50 results on '"Nongnuch, A."'
Search Results
2. MICROPROPAGATION OF AQUARIUM PLANT, ANUBIAS SP. ‘WHITE’ USING ADENINE SULFATE AND 6-BENZYLAMINOPURINE
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Boonmee, Wimonmat, Laohavisuti, Nongnuch, Srisawang, Achara, Jongput, Buppha, Ruangdej, Uscharee, Seesanong, Somkiat, Boonmee, Wimonmat, Laohavisuti, Nongnuch, Srisawang, Achara, Jongput, Buppha, Ruangdej, Uscharee, and Seesanong, Somkiat
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Introduction: Anubias sp. “White” is distinguished from other Anubias species by mutation. The leaves are white and green, which is popular and has great market demand. The growth of this aquarium plant is slow. Method: The combination of adenine sulfate (Ads) and 6-benzyl aminopurine (BAP) into Murashige and Skoog (MS) medium. A comparison of three substrate materials, i.e., filter pads (FP), husk ash granules (HAG) and rockwool (RW) were used in ex-vitro acclimatization of the plantlets. Results: Ads and BAP had combined effects on the plantlets, leaves and roots of the apical bud (p<0.05). The treatment with only BAP at 0.5 mg/L in MS medium obtained the highest number of shoots, which was 7.40 shoots/explant (p<0.05). There is an interaction between 25 mg/L Ads and 1-1.5 mg/L BAP to induce callus. The treatments with HAG were better than the other planting materials in terms of growth performance (p<0.05). HAG yielded the best growth (fresh weight of 0.74 g/plant), which was better than FP and RW, respectively, and showed a significant (p<0.05) difference in terms of root number and plant height except root length. Conclusion: There was an interaction between 25 mg/L Ads and 1-1.5 mg/L BAP to induce callus. The treatment with only BAP at 0.5 mg/L in MS medium obtained the highest number of shoots, which was 7.40 shoots/explant (p<0.05). The HAG as a planting medium was the optimal ex-vitro acclimatization of Anubias sp. ‘white’ plantlets.
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- 2024
3. Practical approaches to mining of clinical datasets : from frameworks to novel feature selection
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Poolsawad, Nongnuch and Kambhampati, Chandra
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004 ,Computer science - Abstract
Research has investigated clinical data that have embedded within them numerous complexities and uncertainties in the form of missing values, class imbalances and high dimensionality. The research in this thesis was motivated by these challenges to minimise these problems whilst, at the same time, maximising classification performance of data and also selecting the significant subset of variables. As such, this led to the proposal of a data mining framework and feature selection method. The proposed framework has a simple algorithmic framework and makes use of a modified form of existing frameworks to address a variety of different data issues, called the Handling Clinical Data Framework (HCDF). The assessment of data mining techniques reveals that missing values imputation and resampling data for class balancing can improve the performance of classification. Next, the proposed feature selection method was introduced; it involves projecting onto principal component method (FS-PPC) and draws on ideas from both feature extraction and feature selection to select a significant subset of features from the data. This method selects features that have high correlation with the principal component by applying symmetrical uncertainty (SU). However, irrelevant and redundant features are removed by using mutual information (MI). However, this method provides confidence in the selected subset of features that will yield realistic results with less time and effort. FS-PPC is able to retain classification performance and meaningful features while consisting of non-redundant features. The proposed methods have been practically applied to analysis of real clinical data and their effectiveness has been assessed. The results show that the proposed methods are enable to minimise the clinical data problems whilst, at the same time, maximising classification performance of data.
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- 2014
4. The relationships between agricultural spot and futures markets : the case of rice
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Tantisantiwong, Nongnuch
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338.14 - Published
- 2005
5. Mixed hydride-electronic conductivity in Rb2CaH4 and Cs2CaH4
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Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Rodenburg, Hendrik P., Mutschke, Alexander, Ngamwongwan, Lappawat, Gulino, Valerio, Kyriakou, Vasileios, Kunkel, Nathalie, Artrith, Nongnuch, Ngene, Peter, Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Rodenburg, Hendrik P., Mutschke, Alexander, Ngamwongwan, Lappawat, Gulino, Valerio, Kyriakou, Vasileios, Kunkel, Nathalie, Artrith, Nongnuch, and Ngene, Peter
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- 2023
6. Ultrafast X-ray imaging of the light-induced phase transition in VO2
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Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Johnson, Allan S., Perez-Salinas, Daniel, Siddiqui, Khalid M., Kim, Sungwon, Choi, Sungwook, Volckaert, Klara, Majchrzak, Paulina E., Ulstrup, Søren, Agarwal, Naman, Hallman, Kent, Haglund, Richard F., Günther, Christian M., Pfau, Bastian, Eisebitt, Stefan, Backes, Dirk, Maccherozzi, Francesco, Fitzpatrick, Ann, Dhesi, Sarnjeet S., Gargiani, Pierluigi, Valvidares, Manuel, Artrith, Nongnuch, de Groot, Frank, Choi, Hyeongi, Jang, Dogeun, Katoch, Abhishek, Kwon, Soonnam, Park, Sang Han, Kim, Hyunjung, Wall, Simon E., Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Johnson, Allan S., Perez-Salinas, Daniel, Siddiqui, Khalid M., Kim, Sungwon, Choi, Sungwook, Volckaert, Klara, Majchrzak, Paulina E., Ulstrup, Søren, Agarwal, Naman, Hallman, Kent, Haglund, Richard F., Günther, Christian M., Pfau, Bastian, Eisebitt, Stefan, Backes, Dirk, Maccherozzi, Francesco, Fitzpatrick, Ann, Dhesi, Sarnjeet S., Gargiani, Pierluigi, Valvidares, Manuel, Artrith, Nongnuch, de Groot, Frank, Choi, Hyeongi, Jang, Dogeun, Katoch, Abhishek, Kwon, Soonnam, Park, Sang Han, Kim, Hyunjung, and Wall, Simon E.
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- 2023
7. Author Correction: Ultrafast X-ray imaging of the light-induced phase transition in VO2
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Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Johnson, Allan S., Perez-Salinas, Daniel, Siddiqui, Khalid M., Kim, Sungwon, Choi, Sungwook, Volckaert, Klara, Majchrzak, Paulina E., Ulstrup, Søren, Agarwal, Naman, Hallman, Kent, Haglund, Richard F., Günther, Christian M., Pfau, Bastian, Eisebitt, Stefan, Backes, Dirk, Maccherozzi, Francesco, Fitzpatrick, Ann, Dhesi, Sarnjeet S., Gargiani, Pierluigi, Valvidares, Manuel, Artrith, Nongnuch, de Groot, Frank, Choi, Hyeongi, Jang, Dogeun, Katoch, Abhishek, Kwon, Soonnam, Park, Sang Han, Kim, Hyunjung, Wall, Simon E., Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Johnson, Allan S., Perez-Salinas, Daniel, Siddiqui, Khalid M., Kim, Sungwon, Choi, Sungwook, Volckaert, Klara, Majchrzak, Paulina E., Ulstrup, Søren, Agarwal, Naman, Hallman, Kent, Haglund, Richard F., Günther, Christian M., Pfau, Bastian, Eisebitt, Stefan, Backes, Dirk, Maccherozzi, Francesco, Fitzpatrick, Ann, Dhesi, Sarnjeet S., Gargiani, Pierluigi, Valvidares, Manuel, Artrith, Nongnuch, de Groot, Frank, Choi, Hyeongi, Jang, Dogeun, Katoch, Abhishek, Kwon, Soonnam, Park, Sang Han, Kim, Hyunjung, and Wall, Simon E.
