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36 results on '"Meijborg, Veronique"'

1. Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

Author

Jensen, Bjarke, Salvatori, Daniela, Schouten, Jacobine, Meijborg, Veronique M F, Lauridsen, Henrik, Agger, Peter, Jensen, Bjarke, Salvatori, Daniela, Schouten, Jacobine, Meijborg, Veronique M F, Lauridsen, Henrik, and Agger, Peter

Abstract

An intricate meshwork of trabeculations lines the luminal side of cardiac ventricles. Compaction, a developmental process, is thought to reduce trabeculations by adding them to the neighboring compact wall which is then enlarged. When pig, a plausible cardiac donor for xenotransplantation, is compared to human, the ventricular walls appear to have fewer trabeculations. We hypothesized the trabecular volume is proportionally smaller in pig than in human. Macroscopically, we observed in 16 pig hearts that the ventricular walls harbor few but large trabeculations. Close inspection revealed a high number of tiny trabeculations, a few hundred, within the recesses of the large trabeculations. While tiny, these were still larger than embryonic trabeculations and even when considering their number, the total tally of trabeculations in pig was much fewer than in human. Volumetrics based on high-resolution MRI of additional six pig hearts compared to six human hearts, revealed the left ventricles were not significantly differently trabeculated (21.5 versus 22.8%, respectively), and the porcine right ventricles were only slightly less trabeculated (42.1 vs 49.3%, respectively). We then analyzed volumetrically 10 pig embryonic hearts from gestational day 14-35. The trabecular and compact layer always grew, as did the intertrabecular recesses, in contrast to what compaction predicts. The proportions of the trabecular and compact layers changed substantially, nonetheless, due to differences in their growth rate rather than compaction. In conclusion, processes that affect the trabecular morphology do not necessarily affect the proportion of trabecular-to-compact myocardium and they are then distinct from compaction.

Published
2024

2. Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

Author

Anatomie en fysiologie, CS_Locomotion, CS_Cancer, Locomotion - Integrating Sciences, Jensen, Bjarke, Salvatori, Daniela, Schouten, Jacobine, Meijborg, Veronique M F, Lauridsen, Henrik, Agger, Peter, Anatomie en fysiologie, CS_Locomotion, CS_Cancer, Locomotion - Integrating Sciences, Jensen, Bjarke, Salvatori, Daniela, Schouten, Jacobine, Meijborg, Veronique M F, Lauridsen, Henrik, and Agger, Peter

Published
2024

3. High-rate pacing suppresses Torsade de Pointes arrhythmias and reduces spatial dispersion of repolarization in the chronic AV-block dog model

Author

Medische Fysiologie, Conductiegroep, Circulatory Health, Loen, Vera, Van Weperen, Valerie Y H, Beekman, Henriëtte D M, Van Bavel, Joanne J A, Meijborg, Veronique M F, Van der Waal, Jeanne G, Coronel, Ruben, van der Heyden, Marcel A G, Vos, Marc A, Medische Fysiologie, Conductiegroep, Circulatory Health, Loen, Vera, Van Weperen, Valerie Y H, Beekman, Henriëtte D M, Van Bavel, Joanne J A, Meijborg, Veronique M F, Van der Waal, Jeanne G, Coronel, Ruben, van der Heyden, Marcel A G, and Vos, Marc A

Published
2023

4. Stellate ganglion stimulation causes spatiotemporal changes in ventricular repolarization in pig.

Author

Meijborg, Veronique MF, Meijborg, Veronique MF, Boukens, Bastiaan JD, Janse, Michiel J, Salavatian, Siamak, Dacey, Michael J, Yoshie, Koji, Opthof, Tobias, Swid, Mohammed Amer, Hoang, Jonathan D, Hanna, Peter, Ardell, Jeffrey, Shivkumar, Kalyanam, Coronel, Ruben, Meijborg, Veronique MF, Meijborg, Veronique MF, Boukens, Bastiaan JD, Janse, Michiel J, Salavatian, Siamak, Dacey, Michael J, Yoshie, Koji, Opthof, Tobias, Swid, Mohammed Amer, Hoang, Jonathan D, Hanna, Peter, Ardell, Jeffrey, Shivkumar, Kalyanam, and Coronel, Ruben

