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16 results on '"McFarlane, Michael"'

1. Volatile organic compound and microbiome profiling in patients with colorectal cancer, their spouses and first degree relatives

Author

McFarlane, Michael J.

Subjects
610, RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Abstract

Colorectal cancer (CRC) is the one of the commonest causes of cancer and cancer related death worldwide. Its aetiology is linked to a number of reversible and irreversible genetic and environmental factors, including age, sex, genetics, smoking and diet. There has been a drive in recent years for non-invasive biomarkers for many malignant and non-malignant diseases across multiple medical specialties. One of the areas of interest is the detection of volatile organic compounds (VOCs) in various bodily substances by means such as mass spectrometry and electronic noses. CRC patients have been shown to be distinguishable from healthy controls using urinary VOC detection in several studies, including two published by the research group at UHCW and the University of Warwick. There has also been much interest in recent years into the role that the intestinal microbiome plays in health and disease in humans. The aim of this thesis was to characterise the urinary VOC and stool microbiome profiles of CRC patients, their spouses and first degree relatives. The aim being to determine whether the urinary VOC profiles could be distinguished using this technology and to try and better understand the underlying mechanism which lead to CRC carcinogenesis. The first degree relatives and spouses were selected as “common gene pool” and “shared environment” control groups respectively. This work was done using an LC-FAIMS-MS hybrid machine to detect urinary VOCs and 16s RNA sequencing using an Illumina Miseq platform. Comparisons were also made between pre-treatment and post-treatment CRC samples to try and determine if there was any change in either VOC or microbiome profiles after CRC treatment. The urinary VOC profiles of CRC subjects could be distinguished from both sets of healthy controls using a 5-fold cross validation and sparse logistics regression and Random Forrest statistical classifiers, achieving sensitivities of 63-69%, specificities of 64-69% and AUC 0.71-0.72. No statistically significant differences could be found in the urinary VOC profiles of pre-operative and post operative samples. Microbiome analysis revealed over 1300 operational taxonomic units (OTUs), with a similarity of >93% between the CRC samples and the control groups, with significantly different bacterial abundances identified in only 82 OTUs (6.2%), mainly Clostridiales bacteria. Pre-treatment and post-treatment sample analysis revealed differences of 17 (3%) and 22 (4%) OTUs at 3 and 6 months respectively, again principally clostridiales. This thesis provides further data on the microbiome composition in CRC. It also provides further proof of the utility of urinary VOCs, for the first time here using LC-FAIMS-MS technology, a variant of the previously utilised FAIMS technology, as a non-invasive biomarker for CRC.

Published
2017

2. Development of novel indicators

Author

McFarlane, Michael

Subjects
540
Abstract

Two indicating systems for measuring the dose of erythmal UV light have been developed. The first system is of a viologen salt, preferably benzyl viologen chloride, dissolved in poly(vinyl alcohol). This viologen dosimeter responds clearly to different wavelengths and intensities of UV light, although the colour change is hampered by the presence of oxygen, and completely reversed in the absence of UV light. Attempts are made to enhance the rate of the reaction of the viologens with UV light by changing the halide of the salt or adding electron donating species. There is no positive effect noted with the addition of these materials, but changing the halide does alter the UV spectrum of the viologen species, resulting in a slower reaction and thus providing a way of retarding the dosimeter if required. This dosimeter shows a demonstrable reaction to both artificial and natural sources of erythemal light. The second UV dosimeter is based on the tetrazolium salts and is shown to behave in a similar way to the viologen dosimeter, with the neotetrazolium chloride salt as a preferred material for use in the dosimeter. This tetrazolium system is shown to respond clearly to different wavelengths and intensities of light, and shows a demonstrable response to erythemal levels of UV. A solvatochromic indicator is developed, using Reichardt's dye adsorbed onto fumed silica to identify and measure the concentration of various solvent vapours. The fumed silica films are shown to be faster in response than polymer systems and have been shown to distinguish between different solvent vapours, but do not do so in a way that correlates with Reichardt's dye in the pure solvent. These films are shown to be more reliable in identifying alcohol vapours in a predictable manner. A review is also carried out on existing methods of assessing the performance of photocatalytic films, comparing them with a new method developed within the Mills group.

Published
2012
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3. Base-induced cyclisations of ortho-substituted nitro-aromatics

Author

McFarlane, Michael David and Smith, D. M.

Subjects
547, QD341.N8M3, Nitroaromatic compounds
Abstract

In Chapter I some of the chemical, biological and physical properties of purine analogues, particularly benzimidazole N-oxides, are briefly discussed. In Chapter II, the preparations of 4-, 5-, 6-, and 7-amino-1H-benzimidazole 3-oxides are described. The methods employed involve base-induced cyclisation of suitably protected aminonitrophenyl glycine derivatives (esters or nitriles) followed by hydrolysis of the ester or nitrile and decarboxylation. In Chapter III, attempts are made to prepare imidazopyridine N-oxides, an area of N-oxide chemistry little explored. Although few derivatives of this class of compound are synthesised, the preparation of the parent 3H-imidazo[4 ,5-b]pyridine 1-oxide is accomplished. In Chapter IV, the possibility of preparing 1-methylbenzimidazole 3-oxides by the methods used in Chapters II and III is investigated, but unexpected results are obtained e.g. cyclisation of O-nitropheny1-sarcosine esters gives 1-hydroxy-4-methylquinoxaline-2, 3-diones. These reactions have instigated an investigation into the general mechanism for the base-induced cyclisations discussed in this thesis.

