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Your search keyword '"Nardella E."' showing total 17 results
Start Over Author "Nardella E." Publication Type Electronic Resources
17 results on '"Nardella E."'

1. Identification of early predictors of clinical outcomes of COVID-19 outbreak in an Italian single center using a machine-learning approach

Author

Rando, Maria Margherita, Biscetti, Federico, Masciocchi, Carlotta, Capocchiano, Nikola Dino, Nicolazzi, Maria Anna, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Pecorini, Giovanni, Colosimo, C, Sanguinetti, Maurizio, Massetti, Massimo, Gasbarrini, Antonio, Flex, Andrea, Rando, M M, Biscetti, F (ORCID:0000-0001-7449-657X), Masciocchi, C, Capocchiano, N D, Nicolazzi, M A, Nardella, E, Cecchini, A L, Pecorini, G (ORCID:0000-0002-0729-6719), Sanguinetti, M (ORCID:0000-0002-9780-7059), Massetti, M (ORCID:0000-0002-7100-8478), Gasbarrini, A (ORCID:0000-0002-7278-4823), Flex, A (ORCID:0000-0003-2664-4165), Rando, Maria Margherita, Biscetti, Federico, Masciocchi, Carlotta, Capocchiano, Nikola Dino, Nicolazzi, Maria Anna, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Pecorini, Giovanni, Colosimo, C, Sanguinetti, Maurizio, Massetti, Massimo, Gasbarrini, Antonio, Flex, Andrea, Rando, M M, Biscetti, F (ORCID:0000-0001-7449-657X), Masciocchi, C, Capocchiano, N D, Nicolazzi, M A, Nardella, E, Cecchini, A L, Pecorini, G (ORCID:0000-0002-0729-6719), Sanguinetti, M (ORCID:0000-0002-9780-7059), Massetti, M (ORCID:0000-0002-7100-8478), Gasbarrini, A (ORCID:0000-0002-7278-4823), and Flex, A (ORCID:0000-0003-2664-4165)

Abstract

OBJECTIVE: SARS-CoV-2 disease (COVID-19) has become a pandemic disease, determining a public health emergency. The use of artificial intelligence in identifying easily available biomarkers capable of predicting the risk for severe disease may be helpful in guiding clinical decisions. The aim of the study was to investigate the ability of interleukin (IL)-6, troponin I, and D-dimer to identify patients with COVID-19 at risk for intensive care unit (ICU)-admission and death by using a machine-learning predictive model. PATIENTS AND METHODS: Data on demographic characteristics, underlying comorbidities, symptoms, physical and radiological findings, and laboratory tests have been retrospectively collected from electronic medical records of patients admitted to Policlinico A. Gemelli Foundation from March 1, 2020, to September 15, 2020, by using artificial intelligence techniques. RESULTS: From an initial cohort of 425 patients, 146 met the inclusion criteria and were enrolled in the study. The in-hospital mortality rate was 15%, and the ICU admission rate was 41%. Patients who died had higher troponin I (p-value<0.01) and IL -6 values (p-value=0.04), compared to those who survived. Patients admitted to ICU had higher lev- els of troponin I (p-value<0.01) and IL-6 (p-val- ue<0.01), compared to those not admitted to ICU. Threshold values to predict in-hospital mortality and ICU admission have been identified. IL-6 levels higher than 15.133 ng/L have been associated with a 22.91% risk of in-hospital mortality, and IL-6 levels higher than 25.65 ng/L have been as- sociated with a 56.16% risk of ICU admission. Troponin I levels higher than 12 ng/L have been associated with a 26.76% risk of in-hospital mortality and troponin I levels higher than 12 ng/L have been associated with a 52.11% risk of ICU admission. CONCLUSIONS: Levels of IL-6 and troponin I are associated with poor COVID-19 outcomes. Cut-off values capable of predicting in-hospi- tal mortality and ICU admi

Published
2023

2. Impact of COVID-19 pandemic on patients affected by peripheral arterial disease: an Italian single-center study

Author

Rando, Maria Margherita, Biscetti, Federico, Masciocchi, Carlotta, Savino, Mariachiara, Nicolazzi, Maria Anna, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Rossini, E, Massetti, Massimo, Gasbarrini, Antonio, Flex, Andrea, Rando, M M, Biscetti, F (ORCID:0000-0001-7449-657X), Masciocchi, C, Savino, M, Nicolazzi, M A, Nardella, E, Cecchini, A L, Massetti, M (ORCID:0000-0002-7100-8478), Gasbarrini, A (ORCID:0000-0002-7278-4823), Flex, A (ORCID:0000-0003-2664-4165), Rando, Maria Margherita, Biscetti, Federico, Masciocchi, Carlotta, Savino, Mariachiara, Nicolazzi, Maria Anna, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Rossini, E, Massetti, Massimo, Gasbarrini, Antonio, Flex, Andrea, Rando, M M, Biscetti, F (ORCID:0000-0001-7449-657X), Masciocchi, C, Savino, M, Nicolazzi, M A, Nardella, E, Cecchini, A L, Massetti, M (ORCID:0000-0002-7100-8478), Gasbarrini, A (ORCID:0000-0002-7278-4823), and Flex, A (ORCID:0000-0003-2664-4165)

Abstract

Objective: Coronavirus disease 2019 (COVID-19) has evolved into a global pandemic, affecting a wide range of medical and surgical specialties. During COVID-19, we assisted in the reallocation of medical resources and services, as well as social distancing measures, and many patients with chronic diseases and comorbidities may have experienced difficulties in obtaining the correct medical care. The aim of the study was to investigate the impact of the COVID-19 pandemic on major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in patients with peripheral arterial disease (PAD) and chronic limb-threatening ischemia (CLTI), compared to previous years. Patients and methods: We evaluated 1,335 hospital admissions of 877 patients with PAD admitted to Policlinico A. Gemelli Hospital between January 2017 and February 2020 and 368 hospital admissions of 272 patients with PAD admitted to the Policlinico A. Gemelli Hospital between March 2020 and March 2021. Data on demographic characteristics, comorbidities, symptoms, physical and radiological findings, laboratory tests, and routine visits before or after discharge were collected from electronic medical records. Results: Emergency room (ER) admissions among PAD patients during COVID-19 were higher than before the pandemic [190 (51.63%) vs. 579 (43.37%), p = 0.01]. A MACE was found in 78 (5.84%) pre-pandemic hospitalizations and 126 (34.24%) pandemic hospitalizations (p < 0.01). A MALE was identified in 942 (70.56%) pre-pandemic hospitalizations and 331 (89.95%) pandemic hospitalizations (p < 0.01). Amputation rates during the pandemic were higher than before the pandemic [80 (21.74%) vs. 191 (14.31%), p < 0.01]. The number of in-hospital deaths did not differ between the pandemic and pre-pandemic periods [11 (2.99%) vs. 51 (3.82%), p = 0.55]. Conclusions: In patients with PAD and CLTI, the number of MACE, MALE, and amputations was higher during the COVID-19 period compared to the thr

Published
2023

3. Inflammatory Cytokines Associated With Failure of Lower-Extremity Endovascular Revascularization (LER): A Prospective Study of a Population With Diabetes.