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- 2023
8. ænet-PyTorch: A GPU-supported implementation for machine learning atomic potentials training
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Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, López-Zorrilla, Jon, Aretxabaleta, Xabier M., Yeu, In Won, Etxebarria, Iñigo, Manzano, Hegoi, Artrith, Nongnuch, Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, López-Zorrilla, Jon, Aretxabaleta, Xabier M., Yeu, In Won, Etxebarria, Iñigo, Manzano, Hegoi, and Artrith, Nongnuch
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- 2023
9. Simulated sulfur K-edge X-ray absorption spectroscopy database of lithium thiophosphate solid electrolytes
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Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Guo, Haoyue, Carbone, Matthew R., Cao, Chuntian, Qu, Jianzhou, Du, Yonghua, Bak, Seong Min, Weiland, Conan, Wang, Feng, Yoo, Shinjae, Artrith, Nongnuch, Urban, Alexander, Lu, Deyu, Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Guo, Haoyue, Carbone, Matthew R., Cao, Chuntian, Qu, Jianzhou, Du, Yonghua, Bak, Seong Min, Weiland, Conan, Wang, Feng, Yoo, Shinjae, Artrith, Nongnuch, Urban, Alexander, and Lu, Deyu
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- 2023
10. Stigma Experienced by Patients Who Recovered from COVID-19 in Post-Vaccination Period in Thailand; Prevalence and Associated Factors
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Techapoonpon,Kamolvisa, Kerdchareon,Nitchawan, Polruamngern,Nongnuch, Chalermrungroj,Teeraphan, Srikhamdokkhae,Orranee, Matangkarat,Premyuda, Techapoonpon,Kamolvisa, Kerdchareon,Nitchawan, Polruamngern,Nongnuch, Chalermrungroj,Teeraphan, Srikhamdokkhae,Orranee, and Matangkarat,Premyuda
- Abstract
Kamolvisa Techapoonpon, Nitchawan Kerdchareon, Nongnuch Polruamngern, Teeraphan Chalermrungroj, Orranee Srikhamdokkhae, Premyuda Matangkarat Department of Psychiatry, Navamindradhiraj University, Vajira Hospital, Bangkok, ThailandCorrespondence: Nitchawan Kerdchareon, Department of Psychiatry, Navamindradhiraj University, Vajira Hospital, 681 Samsen Road, Dusit District, Bangkok, Thailand, 10300, Tel +66 2-244-3187, Email nitchawan@nmu.ac.thPurpose: Social stigma related to coronavirus disease-2019 (COVID-19) has been a public concern since its emergence, especially in the patients who are reintegrating into their society. However, the insights into COVID-19 stigmatization after vaccine availability are limited. This study aimed to estimate the prevalence, severity and associated factors of stigma experienced by patients who recovered from COVID-19 and reintegrated into their communities. The insights gained from this study are not only beneficial to COVID-19 but can also be used as a background information in future epidemics.Patients and Methods: This study consisted of two phases. The first phase involved the translation and validation of the COVID-19-related stigma questionnaire. The second phase was a questionnaire-based cross-sectional survey conducted between January and February 2022, at the Vajira Hospital, Bangkok, Thailand. A series of questionnaires regarding stigma, negative emotions (Depression Anxiety Stress Scale-21), and personal information were administered to COVID-19 patients who were already discharged and returned to their communities from June 2021 to February 28, 2022 (N = 354).Results: The prevalence of stigma among the patients who recovered from COVID-19 was 57.9%. These were classified as mild (28.2%), moderate (21.5%), and severe (8.2%). Pearsonâs correlation analysis revealed that longer admissions (r = - 0.151, p = 0.001) and longer duration from discharge (r = - 0.222, p = 0.001) were related to lower stigma. Higher stigma was asso
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- 2023
11. ænet-PyTorch: A GPU-supported implementation for machine learning atomic potentials training
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Física, Fisika, López Zorrilla, Jon, Méndez Aretxabaleta, Xabier, Yeu, In Won, Etxebarria Altzaga, Iñigo, Manzano Moro, Hegoi, Artrith, Nongnuch, Física, Fisika, López Zorrilla, Jon, Méndez Aretxabaleta, Xabier, Yeu, In Won, Etxebarria Altzaga, Iñigo, Manzano Moro, Hegoi, and Artrith, Nongnuch
- Abstract
In this work, we present ænet-PyTorch, a PyTorch-based implementation for training artificial neural network-based machine learning interatomic potentials. Developed as an extension of the atomic energy network (ænet), ænet-PyTorch provides access to all the tools included in ænet for the application and usage of the potentials. The package has been designed as an alternative to the internal training capabilities of ænet, leveraging the power of graphic processing units to facilitate direct training on forces in addition to energies. This leads to a substantial reduction of the training time by one to two orders of magnitude compared to the central processing unit implementation, enabling direct training on forces for systems beyond small molecules. Here, we demonstrate the main features of ænet-PyTorch and show its performance on open databases. Our results show that training on all the force information within a dataset is not necessary, and including between 10% and 20% of the force information is sufficient to achieve optimally accurate interatomic potentials with the least computational resources.
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- 2023
12. Artificial Intelligence-Aided Mapping of the Structure-Composition-Conductivity Relationships of Glass-Ceramic Lithium Thiophosphate Electrolytes
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Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Guo, Haoyue, Wang, Qian, Urban, Alexander, Artrith, Nongnuch, Sub Materials Chemistry and Catalysis, Materials Chemistry and Catalysis, Guo, Haoyue, Wang, Qian, Urban, Alexander, and Artrith, Nongnuch
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- 2022
13. Data-driven approach to parameterize SCAN+U for an accurate description of 3d transition metal oxide thermochemistry
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Artrith, Nongnuch, Garrido Torres, José Antonio, Urban, Alexander, Hybertsen, Mark S., Artrith, Nongnuch, Garrido Torres, José Antonio, Urban, Alexander, and Hybertsen, Mark S.
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- 2022
14. Three-Decade Successive Establishment of Care for Women/Girls from Families with Haemophilia
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Chuansumrit,Ampaiwan, Sasanakul,Werasak, Sirachainan,Nongnuch, Santiwatana,Suttikarn, Kadegasem,Praguywan, Wongwerawattanakoon,Pakawan, Tungbubpha,Noppawan, Chantaraamporn,Juthamard, Chuansumrit,Ampaiwan, Sasanakul,Werasak, Sirachainan,Nongnuch, Santiwatana,Suttikarn, Kadegasem,Praguywan, Wongwerawattanakoon,Pakawan, Tungbubpha,Noppawan, and Chantaraamporn,Juthamard
- Abstract
Ampaiwan Chuansumrit,1 Werasak Sasanakul,1 Nongnuch Sirachainan,1 Suttikarn Santiwatana,1 Praguywan Kadegasem,1 Pakawan Wongwerawattanakoon,2 Noppawan Tungbubpha,1 Juthamard Chantaraamporn1 1Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Nursing, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Ampaiwan Chuansumrit, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand, Tel +66 2 2011749, Fax +66 2 2011748, Email ampaiwan.jua@mahidol.ac.thObjective: The study aimed to report a 3-decade successive establishment of care for women/girls from families with haemophilia.Methods: A retrospective analysis was conducted on 462 women/girls from 243 families from 1987 to 2021.Results: Combining phenotypic analysis of coagulation factor and genotypic analysis of either linkage analysis or mutation detection confirmed the status of all obligate haemophilia carriers (A118, B19). For potential carrier, 159 proven carriers (A130, B29) and 146 noncarrier status (A126, B20) were diagnosed except 20 potential carriers (A16, B4). Only 54 prenatal diagnoses were requested resulting in normal males (n = 21), males with haemophilia A (n = 12) and females with either normal or carrier status (n = 21). Additionally, 40 women/girls with haemophilia carrier received a diagnosis of severe haemophilia A with Turnerâs syndrome (n = 2) and mild haemophilia (A31, B7). The skewed X-chromosome inactivation of the nonmutant factor VIII/IX carrying X-chromosome of 8% (2/25) was found in mild haemophilia. Factor concentrate and desmopressin are prescribed for these affected women/girls. The response of women/girls with either haemophilia carrier or haemophilia was amazement with their religious beliefs and cultural acceptance.Conclusion: Appropriate care for women/girls from families with haemophilia concerning diagnosis
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- 2022
15. Prominent Mutation of Intron 22 Inversion in Sporadic Hemophilia: Is It Worth the Antenatal Screening?
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Sasanakul,Werasak, Chuansumrit,Ampaiwan, Sirachainan,Nongnuch, Kadegasem,Praguywan, Sasanakul,Werasak, Chuansumrit,Ampaiwan, Sirachainan,Nongnuch, and Kadegasem,Praguywan
- Abstract
Werasak Sasanakul, Ampaiwan Chuansumrit, Nongnuch Sirachainan, Praguywan Kadegasem Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Ampaiwan Chuansumrit, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand, Tel +66 2 2011749, Fax +66 2 2011748, Email ampaiwan.jua@mahidol.ac.thBackground: Adequate replacement for patients with hemophilia is costly, especially in countries with limited resources.Objective: Factor VIII gene mutations among Thai patients with hemophilia A were analyzed for the most common mutation. The cost-effectiveness of finding one female without family history of hemophilia possessing the most common factor VIII mutation was compared with the cost of treating one patient with hemophilia.Methods: In all, 109 unrelated patients with hemophilia A, defined as sporadic cases (n=58) and hereditary cases (n=51), were enrolled for genotypic analysis.Results: Intron 22 inversion was prominently found in 34 sporadic (58.6%) and 27 hereditary (51.9%) cases. The screening for intron 22 inversion among females without family history of hemophilia at antenatal care has been optionally suggested. A female with a positive result will undergo further prenatal diagnosis of hemophilia in her male offspring. On the contrary, a female with a negative test result remains at risk to have a hemophiliac son caused by other factor VIII gene mutations not included in the screening but the risk is not as high as intron 22 inversion. Although the screening of factor VIII mutation among females without family history of hemophilia is against the current practice, it has been initiated due to the inadequate treatment provided to patients with hemophilia in countries with limited resources. The study calculated approximately one female with intron 22 inversion would exist among 17,064 females without family history of hemophilia. The cost of scree
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- 2022
16. Atomic-scale factors that control the rate capability of nanostructured amorphous Si for high-energy-density batteries
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Artrith, Nongnuch, Artrith, Nongnuch, Urban, Alexander, Wang, Yan, Ceder, Gerbrand, Artrith, Nongnuch, Artrith, Nongnuch, Urban, Alexander, Wang, Yan, and Ceder, Gerbrand
- Abstract
Nanostructured Si is the most promising high-capacity anode material to substantially increase the energy density of Li-ion batteries. Among the remaining challenges is its low rate capability as compared to conventional materials. To understand better what controls the diffusion of Li in the amorphous Li-Si alloy, we use a novel machine-learning potential trained on more than 40,000 ab-initio calculations and nanosecond-scale molecular dynamics simulations, to visualize for the first time the delithiation of entire LiSi nanoparticles. Our results show that the Si host is not static but undergoes a dynamic rearrangement from isolated atoms, to chains, and clusters, with the Li diffusion strongly governed by this Si rearrangement. We find that the Li diffusivity is highest when Si segregates into clusters, so that Li diffusion proceeds via hopping between the Si clusters. The average size of Si clusters and the concentration range over which Si clustering occurs can thus function as design criteria for the development of rate-improved anodes based on modified Si.