Published
1988

4. Raising concerns about the Sepsis-3 definitions

Author

Universitat Rovira i Virgili, Catena, Fausto, Yuan, Kuo-Ching, Ulrych, Jan, Trana, Cristian, Talving, Peep, Siribumrungwong, Boonying, Shah, Jay N., Sato, Norio, Kafil, Hossein Samadi, Sakakushev, Boris, Reis, Tarcisio, Pupelis, Guntars, Ponce-de-Leon, Alfredo, Pintar, Tadeja, Picetti, Edoardo, Paolillo, Ciro, Ouadii, Mouaqit, Ordonez, Carlos A., Olaoye, Iyiade, Ofori-Asenso, Richard, Negoi, Ionut, Naidoo, Noel, Moore, Frederick A., Moore, Ernest E., Mesina, Cristian, Memish, Ziad A., McFarlane, Michael, Marwah, Sanjay, Major, Piotr, Manzano-Nunez, Ramiro, Machain, Gustavo M., Litvin, Andrey, Lee, Jae G., Latifi, Rifat, Labricciosa, Francesco M., Isik, Arda, Kok, Kenneth Y. Y., Koike, Kaoru, Khokha, Vladimir, Khamis, Faryal, Kenig, Jakub, Karamarkovic, Aleksandar, Kanj, Souha S., Gomes, Carlos A., Ghnnam, Wagih, Frattima, Sabrina, Fraga, Gustavo P., Ferrada, Paula, Enani, Mushira A., Elmangory, Mutasim M., Dogjani, Agron, Di Saverio, Salomone, Diaz, Jose J., Dhingra, Sameer, Davies, R. Justin, Cui, Yunfeng, de Souza, Hamilton P., De Simone, Belinda, Demetrashvili, Zaza, Jusoh, Asri Che, Beltran, Marcelo A., Baraket, Oussema, Bala, Miklosh, Baiocchi, Gian L., Augustin, Goran, Adesunkanmi, Abdulrashid K., Abu-Zidan, Fikri M., Coccolini, Federico, Giamarellou, Eleni, Bassetti, Matteo, Watkins, Richard R., Rello, Jordi, Hardcastle, Timothy C., Ansaloni, Luca, Kluger, Yoram, Sartelli, Massimo, Universitat Rovira i Virgili, Catena, Fausto, Yuan, Kuo-Ching, Ulrych, Jan, Trana, Cristian, Talving, Peep, Siribumrungwong, Boonying, Shah, Jay N., Sato, Norio, Kafil, Hossein Samadi, Sakakushev, Boris, Reis, Tarcisio, Pupelis, Guntars, Ponce-de-Leon, Alfredo, Pintar, Tadeja, Picetti, Edoardo, Paolillo, Ciro, Ouadii, Mouaqit, Ordonez, Carlos A., Olaoye, Iyiade, Ofori-Asenso, Richard, Negoi, Ionut, Naidoo, Noel, Moore, Frederick A., Moore, Ernest E., Mesina, Cristian, Memish, Ziad A., McFarlane, Michael, Marwah, Sanjay, Major, Piotr, Manzano-Nunez, Ramiro, Machain, Gustavo M., Litvin, Andrey, Lee, Jae G., Latifi, Rifat, Labricciosa, Francesco M., Isik, Arda, Kok, Kenneth Y. Y., Koike, Kaoru, Khokha, Vladimir, Khamis, Faryal, Kenig, Jakub, Karamarkovic, Aleksandar, Kanj, Souha S., Gomes, Carlos A., Ghnnam, Wagih, Frattima, Sabrina, Fraga, Gustavo P., Ferrada, Paula, Enani, Mushira A., Elmangory, Mutasim M., Dogjani, Agron, Di Saverio, Salomone, Diaz, Jose J., Dhingra, Sameer, Davies, R. Justin, Cui, Yunfeng, de Souza, Hamilton P., De Simone, Belinda, Demetrashvili, Zaza, Jusoh, Asri Che, Beltran, Marcelo A., Baraket, Oussema, Bala, Miklosh, Baiocchi, Gian L., Augustin, Goran, Adesunkanmi, Abdulrashid K., Abu-Zidan, Fikri M., Coccolini, Federico, Giamarellou, Eleni, Bassetti, Matteo, Watkins, Richard R., Rello, Jordi, Hardcastle, Timothy C., Ansaloni, Luca, Kluger, Yoram, and Sartelli, Massimo

Abstract

The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in the evolution of our understanding of sepsis. Nevertheless, more than a year after their publication, we have a few concerns regarding the use of the Sepsis-3 definitions.

Published
2018

5. An assessment of candidate genes to assist prognosis in gastric cancer

Author

McFarlane, Michael, Brettschneider, Julia, Gelsthorpe, Adrian, James, Sean, Snead, David, Gopalakrishnan, Kishore, Mehenna, Hisham, Jankowski, Janusz, Arasaradnam, Ramesh, Nwokolo, Chuka, McFarlane, Michael, Brettschneider, Julia, Gelsthorpe, Adrian, James, Sean, Snead, David, Gopalakrishnan, Kishore, Mehenna, Hisham, Jankowski, Janusz, Arasaradnam, Ramesh, and Nwokolo, Chuka

Abstract

Gastric cancer (GC) is the fourth commonest cancer worldwide, with the second highest mortality rate. Its poor mortality is linked to delayed presentation. There is a drive towards non-invasive biomarker screening and monitoring of many different types of cancer, although with limited success so far. We aimed to determine if any genes from a 32-gene panel could be used to determine GC prognosis. We carried out a retrospective study on the expression of 32 genes, selected for their proven or potential links to GC, on historic formalin fixed paraffin-embedded (FFPE) GC specimens from our unit. Gene expression was measured using quantitative nuclease protection assays (qNPA) technology. Following statistical analysis of the results, immunohistochemical staining for eight genes, both discriminating and non-discriminating, was conducted in seven age and sex matched non-metastatic: metastatic GC pairings. The stained samples were reviewed by two blinded consultant histopathologists. Multivariate Cox analysis of the gene expression data revealed metastatic status, age, sex and five genes appeared to influence GC survival. Genes negatively influencing survival included and (relative risks 2.20, 3.73 and 7.53 respectively). Genes conveying survival benefit included and (relative risks 0.10 and 0.24 respectively). Immunohistochemical staining of seven age and sex matched non-metastatic: metastatic pairs revealed no association between gene expression and protein expression. Our study found several genes whose expression may affect GC prognosis. However, immunohistochemical analysis revealed no association between gene expression and protein expression. It remains to be determined whether gene expression or protein expression are reliable means of assessing GC prognosis.