Author

Biscetti, F, Ferraro, Pietro Manuel, Nardella, E, Cecchini, Andrea Leonardo, Santoliquido, A, Pitocco, D, Landolfi, R, Flex, A., Biscetti F (ORCID:0000-0001-7449-657X), Ferraro pietro manuel (ORCID:0000-0002-1379-022X), Nardella E, Cecchini Andrea Leonardo, Santoliquido A (ORCID:0000-0003-1539-4017), Pitocco D (ORCID:0000-0002-6220-686X), Landolfi R (ORCID:0000-0002-7913-8576), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, F, Ferraro, Pietro Manuel, Nardella, E, Cecchini, Andrea Leonardo, Santoliquido, A, Pitocco, D, Landolfi, R, Flex, A., Biscetti F (ORCID:0000-0001-7449-657X), Ferraro pietro manuel (ORCID:0000-0002-1379-022X), Nardella E, Cecchini Andrea Leonardo, Santoliquido A (ORCID:0000-0003-1539-4017), Pitocco D (ORCID:0000-0002-6220-686X), Landolfi R (ORCID:0000-0002-7913-8576), and Flex A. (ORCID:0000-0003-2664-4165)

Published
2019

4. The Role of the Microbiota in the Diabetic Peripheral Artery Disease.

Author

Biscetti, F, Nardella, E, Cecchini, Al, Landolfi, R, Flex, A., Biscetti F (ORCID:0000-0001-7449-657X), Nardella E, Cecchini AL, Landolfi R (ORCID:0000-0002-7913-8576), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, F, Nardella, E, Cecchini, Al, Landolfi, R, Flex, A., Biscetti F (ORCID:0000-0001-7449-657X), Nardella E, Cecchini AL, Landolfi R (ORCID:0000-0002-7913-8576), and Flex A. (ORCID:0000-0003-2664-4165)

Abstract

Vascular complications of diabetes mellitus represent a major public health problem. Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, promotion, and evolution of atherosclerotic disease, even in the diabetic scenario. There is an urgency to develop the knowledge of modern medicine about the link between gut microbiota and its host's metabolic pathways, and it would be useful to understand and justify the interindividual diversity of clinical disease presentation of diabetic vascular complication even if an optimization of pharmacological treatment has been made or in the case of young patients where hypertension, dyslipidemia, and diabetes are not able to justify a very quick progress of atherosclerotic process. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the microbiota in this field, from biomarker to possible therapeutic target.

Published
2019

5. Correction to: Association between carotid plaque vulnerability and high mobility group box‐1 serum levels in a diabetic population (Cardiovascular Diabetology, (2021), 20, 1, (114), 10.1186/s12933-021-01304-8)

Author

Biscetti, Federico, Tinelli, Giovanni, Rando, Maria Margherita, Nardella, E., Cecchini, Andrea Leonardo, Angelini, F., Straface, Gianluca, Filipponi, M., Arena, Vincenzo, Pitocco, Dario, Gasbarrini, Antonio, Massetti, Massimo, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Tinelli G. (ORCID:0000-0002-2212-3226), Rando M. M., Cecchini A. L., Straface G., Arena V. (ORCID:0000-0002-7562-223X), Pitocco D. (ORCID:0000-0002-6220-686X), Gasbarrini A. (ORCID:0000-0002-7278-4823), Massetti M. (ORCID:0000-0002-7100-8478), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, Federico, Tinelli, Giovanni, Rando, Maria Margherita, Nardella, E., Cecchini, Andrea Leonardo, Angelini, F., Straface, Gianluca, Filipponi, M., Arena, Vincenzo, Pitocco, Dario, Gasbarrini, Antonio, Massetti, Massimo, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Tinelli G. (ORCID:0000-0002-2212-3226), Rando M. M., Cecchini A. L., Straface G., Arena V. (ORCID:0000-0002-7562-223X), Pitocco D. (ORCID:0000-0002-6220-686X), Gasbarrini A. (ORCID:0000-0002-7278-4823), Massetti M. (ORCID:0000-0002-7100-8478), and Flex A. (ORCID:0000-0003-2664-4165)

Abstract

Following publication of the original article [1], the authors noticed an error in “Methods/Study population” section. The date “June 1, 2018” which is in the “Study population” section should have been given as “June 1, 2013”. This has been corrected with this erratum.

Published
2021

6. Principal predictors of major adverse limb events in diabetic peripheral artery disease: A narrative review

Author

Biscetti, Federico, Cecchini, Andrea Leonardo, Rando, Maria Margherita, Nardella, E., Gasbarrini, Antonio, Massetti, Massimo, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Cecchini A. L., Rando M. M., Gasbarrini A. (ORCID:0000-0002-7278-4823), Massetti M. (ORCID:0000-0002-7100-8478), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, Federico, Cecchini, Andrea Leonardo, Rando, Maria Margherita, Nardella, E., Gasbarrini, Antonio, Massetti, Massimo, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Cecchini A. L., Rando M. M., Gasbarrini A. (ORCID:0000-0002-7278-4823), Massetti M. (ORCID:0000-0002-7100-8478), and Flex A. (ORCID:0000-0003-2664-4165)

Abstract

Background and aims: The increasing prevalence of diabetes mellitus is causing a massive growth of peripheral artery disease incidences, a disabling complication of diabetic atherosclerosis, which leads often to the amputation of the affected limb. Critical limb ischemia is the terminal disease stage, which requires a prompt intervention to relieve pain and save limbs. However, patients undergoing revascularization often suffer from cardiovascular, cerebrovascular and major adverse limb events with poor outcomes. Furthermore, the same procedure performed in apparently similar patients has various outcomes and lack of an outcome predictive support causes a high lower limb arterial revascularization rate with disastrous effects for patients. We collected the main risk factors of major adverse limb events in a more readable and immediate format of the topic, to propose an overview of parameters to manage effectively peripheral artery disease patients and to propose basics of a new predictive tool to prevent from disabling vascular complications of the disease. Methods: Most recent and updated literature about the prevalence of major adverse limb events in peripheral artery disease was reviewed to identify possible main predictors. Results: In this article, we summarized major risk factors of limb revascularization failure and disabling vascular complications collecting those parameters principally responsible for major adverse limb events, which provides physio-pathological explanation of their role in peripheral artery disease. Conclusion: We evaluated and listed a panel of possible predictors of MALE (Major Adverse Limb Event) in order to contribute to the development of a predictive score, based on a summary of the main risk factors reported in scientific articles, which could improve the management of peripheral artery disease by preventing vascular accidents.