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- 2019
17. International pediatric thrombosis network to advance pediatric thrombosis research: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis
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van Ommen, Heleen, Albisetti, M, Bhatt, M, Bonduel, M, Branchford, Brian, Chalmers, Elizabeth, Chan, A, Goldenberg, NA, Holzhauer, S, Monagle, Paul, Nowak-Gottl, U, Revel-Vilk, Shoshana, Sciuccatie, Gabriela, Sirachainan, Nongnuch, Male, Christoph, van Ommen, Heleen, Albisetti, M, Bhatt, M, Bonduel, M, Branchford, Brian, Chalmers, Elizabeth, Chan, A, Goldenberg, NA, Holzhauer, S, Monagle, Paul, Nowak-Gottl, U, Revel-Vilk, Shoshana, Sciuccatie, Gabriela, Sirachainan, Nongnuch, and Male, Christoph
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Pediatric thromboembolism is a rare and heterogenous disease. As a result, there is a paucity of knowledge with regard to natural history, management, and outcomes of most types of pediatric venous and arterial thromboembolism. International research collaboration is needed to fill these knowledge gaps. Not only randomized controlled trials, but also representative observational studies are required to answer all research questions. Therefore, the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis initiated the International Pediatric Thrombosis Network (IPTN). The aims of the IPTN include (1) development of the Throm-PED registry to facilitate international prospective observational studies, and (2) establishment of a network of pediatric thrombosis centers experienced in effectively conducting clinical trials and observational studies. The IPTN needs dedicated clinicians all over the world and several funding sources to obtain high-quality research data to reach its ultimate goal of improving care in children with thrombosis. The aim of this communication is to call for active participation in the IPTN to all physicians taking care of children with thrombosis worldwide.
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- 2021
18. Constructing first-principles phase diagrams of amorphous LixSi using machine-learning-assisted sampling with an evolutionary algorithm.
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Artrith, Nongnuch, Artrith, Nongnuch, Urban, Alexander, Ceder, Gerbrand, Artrith, Nongnuch, Artrith, Nongnuch, Urban, Alexander, and Ceder, Gerbrand
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The atomistic modeling of amorphous materials requires structure sizes and sampling statistics that are challenging to achieve with first-principles methods. Here, we propose a methodology to speed up the sampling of amorphous and disordered materials using a combination of a genetic algorithm and a specialized machine-learning potential based on artificial neural networks (ANNs). We show for the example of the amorphous LiSi alloy that around 1000 first-principles calculations are sufficient for the ANN-potential assisted sampling of low-energy atomic configurations in the entire amorphous LixSi phase space. The obtained phase diagram is validated by comparison with the results from an extensive sampling of LixSi configurations using molecular dynamics simulations and a general ANN potential trained to ∼45 000 first-principles calculations. This demonstrates the utility of the approach for the first-principles modeling of amorphous materials.
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- 2018
19. Hidden structural and chemical order controls lithium transport in cation-disordered oxides for rechargeable batteries.
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Ji, Huiwen, Ji, Huiwen, Urban, Alexander, Kitchaev, Daniil A, Kwon, Deok-Hwang, Artrith, Nongnuch, Ophus, Colin, Huang, Wenxuan, Cai, Zijian, Shi, Tan, Kim, Jae Chul, Kim, Haegyeom, Ceder, Gerbrand, Ji, Huiwen, Ji, Huiwen, Urban, Alexander, Kitchaev, Daniil A, Kwon, Deok-Hwang, Artrith, Nongnuch, Ophus, Colin, Huang, Wenxuan, Cai, Zijian, Shi, Tan, Kim, Jae Chul, Kim, Haegyeom, and Ceder, Gerbrand
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Structure plays a vital role in determining materials properties. In lithium ion cathode materials, the crystal structure defines the dimensionality and connectivity of interstitial sites, thus determining lithium ion diffusion kinetics. In most conventional cathode materials that are well-ordered, the average structure as seen in diffraction dictates the lithium ion diffusion pathways. Here, we show that this is not the case in a class of recently discovered high-capacity lithium-excess rocksalts. An average structure picture is no longer satisfactory to understand the performance of such disordered materials. Cation short-range order, hidden in diffraction, is not only ubiquitous in these long-range disordered materials, but fully controls the local and macroscopic environments for lithium ion transport. Our discovery identifies a crucial property that has previously been overlooked and provides guidelines for designing and engineering cation-disordered cathode materials.
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- 2019
20. Partial characteristics of hemolytic factors secreted from airborne Aspergillus and Penicillium, and an enhancement of hemolysis by Aspergillus micronesiensis CAMP-like factor via Staphylococcus aureus-sphingomyelinase
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Kaveemongkonrat, Sumonrat, Duangsonk, Kwanjit, Houbraken, Jos, Suwannaphong, Phimchat, Vanittanakom, Nongnuch, Mekaprateep, Malee, Kaveemongkonrat, Sumonrat, Duangsonk, Kwanjit, Houbraken, Jos, Suwannaphong, Phimchat, Vanittanakom, Nongnuch, and Mekaprateep, Malee
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- 2019
21. Assessment of the stated policies of prominent food companies related to obesity and non-communicable disease (NCD) prevention in Thailand
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Cetthakrikul, Nisachol, Phulkerd, Sirinya, Jaichuen, Nongnuch, Sacks, Gary, Tangcharoensathien, Viroj, Cetthakrikul, Nisachol, Phulkerd, Sirinya, Jaichuen, Nongnuch, Sacks, Gary, and Tangcharoensathien, Viroj
- Abstract
OBJECTIVE: To review the publicly available policies and commitments of selected food companies in Thailand relating to obesity and non-communicable diseases (NCDs) prevention, and to assess these stated policies and commitments against global recommendations. METHODS: Nineteen food and beverage companies, including 13 packaged food, three non-alcoholic beverage, two food retailer, and one fast food company were selected, based on their market share by sector and food category. A review of publicly available policies and commitments related to four domains (product reformulation, food marketing, nutrition information and food accessibility) was carried out for each company. Content analysis of all data was conducted, including a comparison of policy content against global recommendations in each domain. RESULTS: Eleven companies (58%) reported at least one policy or commitment across the four domains. The packaged food companies reported policies in all four domains while the beverage companies committed to implement policies in all except the accessibility domain. The food retailers and fast food company only had policies in the reformulation and nutrition information domains. Very few of the policies and commitments covered all of the recommended components in each domain, and most lacked sufficient specificity to allow detailed monitoring and evaluation. CONCLUSION: A small number of the most prominent food companies in Thailand have several nutrition-related policies in place. However, these policies do not sufficiently cover recommended areas for NCD and obesity prevention. Moreover, the extent to which policy statements translate to implementation has yet to be evaluated. Successful implementation of nutrition-related policies by the food industry in Thailand will likely require concrete, measurable indicators to guide both corporate policy making as well as public monitoring. The Thailand Government requires greater capacity to establish effective multi-secto
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- 2019
22. Global benchmarking of children's exposure to television advertising of unhealthy foods and beverages across 22 countries
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Kelly, Bridget, Vandevijvere, Stefanie, Ng, See Hoe, Adams, Jean, Allemandi, Lorena, Bahena-Espina, Liliana, Barquera, Simon, Boyland, Emma J, Calleja, Paul, Carmona-Garces, Isabel Cristina, Castronuovo, Luciana, Cauchi, Daniel, Correa, Teresa, Corvalan, Camila, Cosenza-Quintana, Emma, Fernandez-Escobar, Carlos, Gonzalez-Zapata, Laura, Halford, Jason C, Jaichuen, Nongnuch, Jensen, Melissa, Karupaiah, Tilakavati, Kaur, Asha, Kroker-Lobos, Maria, Mchiza, Zandile, Miklavec, Krista, Parker, Whadi-ah, Potvin Kent, Monique, Pravst, Igor, Ramirez-Zea, Manuel, Reiff, Sascha, Reyes, Marcela, Royo-Bordonada, Miguel, Rueangsom, Putthipanya, Scarborough, Peter, Tiscornia, Maria, Tolentino-Mayo, Lizbeth, Wate, Jillian, White, Martin, Zamora-Corrales, Irina, Zeng, Lingxia, Swinburn, Boyd A, Kelly, Bridget, Vandevijvere, Stefanie, Ng, See Hoe, Adams, Jean, Allemandi, Lorena, Bahena-Espina, Liliana, Barquera, Simon, Boyland, Emma J, Calleja, Paul, Carmona-Garces, Isabel Cristina, Castronuovo, Luciana, Cauchi, Daniel, Correa, Teresa, Corvalan, Camila, Cosenza-Quintana, Emma, Fernandez-Escobar, Carlos, Gonzalez-Zapata, Laura, Halford, Jason C, Jaichuen, Nongnuch, Jensen, Melissa, Karupaiah, Tilakavati, Kaur, Asha, Kroker-Lobos, Maria, Mchiza, Zandile, Miklavec, Krista, Parker, Whadi-ah, Potvin Kent, Monique, Pravst, Igor, Ramirez-Zea, Manuel, Reiff, Sascha, Reyes, Marcela, Royo-Bordonada, Miguel, Rueangsom, Putthipanya, Scarborough, Peter, Tiscornia, Maria, Tolentino-Mayo, Lizbeth, Wate, Jillian, White, Martin, Zamora-Corrales, Irina, Zeng, Lingxia, and Swinburn, Boyd A
- Abstract
Restricting children's exposures to marketing of unhealthy foods and beverages is a global obesity prevention priority. Monitoring marketing exposures supports informed policymaking. This study presents a global overview of children's television advertising exposure to healthy and unhealthy products. Twenty-two countries contributed data, captured between 2008 and 2017. Advertisements were coded for the nature of foods and beverages, using the 2015 World Health Organization (WHO) Europe Nutrient Profile Model (should be permitted/not-permitted to be advertised). Peak viewing times were defined as the top five hour timeslots for children. On average, there were four times more advertisements for foods/beverages that should not be permitted than for permitted foods/beverages. The frequency of food/beverages advertisements that should not be permitted per hour was higher during peak viewing times compared with other times (P < 0.001). During peak viewing times, food and beverage advertisements that should not be permitted were higher in countries with industry self-regulatory programmes for responsible advertising compared with countries with no policies. Globally, children are exposed to a large volume of television advertisements for unhealthy foods and beverages, despite the implementation of food industry programmes. Governments should enact regulation to protect children from television advertising of unhealthy products that undermine their health.