Published
2018

6. The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship-results from an international cross-sectional survey

Author

Sartelli, Massimo, Labricciosa, Francesco M., Barbadoro, Pamela, Pagani, Leonardo, Ansaloni, Luca, Brink, Adrian J., Carlet, Jean, Khanna, Ashish, Chichom-Mefire, Alain, Coccolini, Federico, Di Saverio, Salomone, May, Addison K., Viale, Pierluigi, Watkins, Richard R., Scudeller, Luigia, Abbo, Lilian M., Abu-Zidan, FikriM., Adesunkanmi, Abdulrashid K., Al-Dahir, Sara, Al-Hasan, Majdi N., Alis, Halil, Alves, Carlos, Araujo da Silva, Andre R., Augustin, Goran, Bala, Miklosh, Barie, Philip S., Beltran, Marcelo A., Bhangu, Aneel, Bouchra, Belefquih, Brecher, Stephen M., Cainzos, Miguel A., Camacho-Ortiz, Adrian, Catani, Marco, Chandy, Sujith J., Jusoh, Asri Che, Cherry-Bukowiec, Jill R., Chiara, Osvaldo, Colak, Elif, Cornely, Oliver A., Cui, Yunfeng, Demetrashvili, Zaza, De Simone, Belinda, De Waele, Jan J., Dhingra, Sameer, Di Marzo, Francesco, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, ThereseM., Elmangory, Mutasim M., Enani, Mushira A., Ferrada, Paula, Foianini, J. Esteban, Gachabayov, Mahir, Gandhi, Chinmay, Ghnnam, Wagih Mommtaz, Giamarellou, Helen, Gkiokas, Georgios, Gomi, Harumi, Goranovic, Tatjana, Griffiths, Ewen A., Guerra Gronerth, Rosio I., Haidamus Monteiro, Julio C., Hardcastle, Timothy C., Hecker, Andreas, Hodonou, Adrien M., Ioannidis, Orestis, Isik, Arda, Iskandar, Katia A., Kafil, Hossein S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar R., Kenig, Jakub, Kerschaever, Ivan, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Hong B., Ko, Wen-Chien, Koike, Kaoru, Kozlovska, Iryna, Kumar, Anand, Lagunes, Leonel, Latifi, Rifat, Lee, Jae G., Lee, Young R., Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Lowman, Warren, Machain, Gustavo M., Maegele, Marc, Major, Piotr, Malama, Sydney, Manzano-Nunez, Ramiro, Marinis, Athanasios, Martinez Casas, Isidro, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael E., Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Mishra, ShyamK., Moore, Ernest E., Munyika, Akutu, Mylonakis, Eleftherios, Napolitano, Lena, Negoi, Ionut, Nestorovic, Milica D., Nicolau, David P., Omari, Abdelkarim H., Ordonez, Carlos A., Paiva, Jose-Artur, Pant, Narayan D., Parreira, Jose G., Pedziwiatr, Michal, Pereira, BrunoM., Ponce-de-Leon, Alfredo, Poulakou, Garyphallia, Preller, Jacobus, Pulcini, Celine, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reis, Tarcisio, Rems, Miran, Rizoli, Sandro, Roberts, Jason, Pereira, Nuno Rocha, Rodriguez-Bano, Jesus, Sakakushev, Boris, Sanders, James, Santos, Natalia, Sato, Norio, Sawyer, Robert G., Scarpelini, Sandro, Scoccia, Loredana, Shafiq, Nusrat, Shelat, Vishalkumar, Sifri, Costi D., Siribumrungwong, Boonying, Soreide, Kjetil, Soto, Rodolfo, de Souza, Hamilton P., Talving, Peep, Trung, Ngo Tat, Tessier, Jeffrey M., Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Van Goor, Harry, Vereczkei, Andras, Wagenlehner, Floriann, Xiao, Yonghong, Yuan, Kuo-Ching, Wechsler-Foerdoes, Agnes, Zahar, Jean-Ralph, Zakrison, Tanya L., Zuckerbraun, Brian, Zuidema, Wietse P., Catena, Fausto, Sartelli, Massimo, Labricciosa, Francesco M., Barbadoro, Pamela, Pagani, Leonardo, Ansaloni, Luca, Brink, Adrian J., Carlet, Jean, Khanna, Ashish, Chichom-Mefire, Alain, Coccolini, Federico, Di Saverio, Salomone, May, Addison K., Viale, Pierluigi, Watkins, Richard R., Scudeller, Luigia, Abbo, Lilian M., Abu-Zidan, FikriM., Adesunkanmi, Abdulrashid K., Al-Dahir, Sara, Al-Hasan, Majdi N., Alis, Halil, Alves, Carlos, Araujo da Silva, Andre R., Augustin, Goran, Bala, Miklosh, Barie, Philip S., Beltran, Marcelo A., Bhangu, Aneel, Bouchra, Belefquih, Brecher, Stephen M., Cainzos, Miguel A., Camacho-Ortiz, Adrian, Catani, Marco, Chandy, Sujith J., Jusoh, Asri Che, Cherry-Bukowiec, Jill R., Chiara, Osvaldo, Colak, Elif, Cornely, Oliver A., Cui, Yunfeng, Demetrashvili, Zaza, De Simone, Belinda, De Waele, Jan J., Dhingra, Sameer, Di Marzo, Francesco, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, ThereseM., Elmangory, Mutasim M., Enani, Mushira A., Ferrada, Paula, Foianini, J. Esteban, Gachabayov, Mahir, Gandhi, Chinmay, Ghnnam, Wagih Mommtaz, Giamarellou, Helen, Gkiokas, Georgios, Gomi, Harumi, Goranovic, Tatjana, Griffiths, Ewen A., Guerra Gronerth, Rosio I., Haidamus Monteiro, Julio C., Hardcastle, Timothy C., Hecker, Andreas, Hodonou, Adrien M., Ioannidis, Orestis, Isik, Arda, Iskandar, Katia A., Kafil, Hossein S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar R., Kenig, Jakub, Kerschaever, Ivan, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Hong B., Ko, Wen-Chien, Koike, Kaoru, Kozlovska, Iryna, Kumar, Anand, Lagunes, Leonel, Latifi, Rifat, Lee, Jae G., Lee, Young R., Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Lowman, Warren, Machain, Gustavo M., Maegele, Marc, Major, Piotr, Malama, Sydney, Manzano-Nunez, Ramiro, Marinis, Athanasios, Martinez Casas, Isidro, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael E., Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Mishra, ShyamK., Moore, Ernest E., Munyika, Akutu, Mylonakis, Eleftherios, Napolitano, Lena, Negoi, Ionut, Nestorovic, Milica D., Nicolau, David P., Omari, Abdelkarim H., Ordonez, Carlos A., Paiva, Jose-Artur, Pant, Narayan D., Parreira, Jose G., Pedziwiatr, Michal, Pereira, BrunoM., Ponce-de-Leon, Alfredo, Poulakou, Garyphallia, Preller, Jacobus, Pulcini, Celine, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reis, Tarcisio, Rems, Miran, Rizoli, Sandro, Roberts, Jason, Pereira, Nuno Rocha, Rodriguez-Bano, Jesus, Sakakushev, Boris, Sanders, James, Santos, Natalia, Sato, Norio, Sawyer, Robert G., Scarpelini, Sandro, Scoccia, Loredana, Shafiq, Nusrat, Shelat, Vishalkumar, Sifri, Costi D., Siribumrungwong, Boonying, Soreide, Kjetil, Soto, Rodolfo, de Souza, Hamilton P., Talving, Peep, Trung, Ngo Tat, Tessier, Jeffrey M., Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Van Goor, Harry, Vereczkei, Andras, Wagenlehner, Floriann, Xiao, Yonghong, Yuan, Kuo-Ching, Wechsler-Foerdoes, Agnes, Zahar, Jean-Ralph, Zakrison, Tanya L., Zuckerbraun, Brian, Zuidema, Wietse P., and Catena, Fausto