Published
2021

7. Association between carotid plaque vulnerability and high mobility group box-1 serum levels in a diabetic population

Author

Biscetti, Federico, Tinelli, Giovanni, Rando, Maria Margherita, Nardella, E., Cecchini, Andrea Leonardo, Angelini, F., Straface, Gianluca, Filipponi, M., Arena, Vincenzo, Pitocco, Dario, Gasbarrini, Antonio, Massetti, Massimo, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Tinelli G. (ORCID:0000-0002-2212-3226), Rando M. M., Cecchini A. L., Straface G., Arena V. (ORCID:0000-0002-7562-223X), Pitocco D. (ORCID:0000-0002-6220-686X), Gasbarrini A. (ORCID:0000-0002-7278-4823), Massetti M. (ORCID:0000-0002-7100-8478), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, Federico, Tinelli, Giovanni, Rando, Maria Margherita, Nardella, E., Cecchini, Andrea Leonardo, Angelini, F., Straface, Gianluca, Filipponi, M., Arena, Vincenzo, Pitocco, Dario, Gasbarrini, Antonio, Massetti, Massimo, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Tinelli G. (ORCID:0000-0002-2212-3226), Rando M. M., Cecchini A. L., Straface G., Arena V. (ORCID:0000-0002-7562-223X), Pitocco D. (ORCID:0000-0002-6220-686X), Gasbarrini A. (ORCID:0000-0002-7278-4823), Massetti M. (ORCID:0000-0002-7100-8478), and Flex A. (ORCID:0000-0003-2664-4165)

Abstract

Background: Carotid atherosclerosis represents one of the complications of diabetes mellitus. In particular, plaque instability contributes to disease progression and stroke incidence. High mobility group box-1 (HMGB1) is a nuclear protein involved in promotion and progression of atherosclerosis and cardiovascular diseases. The aim of this study was to analyze the relationship between HMGB1 serum levels, main inflammatory cytokines, the presence of internal carotid stenosis and unstable plaque in a diabetic population. Research design and methods: We studied 873 diabetic patients, including 347 patients with internal carotid artery stenosis (ICAS) who underwent carotid endarterectomy and 526 diabetic patients without internal carotid artery stenosis (WICAS). At baseline, HMGB1 and the main inflammatory cytokines serum levels were evaluated. For ICAS patients, the histological features of carotid plaque were also collected to differentiate them in patients with stable or unstable atherosclerotic lesions. Results: We found that HMGB1 serum levels, osteoprotegerin, high-sensitivity C-reactive protein, tumor necrosis factor-alpha and interleukin-6, were significantly higher in diabetic ICAS patients compared to diabetic WICAS patients. Among ICAS patients, individuals with unstable plaque had higher levels of these cytokines, compared to patients with stable plaque. A multivariable stepwise logistic regression analysis showed that HMGB1 and osteoprotegerin remained independently associated with unstable plaque in ICAS patients. Conclusions: The present study demonstrated that HMGB1 is an independent risk factor for carotid plaque vulnerability in an Italian population with diabetes mellitus, representing a promising biomarker of carotid plaque instability and a possible molecular target to treat unstable carotid plaques and to prevent stroke.

Published
2021

8. Biliary tract microbiota: A new kid on the block of liver diseases?

Author

Nicoletti, Alberto, Ponziani, Francesca Romana, Nardella, E., Ianiro, Gianluca, Gasbarrini, Antonio, Dal Verme, L. Z., Nicoletti A., Ponziani F. R. (ORCID:0000-0002-5924-6238), Ianiro G. (ORCID:0000-0002-8318-0515), Gasbarrini A. (ORCID:0000-0002-7278-4823), Nicoletti, Alberto, Ponziani, Francesca Romana, Nardella, E., Ianiro, Gianluca, Gasbarrini, Antonio, Dal Verme, L. Z., Nicoletti A., Ponziani F. R. (ORCID:0000-0002-5924-6238), Ianiro G. (ORCID:0000-0002-8318-0515), and Gasbarrini A. (ORCID:0000-0002-7278-4823)

Abstract

– The microbiome plays a crucial role in maintaining the homeostasis of the organism. Recent evidence has provided novel insights for understanding the interaction between the microbiota and the host. However, the vast majority of such studies have analyzed the interactions taking place in the intestinal tract. The biliary tree has traditionally been considered sterile under normal conditions. However, the advent of metagenomic techniques has revealed an unexpectedly rich bacterial community in the biliary tract. Associations between specific microbiological patterns and inflammatory biliary diseases and cancer have been recently described. Hence, biliary dysbiosis may be a primary trigger in the pathogenesis of biliary diseases. In particular, recent studies have suggested that microorganisms could play a significant role in the development of gallstones, pathogenesis of autoimmune cholangiopathies and biliary carcinogenesis. Moreover, the intimate connection between the biliary tract, liver and pancreas, could reveal hidden influences on the development of diseases of these organs. Further studies are needed to deepen the comprehension of the influence of the biliary microbiota in human pathology. This knowledge could lead to the formulation of strategies for modulating the biliary microbiota in order to treat and prevent these pathological conditions.