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- 2019
23. Intracardiac thrombus in a patient with catastrophic antiphospholipid syndrome: an autopsy case report and review of the literature
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Waisayarat,Jariya, Plumworasawat,Sirithep, Vilaiyuk,Soamarat, Sirachainan,Nongnuch, Waisayarat,Jariya, Plumworasawat,Sirithep, Vilaiyuk,Soamarat, and Sirachainan,Nongnuch
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Jariya Waisayarat,1 Sirithep Plumworasawat,1 Soamarat Vilaiyuk,2 Nongnuch Sirachainan21Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandAbstract: Antiphospholipid syndrome (APS) is an autoantibody-mediated acquired thrombophilia characterized by venous and/or arterial thromboses, pregnancy morbidity (predominantly repeated fetal losses), and the presence of phospholipid antibodies. The estimated annual incidence of APS is 5 new cases per 100,000 people. The most common thrombotic events in patients with APS in order of frequency are stroke, transient ischemic attack, deep vein thrombosis, and pulmonary embolism. Patients with APS may develop an intracardiac thrombus, which is a life-threatening complication with a high risk of increased morbidity and mortality; however, it is treatable by surgical removal, extensive anticoagulant administration, and prevention of other complications. Catastrophic APS, which is a rare and severe condition diagnosed based on rapidly progressive thromboembolic events involving three or more organs, systems, or tissues, occurs in less than 1% of all patients with APS. We herein report an autopsy case of catastrophic APS in a 12-year-old Thai boy with multiple thromboembolic events including intracardiac thrombus formation with a positive lupus anticoagulant test result. To the best of our knowledge, this is the youngest reported patient with APS to date.Keywords: antiphospholipid syndrome, intracardiac thrombus, catastrophic antiphospholipid syndrome, antiphospholipid antibodies  
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- 2019
24. An L$_0$L$_1$-norm compressive sensing paradigm for the construction of sparse predictive lattice models using mixed integer quadratic programming
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Huang, Wenxuan, Huang, Wenxuan, Urban, Alexander, Xiao, Penghao, Rong, Ziqin, Das, Hena, Chen, Tina, Artrith, Nongnuch, Toumar, Alexandra, Ceder, Gerbrand, Huang, Wenxuan, Huang, Wenxuan, Urban, Alexander, Xiao, Penghao, Rong, Ziqin, Das, Hena, Chen, Tina, Artrith, Nongnuch, Toumar, Alexandra, and Ceder, Gerbrand
- Abstract
First-principles based lattice models allow the modeling of ab initio thermodynamics of crystalline mixtures for applications such as the construction of phase diagrams and the identification of ground state atomic orderings. The recent development of compressive sensing approaches for the construction of lattice models has further enabled the systematic construction of sparse physical models without the need for human intuition other than requiring the compactness of effective cluster interactions. However, conventional compressive sensing based on L1-norm regularization is strictly only applicable to certain classes of optimization problems and is otherwise not guaranteed to generate optimally sparse and transferable results, so that the method can only be applied to some materials science applications. In this paper, we illustrate a more robust L0L1-norm compressive-sensing method that removes the limitations of conventional compressive sensing and generally results in sparser lattice models that are at least as predictive as those obtained from L1-norm compressive sensing. Apart from the theory, a practical implementation based on state-of-the-art mixed-integer quadratic programming (MIQP) is proposed. The robustness of our methodology is illustrated for four different transition-metal oxides with relevance as battery cathode materials: Li2xTi2(1-x)O2, Li2xNi2yO2, MgxCr2O4, and NaxCrO2. This method provides a practical and robust approach for the construction of sparser and more predictive lattice models, improving on the compressive sensing paradigm and making it applicable to a much broader range of applications.
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- 2018
25. Corporate political activity of major food companies in Thailand: an assessment and policy recommendations
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Jaichuen, Nongnuch, Phulkerd, Sirinya, Certthkrikul, Nisachol, Sacks, Gary, Tangcharoensathien, Viroj, Jaichuen, Nongnuch, Phulkerd, Sirinya, Certthkrikul, Nisachol, Sacks, Gary, and Tangcharoensathien, Viroj
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BACKGROUND: The food industry can influence individual and population level food consumption behaviours, shape public preferences and interfere with government policy on obesity prevention and NCDs. This paper identifies the Corporate Political Activity (CPA) of major food companies in Thailand which relate to obesity and NCDs. METHODS: Using the INFORMAS framework to classify CPA, we reviewed publicly available information by 12 food companies between August 2011 and July 2016 in order to identify, analyse and classify the CPA contents. Semi-structured interviews with 17 key stakeholders who are experts in this field supplemented evidence from the document review. Data analysis applied a thematic approach. RESULTS: Food industry in Thailand applied a variety of CPA strategies and practices. The two most common strategies were constituency building and information and messaging. CONCLUSION: The diverse range of CPA strategies which influence government policy and public opinion can undermine efforts to prevent obesity and diet-related NCDs. We recommend systematic monitoring of their CPA, strengthening mechanisms to hold the food industry accountable for their role in protecting and promoting the nutrition and health of the population, introducing mandatory registration of lobbyists, mandatory disclosure of political donations, and stronger oversight of conflicts of interest among the government actors.
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- 2018
26. Unhealthy food and non-alcoholic beverage advertising on children's, youth and family free-to-air and digital television programmes in Thailand
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Jaichuen, Nongnuch, Vandevijvere, Stefanie, Kelly, Bridget, Vongmongkol, Vuthiphan, Phulkerd, Sirinya, Tangcharoensathien, Viroj, Jaichuen, Nongnuch, Vandevijvere, Stefanie, Kelly, Bridget, Vongmongkol, Vuthiphan, Phulkerd, Sirinya, and Tangcharoensathien, Viroj
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Background: Food advertising is a key factor which influences children's food preferences. This study assessed the rates, nutritional quality and contents of food and beverage advertising in children's, youth and family television programmes in Thailand. Methods: Free TV was recorded for two weeks in March 2014 from six to ten am and three to eight pm on weekends and three to eight pm on weekdays across all four channels; a total of 344 h recorded. Digital TV was recorded across three channels for one week for 24 h per day in October 2014; a total 504 h recorded. Results: For Free TV, 1359 food advertisements were identified, with on average 2.9 non-core food advertisements per hour per channel. The most frequently advertised food products on free TV were sugar-sweetened drinks. The rates of advertisements containing promotional characters and premium offers were significantly higher for non-core than core foods, 1.2 versus 0.03 and 0.6 versus 0.0 per hour respectively. For Digital TV, 693 food advertisements were identified, with an average of one non-core food advertisement per hour per channel. The most frequently advertised food products on digital TV were baby and toddler milk formulae. Conclusions: Food and beverage advertising on Thai television is predominantly unhealthy. Therefore, the Government and related agencies should introduce and enforce policies to address this issue. Current regulations should be adapted to control both the frequency and nature of unhealthy on-air food marketing to protect the health of Thai children.
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- 2018
27. The impact of introducing the early warning scoring system and protocol on clinical outcomes in tertiary referral university hospital
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Sutherasan,Yuda, Theerawit,Pongdhep, Suporn,Alongkot, Nongnuch,Arkom, Phanachet,Pariya, Kositchaiwat,Chomsri, Sutherasan,Yuda, Theerawit,Pongdhep, Suporn,Alongkot, Nongnuch,Arkom, Phanachet,Pariya, and Kositchaiwat,Chomsri
- Abstract
Yuda Sutherasan,1 Pongdhep Theerawit,1 Alongkot Suporn,2 Arkom Nongnuch,3 Pariya Phanachet,4 Chomsri Kositchaiwat5 1Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Renal Unit, Department of Medicine, Faculty of Medicine Ramathibodi Hospital Mahidol University, Bangkok, Thailand; 4Division of Nutrition and Biochemical Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 5Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Purpose: The aim of this study was to evaluate the impact of a hospital protocol in response to patient deterioration in general wards, stratified using the national early warning score (NEWS), on primary patient outcomes of in-hospital mortality and percentage of patients transferred to the intensive care unit (ICU).Patients and methods: We conducted a prospective observational cohort study among adult medical patients admitted to a university hospital in Bangkok. A 4-month pre-protocol period (November 2015 to February 2016) was assigned to a control group and a protocol period (March 2016 to June 2016) was allocated to a protocol group. On admission, vital signs (respiratory rate, pulse rate, systolic blood pressure, and temperature), oxygen saturation, presence of oxygen supplementation, and neurological status were used to calculate NEWS. Patients were categorized as low, moderate, or high risk based on the NEWS. During protocol period, when patients’ conditions are critical and they are at imminent risk, the NEWS detects the event and triggers a systematic response. The response enables closed monitoring and early treatment by expert physicians to rapidly st
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- 2018
28. Electronic-Structure Origin of Cation Disorder in Transition-Metal Oxides.
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Urban, Alexander, Urban, Alexander, Abdellahi, Aziz, Dacek, Stephen, Artrith, Nongnuch, Ceder, Gerbrand, Urban, Alexander, Urban, Alexander, Abdellahi, Aziz, Dacek, Stephen, Artrith, Nongnuch, and Ceder, Gerbrand
- Abstract
Cation disorder is an important design criterion for technologically relevant transition-metal (TM) oxides, such as radiation-tolerant ceramics and Li-ion battery electrodes. In this Letter, we use a combination of first-principles calculations, normal mode analysis, and band-structure arguments to pinpoint a specific electronic-structure effect that influences the stability of disordered phases. We find that the electronic configuration of a TM ion determines to what extent the structural energy is affected by site distortions. This mechanism explains the stability of disordered phases with large ionic radius differences and provides a concrete guideline for the discovery of novel disordered compositions.