Abstract

Background: Antimicrobial Stewardship Programs (ASPs) have been promoted to optimize antimicrobial usage and patient outcomes, and to reduce the emergence of antimicrobial-resistant organisms. However, the best strategies for an ASP are not definitively established and are likely to vary based on local culture, policy, and routine clinical practice, and probably limited resources in middle-income countries. The aim of this study is to evaluate structures and resources of antimicrobial stewardship teams (ASTs) in surgical departments from different regions of the world. Methods: A cross-sectional web-based survey was conducted in 2016 on 173 physicians who participated in the AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections) project and on 658 international experts in the fields of ASPs, infection control, and infections in surgery. Results: The response rate was 19.4%. One hundred fifty-six (98.7%) participants stated their hospital had a multidisciplinary AST. The median number of physicians working inside the team was five [interquartile range 4-6]. An infectious disease specialist, a microbiologist and an infection control specialist were, respectively, present in 80.1, 76.3, and 67.9% of the ASTs. A surgeon was a component in 59.0% of cases and was significantly more likely to be present in university hospitals (89.5%, p < 0.05) compared to community teaching (83.3%) and community hospitals (66.7%). Protocols for pre-operative prophylaxis and for antimicrobial treatment of surgical infections were respectively implemented in 96.2 and 82.3% of the hospitals. The majority of the surgical departments implemented both persuasive and restrictive interventions (72.8%). The most common types of interventions in surgical departments were dissemination of educational materials (62.5%), expert approval (61.0%), audit and feedback (55.1%), educational outreach (53.7%), and compulsory order forms (51.5%). Conclusion: T