Published
2020

9. Association between omentin-1 and major cardiovascular events after lower extremity endovascular revascularization in diabetic patients: A prospective cohort study

Author

Biscetti, Federico, Nardella, Elisabetta, Rando, M. M., Cecchini, Andrea Leonardo, Angelini, F., Cina, Alessandro, Iezzi, Roberto, Filipponi, M., Santoliquido, Angelo, Pitocco, Dario, Landolfi, Raffaele, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Cina A., Iezzi R. (ORCID:0000-0002-2791-481X), Santoliquido A. (ORCID:0000-0003-1539-4017), Pitocco D. (ORCID:0000-0002-6220-686X), Landolfi R. (ORCID:0000-0002-7913-8576), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, Federico, Nardella, Elisabetta, Rando, M. M., Cecchini, Andrea Leonardo, Angelini, F., Cina, Alessandro, Iezzi, Roberto, Filipponi, M., Santoliquido, Angelo, Pitocco, Dario, Landolfi, Raffaele, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Cina A., Iezzi R. (ORCID:0000-0002-2791-481X), Santoliquido A. (ORCID:0000-0003-1539-4017), Pitocco D. (ORCID:0000-0002-6220-686X), Landolfi R. (ORCID:0000-0002-7913-8576), and Flex A. (ORCID:0000-0003-2664-4165)

Abstract

Background: Cardiovascular complications represent the major cause of morbidity and mortality of type 2 diabetes mellitus (T2DM) patients. In particular, peripheral artery disease (PAD) represents a frequent T2DM vascular complication and a risk factor for the development of major adverse cardiovascular events (MACE). Among adipokines, omentin-1 serum levels are reduced in T2DM patients with PAD and are inversely related to disease severity. Objective: To study the relationship between omentin-1 levels, at baseline, with outcomes after endovascular procedures in T2DM patients with PAD and chronic limb-threatening ischemia (CLTI). Research design and methods: We enrolled for our prospective non-randomized study, 207 T2DM patients with PAD and CLTI, requiring revascularization. Omentin-1 serum levels were collected before revascularization and patients incidence outcomes were evaluated at 1, 3, 6 and 12 months. Results: Omentin-1 was reduced in patients with more severe disease (27.24 ± 4.83 vs 30.82 ± 5.48 ng/mL, p < 0.001). Overall, 84 MACE and 96 major adverse limb events (MALE) occurred during the 12-month follow-up. We observed that omentin-1 levels were lower in patients with MACE (26.02 ± 4.05 vs 31.33 ± 5.29 ng/mL, p < 0.001) and MALE (26.67 ± 4.21 vs 31.34 ± 5.54 ng/mL, p < 0.001). The association between omentin-1, MACE and MALE remained significant after adjusting for major risk factors in a multivariate analysis. Receiver operating characteristics (ROC) curve using omentin-1 levels predicted incidence events (area under the curve = 0.80). Conclusions: We demonstrated that reduced omentin-1 levels, at baseline, are related with worse vascular outcomes in T2DM patients with PAD and CLTI undergoing an endovascular procedure.

Published
2020

10. Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

Author

Biscetti, Federico, Rando, M. M., Nardella, Elisabetta, Cecchini, Andrea Leonardo, Bruno, Piergiorgio, Landolfi, Raffaele, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Bruno P. (ORCID:0000-0002-1075-5808), Landolfi R. (ORCID:0000-0002-7913-8576), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, Federico, Rando, M. M., Nardella, Elisabetta, Cecchini, Andrea Leonardo, Bruno, Piergiorgio, Landolfi, Raffaele, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Bruno P. (ORCID:0000-0002-1075-5808), Landolfi R. (ORCID:0000-0002-7913-8576), and Flex A. (ORCID:0000-0003-2664-4165)

Abstract

The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

Published
2020

11. Biomarkers of vascular disease in diabetes: the adipose-immune system cross talk

Author

Biscetti, Federico, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Flex, Andrea, Landolfi, Raffaele, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Flex A. (ORCID:0000-0003-2664-4165), Landolfi R. (ORCID:0000-0002-7913-8576), Biscetti, Federico, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Flex, Andrea, Landolfi, Raffaele, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Flex A. (ORCID:0000-0003-2664-4165), and Landolfi R. (ORCID:0000-0002-7913-8576)

Abstract

Experimental and clinical studies aimed at investigating the mechanism(s) underlying vascular complications of diabetes indicate that a great number of molecules are involved in the pathogenesis of these complications. Most of these molecules are inflammatory mediators or markers generated by immune or adipose tissue. Some of them, i.e. resistin and sortilin, have been shown to be involved in the cross talk between adipocytes and inflammatory cells. This interaction is an attractive area of research, particularly in type 2 diabetes and obesity. Other proteins, such as adiponectin and visfatin, appear to be more promising as possible vascular markers. In addition, some molecules involved in calcium/phosphorus metabolism, such as klotho and FGF23, have an involvement in the pathogenesis of diabetic vasculopathy, which appears to be dependent on the degree of vascular impairment. Inflammatory markers are a promising tool for treatment decisions while measuring plasma levels of adipokines, sortilin, Klotho and FGF23 in adequately sized longitudinal studies is expected to allow a more precise characterization of diabetic vascular disease and the optimal use of personalized treatment strategies.

Published
2020

12. Sortilin levels correlate with major cardiovascular events of diabetic patients with peripheral artery disease following revascularization: A prospective study

Author

Biscetti, Federico, Nardella, Elisabetta, Rando, M. M., Cecchini, Andrea Leonardo, Bonadia, N., Bruno, Piergiorgio, Angelini, F., Di Stasi, Carmine, Contegiacomo, Andrea, Santoliquido, Angelo, Pitocco, Dario, Landolfi, Raffaele, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Bruno P. (ORCID:0000-0002-1075-5808), Di Stasi C. (ORCID:0000-0002-6822-3599), Contegiacomo A. (ORCID:0000-0003-1489-6314), Santoliquido A. (ORCID:0000-0003-1539-4017), Pitocco D. (ORCID:0000-0002-6220-686X), Landolfi R. (ORCID:0000-0002-7913-8576), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, Federico, Nardella, Elisabetta, Rando, M. M., Cecchini, Andrea Leonardo, Bonadia, N., Bruno, Piergiorgio, Angelini, F., Di Stasi, Carmine, Contegiacomo, Andrea, Santoliquido, Angelo, Pitocco, Dario, Landolfi, Raffaele, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Bruno P. (ORCID:0000-0002-1075-5808), Di Stasi C. (ORCID:0000-0002-6822-3599), Contegiacomo A. (ORCID:0000-0003-1489-6314), Santoliquido A. (ORCID:0000-0003-1539-4017), Pitocco D. (ORCID:0000-0002-6220-686X), Landolfi R. (ORCID:0000-0002-7913-8576), and Flex A. (ORCID:0000-0003-2664-4165)