Abstract

BackgroundDispersion in ventricular repolarization is relevant for arrhythmogenesis.ObjectiveThe purpose of this study was to determine the spatiotemporal effects of sympathetic stimulation on ventricular repolarization.MethodsIn 5 anesthetized female open-chest pigs, ventricular repolarization was measured from the anterior, lateral, and posterior walls of the left ventricle (LV) and right ventricle using up to 40 transmural plunge needles (4 electrodes each) before and after left stellate ganglion stimulation (LSGS) and right stellate ganglion stimulation. In addition, LSGS was performed in 3 pigs (2 male, 1 female) before and after verapamil (5-10 mg/h) administration.ResultsLSGS yielded a biphasic response in repolarization in the lateral and posterior walls of the LV, with prolongation at ∼5 seconds (10 ± 1.5 ms) and shortening at 20-30 seconds of stimulation (-28.9 ± 4.4 ms) during a monotonic pressure increase. While the initial prolongation was abolished by verapamil, late shortening was augmented. Sequential transections of the vagal nerve and stellate ganglia augmented repolarization dispersion responses to LSGS in 2 of 5 hearts. An equal pressure increase by aortic occlusion resulted in a homogeneous shortening of repolarization in the LV, and the effects were smaller than those during LSGS. Right stellate stimulation shortened repolarization mainly in the anterior LV wall, but the effects were smaller than those of LSGS.ConclusionLSGS first prolongs (through the L-type calcium current) and then shortens repolarization. The effect of LSGS was prominent in the posterior and lateral, not the anterior, LV walls.

Published
2020

5. Mechanism of ventricular premature beats elicited by left stellate ganglion stimulation during acute ischaemia of the anterior left ventricle.

Author

Boukens, Bastiaan JD, Boukens, Bastiaan JD, Dacey, Michael, Meijborg, Veronique MF, Janse, Michiel J, Hadaya, Joseph, Hanna, Peter, Swid, M Amer, Opthof, Tobias, Ardell, Jeffrey L, Shivkumar, Kalyanam, Coronel, Ruben, Boukens, Bastiaan JD, Boukens, Bastiaan JD, Dacey, Michael, Meijborg, Veronique MF, Janse, Michiel J, Hadaya, Joseph, Hanna, Peter, Swid, M Amer, Opthof, Tobias, Ardell, Jeffrey L, Shivkumar, Kalyanam, and Coronel, Ruben

Abstract

AimsEnhanced sympathetic activity during acute ischaemia is arrhythmogenic, but the underlying mechanism is unknown. During ischaemia, a diastolic current flows from the ischaemic to the non-ischaemic myocardium. This 'injury' current can cause ventricular premature beats (VPBs) originating in the non-ischaemic myocardium, especially during a deeply negative T wave in the ischaemic zone. We reasoned that shortening of repolarization in myocardium adjacent to ischaemic myocardium increases the 'injury' current and causes earlier deeply negative T waves in the ischaemic zone, and re-excitation of the normal myocardium. We tested this hypothesis by activation and repolarization mapping during stimulation of the left stellate ganglion (LSG) during left anterior descending coronary artery (LAD) occlusion.Methods and resultsIn nine pigs, five subsequent episodes of acute ischaemia, separated by 20 min of reperfusion, were produced by occlusion of the LAD and 121 epicardial local unipolar electrograms were recorded. During the third occlusion, left stellate ganglion stimulation (LSGS) was initiated after 3 min for a 30-s period, causing a shortening of repolarization in the normal myocardium by about 100 ms. This resulted in more negative T waves in the ischaemic zone and more VPBs than during the second, control, occlusion. Following the decentralization of the LSG (including removal of the right stellate ganglion and bilateral cervical vagotomy), fewer VPBs occurred during ischaemia without LSGS. During LSGS, the number of VPBs was similar to that recorded before decentralization.ConclusionLSGS, by virtue of shortening of repolarization in the non-ischaemic myocardium by about 100 ms, causes deeply negative T waves in the ischaemic tissue and VPBs originating from the normal tissue adjacent to the ischaemic border.