Published
2017

7. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author

Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Carlet, Jean, Brink, Adrian, Hardcastle, Timothy C., Khanna, Ashish, Chicom-Mefire, Alain, Rodriguez-Bano, Jesus, Nathwani, Dilip, Mendelson, Marc, Watkins, Richard R., Pulcini, Celine, Beovic, Bojana, May, Addison K., Itani, Kamal M. F., Mazuski, John E., Fry, Donald E., Coccolini, Federico, Rasa, Kemal, Montravers, Philippe, Eckmann, Christian, Abbo, Lilian M., Abubakar, Salisu, Abu-Zidan, Fikri M., Adesunkanmi, Abdulrashid Kayode, Al-Hasan, Majdi N., Althani, Asma A., Ticas, Jorge Eduardo Alvarenga, Ansari, Shamshul, Ansumana, Rashid, Araujo da Silva, Andre Ricardo, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussema, Bassett, Matteo, Bellanova, Giovanni, Beltran, Marcelo A., Ben-Ishay, Ofir, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Bueno, Juan, Cainzos, Miguel A., Cairns, Kelly, Camacho-Ortiz, Adrian, Ceresoli, Marco, Chandy, Sujith J., Cherry-Bukowiec, Jill R., Cirocchi, Roberto, Colak, Elif, Corcione, Antonio, Cornely, Oliver A., Cortese, Francesco, Cui, Yunfeng, Curcio, Daniel, Damaskos, Dimitris, Das, Koray, Delibegovic, Samir, Deme-Trashvili, Zaza, De Simone, Belinda, de Souza, Hamilton Petry, De Waele, Jan, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, Therese M., Dupont, Herve, Egiev, Valery N., Eid, Hani O., Elmangory, Mutasim, Marei, Hany El-Sayed, Enani, Mushira Abdulaziz, Escandon-Vargas, Kevin, Faro Junior, Mario P., Ferrada, Paula, Foghetti, Domitilla, Foianini, Esteban, Fraga, Gustavo P., Frattima, Sabrina, Gandhi, Chinmay, Gattuso, Gianni, Giamarellou, Eleni, Ghnnam, Wagih, Gkiokas, George, Girardis, Massimo, Goff, Debbie A., Gomes, Carlos Augusto, Gomi, Harumi, Guerra Gronerth, Rosio Isabel, Guirao, Xavier, Guzman-Blanco, Manuel, Haque, Mainul, Hecker, Andreas, Hell, Markus, Herzog, Torsten, Hicks, Lauri, Kafka-Ritsch, Reinhold, Kao, Lillian S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kashuk, Jeffry, Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kirkpatrick, Andrew W., Korner, Hartwig, Koike, Kaoru, Kok, Kenneth Y. Y., Kon, Kateryna, Kong, Victor, Inaba, Kenji, Ioannidis, Orestis, Isik, Arda, Iskandar, Katia, Labbate, Maurizio, Labricciosa, Francesco M., Lagrou, Katrien, Lagunes, Leonel, Latifi, Rifat, Lasithiotakis, Kostas, Laxminarayan, Ramanan, Lee, Jae Gil, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Liau, Kui-Hin, Litvin, Andrey, Loho, Tonny, Lowman, Warren, Machain, Gustavo M., Maier, Ronald V., Manzano-Nunez, Ramiro, Marinis, Athanasios, Marmorale, Cristina, Martin-Loeches, Ignacio, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael, de Melo, Renato Bessa, Melotti, Maria Rita, Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Menichetti, Francesco, Mishra, Shyam Kumar, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Napolitano, Lena, Negoi, Ionut, Nicolau, David P., Nikolopoulos, Ioannis, Nord, Carl Erik, Ofori-Asenso, Richard, Olaoye, Iyiade, Omari, Abdelkarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Ouedraogo, Abdoul-Salam, Pagani, Leonardo, Paiva, Jose Artur, Parreira, Jose Gustavo, Pata, Francesco, Pereira, Jorge, Pereira, Nuno R., Petrosillo, Nicola, Picetti, Edoardo, Pintar, Tadeja, Ponce-de-Leon, Alfredo, Popovski, Zagorka, Poulakou, Garyphallia, Preller, Jacobus, Guerrero, Adrian Puello, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reichert, Martin, Reinhart, Konrad, Rems, Miran, Rello, Jordi, Rizoli, Sandro, Roberts, Jason, Rubio-Perez, Ines, Ruppc, Etienne, Sakakushev, Boris, Sall, Ibrahima, Kafil, Hossein Samadi, Sanders, James, Sato, Norio, Sawyer, Robert G., Scalea, Thomas, Scibe, Rodolfo, Scudeller, Luigia, Segovia Lohse, Helmut, Sganga, Gabriele, Shafiq, Nusrat, Shah, Jay N., Spigaglia, Patrizia, Suroowan, Shanoo, Tsioutis, Constantinos, Sifri, Costi D., Siribumrungwong, Boonying, Sugrue, Michael, Talving, Peep, Tan, Boun Kim, Tarasconi, Antonio, Tascini, Carlo, Tilsed, Jonathan, Timsit, Jean-Francois, Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Velmahos, George, Vereczkei, Andras G., Viale, Pierluigi, Vila Estape, Jordi, Viscoli, Claudio, Wagenlehner, Florian, Wright, Brian J., Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean Ralph, Mergulhao, Paulo, Catena, Fausto, Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Carlet, Jean, Brink, Adrian, Hardcastle, Timothy C., Khanna, Ashish, Chicom-Mefire, Alain, Rodriguez-Bano, Jesus, Nathwani, Dilip, Mendelson, Marc, Watkins, Richard R., Pulcini, Celine, Beovic, Bojana, May, Addison K., Itani, Kamal M. F., Mazuski, John E., Fry, Donald E., Coccolini, Federico, Rasa, Kemal, Montravers, Philippe, Eckmann, Christian, Abbo, Lilian M., Abubakar, Salisu, Abu-Zidan, Fikri M., Adesunkanmi, Abdulrashid Kayode, Al-Hasan, Majdi N., Althani, Asma A., Ticas, Jorge Eduardo Alvarenga, Ansari, Shamshul, Ansumana, Rashid, Araujo da Silva, Andre Ricardo, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussema, Bassett, Matteo, Bellanova, Giovanni, Beltran, Marcelo A., Ben-Ishay, Ofir, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Bueno, Juan, Cainzos, Miguel A., Cairns, Kelly, Camacho-Ortiz, Adrian, Ceresoli, Marco, Chandy, Sujith J., Cherry-Bukowiec, Jill R., Cirocchi, Roberto, Colak, Elif, Corcione, Antonio, Cornely, Oliver A., Cortese, Francesco, Cui, Yunfeng, Curcio, Daniel, Damaskos, Dimitris, Das, Koray, Delibegovic, Samir, Deme-Trashvili, Zaza, De Simone, Belinda, de Souza, Hamilton Petry, De Waele, Jan, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, Therese M., Dupont, Herve, Egiev, Valery N., Eid, Hani O., Elmangory, Mutasim, Marei, Hany El-Sayed, Enani, Mushira Abdulaziz, Escandon-Vargas, Kevin, Faro Junior, Mario P., Ferrada, Paula, Foghetti, Domitilla, Foianini, Esteban, Fraga, Gustavo P., Frattima, Sabrina, Gandhi, Chinmay, Gattuso, Gianni, Giamarellou, Eleni, Ghnnam, Wagih, Gkiokas, George, Girardis, Massimo, Goff, Debbie A., Gomes, Carlos Augusto, Gomi, Harumi, Guerra Gronerth, Rosio Isabel, Guirao, Xavier, Guzman-Blanco, Manuel, Haque, Mainul, Hecker, Andreas, Hell, Markus, Herzog, Torsten, Hicks, Lauri, Kafka-Ritsch, Reinhold, Kao, Lillian S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kashuk, Jeffry, Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kirkpatrick, Andrew W., Korner, Hartwig, Koike, Kaoru, Kok, Kenneth Y. Y., Kon, Kateryna, Kong, Victor, Inaba, Kenji, Ioannidis, Orestis, Isik, Arda, Iskandar, Katia, Labbate, Maurizio, Labricciosa, Francesco M., Lagrou, Katrien, Lagunes, Leonel, Latifi, Rifat, Lasithiotakis, Kostas, Laxminarayan, Ramanan, Lee, Jae Gil, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Liau, Kui-Hin, Litvin, Andrey, Loho, Tonny, Lowman, Warren, Machain, Gustavo M., Maier, Ronald V., Manzano-Nunez, Ramiro, Marinis, Athanasios, Marmorale, Cristina, Martin-Loeches, Ignacio, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael, de Melo, Renato Bessa, Melotti, Maria Rita, Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Menichetti, Francesco, Mishra, Shyam Kumar, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Napolitano, Lena, Negoi, Ionut, Nicolau, David P., Nikolopoulos, Ioannis, Nord, Carl Erik, Ofori-Asenso, Richard, Olaoye, Iyiade, Omari, Abdelkarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Ouedraogo, Abdoul-Salam, Pagani, Leonardo, Paiva, Jose Artur, Parreira, Jose Gustavo, Pata, Francesco, Pereira, Jorge, Pereira, Nuno R., Petrosillo, Nicola, Picetti, Edoardo, Pintar, Tadeja, Ponce-de-Leon, Alfredo, Popovski, Zagorka, Poulakou, Garyphallia, Preller, Jacobus, Guerrero, Adrian Puello, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reichert, Martin, Reinhart, Konrad, Rems, Miran, Rello, Jordi, Rizoli, Sandro, Roberts, Jason, Rubio-Perez, Ines, Ruppc, Etienne, Sakakushev, Boris, Sall, Ibrahima, Kafil, Hossein Samadi, Sanders, James, Sato, Norio, Sawyer, Robert G., Scalea, Thomas, Scibe, Rodolfo, Scudeller, Luigia, Segovia Lohse, Helmut, Sganga, Gabriele, Shafiq, Nusrat, Shah, Jay N., Spigaglia, Patrizia, Suroowan, Shanoo, Tsioutis, Constantinos, Sifri, Costi D., Siribumrungwong, Boonying, Sugrue, Michael, Talving, Peep, Tan, Boun Kim, Tarasconi, Antonio, Tascini, Carlo, Tilsed, Jonathan, Timsit, Jean-Francois, Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Velmahos, George, Vereczkei, Andras G., Viale, Pierluigi, Vila Estape, Jordi, Viscoli, Claudio, Wagenlehner, Florian, Wright, Brian J., Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean Ralph, Mergulhao, Paulo, and Catena, Fausto