Abstract

Background: Peripheral artery disease (PAD) represents one of the most relevant vascular complications of type 2 diabetes mellitus (T2DM). Moreover, T2DM patients suffering from PAD have an increased risk of major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Sortilin, a protein involved in apolipoproteins trafficking, is associated with lower limb PAD in T2DM patients. Objective: To evaluate the relationship between baseline serum levels of sortilin, MACE and MALE occurrence after revascularization of T2DM patients with PAD and chronic limb-threatening ischemia (CLTI). Research design and methods: We performed a prospective non-randomized study including 230 statin-free T2DM patients with PAD and CLTI. Sortilin levels were measured before the endovascular intervention and incident outcomes were assessed during a 12 month follow-up. Results: Sortilin levels were significantly increased in individuals with more aggressive PAD (2.25 ± 0.51 ng/mL vs 1.44 ± 0.47 ng/mL, p < 0.001). During follow-up, 83 MACE and 116 MALE occurred. In patients, who then developed MACE and MALE, sortilin was higher. In particular, 2.46 ± 0.53 ng/mL vs 1.55 ± 0.42 ng/mL, p < 0.001 for MACE and 2.10 ± 0.54 ng/mL vs 1.65 ± 0.65 ng/mL, p < 0.001 for MALE. After adjusting for traditional atherosclerosis risk factors, the association between sortilin and vascular outcomes remained significant in a multivariate analysis. In our receiver operating characteristics (ROC) curve analysis using sortilin levels the prediction of MACE incidence improved (area under the curve [AUC] = 0.94) and MALE (AUC = 0.72). Conclusions: This study demonstrates that sortilin correlates with incidence of MACE and MALE after endovascular revascularization in a diabetic population with PAD and CLTI.