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- 2017
29. Elucidating the Nature of the Active Phase in Copper/Ceria Catalysts for CO Oxidation
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Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Department of Materials Science and Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Massachusetts Institute of Technology. Research Laboratory of Electronics, Shao-Horn, Yang, Elias, Joseph Spanjaard, Artrith, Nongnuch, Giordano, Livia, Kolpak, Alexie M., Bugnet, Matthieu, Botton, Gianluigi A., Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Department of Materials Science and Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Massachusetts Institute of Technology. Research Laboratory of Electronics, Shao-Horn, Yang, Elias, Joseph Spanjaard, Artrith, Nongnuch, Giordano, Livia, Kolpak, Alexie M., Bugnet, Matthieu, and Botton, Gianluigi A.
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The active phase responsible for low-temperature CO oxidation in nanoparticulate CuO/CeO[subscript 2] catalysts was identified as surface-substituted Cu[subscript y]Ce[subscript 1–y]O[subscript 2–x]. Contrary to previous studies, our measurements on a library of well-defined CuO/CeO[subscript 2] catalysts have proven that the CuO phase is a spectator species, whereas the surface-substituted Cu[subscript y]Ce[subscript 1–y]O[subscript 2–x] phase is active for CO oxidation. Using in situ X-ray absorption spectroscopy, we found that the copper ions in Cu[subscript y]Ce[subscript 1–y]O[subscript 2–x] remain at high oxidation states (Cu[superscript 3+] and Cu[superscript 2+]) under oxygen-rich catalytic conditions without any evidence for Cu+. Artificial neural network potential Monte Carlo simulations suggest that Cu[superscript 3+] and Cu[superscript 2+] preferentially segregate to the {100} surface of the Cu[subscript y]Ce[subscript 1–y]O[subscript 2–x] nanoparticle, which is supported by aberration-corrected electron microscopy measurements. These results pave the way for understanding, at the atomic level, the mechanisms and descriptors pertinent for CO oxidation on these materials and hence the rational design of next-generation catalysts., National Science Foundation (U.S.) (grant number ACI-1053575), United States. Department of Energy. Office of Science (Contract No. DE-AC02- 05CH11231), United States. Department of Energy. Office of Basic Energy Sciences (Contract No. DE-AC02-98CH10886), Philip Morris International, National Science Foundation (U.S.) (Graduate Research Fellowship under Grant No. DGE-1122374), Schlumberger Foundation. Faculty for the Future (fellowship)
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- 2017
30. Electronic-Structure Origin of Cation Disorder in Transition-Metal Oxides
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Massachusetts Institute of Technology. Department of Materials Science and Engineering, Abdellahi, Aziz, Dacek, Stephen Thomas, Urban, Alexander, Artrith, Nongnuch, Ceder, Gerbrand, Massachusetts Institute of Technology. Department of Materials Science and Engineering, Abdellahi, Aziz, Dacek, Stephen Thomas, Urban, Alexander, Artrith, Nongnuch, and Ceder, Gerbrand
- Abstract
Cation disorder is an important design criterion for technologically relevant transition-metal (TM) oxides, such as radiation-tolerant ceramics and Li-ion battery electrodes. In this Letter, we use a combination of first-principles calculations, normal mode analysis, and band-structure arguments to pinpoint a specific electronic-structure effect that influences the stability of disordered phases. We find that the electronic configuration of a TM ion determines to what extent the structural energy is affected by site distortions. This mechanism explains the stability of disordered phases with large ionic radius differences and provides a concrete guideline for the discovery of novel disordered compositions.
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- 2017
31. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.
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Torchia, Jonathon, Torchia, Jonathon, Golbourn, Brian, Feng, Shengrui, Ho, King Ching, Sin-Chan, Patrick, Vasiljevic, Alexandre, Norman, Joseph D, Guilhamon, Paul, Garzia, Livia, Agamez, Natalia R, Lu, Mei, Chan, Tiffany S, Picard, Daniel, de Antonellis, Pasqualino, Khuong-Quang, Dong-Anh, Planello, Aline C, Zeller, Constanze, Barsyte-Lovejoy, Dalia, Lafay-Cousin, Lucie, Letourneau, Louis, Bourgey, Mathieu, Yu, Man, Gendoo, Deena MA, Dzamba, Misko, Barszczyk, Mark, Medina, Tiago, Riemenschneider, Alexandra N, Morrissy, A Sorana, Ra, Young-Shin, Ramaswamy, Vijay, Remke, Marc, Dunham, Christopher P, Yip, Stephen, Ng, Ho-Keung, Lu, Jian-Qiang, Mehta, Vivek, Albrecht, Steffen, Pimentel, Jose, Chan, Jennifer A, Somers, Gino R, Faria, Claudia C, Roque, Lucia, Fouladi, Maryam, Hoffman, Lindsey M, Moore, Andrew S, Wang, Yin, Choi, Seung Ah, Hansford, Jordan R, Catchpoole, Daniel, Birks, Diane K, Foreman, Nicholas K, Strother, Doug, Klekner, Almos, Bognár, Laszló, Garami, Miklós, Hauser, Péter, Hortobágyi, Tibor, Wilson, Beverly, Hukin, Juliette, Carret, Anne-Sophie, Van Meter, Timothy E, Hwang, Eugene I, Gajjar, Amar, Chiou, Shih-Hwa, Nakamura, Hideo, Toledano, Helen, Fried, Iris, Fults, Daniel, Wataya, Takafumi, Fryer, Chris, Eisenstat, David D, Scheinemann, Katrin, Fleming, Adam J, Johnston, Donna L, Michaud, Jean, Zelcer, Shayna, Hammond, Robert, Afzal, Samina, Ramsay, David A, Sirachainan, Nongnuch, Hongeng, Suradej, Larbcharoensub, Noppadol, Grundy, Richard G, Lulla, Rishi R, Fangusaro, Jason R, Druker, Harriet, Bartels, Ute, Grant, Ronald, Malkin, David, McGlade, C Jane, Nicolaides, Theodore, Tihan, Tarik, Phillips, Joanna, Majewski, Jacek, Montpetit, Alexandre, Bourque, Guillaume, Bader, Gary D, Reddy, Alyssa T, Gillespie, G Yancey, Warmuth-Metz, Monika, Torchia, Jonathon, Torchia, Jonathon, Golbourn, Brian, Feng, Shengrui, Ho, King Ching, Sin-Chan, Patrick, Vasiljevic, Alexandre, Norman, Joseph D, Guilhamon, Paul, Garzia, Livia, Agamez, Natalia R, Lu, Mei, Chan, Tiffany S, Picard, Daniel, de Antonellis, Pasqualino, Khuong-Quang, Dong-Anh, Planello, Aline C, Zeller, Constanze, Barsyte-Lovejoy, Dalia, Lafay-Cousin, Lucie, Letourneau, Louis, Bourgey, Mathieu, Yu, Man, Gendoo, Deena MA, Dzamba, Misko, Barszczyk, Mark, Medina, Tiago, Riemenschneider, Alexandra N, Morrissy, A Sorana, Ra, Young-Shin, Ramaswamy, Vijay, Remke, Marc, Dunham, Christopher P, Yip, Stephen, Ng, Ho-Keung, Lu, Jian-Qiang, Mehta, Vivek, Albrecht, Steffen, Pimentel, Jose, Chan, Jennifer A, Somers, Gino R, Faria, Claudia C, Roque, Lucia, Fouladi, Maryam, Hoffman, Lindsey M, Moore, Andrew S, Wang, Yin, Choi, Seung Ah, Hansford, Jordan R, Catchpoole, Daniel, Birks, Diane K, Foreman, Nicholas K, Strother, Doug, Klekner, Almos, Bognár, Laszló, Garami, Miklós, Hauser, Péter, Hortobágyi, Tibor, Wilson, Beverly, Hukin, Juliette, Carret, Anne-Sophie, Van Meter, Timothy E, Hwang, Eugene I, Gajjar, Amar, Chiou, Shih-Hwa, Nakamura, Hideo, Toledano, Helen, Fried, Iris, Fults, Daniel, Wataya, Takafumi, Fryer, Chris, Eisenstat, David D, Scheinemann, Katrin, Fleming, Adam J, Johnston, Donna L, Michaud, Jean, Zelcer, Shayna, Hammond, Robert, Afzal, Samina, Ramsay, David A, Sirachainan, Nongnuch, Hongeng, Suradej, Larbcharoensub, Noppadol, Grundy, Richard G, Lulla, Rishi R, Fangusaro, Jason R, Druker, Harriet, Bartels, Ute, Grant, Ronald, Malkin, David, McGlade, C Jane, Nicolaides, Theodore, Tihan, Tarik, Phillips, Joanna, Majewski, Jacek, Montpetit, Alexandre, Bourque, Guillaume, Bader, Gary D, Reddy, Alyssa T, Gillespie, G Yancey, and Warmuth-Metz, Monika
- Abstract
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.