Abstract

This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.

Published
2017

8. WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting

Author

Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Coccolini, Federico, Griffiths, Ewen A., Abu-Zidan, Fikri M., Di Saverio, Salomone, Ulrych, Jan, Kluger, Yoram, Ben-Ishay, Ofir, Moore, Frederick A., Ivatury, Rao R., Coimbra, Raul, Peitzman, Andrew B., Leppaniemi, Ari, Fraga, Gustavo P., Maier, Ronald V., Chiara, Osvaldo, Kashuk, Jeffry, Sakakushev, Boris, Weber, Dieter G., Latifi, Rifat, Biffl, Walter, Bala, Miklosh, Karamarkovic, Aleksandar, Inaba, Kenji, Ordonez, Carlos A., Hecker, Andreas, Augustin, Goran, Demetrashvili, Zaza, Melo, Renato Bessa, Marwah, Sanjay, Zachariah, Sanoop K., Shelat, Vishal G., McFarlane, Michael, Rems, Miran, Gomes, Carlos Augusto, Faro, Mario Paulo, Júnior, Gerson Alves Pereira, Negoi, Ionut, Cui, Yunfeng, Sato, Norio, Vereczkei, Andras, Bellanova, Giovanni, Birindelli, Arianna, Di Carlo, Isidoro, Kok, Kenneth Y, Gachabayov, Mahir, Gkiokas, Georgios, Bouliaris, Konstantinos, Çolak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, Moore, Ernest E., Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Coccolini, Federico, Griffiths, Ewen A., Abu-Zidan, Fikri M., Di Saverio, Salomone, Ulrych, Jan, Kluger, Yoram, Ben-Ishay, Ofir, Moore, Frederick A., Ivatury, Rao R., Coimbra, Raul, Peitzman, Andrew B., Leppaniemi, Ari, Fraga, Gustavo P., Maier, Ronald V., Chiara, Osvaldo, Kashuk, Jeffry, Sakakushev, Boris, Weber, Dieter G., Latifi, Rifat, Biffl, Walter, Bala, Miklosh, Karamarkovic, Aleksandar, Inaba, Kenji, Ordonez, Carlos A., Hecker, Andreas, Augustin, Goran, Demetrashvili, Zaza, Melo, Renato Bessa, Marwah, Sanjay, Zachariah, Sanoop K., Shelat, Vishal G., McFarlane, Michael, Rems, Miran, Gomes, Carlos Augusto, Faro, Mario Paulo, Júnior, Gerson Alves Pereira, Negoi, Ionut, Cui, Yunfeng, Sato, Norio, Vereczkei, Andras, Bellanova, Giovanni, Birindelli, Arianna, Di Carlo, Isidoro, Kok, Kenneth Y, Gachabayov, Mahir, Gkiokas, Georgios, Bouliaris, Konstantinos, Çolak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, and Moore, Ernest E.