Published
2020

13. Assessment of neurological manifestations in hospitalized patients with COVID-19

Author

Luigetti, Marco, Iorio, Raffaele, Bentivoglio, Anna Rita, Tricoli, Luca, Riso, Vittorio, Marotta, Jessica, Piano, Carla, Primiano, Guido Alessandro, Zileri Del Verme, L., Lo Monaco, Maria Rita, Calabresi, Paolo, Abbate, V., Acampora, N., Addolorato, G., Agostini, F., Ainora, M. E., Akacha, K., Amato, E., Andreani, F., Andriollo, G., Annetta, Maria Giuseppina, Annicchiarico, B. E., Antonelli, Massimo, Antonucci, G., Anzellotti, G. M., Armuzzi, A., Baldi, F., Barattucci, I., Barillaro, C., Barone, F., Bellantone, R. D. A., Bellieni, A., Bello, G., Benicchi, A., Benvenuto, F., Berardini, L., Berloco, F., Bernabei, R., Bianchi, A., Biasucci, D. G., Biasucci, L. M., Bibbo, S., Bini, A., Bisanti, A., Biscetti, F., Bocci, M. G., Bonadia, N., Bongiovanni, F., Borghetti, A., Bosco, G., Bosello, Silvia Laura, Bove, V., Bramato, G., Brandi, V., Bruni, T., Bruno, C., Bruno, D., Bungaro, M. C., Buonomo, A., Burzo, L., Calabrese, A., Calvello, M. R., Cambieri, A., Cambise, C., Camma, G., Candelli, M., Canistro, G., Cantanale, A., Capalbo, G., Capaldi, L., Capone, E., Capristo, E., Carbone, L., Cardone, S., Carelli, S., Carfi, A., Carnicelli, A., Caruso, C., Casciaro, F. A., Catalano, L., Cauda, R., Cecchini, A. L., Cerrito, L., Cesarano, M., Chiarito, A., Cianci, Rossella, Cicchinelli, S., Ciccullo, A., Cicetti, M., Ciciarello, F., Cingolani, A., Cipriani, M. C., Consalvo, M. L., Coppola, G., Corbo, G. M., Corsello, A., Costante, F., Costanzi, M., Covino, M., Crupi, D., Cutuli, S. L., D'Addio, S., D'Alessandro, A., D'Alfonso, M. E., D'Angelo, E., D'Aversa, F., Damiano, F., De Berardinis, G. M., De Cunzo, T., De Gaetano, D. K., De Luca, G., De Matteis, G., De Pascale, G., De Santis, P., De Siena, M., De Vito, F., Del Gatto, V., Del Giacomo, P., Del Zompo, F., Dell'Anna, A. M., Della, P. D., Di Gialleonardo, L., Di Giambenedetto, S., Di Luca, R., Di Maurizio, L., Di Muro, M., Dusina, A., Eleuteri, D., Esperide, A., Fachechi, D., Faliero, D., Falsiroli, C., Fantoni, M., Fedele, A., Feliciani, D., Ferrante, C., Ferrone, G., Festa, R., Fiore, M. C., Flex, A., Forte, E., Franceschi, Francesco, Francesconi, A., Franza, L., Funaro, B., Fuorlo, M., Fusco, D., Gabrielli, M., Gaetani, E., Galletta, C., Gallo, A., Gambassi, G., Garcovich, M., Gasbarrini, A., Gasparrini, I., Gelli, S., Giampietro, A., Gigante, L., Giuliano, G., Giupponi, B., Gremese, E., Grieco, Domenico Luca, Guerrera, M., Guglielmi, V., Guidone, C., Gulli, A., Iaconelli, A., Iafrati, A., Ianiro, Gianluca, Iaquinta, A., Impagnatiello, M., Inchingolo, R., Intini, E., Iorio, R., Izzi, I. M., Jovanovic, T., Kadhim, C., La Macchia, R., La Milia, D. I., Landi, F., Landi, G., Landi, R., Landolfi, R., Leo, M., Leone, P. M., Levantesi, L., Liguori, A., Liperoti, R., Lizzio, M. M., Lo Monaco Maria, R., Locantore, P., Lombardi, F., Lombardi, G., Lopetuso, L., Loria, V., Losito, A. R., Lucia, M. B. P., Macagno, F., Macerola, N., Maggi, G., Maiuro, G., Mancarella, F., Mangiola, F., Manno, A., Marchesini, D., Maresca, G. M., Marrone, G., Martis, I., Martone, A. M., Marzetti, Emanuele, Mattana, C., Matteo, M. V., Maviglia, R., Mazzarella, A., Memoli, C., Miele, Luca, Migneco, A., Mignini, I., Milani, A., Milardi, D., Montalto, M., Montemurro, G., Monti, F., Montini, Luca, Morena, T. C., Morra, V., Morretta, C., Moschese, D., Murace, C. A., Murdolo, M., Murri, Rita, Napoli, M., Nardella, E., Natalello, G., Natalini, D., Navarra, S. M., Nesci, A., Nicoletti, A., Nicoletti, R., Nicoletti, T. F., Nicolo, R., Nicolotti, N., Nista, E. C., Nuzzo, E., Oggiano, M., Ojetti, V., Pagano, F. C., Paiano, G., Pais, C., Pallavicini, F., Palombo, A., Paolillo, F., Papa, Alfredo, Papanice, D., Papparella, L. G., Paratore, M., Parrinello, G., Pasciuto, G., Pasculli, P., Pecorini, G., Perniola, S., Pero, E., Petricca, L., Petrucci, M., Picarelli, C., Piccioni, A., Piccolo, A., Piervincenzi, E., Pignataro, G., Pignataro, R., Pintaudi, G., Pisapia, L., Pizzoferrato, M., Pizzolante, F., Pola, R., Policola, C., Pompili, M., Pontecorvi, F., Pontecorvi, V., Ponziani, F., Popolla, V., Porceddu, E., Porfidia, A., Porro, L. M., Potenza, A., Pozzana, F., Privitera, G., Pugliese, D., Pulcini, G., Racco, S., Raffaelli, F., Ramunno, V., Rapaccini, G. L., Richeldi, Luca, Rinninella, Emanuele, Rocchi, S., Romano, B., Romano, S., Rosa, F., Rossi, L., Rossi, R., Rossini, E., Rota, E., Rovedi, F., Rubino, C., Rumi, G., Russo, A., Sabia, L., Salerno, A., Salini, S., Salvatore, L., Samori, D., Sandroni, Claudio, Sanguinetti, M., Santarelli, L., Santini, P., Santolamazza, D., Santoliquido, A., Santopaolo, F., Santoro, M. C., Sardeo, F., Sarnari, C., Saviano, A., Saviano, L., Scaldaferri, Franco, Scarascia, R., Schepis, T., Schiavello, F., Scoppettuolo, G., Sedda, D., Sessa, F., Sestito, L., Settanni, C., Siciliano, M., Siciliano, V., Sicuranza, R., Simeoni, B., Simonetti, J., Smargiassi, A., Soave, P. M., Sonnino, C., Staiti, D., Stella, C., Stella, L., Stival, E., Taddei, E., Talerico, R., Tamburello, E., Tamburrini, E., Tanzarella, E. S., Tarascio, E., Tarli, C., Tersali, A., Tilli, P., Timpano, J., Torelli, E., Torrini, F., Tosato, M., Tosoni, A., Tricoli, L., Tritto, M., Tumbarello, M., Tummolo, A. M., Vallecoccia, M. S., Valletta, F., Varone, F., Vassalli, F., Ventura, G., Verardi, L., Vetrone, L., Vetrugno, G., Visconti, E., Visconti, F., Viviani, A., Zaccaria, R., Zaccone, C., Zelano, L., Zileri Dal Verme, L., Zuccala, G., Luigetti M. (ORCID:0000-0001-7539-505X), Iorio R. (ORCID:0000-0002-6270-0956), Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Tricoli L., Riso V., Marotta J., Piano C., Primiano G., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Calabresi P. (ORCID:0000-0003-0326-5509), Annetta M. G. (ORCID:0000-0001-7574-1311), Antonelli M. (ORCID:0000-0003-3007-1670), Bosello S. (ORCID:0000-0002-4837-447X), Cianci R. (ORCID:0000-0001-5378-8442), Franceschi F. (ORCID:0000-0001-6266-445X), Grieco D. L. (ORCID:0000-0002-4557-6308), Ianiro G. (ORCID:0000-0002-8318-0515), Marzetti E. (ORCID:0000-0001-9567-6983), Miele L. (ORCID:0000-0003-3464-0068), Montini L. (ORCID:0000-0003-4602-5134), Murri R. (ORCID:0000-0003-4263-7854), Papa A. (ORCID:0000-0002-4186-7298), Richeldi L. (ORCID:0000-0001-8594-1448), Rinninella E. (ORCID:0000-0002-9165-2367), Sandroni C. (ORCID:0000-0002-8878-2611), Scaldaferri