Published
2021

6. Mechanism of ventricular premature beats elicited by left stellate ganglion stimulation during acute ischaemia of the anterior left ventricle.

Author

Boukens, Bastiaan JD, Boukens, Bastiaan JD, Dacey, Michael, Meijborg, Veronique MF, Janse, Michiel J, Hadaya, Joseph, Hanna, Peter, Swid, M Amer, Opthof, Tobias, Ardell, Jeffrey L, Shivkumar, Kalyanam, Coronel, Ruben, Boukens, Bastiaan JD, Boukens, Bastiaan JD, Dacey, Michael, Meijborg, Veronique MF, Janse, Michiel J, Hadaya, Joseph, Hanna, Peter, Swid, M Amer, Opthof, Tobias, Ardell, Jeffrey L, Shivkumar, Kalyanam, and Coronel, Ruben

Abstract

AimsEnhanced sympathetic activity during acute ischaemia is arrhythmogenic, but the underlying mechanism is unknown. During ischaemia, a diastolic current flows from the ischaemic to the non-ischaemic myocardium. This 'injury' current can cause ventricular premature beats (VPBs) originating in the non-ischaemic myocardium, especially during a deeply negative T wave in the ischaemic zone. We reasoned that shortening of repolarization in myocardium adjacent to ischaemic myocardium increases the 'injury' current and causes earlier deeply negative T waves in the ischaemic zone, and re-excitation of the normal myocardium. We tested this hypothesis by activation and repolarization mapping during stimulation of the left stellate ganglion (LSG) during left anterior descending coronary artery (LAD) occlusion.Methods and resultsIn nine pigs, five subsequent episodes of acute ischaemia, separated by 20 min of reperfusion, were produced by occlusion of the LAD and 121 epicardial local unipolar electrograms were recorded. During the third occlusion, left stellate ganglion stimulation (LSGS) was initiated after 3 min for a 30-s period, causing a shortening of repolarization in the normal myocardium by about 100 ms. This resulted in more negative T waves in the ischaemic zone and more VPBs than during the second, control, occlusion. Following the decentralization of the LSG (including removal of the right stellate ganglion and bilateral cervical vagotomy), fewer VPBs occurred during ischaemia without LSGS. During LSGS, the number of VPBs was similar to that recorded before decentralization.ConclusionLSGS, by virtue of shortening of repolarization in the non-ischaemic myocardium by about 100 ms, causes deeply negative T waves in the ischaemic tissue and VPBs originating from the normal tissue adjacent to the ischaemic border.

Published
2021

7. Interplay between temporal and spatial dispersion of repolarization in the initiation and perpetuation of torsades de pointes in the chronic atrioventricular block dog

Author

Medische Fysiologie, Circulatory Health, Smoczyńska, Agnieszka, Aarnink, Errol W, Dunnink, Albert, Bossu, Alexandre, van Weperen, Valerie Y H, Meijborg, Veronique M F, Beekman, Henriëtte D M, Coronel, R, Vos, Marc A, Medische Fysiologie, Circulatory Health, Smoczyńska, Agnieszka, Aarnink, Errol W, Dunnink, Albert, Bossu, Alexandre, van Weperen, Valerie Y H, Meijborg, Veronique M F, Beekman, Henriëtte D M, Coronel, R, and Vos, Marc A

Published
2021

8. Severe Bradycardia Increases the Incidence and Severity of Torsade de Pointes Arrhythmias by Augmenting Preexistent Spatial Dispersion of Repolarization in the CAVB Dog Model

Author

Medische Fysiologie, Circulatory Health, van Weperen, Valerie Y.H., Dunnink, Albert, Bossu, Alexandre, Beekman, Jet D.M., Meijborg, Veronique M.F., de Bakker, Jacques M.T., Coronel, Ruben, Varkevisser, Rosanne, van der Heyden, Marcel A.G., Vos, Marc A., Medische Fysiologie, Circulatory Health, van Weperen, Valerie Y.H., Dunnink, Albert, Bossu, Alexandre, Beekman, Jet D.M., Meijborg, Veronique M.F., de Bakker, Jacques M.T., Coronel, Ruben, Varkevisser, Rosanne, van der Heyden, Marcel A.G., and Vos, Marc A.

