1. Eosinophilic and Noneosinophilic Asthma
- Author
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Liam G. Heaney, Luis Perez de Llano, Mona Al-Ahmad, Vibeke Backer, John Busby, G. Walter Canonica, George C. Christoff, Borja G. Cosio, J. Mark FitzGerald, Enrico Heffler, Takashi Iwanaga, David J. Jackson, Andrew N. Menzies-Gow, Nikos G. Papadopoulos, Andriana I. Papaioannou, Paul E. Pfeffer, Todor A. Popov, Celeste M. Porsbjerg, Chin Kook Rhee, Mohsen Sadatsafavi, Yuji Tohda, Eileen Wang, Michael E. Wechsler, Marianna Alacqua, Alan Altraja, Leif Bjermer, Unnur S. Björnsdóttir, Arnaud Bourdin, G.G.O. (Guy) Brusselle, Roland Buhl, Richard W. Costello, Mark Hew, Mariko Siyue Koh, Sverre Lehmann, Lauri Lehtimäki, Matthew Peters, Camille Taillé, Christian Taube, Trung N. Tran, James Zangrilli, Lakmini Bulathsinhala, Victoria A. Carter, Isha Chaudhry, Neva Eleangovan, Naeimeh Hosseini, Marjan Kerkhof, Ruth Murray, Chris A. Price, David B. Price, Liam G. Heaney, Luis Perez de Llano, Mona Al-Ahmad, Vibeke Backer, John Busby, G. Walter Canonica, George C. Christoff, Borja G. Cosio, J. Mark FitzGerald, Enrico Heffler, Takashi Iwanaga, David J. Jackson, Andrew N. Menzies-Gow, Nikos G. Papadopoulos, Andriana I. Papaioannou, Paul E. Pfeffer, Todor A. Popov, Celeste M. Porsbjerg, Chin Kook Rhee, Mohsen Sadatsafavi, Yuji Tohda, Eileen Wang, Michael E. Wechsler, Marianna Alacqua, Alan Altraja, Leif Bjermer, Unnur S. Björnsdóttir, Arnaud Bourdin, G.G.O. (Guy) Brusselle, Roland Buhl, Richard W. Costello, Mark Hew, Mariko Siyue Koh, Sverre Lehmann, Lauri Lehtimäki, Matthew Peters, Camille Taillé, Christian Taube, Trung N. Tran, James Zangrilli, Lakmini Bulathsinhala, Victoria A. Carter, Isha Chaudhry, Neva Eleangovan, Naeimeh Hosseini, Marjan Kerkhof, Ruth Murray, Chris A. Price, and David B. Price
- Abstract
Background: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. Research Question: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these phenotypes be differentiated by clinical and biomarker variables? Study Design and Methods: This was an historical registry study. Adult patients with severe asthma and available blood eosinophil count (BEC) from 11 countries enrolled in the International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood of eosinophilic phenotype using a predefined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Demographic and clinical characteristics were defined at baseline (ie, 1 yea
- Published
- 2021
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