Paul, Kirarock, Wendy, Roberts, Elishia, Malek, Mehrnoush, Sanchez-Schmitz, Guzmán, Singh, Amrit, Angelidou, Asimenia, Smolen, Kinga K., Vo, Diana, Kraft, Ken, McEnaney, Kerry, Vignolo, Sofia, Marchant, Arnaud, Brinkman, Ryan R., Ozonoff, Al, Hancock, Robert E.W., van den Biggelaar, Anita H.J., Steen, Hanno, Tebbutt, Scott J., Kampmann, Beate, Levy, Ofer, Kollmann, Tobias R., Lee, Amy H., Shannon, Casey P., Amenyogbe, Nelly, Bennike, Tue B., Diray-Arce, Joann, Idoko, Olubukola T., Gill, Erin E., Ben-Othman, Rym, Pomat, William S., van Haren, Simon D., Cao, Kim-Anh Lê, Cox, Momoudou, Darboe, Alansana, Falsafi, Reza, Ferrari, Davide, Harbeson, Daniel J., He, Daniel, Bing, Cai, Hinshaw, Samuel J., Ndure, Jorjoh, Njie-Jobe, Jainaba, Pettengill, Matthew A., Richmond, Peter C., Ford, Rebecca, Saleu, Gerard, Masiria, Geraldine, Matlam, John Paul, Kirarock, Wendy, Roberts, Elishia, Malek, Mehrnoush, Sanchez-Schmitz, Guzmán, Singh, Amrit, Angelidou, Asimenia, Smolen, Kinga K., Vo, Diana, Kraft, Ken, McEnaney, Kerry, Vignolo, Sofia, Marchant, Arnaud, Brinkman, Ryan R., Ozonoff, Al, Hancock, Robert E.W., van den Biggelaar, Anita H.J., Steen, Hanno, Tebbutt, Scott J., Kampmann, Beate, Levy, Ofer, and Kollmann, Tobias R.

Abstract

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data fromblood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.

Published
2019

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