Published
2021

9. Investigating the physiology of normothermic ex vivo heart perfusion in an isolated slaughterhouse porcine model used for device testing and training

Author

Kappler, Benjamin, Ledezma, Carlos A., van Tuijl, Sjoerd, Meijborg, Veronique, Boukens, Bastiaan J., Ergin, Bülent, Tan, P. J., Stijnen, Marco, Ince, Can, Díaz-Zuccarini, Vanessa, de Mol, Bas A.J.M., Kappler, Benjamin, Ledezma, Carlos A., van Tuijl, Sjoerd, Meijborg, Veronique, Boukens, Bastiaan J., Ergin, Bülent, Tan, P. J., Stijnen, Marco, Ince, Can, Díaz-Zuccarini, Vanessa, and de Mol, Bas A.J.M.

Abstract

BACKGROUND: The PhysioHeart™ is a mature acute platform, based isolated slaughterhouse hearts and able to validate cardiac devices and techniques in working mode. Despite perfusion, myocardial edema and time-dependent function degradation are reported. Therefore, monitoring several variables is necessary to identify which of these should be controlled to preserve the heart function. This study presents biochemical, electrophysiological and hemodynamic changes in the PhysioHeart™ to understand the pitfalls of ex vivo slaughterhouse heart hemoperfusion. METHODS: Seven porcine hearts were harvested, arrested and revived using the PhysioHeart™. Cardiac output, SaO2, glucose and pH were maintained at physiological levels. Blood analyses were performed hourly and unipolar epicardial electrograms (UEG), pressures and flows were recorded to assess the physiological performance. RESULTS: Normal cardiac performance was attained in terms of mean cardiac output (5.1 ± 1.7 l/min) and pressures but deteriorated over time. Across the experiments, homeostasis was maintained for 171.4 ± 54 min, osmolarity and blood electrolytes increased significantly between 10 and 80%, heart weight increased by 144 ± 41 g, free fatty acids (- 60%), glucose and lactate diminished, ammonia increased by 273 ± 76% and myocardial necrosis and UEG alterations appeared and aggravated. Progressively deteriorating electrophysiological and hemodynamic functions can be explained by reperfusion injury, waste product intoxication (i.e. hyperammonemia), lack of essential nutrients, ion imbalances and cardiac necrosis as a consequence of hepatological and nephrological plasma clearance absence. CONCLUSIONS: The PhysioHeart™ is an acute model, suitable for cardiac device and therapy assessment, which can precede conventional animal studies. However, observations indicate that ex vivo slaughterhouse hearts resemble cardiac physiology of deteriorating hearts in a multi-organ failure situation and signalize the n

Published
2019

10. Investigating the physiology of normothermic ex vivo heart perfusion in an isolated slaughterhouse porcine model used for device testing and training

Author

Kappler, Benjamin, Ledezma, Carlos A., van Tuijl, Sjoerd, Meijborg, Veronique, Boukens, Bastiaan J., Ergin, Bülent, Tan, P. J., Stijnen, Marco, Ince, Can, Díaz-Zuccarini, Vanessa, de Mol, Bas A.J.M., Kappler, Benjamin, Ledezma, Carlos A., van Tuijl, Sjoerd, Meijborg, Veronique, Boukens, Bastiaan J., Ergin, Bülent, Tan, P. J., Stijnen, Marco, Ince, Can, Díaz-Zuccarini, Vanessa, and de Mol, Bas A.J.M.