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- 2016
32. Molecular subgroups of atypical teratoid rhabdoid tumours in children : an integrated genomic and clinicopathological analysis
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Torchia, Jonathon, Picard, Daniel, Lafay-Cousin, Lucie, Hawkins, Cynthia E., Kim, Seung-Ki, Letourneau, Louis, Ra, Young-Shin, Ho, King Ching, Chan, Tiffany Sin Yu, Sin-Chan, Patrick, Dunham, Christopher P., Yip, Stephen, Ng, Ho-Keung, Lu, Jian-Qiang, Albrecht, Steffen, Pimentel, Jose, Chan, Jennifer A., Somers, Gino R., Zielenska, Maria, Faria, Claudia C., Roque, Lucia, Baskin, Berivan, Birks, Diane, Foreman, Nick, Strother, Douglas, Klekner, Almos, Garami, Miklos, Hauser, Peter, Hortobagyi, Tibor, Bognar, Laszlo, Wilson, Beverly, Hukin, Juliette, Carret, Anne-Sophie, Van Meter, Timothy E., Nakamura, Hideo, Toledano, Helen, Fried, Iris, Fults, Daniel, Wataya, Takafumi, Fryer, Chris, Eisenstat, David D., Scheineman, Katrin, Johnston, Donna, Michaud, Jean, Zelcer, Shayna, Hammond, Robert, Ramsay, David A., Fleming, Adam J., Lulla, Rishi R., Fangusaro, Jason R., Sirachainan, Nongnuch, Larbcharoensub, Noppadol, Hongeng, Suradej, Barakzai, Muhammad Abrar, Montpetit, Alexandre, Stephens, Derek, Grundy, Richard G., Schueller, Ulrich, Nicolaides, Theodore, Tihan, Tarik, Phillips, Joanna, Taylor, Michael D., Rutka, James T., Dirks, Peter, Bader, Gary D., Warmuth-Metz, Monika, Rutkowski, Stefan, Pietsch, Torsten, Judkins, Alexander R., Jabado, Nada, Bouffet, Eric, Huang, Annie, Torchia, Jonathon, Picard, Daniel, Lafay-Cousin, Lucie, Hawkins, Cynthia E., Kim, Seung-Ki, Letourneau, Louis, Ra, Young-Shin, Ho, King Ching, Chan, Tiffany Sin Yu, Sin-Chan, Patrick, Dunham, Christopher P., Yip, Stephen, Ng, Ho-Keung, Lu, Jian-Qiang, Albrecht, Steffen, Pimentel, Jose, Chan, Jennifer A., Somers, Gino R., Zielenska, Maria, Faria, Claudia C., Roque, Lucia, Baskin, Berivan, Birks, Diane, Foreman, Nick, Strother, Douglas, Klekner, Almos, Garami, Miklos, Hauser, Peter, Hortobagyi, Tibor, Bognar, Laszlo, Wilson, Beverly, Hukin, Juliette, Carret, Anne-Sophie, Van Meter, Timothy E., Nakamura, Hideo, Toledano, Helen, Fried, Iris, Fults, Daniel, Wataya, Takafumi, Fryer, Chris, Eisenstat, David D., Scheineman, Katrin, Johnston, Donna, Michaud, Jean, Zelcer, Shayna, Hammond, Robert, Ramsay, David A., Fleming, Adam J., Lulla, Rishi R., Fangusaro, Jason R., Sirachainan, Nongnuch, Larbcharoensub, Noppadol, Hongeng, Suradej, Barakzai, Muhammad Abrar, Montpetit, Alexandre, Stephens, Derek, Grundy, Richard G., Schueller, Ulrich, Nicolaides, Theodore, Tihan, Tarik, Phillips, Joanna, Taylor, Michael D., Rutka, James T., Dirks, Peter, Bader, Gary D., Warmuth-Metz, Monika, Rutkowski, Stefan, Pietsch, Torsten, Judkins, Alexander R., Jabado, Nada, Bouffet, Eric, and Huang, Annie
- Abstract
Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of biological understanding of the substantial clinical heterogeneity of these tumours restricts therapeutic advances. We integrated genomic and clinicopathological analyses of a cohort of patients with atypical teratoid rhabdoid tumours to find out the molecular basis for clinical heterogeneity in these tumours. Methods We obtained 259 rhabdoid tumours from 37 international institutions and assessed transcriptional profiles in 43 primary tumours and copy number profiles in 38 primary tumours to discover molecular subgroups of atypical teratoid rhabdoid tumours. We used gene and pathway enrichment analyses to discover group-specific molecular markers and did immunohistochemical analyses on 125 primary tumours to evaluate clinicopathological significance of molecular subgroup and ASCL1-NOTCH signalling. Findings Transcriptional analyses identified two atypical teratoid rhabdoid tumour subgroups with differential enrichment of genetic pathways, and distinct clinicopathological and survival features. Expression of ASCL1, a regulator of NOTCH signalling, correlated with supratentorial location (p=0.004) and superior 5-year overall survival (35%, 95% CI 13-57, and 20%, 6-34, for ASCL1-positive and ASCL1-negative tumours, respectively; p=0.033) in 70 patients who received multimodal treatment. ASCL1 expression also correlated with superior 5-year overall survival (34%, 7-61, and 9%, 0-21, for ASCL1-positive and ASCL1-negative tumours, respectively; p=0.001) in 39 patients who received only chemotherapy without radiation. Cox hazard ratios for overall survival in patients with differential ASCL1 enrichment treated with chemotherapy with or without radiation were 2.02 (95% CI 1.04-3.85; p=0.038) and 3.98 (1.71-9.26; p=0.001). Integrated analyses of molecular subgroupings with clinical prognostic factor
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- 2015
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33. A survey for potentially zoonotic gastrointestinal parasites of dogs and pigs in Cambodia
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Inpankaew, Tawin, Murrell, Kenneth Darwin, Pinyopanuwat, Nongnuch, Chhoun, Chamnan, Khov, Kuong, Sem, Tharin, Sorn, San, Muth, Sinuon, Dalsgaard, Anders, Inpankaew, Tawin, Murrell, Kenneth Darwin, Pinyopanuwat, Nongnuch, Chhoun, Chamnan, Khov, Kuong, Sem, Tharin, Sorn, San, Muth, Sinuon, and Dalsgaard, Anders
- Abstract
There is little information available on parasites of zoonotic significance in Cambodia. In 2011, in an effort to obtain data on potentially zoonotic gastrointestinal parasites in domestic animals, 50 dogs and 30 pigs residing in 38 households located in Ang Svay Check village, Takeo province, Cambodia were examined for parasites from faecal samples. The samples were processed using the formalin-ethyl acetate concentration technique (FECT). Hookworms were the most common zoonotic parasite found in dogs (80.0%) followed by Echinostomes (18.0%). While, in pigs, Fasciolopsis buski was the most common zoonotic parasite (30.0%) followed by Ascaris suum (13.3%). This study provides baseline data on gastrointestinal parasites in dogs and pigs from Cambodia and underscores the importance of domestic animals as reservoir hosts for human parasites for Cambodian veterinary and public health agencies. Follow-up studies are required to further taxonomically characterize these dog and pig parasites and to determine their role in human parasites in this community.
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- 2015
34. MEDULLOBLASTOMA
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Morfouace, Marie, Morfouace, Marie, Shelat, Anang, Megan, Jacus, Freeman, Burgess B, Robinson, Sarah, Throm, Stacy, Olson, James M, Li, Xiao-Nan, Guy, Kip R, Robinson, Giles, Stewart, Clinton, Gajjar, Amar, Roussel, Martine, Sirachainan, Nongnuch, Pakakasama, Samart, Anurathapan, Usanarat, Hansasuta, Ake, Dhanachai, Mantana, Khongkhatithum, Chaiyos, Hongeng, Suradej, Feroze, Abdullah, Lee, Kyu-Sun, Gholamin, Sharareh, Wu, Zhihao, Lu, Bingwei, Mitra, Siddhartha, Cheshier, Samuel, Northcott, Paul, Lee, Catherine, Zichner, Thomas, Lichter, Peter, Korbel, Jan, Wechsler-Reya, Robert, Pfister, Stefan, Project, ICGC PedBrain Tumor, Li, Kay Ka-Wai, Xia, Tian, Ma, Fanny Man Ting, Zhang, Rong, Zhou, Liangfu, Lau, Kin-Mang, Ng, Ho-Keung, Lafay-Cousin, Lucie, Chi, Susan, Madden, Jennifer, Smith, Amy, Wells, Elisabeth, Owens, Emily, Strother, Douglas, Foreman, Nicholas, Packer, Roger, Bouffet, Eric, Wataya, Takafumi, Peacock, John, Taylor, Michael D, Ivanov, Delyan, Garnett, Martin, Parker, Terry, Alexander, Cameron, Meijer, Lisethe, Grundy, Richard, Gellert, Paul, Ashford, Marianne, Walker, David, Hayase, Tomomi, Kawahara, Yuta, Yagi, Masaki, Minami, Takaomi, Kanai, Nobuyuki, Yamaguchi, Takehiko, Gomi, Akira, Morimoto, Akira, Hill, Rebecca, Kuijper, Sanne, Lindsey, Janet, Schwalbe, Ed, Barker, Karen, Boult, Jessica, Williamson, Daniel, Ahmad, Zai, Hallsworth, Albert, Ryan, Sarra, Poon, Evon, Robinson, Simon, Ruddle, Ruth, Raynaud, Florence, Howell, Louise, Kwok, Colin, Joshi, Abhijit, Nicholson, Sarah Leigh, Crosier, Stephen, Wharton, Stephen, Robson, Keith, Michalski, Antony, Hargrave, Darren, Jacques, Thomas, Pizer, Barry, Bailey, Simon, Swartling, Fredrik, Petrie, Kevin, Morfouace, Marie, Morfouace, Marie, Shelat, Anang, Megan, Jacus, Freeman, Burgess B, Robinson, Sarah, Throm, Stacy, Olson, James M, Li, Xiao-Nan, Guy, Kip R, Robinson, Giles, Stewart, Clinton, Gajjar, Amar, Roussel, Martine, Sirachainan, Nongnuch, Pakakasama, Samart, Anurathapan, Usanarat, Hansasuta, Ake, Dhanachai, Mantana, Khongkhatithum, Chaiyos, Hongeng, Suradej, Feroze, Abdullah, Lee, Kyu-Sun, Gholamin, Sharareh, Wu, Zhihao, Lu, Bingwei, Mitra, Siddhartha, Cheshier, Samuel, Northcott, Paul, Lee, Catherine, Zichner, Thomas, Lichter, Peter, Korbel, Jan, Wechsler-Reya, Robert, Pfister, Stefan, Project, ICGC PedBrain Tumor, Li, Kay Ka-Wai, Xia, Tian, Ma, Fanny Man Ting, Zhang, Rong, Zhou, Liangfu, Lau, Kin-Mang, Ng, Ho-Keung, Lafay-Cousin, Lucie, Chi, Susan, Madden, Jennifer, Smith, Amy, Wells, Elisabeth, Owens, Emily, Strother, Douglas, Foreman, Nicholas, Packer, Roger, Bouffet, Eric, Wataya, Takafumi, Peacock, John, Taylor, Michael D, Ivanov, Delyan, Garnett, Martin, Parker, Terry, Alexander, Cameron, Meijer, Lisethe, Grundy, Richard, Gellert, Paul, Ashford, Marianne, Walker, David, Hayase, Tomomi, Kawahara, Yuta, Yagi, Masaki, Minami, Takaomi, Kanai, Nobuyuki, Yamaguchi, Takehiko, Gomi, Akira, Morimoto, Akira, Hill, Rebecca, Kuijper, Sanne, Lindsey, Janet, Schwalbe, Ed, Barker, Karen, Boult, Jessica, Williamson, Daniel, Ahmad, Zai, Hallsworth, Albert, Ryan, Sarra, Poon, Evon, Robinson, Simon, Ruddle, Ruth, Raynaud, Florence, Howell, Louise, Kwok, Colin, Joshi, Abhijit, Nicholson, Sarah Leigh, Crosier, Stephen, Wharton, Stephen, Robson, Keith, Michalski, Antony, Hargrave, Darren, Jacques, Thomas, Pizer, Barry, Bailey, Simon, Swartling, Fredrik, and Petrie, Kevin