Abstract

Acute left sided colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in acute setting. A World Society of Emergency Surgery (WSES) Consensus Conference on acute diverticulitis was held during the 3rd World Congress of the WSES in Jerusalem, Israel, on July 7th, 2015. During this consensus conference the guidelines for the management of acute left sided colonic diverticulitis in the emergency setting were presented and discussed. This document represents the executive summary of the final guidelines approved by the consensus conference.

Published
2016

9. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Author

UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, Viale, Perluigi, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, and Viale, Perluigi

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

10. WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting

Author

University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Coccolini, Federico, Griffiths, Ewen A., Abu-Zidan, Fikri M., Di Saverio, Salomone, Ulrych, Jan, Kluger, Yoram, Ben-Ishay, Ofir, Moore, Frederick A., Ivatury, Rao R., Coimbra, Raul, Peitzman, Andrew B., Leppäniemi, Ari, Fraga, Gustavo P., Maier, Ronald V., Chiara, Osvaldo, Kashuk, Jeffry, Sakakushev, Boris, Weber, Dieter G., Latifi, Rifat, Biffl, Walter, Bala, Miklosh, Karamarkovic, Aleksandar, Inaba, Kenji, Ordonez, Carlos A., Hecker, Andreas, Augustin, Goran, Demetrashvili, Zaza, Melo, Renato Bessa, Marwah, Sanjay, Zachariah, Sanoop K., Shelat, Vishal G., McFarlane, Michael, Rems, Miran, Gomes, Carlos Augusto, Faro, Mario Paulo, Pereira Junior, Gerson Alves, Negoi, Ionut, Cui, Yunfeng, Sato, Norio, Vereczkei, Andras, Bellanova, Giovanni, Birindelli, Arianna, Di Carlo, Isidoro, Kok, Kenneth Y., Gachabayov, Mahir, Gkiokas, Georgios, Bouliaris, Konstantinos, Colak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, Moore, Ernest E., University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Coccolini, Federico, Griffiths, Ewen A., Abu-Zidan, Fikri M., Di Saverio, Salomone, Ulrych, Jan, Kluger, Yoram, Ben-Ishay, Ofir, Moore, Frederick A., Ivatury, Rao R., Coimbra, Raul, Peitzman, Andrew B., Leppäniemi, Ari, Fraga, Gustavo P., Maier, Ronald V., Chiara, Osvaldo, Kashuk, Jeffry, Sakakushev, Boris, Weber, Dieter G., Latifi, Rifat, Biffl, Walter, Bala, Miklosh, Karamarkovic, Aleksandar, Inaba, Kenji, Ordonez, Carlos A., Hecker, Andreas, Augustin, Goran, Demetrashvili, Zaza, Melo, Renato Bessa, Marwah, Sanjay, Zachariah, Sanoop K., Shelat, Vishal G., McFarlane, Michael, Rems, Miran, Gomes, Carlos Augusto, Faro, Mario Paulo, Pereira Junior, Gerson Alves, Negoi, Ionut, Cui, Yunfeng, Sato, Norio, Vereczkei, Andras, Bellanova, Giovanni, Birindelli, Arianna, Di Carlo, Isidoro, Kok, Kenneth Y., Gachabayov, Mahir, Gkiokas, Georgios, Bouliaris, Konstantinos, Colak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, and Moore, Ernest E.

Abstract

Acute left sided colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in acute setting. A World Society of Emergency Surgery (WSES) Consensus Conference on acute diverticulitis was held during the 3rd World Congress of the WSES in Jerusalem, Israel, on July 7th, 2015. During this consensus conference the guidelines for the management of acute left sided colonic diverticulitis in the emergency setting were presented and discussed. This document represents the executive summary of the final guidelines approved by the consensus conference.

Published
2016

11. Antimicrobials

Author

University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, and Viale, Perluigi