Abstract

BACKGROUND: The PhysioHeart™ is a mature acute platform, based isolated slaughterhouse hearts and able to validate cardiac devices and techniques in working mode. Despite perfusion, myocardial edema and time-dependent function degradation are reported. Therefore, monitoring several variables is necessary to identify which of these should be controlled to preserve the heart function. This study presents biochemical, electrophysiological and hemodynamic changes in the PhysioHeart™ to understand the pitfalls of ex vivo slaughterhouse heart hemoperfusion. METHODS: Seven porcine hearts were harvested, arrested and revived using the PhysioHeart™. Cardiac output, SaO2, glucose and pH were maintained at physiological levels. Blood analyses were performed hourly and unipolar epicardial electrograms (UEG), pressures and flows were recorded to assess the physiological performance. RESULTS: Normal cardiac performance was attained in terms of mean cardiac output (5.1 ± 1.7 l/min) and pressures but deteriorated over time. Across the experiments, homeostasis was maintained for 171.4 ± 54 min, osmolarity and blood electrolytes increased significantly between 10 and 80%, heart weight increased by 144 ± 41 g, free fatty acids (- 60%), glucose and lactate diminished, ammonia increased by 273 ± 76% and myocardial necrosis and UEG alterations appeared and aggravated. Progressively deteriorating electrophysiological and hemodynamic functions can be explained by reperfusion injury, waste product intoxication (i.e. hyperammonemia), lack of essential nutrients, ion imbalances and cardiac necrosis as a consequence of hepatological and nephrological plasma clearance absence. CONCLUSIONS: The PhysioHeart™ is an acute model, suitable for cardiac device and therapy assessment, which can precede conventional animal studies. However, observations indicate that ex vivo slaughterhouse hearts resemble cardiac physiology of deteriorating hearts in a multi-organ failure situation and signalize the n

Published
2019

11. Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Author

Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, Vos, Marc A, Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, and Vos, Marc A

Published
2018

12. Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Author

Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, Vos, Marc A, Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, and Vos, Marc A

Published
2018

13. Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Author

Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, Vos, Marc A, Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, and Vos, Marc A

Published
2018

14. Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Author

Medische Fysiologie, Circulatory Health, Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, Vos, Marc A, Medische Fysiologie, Circulatory Health, Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, and Vos, Marc A

Published
2018

16. Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry

Author

Vandersickel, Nele, Bossu, Alexandre, De Neve, Jan, Dunnink, Albert, Meijborg, Veronique M F, van der Heyden, Marcel A.G., Beekman, Jet D.M., De Bakker, Jacques M.T., Vos, Marc A., Panfilov, Alexander V, Vandersickel, Nele, Bossu, Alexandre, De Neve, Jan, Dunnink, Albert, Meijborg, Veronique M F, van der Heyden, Marcel A.G., Beekman, Jet D.M., De Bakker, Jacques M.T., Vos, Marc A., and Panfilov, Alexander V

Published
2017

17. Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry

Author

Vandersickel, Nele, Bossu, Alexandre, De Neve, Jan, Dunnink, Albert, Meijborg, Veronique M F, van der Heyden, Marcel A.G., Beekman, Jet D.M., De Bakker, Jacques M.T., Vos, Marc A., Panfilov, Alexander V, Vandersickel, Nele, Bossu, Alexandre, De Neve, Jan, Dunnink, Albert, Meijborg, Veronique M F, van der Heyden, Marcel A.G., Beekman, Jet D.M., De Bakker, Jacques M.T., Vos, Marc A., and Panfilov, Alexander V

Published
2017

18. Local transmural action potential gradients are absent in the isolated, intact dog heart but present in the corresponding coronary-perfused wedge

Author

Boukens, Bastiaan J., Meijborg, Veronique M F, Belterman, Charly N. W., Opthof, Tobias, Janse, Michiel J, Schuessler, Richard B., Coronel, Ruben, Efimov, Igor R., Boukens, Bastiaan J., Meijborg, Veronique M F, Belterman, Charly N. W., Opthof, Tobias, Janse, Michiel J, Schuessler, Richard B., Coronel, Ruben, and Efimov, Igor R.