- Abstract
BACKGROUND: LMD in children with recurrent medulloblastoma and other PNETs carries a poor prognosis and novel therapies are urgently needed to improve disease control. Somatostatin receptor-2 (SSR-2)is overexpressed in medulloblastoma and other central PNETs and can serve as a target for radionuclide tagged somatostatin analogues like 177Lu-DOTA-TATE that has shown considerable efficacy in adults with SSR-2 positive neuro-endocrine tumors. As a preliminary step prior to testing this agent in children with LMD, we performed an efficacy study of i.t. 177Lu-DOTA-TATE in athymic rats bearing LMD from MBL. METHODS: The subarachnoid space was accessed through the animal's cervical spine and a catheter was threaded along the dorsal aspect of spinal cord to the lumbar region and injected with 1 x 107 D341 human MBL cells and treatment initiated 3 days later. Groups of 10 animals received a single i.t. dose of 2, 3, or 5 mCi of 177Lu- DOTA-TATE or saline control. Animals were followed 300 days for survival. RESULTS: Treatment with 2 mCi resulted in an increase in median survival of 58.3% compared with saline control (p < 0.001). Treatment with 5.0 mCi of 177Lu-DOTA-TATE increased median survival by 75.0% compared with the saline control group while a single dose of 3.0 mCi 177Lu-DOTA-TATE increased median survival compared with saline controls by 519.4%. Long-term survivors were seen in 0 of 10 animals treated with saline, 4 of 11 treated with 3 mCi, and 3 of 12 treated with 5.0 mCi. CONCLUSION: Intrathecal 177Lu- DOTA TATE is efficacious in controlling LMD from medulloblastoma in athymic rats. A phase I trial of this agent is being planned in children with LMD from recurrent MBL and other CNS PNETs. INTRODUCTION: Medulloblastoma/PNET is the most common malignant brain tumor in children. For children older than 3 years, the treatment of high risk group includes surgery, craniospinal (CSI) radiation therapy (30-36 Gy) plus local boost radiotherapy (54-56 Gy) and adjuvant c
- Published
- 2014
35. Thai multi-document summarization based on Thai elementary discourse units
- Author
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Thanaruk Theeramunkong, advisor, Ekawit Nantajeewarawat, co-advisor, Nongnuch Ketui, Thanaruk Theeramunkong, advisor, Ekawit Nantajeewarawat, co-advisor, and Nongnuch Ketui
- Abstract
Best Dissertation 2013 in Science and Technology
- Published
- 2013
36. Age-earnings and age-productivity profiles of self-employed workers in Thailand
- Author
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Nongnuch Soonthornchawakan, advisor, Suthasinee Khunkarnrai, Nongnuch Soonthornchawakan, advisor, and Suthasinee Khunkarnrai
- Published
- 2013
37. Critical appraisal of the role of recombinant activated factor VII in the treatment of hemophilia patients with inhibitors
- Author
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Chuansumrit,Ampaiwan, Angchaisuksiri,Pantep, Sirachainan,Nongnuch, Chuansumrit,Ampaiwan, Angchaisuksiri,Pantep, and Sirachainan,Nongnuch
- Abstract
Ampaiwan Chuansumrit1, Pantep Angchaisuksiri2, Nongnuch Sirachainan11Departments of Pediatrics and 2Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandAbstract: Hemophilia patients with inhibitors faced the constraint of inadequate treatment for several years before the era of recombinant factor VIIa (rFVII). Initially, rFVIIa was used in the compassionate-use programs. After a worldwide license was issued, more than 1.5 million doses were administered. Bleeding of joints and muscles was controlled effectively by means of an early home treatment program, with either a standard dose of 90 μg/kg every 2 to 3 hours for a few doses or a single dose of 270 μg/kg. For more serious bleeding episodes or minor surgery, an initial dose of 90 μg/kg was given every 2 hours for 24 to 48 hours followed by increased intervals of 3 to 6 hours according to the severity of bleeding and efficacy of bleeding control. In cases of major surgery such as orthopedic procedures, the same regimen can be applied except for a higher initial dose of 120 to 180 μg/kg. However, increasing the dose should be considered if there are unexpected bleeding complications since the half-life and clearance of rFVIIa differ between individuals. In addition, prophylaxis is administered to a small number of patients. Finally, the reported thromboembolic events found in hemophilia patients with inhibitors receiving rFVIIa are extremely low, much less than 1%.Keywords: bleeding disorder, hemophilia, inhibitor, NovoSeven, recombinant factor VIIa
- Published
- 2010
38. Seroprevalence of Brucella abortus, Neospara caninum, and Toxoplasma gondii infections of dairy cows in South of Thailand
- Author
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Jittapalapong, Sathaporn, Pinyopanuwat, Nongnuch, Chimnoi, Wissanuwat, Kengradomkij, Chanya, Arunvipas, Pipat, Sarataphan, Nachai, Aruyama, S., Desquesnes, Marc, Jittapalapong, Sathaporn, Pinyopanuwat, Nongnuch, Chimnoi, Wissanuwat, Kengradomkij, Chanya, Arunvipas, Pipat, Sarataphan, Nachai, Aruyama, S., and Desquesnes, Marc
- Published
- 2008
39. Investigating the effectiveness of implementing pre-reading activities as facilitators of successful reading comprehension of staff of the Office of the Ombudsman
- Author
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Nongnuch Naowarat. and Nongnuch Naowarat.
- Published
- 2005
40. The determinants of foreign portfolio investment in Thailand.
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Nongnuch Soonthornchawakan and Nongnuch Soonthornchawakan
- Published
- 1990
41. Taking advantage of Ramadan and January in Muslim countries
- Author
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Halari, Anwar, Helliar, Christine, Power, David, Tantisantiwong, Nongnuch, Halari, Anwar, Helliar, Christine, Power, David, and Tantisantiwong, Nongnuch
- Abstract
Studies have shown that religious beliefs and practice play an important role in influencing share price behaviour. Evidence of a Ramadan effect has been documented in Muslim countries suggesting an increase in mean returns as well as a reduction in volatility during the ninth month of the Islamic calendar. In addition to the Ramadan effect, studies have also documented a January effect in Muslim countries. The current study investigates what happens when the Ramadan effect and the January effect occur at the same time. Controlling for the effects of financial crises and time-varying volatility in returns, the results for individual company data from four countries with sizeable Muslim populations indicate higher returns and lower volatility when these two effects overlap, except in one, arguably more Western country, Turkey.
42. East Meets West: When the Islamic and Gregorian Calendars Coincide
- Author
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Tantisantiwong, Nongnuch, Halari, Anwar, Helliar, Christine, Power, David, Tantisantiwong, Nongnuch, Halari, Anwar, Helliar, Christine, and Power, David
- Abstract
Recent research has documented that at the time of religious celebrations in Muslim countries, such as Ramadan, there is a “festival” effect in share returns. In the Gregorian calendar, December is also a time of celebration and festivities which may be associated with patterns in the behaviour of security prices. Further, the first month of the year in the Islamic calendar, Muharram, is a time of sadness and mourning for some believers, and there may be an effect when the Islamic first month of the year overlaps with the first month of the Gregorian year - January. Over a 33-year cycle, each Islamic month falls in a Gregorian month for about 5-6 consecutive years; when this happens, an Islamic (Eastern) calendar effect may interact with a Gregorian (Western) calendar effect. The current paper addresses this issue by examining the behaviour of share returns and volatility for individual companies listed in Muslim countries’ stock exchanges when the two calendars coincide for: (i) religious festival effects; (ii) first-month-of-the-year effects; and (iii) the two most common effects reported in the Islamic and Gregorian calendars (Ramadan and January). The results show that the Western and Eastern effects interact more prominently in larger companies and in larger or more developed markets.
43. Islamic calendar anomalies: Evidence from Pakistani firm-level data
- Author
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Halari, Anwar, Tantisantiwong, Nongnuch, Power, David M., Helliar, Christine, Halari, Anwar, Tantisantiwong, Nongnuch, Power, David M., and Helliar, Christine
- Abstract
Most prior research has tested for monthly regularities based on the Gregorian calendar; by contrast, little attention has been given to other calendars based on different religions or cultures. This paper examines Islamic monthly anomalies in a stock market located within a Muslim country – Pakistan. The study employs data for 106 companies listed on the Karachi Stock Exchange (KSE) over the period from 1995to 2011 and an asymmetric generalized autoregressive conditional heteroscedasticity model to examine whether the mean value and volatility of share returns in the KSE vary with Islamic months. The results from the model offer very little statistical evidence of a monthly seasonal anomaly in average returns, but there is evidence of monthly patterns in the volatility of returns for KSE equities. This finding suggests that investors can formulate an investment strategy and choose a trading time in order to outperform on a risk-adjusted basis.