F. (ORCID:0000-0001-8334-7541), Luigetti, Marco, Iorio, Raffaele, Bentivoglio, Anna Rita, Tricoli, Luca, Riso, Vittorio, Marotta, Jessica, Piano, Carla, Primiano, Guido Alessandro, Zileri Del Verme, L., Lo Monaco, Maria Rita, Calabresi, Paolo, Abbate, V., Acampora, N., Addolorato, G., Agostini, F., Ainora, M. E., Akacha, K., Amato, E., Andreani, F., Andriollo, G., Annetta, Maria Giuseppina, Annicchiarico, B. E., Antonelli, Massimo, Antonucci, G., Anzellotti, G. M., Armuzzi, A., Baldi, F., Barattucci, I., Barillaro, C., Barone, F., Bellantone, R. D. A., Bellieni, A., Bello, G., Benicchi, A., Benvenuto, F., Berardini, L., Berloco, F., Bernabei, R., Bianchi, A., Biasucci, D. G., Biasucci, L. M., Bibbo, S., Bini, A., Bisanti, A., Biscetti, F., Bocci, M. G., Bonadia, N., Bongiovanni, F., Borghetti, A., Bosco, G., Bosello, Silvia Laura, Bove, V., Bramato, G., Brandi, V., Bruni, T., Bruno, C., Bruno, D., Bungaro, M. C., Buonomo, A., Burzo, L., Calabrese, A., Calvello, M. R., Cambieri, A., Cambise, C., Camma, G., Candelli, M., Canistro, G., Cantanale, A., Capalbo, G., Capaldi, L., Capone, E., Capristo, E., Carbone, L., Cardone, S., Carelli, S., Carfi, A., Carnicelli, A., Caruso, C., Casciaro, F. A., Catalano, L., Cauda, R., Cecchini, A. L., Cerrito, L., Cesarano, M., Chiarito, A., Cianci, Rossella, Cicchinelli, S., Ciccullo, A., Cicetti, M., Ciciarello, F., Cingolani, A., Cipriani, M. C., Consalvo, M. L., Coppola, G., Corbo, G. M., Corsello, A., Costante, F., Costanzi, M., Covino, M., Crupi, D., Cutuli, S. L., D'Addio, S., D'Alessandro, A., D'Alfonso, M. E., D'Angelo, E., D'Aversa, F., Damiano, F., De Berardinis, G. M., De Cunzo, T., De Gaetano, D. K., De Luca, G., De Matteis, G., De Pascale, G., De Santis, P., De Siena, M., De Vito, F., Del Gatto, V., Del Giacomo, P., Del Zompo, F., Dell'Anna, A. M., Della, P. D., Di Gialleonardo, L., Di Giambenedetto, S., Di Luca, R., Di Maurizio, L., Di Muro, M., Dusina, A., Eleuteri, D., Esperide, A., Fachechi, D., Faliero, D., Falsiroli, C., Fantoni, M., Fedele, A., Feliciani, D., Ferrante, C., Ferrone, G., Festa, R., Fiore, M. C., Flex, A., Forte, E., Franceschi, Francesco, Francesconi, A., Franza, L., Funaro, B., Fuorlo, M., Fusco, D., Gabrielli, M., Gaetani, E., Galletta, C., Gallo, A., Gambassi, G., Garcovich, M., Gasbarrini, A., Gasparrini, I., Gelli, S., Giampietro, A., Gigante, L., Giuliano, G., Giupponi, B., Gremese, E., Grieco, Domenico Luca, Guerrera, M., Guglielmi, V., Guidone, C., Gulli, A., Iaconelli, A., Iafrati, A., Ianiro, Gianluca, Iaquinta, A., Impagnatiello, M., Inchingolo, R., Intini, E., Iorio, R., Izzi, I. M., Jovanovic, T., Kadhim, C., La Macchia, R., La Milia, D. I., Landi, F., Landi, G., Landi, R., Landolfi, R., Leo, M., Leone, P. M., Levantesi, L., Liguori, A., Liperoti, R., Lizzio, M. M., Lo Monaco Maria, R., Locantore, P., Lombardi, F., Lombardi, G., Lopetuso, L., Loria, V., Losito, A. R., Lucia, M. B. P., Macagno, F., Macerola, N., Maggi, G., Maiuro, G., Mancarella, F., Mangiola, F., Manno, A., Marchesini, D., Maresca, G. M., Marrone, G., Martis, I., Martone, A. M., Marzetti, Emanuele, Mattana, C., Matteo, M. V., Maviglia, R., Mazzarella, A., Memoli, C., Miele, Luca, Migneco, A., Mignini, I., Milani, A., Milardi, D., Montalto, M., Montemurro, G., Monti, F., Montini, Luca, Morena, T. C., Morra, V., Morretta, C., Moschese, D., Murace, C. A., Murdolo, M., Murri, Rita, Napoli, M., Nardella, E., Natalello, G., Natalini, D., Navarra, S. M., Nesci, A., Nicoletti, A., Nicoletti, R., Nicoletti, T. F., Nicolo, R., Nicolotti, N., Nista, E. C., Nuzzo, E., Oggiano, M., Ojetti, V., Pagano, F. C., Paiano, G., Pais, C., Pallavicini, F., Palombo, A., Paolillo, F., Papa, Alfredo, Papanice, D., Papparella, L. G., Paratore, M., Parrinello, G., Pasciuto, G., Pasculli, P., Pecorini, G., Perniola, S., Pero, E., Petricca, L., Petrucci, M., Picarelli, C., Piccioni, A., Piccolo, A., Piervincenzi, E., Pignataro, G., Pignataro, R., Pintaudi, G., Pisapia, L., Pizzoferrato, M., Pizzolante, F., Pola, R., Policola, C., Pompili, M., Pontecorvi, F., Pontecorvi, V., Ponziani, F., Popolla, V., Porceddu, E., Porfidia, A., Porro, L. M., Potenza, A., Pozzana, F., Privitera, G., Pugliese, D., Pulcini, G., Racco, S., Raffaelli, F., Ramunno, V., Rapaccini, G. L., Richeldi, Luca, Rinninella, Emanuele, Rocchi, S., Romano, B., Romano, S., Rosa, F., Rossi, L., Rossi, R., Rossini, E., Rota, E., Rovedi, F., Rubino, C., Rumi, G., Russo, A., Sabia, L., Salerno, A., Salini, S., Salvatore, L., Samori, D., Sandroni, Claudio, Sanguinetti, M., Santarelli, L., Santini, P., Santolamazza, D., Santoliquido, A., Santopaolo, F., Santoro, M. C., Sardeo, F., Sarnari, C., Saviano, A., Saviano, L., Scaldaferri, Franco, Scarascia, R., Schepis, T., Schiavello, F., Scoppettuolo, G., Sedda, D., Sessa, F., Sestito, L., Settanni, C., Siciliano, M., Siciliano, V., Sicuranza, R., Simeoni, B., Simonetti, J., Smargiassi, A., Soave, P. M., Sonnino, C., Staiti, D., Stella, C., Stella, L., Stival, E., Taddei, E., Talerico, R., Tamburello, E., Tamburrini, E., Tanzarella, E. S., Tarascio, E., Tarli, C., Tersali, A., Tilli, P., Timpano, J., Torelli, E., Torrini, F., Tosato, M., Tosoni, A., Tricoli, L., Tritto, M., Tumbarello, M., Tummolo, A. M., Vallecoccia, M. S., Valletta, F., Varone, F., Vassalli, F., Ventura, G., Verardi, L., Vetrone, L., Vetrugno, G., Visconti, E., Visconti, F., Viviani, A., Zaccaria, R., Zaccone, C., Zelano, L., Zileri Dal Verme, L., Zuccala, G., Luigetti M. (ORCID:0000-0001-7539-505X), Iorio R. (ORCID:0000-0002-6270-0956), Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Tricoli L., Riso V., Marotta J., Piano C., Primiano G., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Calabresi P. (ORCID:0000-0003-0326-5509), Annetta M. G. (ORCID:0000-0001-7574-1311), Antonelli M. (ORCID:0000-0003-3007-1670), Bosello S. (ORCID:0000-0002-4837-447X), Cianci R. (ORCID:0000-0001-5378-8442), Franceschi F. (ORCID:0000-0001-6266-445X), Grieco D. L. (ORCID:0000-0002-4557-6308), Ianiro G. (ORCID:0000-0002-8318-0515), Marzetti E. (ORCID:0000-0001-9567-6983), Miele L. (ORCID:0000-0003-3464-0068), Montini L. (ORCID:0000-0003-4602-5134), Murri R. (ORCID:0000-0003-4263-7854), Papa A. (ORCID:0000-0002-4186-7298), Richeldi L. (ORCID:0000-0001-8594-1448), Rinninella E. (ORCID:0000-0002-9165-2367), Sandroni C. (ORCID:0000-0002-8878-2611), and Scaldaferri F. (ORCID:0000-0001-8334-7541)