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

12. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, and Viale, Perluigi

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

13. A proposal for a CT driven classification of left colon acute diverticulitis.

Author

30409205, Sartelli, Massimo, Moore, Frederick A, Ansaloni, Luca, Di Saverio, Salomone, Coccolini, Federico, Griffiths, Ewen A, Coimbra, Raul, Agresta, Ferdinando, Sakakushev, Boris, Ordoñez, Carlos A, Abu-Zidan, Fikri M, Karamarkovic, Aleksandar, Augustin, Goran, Costa Navarro, David, Ulrych, Jan, Demetrashvili, Zaza, Melo, Renato B, Marwah, Sanjay, Zachariah, Sanoop K, Wani, Imtiaz, Shelat, Vishal G, Kim, Jae, McFarlane, Michael, Pintar, Tadaja, Rems, Miran, Bala, Miklosh, Ben-Ishay, Offir, Gomes, Carlos, Faro, Mario, Pereira, Gerson, Catani, Marco, Baiocchi, Gianluca, Bini, Roberto, Anania, Gabriele, Negoi, Ionut, Kecbaja, Zurabs, Omari, Abdelkarim H, Cui, Yunfeng, Kenig, Jakub, Sato, Norio, Vereczkei, Andras, Skrovina, Matej, Das, Koray, Bellanova, Giovanni, Di Carlo, Isidoro, Segovia Lohse, Helmut A, Kong, Victor, Kok, Kenneth Y, Massalou, Damien, Smirnov, Dmitry, Gachabayov, Mahir, Gkiokas, Georgios, Marinis, Athanasios, Spyropoulos, Charalampos, Nikolopoulos, Ioannis, Bouliaris, Konstantinos, Tepp, Jaan, Lohsiriwat, Varut, Çolak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, Abbas, Ashraf, Tranà, Cristian, Caproli, Emanuele, Soldatenkova, Darija, Corcione, Francesco, Piazza, Diego, Catena, Fausto, 30409205, Sartelli, Massimo, Moore, Frederick A, Ansaloni, Luca, Di Saverio, Salomone, Coccolini, Federico, Griffiths, Ewen A, Coimbra, Raul, Agresta, Ferdinando, Sakakushev, Boris, Ordoñez, Carlos A, Abu-Zidan, Fikri M, Karamarkovic, Aleksandar, Augustin, Goran, Costa Navarro, David, Ulrych, Jan, Demetrashvili, Zaza, Melo, Renato B, Marwah, Sanjay, Zachariah, Sanoop K, Wani, Imtiaz, Shelat, Vishal G, Kim, Jae, McFarlane, Michael, Pintar, Tadaja, Rems, Miran, Bala, Miklosh, Ben-Ishay, Offir, Gomes, Carlos, Faro, Mario, Pereira, Gerson, Catani, Marco, Baiocchi, Gianluca, Bini, Roberto, Anania, Gabriele, Negoi, Ionut, Kecbaja, Zurabs, Omari, Abdelkarim H, Cui, Yunfeng, Kenig, Jakub, Sato, Norio, Vereczkei, Andras, Skrovina, Matej, Das, Koray, Bellanova, Giovanni, Di Carlo, Isidoro, Segovia Lohse, Helmut A, Kong, Victor, Kok, Kenneth Y, Massalou, Damien, Smirnov, Dmitry, Gachabayov, Mahir, Gkiokas, Georgios, Marinis, Athanasios, Spyropoulos, Charalampos, Nikolopoulos, Ioannis, Bouliaris, Konstantinos, Tepp, Jaan, Lohsiriwat, Varut, Çolak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, Abbas, Ashraf, Tranà, Cristian, Caproli, Emanuele, Soldatenkova, Darija, Corcione, Francesco, Piazza, Diego, and Catena, Fausto

Abstract

Computed tomography (CT) imaging is the most appropriate diagnostic tool to confirm suspected left colonic diverticulitis. However, the utility of CT imaging goes beyond accurate diagnosis of diverticulitis; the grade of severity on CT imaging may drive treatment planning of patients presenting with acute diverticulitis. The appropriate management of left colon acute diverticulitis remains still debated because of the vast spectrum of clinical presentations and different approaches to treatment proposed. The authors present a new simple classification system based on both CT scan results driving decisions making management of acute diverticulitis that may be universally accepted for day to day practice.

Published
2015

14. Metal-catalyzed cross-coupling reactions with dithiolanes and dithianes

Author

Schweizer, Frank (Chemistry) Sorensen, John (Chemistry) Liu, Song (Textile Sciences), Hultin, Philip G. (Chemistry), McFarlane, Michael Thomas, Schweizer, Frank (Chemistry) Sorensen, John (Chemistry) Liu, Song (Textile Sciences), Hultin, Philip G. (Chemistry), and McFarlane, Michael Thomas

Abstract

Creating new carbon-carbon bonds is one of the most important and challenging reactions in organic synthesis. Metal-catalyzed cross-coupling reactions have emerged as one of the preferred methods of producing new carbon-carbon bonds, and this work led to the 2010 Nobel Prize in Chemistry. This thesis was aimed at expanding the current research in the area of metal-catalyzed cross-coupling reactions to include new applications with dithiolane and dithiane protecting groups. 1,3-Dithiolane and 1,3-dithiane derivatives are particularly interesting molecules in that they can be deprotonated by a strong base to form anions, which can then be used for carbon-carbon bond synthesis. This thesis describes the investigation into the use of dithiolanes and dithianes in metal-catalyzed cross-coupling reactions, as well as some of the challenges faced in performing this sulfur-based chemistry.

Published
2012

15. Target Mass Monitoring and Instrumentation in the Daya Bay Antineutrino Detectors

Author

Band, Henry R., Cherwinka, Jeffrey J., Greenler, Lee S., Heeger, Karsten M., Hinrichs, Paul, Kang, Li, Lewis, Christine A., Li, Shanfeng, Lin, Shengxin, McFarlane, Michael C., Wang, Wei, Webber, David M., Wei, Yadong, Wise, Thomas S., Xiao, Qiang, Yang, Li, Zhang, Zhijian, Band, Henry R., Cherwinka, Jeffrey J., Greenler, Lee S., Heeger, Karsten M., Hinrichs, Paul, Kang, Li, Lewis, Christine A., Li, Shanfeng, Lin, Shengxin, McFarlane, Michael C., Wang, Wei, Webber, David M., Wei, Yadong, Wise, Thomas S., Xiao, Qiang, Yang, Li, and Zhang, Zhijian

Abstract

The Daya Bay experiment measures sin^2 2{\theta}_13 using functionally identical antineutrino detectors located at distances of 300 to 2000 meters from the Daya Bay nuclear power complex. Each detector consists of three nested fluid volumes surrounded by photomultiplier tubes. These volumes are coupled to overflow tanks on top of the detector to allow for thermal expansion of the liquid. Antineutrinos are detected through the inverse beta decay reaction on the proton-rich scintillator target. A precise and continuous measurement of the detector's central target mass is achieved by monitoring the the fluid level in the overflow tanks with cameras and ultrasonic and capacitive sensors. In addition, the monitoring system records detector temperature and levelness at multiple positions. This monitoring information allows the precise determination of the detectors' effective number of target protons during data taking. We present the design, calibration, installation and in-situ tests of the Daya Bay real-time antineutrino detector monitoring sensors and readout electronics., Comment: 22 pages, 20 figures; accepted by JINST. Changes in v2: minor revisions to incorporate editorial feedback from JINST

Published
2012
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