44. Islamic Calendar Anomalies: Pakistani Practitioners' Perspective
- Author
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Halari, Anwar, Helliar, Christine, Power, David, Tantisantiwong, Nongnuch, Halari, Anwar, Helliar, Christine, Power, David, and Tantisantiwong, Nongnuch
- Abstract
Studies on Islamic calendar anomalies in financial markets tend to apply quantitative analysis to historic share prices. Surprisingly, there is a lack of research investigating whether the participants of such markets are aware of these anomalies and whether these anomalies affect their investment practice. Or is it a case that these practitioners are completely unaware of the anomalies present in these markets and are missing out on profitable opportunities? The purpose of this paper is to analyse the views of influential participants within the Pakistani stock market.
45. Islamic Calendar Anomalies: Pakistani Practitioners' Perspective
- Author
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Halari, Anwar, Helliar, Christine, Power, David, Tantisantiwong, Nongnuch, Halari, Anwar, Helliar, Christine, Power, David, and Tantisantiwong, Nongnuch
- Abstract
Studies on Islamic calendar anomalies in financial markets tend to apply quantitative analysis to historic share prices. Surprisingly, there is a lack of research investigating whether the participants of such markets are aware of these anomalies and whether these anomalies affect their investment practice. Or is it a case that these practitioners are completely unaware of the anomalies present in these markets and are missing out on profitable opportunities? The purpose of this paper is to analyse the views of influential participants within the Pakistani stock market.
46. East Meets West: When the Islamic and Gregorian Calendars Coincide
- Author
-
Tantisantiwong, Nongnuch, Halari, Anwar, Helliar, Christine, Power, David, Tantisantiwong, Nongnuch, Halari, Anwar, Helliar, Christine, and Power, David
- Abstract
Recent research has documented that at the time of religious celebrations in Muslim countries, such as Ramadan, there is a “festival” effect in share returns. In the Gregorian calendar, December is also a time of celebration and festivities which may be associated with patterns in the behaviour of security prices. Further, the first month of the year in the Islamic calendar, Muharram, is a time of sadness and mourning for some believers, and there may be an effect when the Islamic first month of the year overlaps with the first month of the Gregorian year - January. Over a 33-year cycle, each Islamic month falls in a Gregorian month for about 5-6 consecutive years; when this happens, an Islamic (Eastern) calendar effect may interact with a Gregorian (Western) calendar effect. The current paper addresses this issue by examining the behaviour of share returns and volatility for individual companies listed in Muslim countries’ stock exchanges when the two calendars coincide for: (i) religious festival effects; (ii) first-month-of-the-year effects; and (iii) the two most common effects reported in the Islamic and Gregorian calendars (Ramadan and January). The results show that the Western and Eastern effects interact more prominently in larger companies and in larger or more developed markets.
47. Taking advantage of Ramadan and January in Muslim countries
- Author
-
Halari, Anwar, Helliar, Christine, Power, David, Tantisantiwong, Nongnuch, Halari, Anwar, Helliar, Christine, Power, David, and Tantisantiwong, Nongnuch
- Abstract
Studies have shown that religious beliefs and practice play an important role in influencing share price behaviour. Evidence of a Ramadan effect has been documented in Muslim countries suggesting an increase in mean returns as well as a reduction in volatility during the ninth month of the Islamic calendar. In addition to the Ramadan effect, studies have also documented a January effect in Muslim countries. The current study investigates what happens when the Ramadan effect and the January effect occur at the same time. Controlling for the effects of financial crises and time-varying volatility in returns, the results for individual company data from four countries with sizeable Muslim populations indicate higher returns and lower volatility when these two effects overlap, except in one, arguably more Western country, Turkey.
48. Islamic calendar anomalies: Evidence from Pakistani firm-level data
- Author
-
Halari, Anwar, Tantisantiwong, Nongnuch, Power, David M., Helliar, Christine, Halari, Anwar, Tantisantiwong, Nongnuch, Power, David M., and Helliar, Christine
- Abstract
Most prior research has tested for monthly regularities based on the Gregorian calendar; by contrast, little attention has been given to other calendars based on different religions or cultures. This paper examines Islamic monthly anomalies in a stock market located within a Muslim country – Pakistan. The study employs data for 106 companies listed on the Karachi Stock Exchange (KSE) over the period from 1995to 2011 and an asymmetric generalized autoregressive conditional heteroscedasticity model to examine whether the mean value and volatility of share returns in the KSE vary with Islamic months. The results from the model offer very little statistical evidence of a monthly seasonal anomaly in average returns, but there is evidence of monthly patterns in the volatility of returns for KSE equities. This finding suggests that investors can formulate an investment strategy and choose a trading time in order to outperform on a risk-adjusted basis.
49. Transmission of credit risk in Asia
- Author
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Zha, Yiling, Power, David, and Tantisantiwong, Nongnuch
- Abstract
Since the onset of the 2008 global financial crisis, significant spillover effects between the credit default swap (CDS) spreads of sovereigns and banks have been evidenced in the US and several European countries. Even though systemic risk seems more likely to be associated with banks, the role of non-financial firms in linking sovereigns and financial institutions is often crucial within Asian economies. This thesis attempts to facilitate an understanding of the credit risk transmission in Asia by analysing data for non-financial firms. Data for three East Asia countries (i.e. China, Japan and South Korea) and two Southeast Asia countries (i.e. Malaysia and Singapore) are analysed in order to test whether geographical proximity has an influence on credit risk interdependence in Asia. In addition, this thesis uses 1-year and 5-year CDS data enabling a comparison of findings between risk assessments over different horizons. The findings of the variation of credit risk transmission should provide some insights into either direct or indirect credit risk interdependence between sovereigns, financial institutions and non-financial firms. This thesis initially incorporates the changes in the CDS spreads of a sovereign debtor and that of domestic financial institutions and non-financial firms via a multivariate GARCH model; thus, spillovers in mean spreads as well as the volatility of spreads are considered. This analysis is then extended in a number of ways. Credit risk transmission is split to four groups: (i) domestic intra-sectoral, (ii) domestic cross-sectoral, (iii) regional intra-sectoral and (iv) regional cross-sectoral. The main findings evidence the strong credit risk interdependence exist within Asia given that shocks from common creditors such as Japan appears to spill over shocks to sovereigns and non-financial firms. Finally, this thesis uses a panel model to examine the effects of corporate and market factors on credit risk correlations. The findings from this part confirm the significance of trade links to credit risk interdependence in Asia. Moreover, credit risk correlations increase as the time-horizon gets longer.
- Published
- 2019
50. An analysis of monthly calendar anomalies in the Pakistani stock market : a study of the Gregorian and Islamic calendars
- Author
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Halari, Anwar, Power, David, and Tantisantiwong, Nongnuch
- Subjects
658 ,Islamic calendar anomalies ,Stock returns ,Conditional volatility ,Behavioural finance ,Calendar anomalies ,Stock market efficiency ,Monthly calendar anomalies ,Karachi stock exchange ,Pakistani stock exchange - Abstract
Most of the prior research in the area of monthly regularities has been based on the Gregorian calendar; by contrast, little attention has been given to other calendars based on different religions or cultures. This thesis examines monthly calendar anomalies in the Pakistani stock market for both the Gregorian calendar and its Islamic counterpart. This is one of the first studies to investigate both calendars for monthly seasonality in one investigation on the same dataset. Empirical studies of the Pakistani stock market that have examined monthly calendar anomalies are relatively sparse when compared with investigations from other emerging markets throughout the world. Even the findings from the small number of Pakistani investigations that have examined for the presence of monthly calendar anomalies have arrived at different conclusions about the predictability of equity returns at different times within a year. Since the conclusions of these findings have been mixed, the current study undertakes further work on this topic to offer some clarity in this area; this thesis arrives at a firm conclusion about the monthly calendar anomaly. For the purpose of this thesis, both qualitative and quantitative research methods were employed. Firstly, 19 face-to-face interviews were conducted with brokers, regulators and individual investors to ascertain their views about share price regularities with regards to monthly calendar anomalies and to gain some insights about the role of investor sentiment in the Pakistani stock markets. Secondly, share returns for a sample of 106 companies listed on the KSE over the 17 year period from 1995 to 2011 were analysed to determine whether Pakistani stock markets are weak-form efficient or whether security price changes can be predicted from knowledge of the month when the return is earned; it also investigates whether there is a change in the risk (volatility) of shares in different months which might explain any pattern in returns. To answer these questions various research methods were employed. The results of the interviews suggest that most respondents believed that share prices exhibit patterns in certain months of the year. The most common pattern highlighted by the interviewees related to the month of January for the Gregorian calendar and Ramadan for the Islamic calendar. Interviewees also argued that volatility declined during the religious month of Ramadan; they attributed these changes to investor sentiment and religious duties. Overall, the results suggested that monthly calendar anomalies may be present in the market and that these are studied by investors in an attempt to earn profit. The results from the quantitative analyses supported the findings from the interviews. Initial analyses suggested that returns varied significantly during certain months which indicate that the market might not be efficient. Further, investigations for seasonality in both the mean and volatility of returns offered conflicting evidence; very little statistical evidence of monthly seasonal anomalies was identified in average returns. However, monthly patterns were present in the variance of equity price changes in Pakistan. Overall, the results confirm that whatever monthly seasonality may be present in the equity prices of Pakistani companies, it is more pronounced in the volatility data than in the mean return numbers. These findings may have useful implications for trading strategies and investment decisions; investors may look to gain from managing the risk of their portfolios due to time varying volatility documented in the findings of this thesis. Further, the results of this thesis have interesting implications for our understanding of the dynamics of equity volatility in the Pakistani stock market.
- Published
- 2013
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