Abstract

Background and purpose: The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods: Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results: In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions: Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.

Published
2020

14. High mobility group box-1 and diabetes mellitus complications: State of the art and future perspectives

Author

Biscetti, Federico, Rando, M. M., Nardella, Elisabetta, Cecchini, Andrea Leonardo, Pecorini, Giovanni, Landolfi, Raffaele, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Pecorini G. (ORCID:0000-0002-0729-6719), Landolfi R. (ORCID:0000-0002-7913-8576), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, Federico, Rando, M. M., Nardella, Elisabetta, Cecchini, Andrea Leonardo, Pecorini, Giovanni, Landolfi, Raffaele, Flex, Andrea, Biscetti F. (ORCID:0000-0001-7449-657X), Nardella E., Cecchini A. L., Pecorini G. (ORCID:0000-0002-0729-6719), Landolfi R. (ORCID:0000-0002-7913-8576), and Flex A. (ORCID:0000-0003-2664-4165)

Abstract

Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied, not all players responsible for these complications have been defined yet. High Mobility Group Box-1 (HMGB1) is a non-histone nuclear protein that has been implicated in many pathological processes, from sepsis to ischemia. The purpose of this review is to take stock of all the most recent data available on the role of HMGB1 in the complications of DM.

Published
2019

15. The Role of the Stem Cells Therapy in the Peripheral Artery Disease.

Author

Biscetti, Federico, Bonadia, N, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Landolfi, Raffaele, Flex, Andrea, Biscetti F (ORCID:0000-0001-7449-657X), Nardella E, Landolfi R (ORCID:0000-0002-7913-8576), Flex A. (ORCID:0000-0003-2664-4165), Biscetti, Federico, Bonadia, N, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Landolfi, Raffaele, Flex, Andrea, Biscetti F (ORCID:0000-0001-7449-657X), Nardella E, Landolfi R (ORCID:0000-0002-7913-8576), and Flex A. (ORCID:0000-0003-2664-4165)

Abstract

Vascular complications of diabetes mellitus are an important issue for all clinicians involved in the management of this complex pathology. Although many therapeutic advances have been reached, peripheral arterial disease is still an unsolved problem that each year compromises the quality of life and life span of affected patients. Oftentimes, patients, after ineffective attempts of revascularization, undergo greater amputations. At the moment, there is no effective and definitive treatment available. In this scenario, the therapeutic use of stem cells could be an interesting option. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the stem cells therapy in this field, from biomarker to possible therapeutic target.

Published
2019

16. Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease.

Author

Biscetti, Federico, Nardella, Elisabetta, Bonadia, N, Angelini, F, Pitocco, Dario, Santoliquido, Angelo, Filipponi, M, Landolfi, Raffaele, Flex, Andrea, Biscetti F (ORCID:0000-0001-7449-657X), Nardella E, Pitocco D (ORCID:0000-0002-6220-686X), Santoliquido A (ORCID:0000-0003-1539-4017), Landolfi R (ORCID:0000-0002-7913-8576), Flex A (ORCID:0000-0003-2664-4165), Biscetti, Federico, Nardella, Elisabetta, Bonadia, N, Angelini, F, Pitocco, Dario, Santoliquido, Angelo, Filipponi, M, Landolfi, Raffaele, Flex, Andrea, Biscetti F (ORCID:0000-0001-7449-657X), Nardella E, Pitocco D (ORCID:0000-0002-6220-686X), Santoliquido A (ORCID:0000-0003-1539-4017), Landolfi R (ORCID:0000-0002-7913-8576), and Flex A (ORCID:0000-0003-2664-4165)

Abstract

BACKGROUND: Type-2 diabetes mellitus is one of the major risk factors of atherosclerosis, particularly in peripheral artery disease (PAD). Several studies have documented a correlation between omentin-1 serum levels, atherosclerosis, and cardiovascular diseases. However, a clear link between circulating omentin-1 and PAD in diabetic patients has yet to be established. The aim of this study was to investigate the potential role of omentin-1 in PAD in type-2 diabetic patients. METHODS: In this cross-sectional study, we analyzed omentin-1 serum levels by ELISA in 600 type-2 diabetic patients with (n = 300) and without (n = 300) PAD at Fontaine's stage II, III, or IV. RESULTS: We found that omentin-1 serum levels were significantly lower in diabetic patients with PAD than in diabetic controls (29.46 vs 49.24 ng/mL, P < 0.001) and that the levels gradually decreased in proportion to disease severity (P < 0.05). The association between omentin-1 levels and PAD remained significant after adjusting for major risk factors in a multivariate analysis. CONCLUSIONS: Our results suggest that omentin-1 is reduced in type 2 diabetic patients with PAD and that omentin-1 levels are related to disease severity.

Published
2019

17. Office-based anesthesia in Belgium?

Author

UCL - MD/CHIR - Département de chirurgie, UCL - (SLuc) Service d'anesthésiologie, Ferrant, Tanguy, Nardella, E, Van Boven, Michel, UCL - MD/CHIR - Département de chirurgie, UCL - (SLuc) Service d'anesthésiologie, Ferrant, Tanguy, Nardella, E, and Van Boven, Michel

Abstract

For many years, office based anesthesia (OBA), has been considerably increasing in the US. This type of practice is starting to develop in Belgium. On the other side of the atlantic, legislation concerning this practice is becoming more and more precise, whereas the same isn't true in our country. It seems therefore opportune to try and define the different points of view. This article will define the position of the legislator, insurance companies and finally, of the professional organizations. OBA practice is developping insidiously here, and we should therefore ask ourselves serious questions regarding the legal repercussions that it could have. To conclude, we can say that if for a couple of years, the US have started to legislate and propose guidelines, as well as creating special accreditation organizations to inspect and advise the offices, the same is not the case in Belgium. The OBA phenomenon arrived much later here and is really at its very beginnings, but it seems however important to anticipate and clearly regulate this practice in our country.

Published
2008

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