Published
2017

21. Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry

Author

Vandersickel, Nele, Bossu, Alexandre, De Neve, Jan, Dunnink, Albert, Meijborg, Veronique M F, van der Heyden, Marcel A.G., Beekman, Jet D.M., De Bakker, Jacques M.T., Vos, Marc A., Panfilov, Alexander V, Vandersickel, Nele, Bossu, Alexandre, De Neve, Jan, Dunnink, Albert, Meijborg, Veronique M F, van der Heyden, Marcel A.G., Beekman, Jet D.M., De Bakker, Jacques M.T., Vos, Marc A., and Panfilov, Alexander V

Published
2017

22. Local transmural action potential gradients are absent in the isolated, intact dog heart but present in the corresponding coronary-perfused wedge

Author

Boukens, Bastiaan J., Meijborg, Veronique M F, Belterman, Charly N. W., Opthof, Tobias, Janse, Michiel J, Schuessler, Richard B., Coronel, Ruben, Efimov, Igor R., Boukens, Bastiaan J., Meijborg, Veronique M F, Belterman, Charly N. W., Opthof, Tobias, Janse, Michiel J, Schuessler, Richard B., Coronel, Ruben, and Efimov, Igor R.

Published
2017

23. Local transmural action potential gradients are absent in the isolated, intact dog heart but present in the corresponding coronary-perfused wedge

Author

Medische Fysiologie, Circulatory Health, Boukens, Bastiaan J., Meijborg, Veronique M F, Belterman, Charly N. W., Opthof, Tobias, Janse, Michiel J, Schuessler, Richard B., Coronel, Ruben, Efimov, Igor R., Medische Fysiologie, Circulatory Health, Boukens, Bastiaan J., Meijborg, Veronique M F, Belterman, Charly N. W., Opthof, Tobias, Janse, Michiel J, Schuessler, Richard B., Coronel, Ruben, and Efimov, Igor R.

Published
2017

24. Torsade de pointes arrhythmias arise at the site of maximal heterogeneity of repolarization in the chronic complete atrioventricular block dog

Author

Medische Fysiologie, Circulatory Health, Team Onderzoek, Cardiologie Arts-onderzoekers, Dunnink, Albert, Stams, Thom R G, Bossu, Alexandre, Meijborg, Veronique M F, Beekman, Jet D.M., Wijers, Sofieke C., De Bakker, Jacques M.T., Vos, Marc A., Medische Fysiologie, Circulatory Health, Team Onderzoek, Cardiologie Arts-onderzoekers, Dunnink, Albert, Stams, Thom R G, Bossu, Alexandre, Meijborg, Veronique M F, Beekman, Jet D.M., Wijers, Sofieke C., De Bakker, Jacques M.T., and Vos, Marc A.

Published
2017

25. Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry

Author

Medische Fysiologie, UMC Utrecht, Circulatory Health, Vandersickel, Nele, Bossu, Alexandre, De Neve, Jan, Dunnink, Albert, Meijborg, Veronique M F, van der Heyden, Marcel A.G., Beekman, Jet D.M., De Bakker, Jacques M.T., Vos, Marc A., Panfilov, Alexander V, Medische Fysiologie, UMC Utrecht, Circulatory Health, Vandersickel, Nele, Bossu, Alexandre, De Neve, Jan, Dunnink, Albert, Meijborg, Veronique M F, van der Heyden, Marcel A.G., Beekman, Jet D.M., De Bakker, Jacques M.T., Vos, Marc A., and Panfilov, Alexander V

Published
2017

29. Dispersion in ventricular repolarization in the human, canine and porcine heart

Author

Medische Fysiologie, Circulatory Health, Opthof, Tobias, Janse, Michiel J., Meijborg, Veronique M F, Cinca, Juan, Rosen, Michael R., Coronel, Ruben, Medische Fysiologie, Circulatory Health, Opthof, Tobias, Janse, Michiel J., Meijborg, Veronique M F, Cinca, Juan, Rosen, Michael R., and Coronel, Ruben

Published
2016

35. Interventricular dispersion in repolarization causes bifid T waves in dogs with dofetilide-induced long QT syndrome

Author

Medische Fysiologie, Circulatory Health, Meijborg, Veronique M F, Chauveau, Samuel, Janse, Michiel J, Anyukhovsky, Evgeny P, Danilo, Peter R, Rosen, Michael R, Opthof, Tobias, Coronel, Ruben, Medische Fysiologie, Circulatory Health, Meijborg, Veronique M F, Chauveau, Samuel, Janse, Michiel J, Anyukhovsky, Evgeny P, Danilo, Peter R, Rosen, Michael R, Opthof, Tobias, and Coronel, Ruben

Published
2015

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