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14 results on '"Oh, Esther"'

1. The Delphi Delirium Management Algorithms: A practical tool for clinicians, the result of a modified Delphi expert consensus approach

Author

AIOS Anesthesiologie, AIOS Psychiatrie, Brain, Ottens, Thomas H, Hermes, Carsten, Page, Valerie, Oldham, Mark, Arora, Rakesh, Bienvenu, O Joseph, van den Boogaard, Mark, Caplan, Gideon, Devlin, John W, Friedrich, Michaela-Elena, van Gool, Willem A, Hanison, James, Hansen, Hans-Christian, Inouye, Sharon K, Kamholz, Barbara, Kotfis, Katarzyna, Maas, Matthew B, MacLullich, Alasdair M J, Marcantonio, Edward R, Morandi, Alessandro, van Munster, Barbara C, Müller-Werdan, Ursula, Negro, Alessandra, Neufeld, Karin J, Nydahl, Peter, Oh, Esther S, Pandharipande, Pratik, Radtke, Finn M, Raedt, Sylvie De, Rosenthal, Lisa J, Sanders, Robert, Spies, Claudia D, Vardy, Emma R L C, Wijdicks, Eelco F, Slooter, Arjen J C, AIOS Anesthesiologie, AIOS Psychiatrie, Brain, Ottens, Thomas H, Hermes, Carsten, Page, Valerie, Oldham, Mark, Arora, Rakesh, Bienvenu, O Joseph, van den Boogaard, Mark, Caplan, Gideon, Devlin, John W, Friedrich, Michaela-Elena, van Gool, Willem A, Hanison, James, Hansen, Hans-Christian, Inouye, Sharon K, Kamholz, Barbara, Kotfis, Katarzyna, Maas, Matthew B, MacLullich, Alasdair M J, Marcantonio, Edward R, Morandi, Alessandro, van Munster, Barbara C, Müller-Werdan, Ursula, Negro, Alessandra, Neufeld, Karin J, Nydahl, Peter, Oh, Esther S, Pandharipande, Pratik, Radtke, Finn M, Raedt, Sylvie De, Rosenthal, Lisa J, Sanders, Robert, Spies, Claudia D, Vardy, Emma R L C, Wijdicks, Eelco F, and Slooter, Arjen J C

Published
2024

2. Advancing specificity in delirium: The delirium subtyping initiative

Author

AIOS Psychiatrie, Brain, Affectieve & Psychotische Med., Bowman, Emily M L, Brummel, Nathan E, Caplan, Gideon A, Cunningham, Colm, Evered, Lis A, Fiest, Kirsten M, Girard, Timothy D, Jackson, Thomas A, LaHue, Sara C, Lindroth, Heidi L, Maclullich, Alasdair M J, McAuley, Daniel F, Oh, Esther S, Oldham, Mark A, Page, Valerie J, Pandharipande, Pratik P, Potter, Kelly M, Sinha, Pratik, Slooter, Arjen J C, Sweeney, Aoife M, Tieges, Zoë, Van Dellen, Edwin, Wilcox, Mary Elizabeth, Zetterberg, Henrik, Cunningham, Emma L, AIOS Psychiatrie, Brain, Affectieve & Psychotische Med., Bowman, Emily M L, Brummel, Nathan E, Caplan, Gideon A, Cunningham, Colm, Evered, Lis A, Fiest, Kirsten M, Girard, Timothy D, Jackson, Thomas A, LaHue, Sara C, Lindroth, Heidi L, Maclullich, Alasdair M J, McAuley, Daniel F, Oh, Esther S, Oldham, Mark A, Page, Valerie J, Pandharipande, Pratik P, Potter, Kelly M, Sinha, Pratik, Slooter, Arjen J C, Sweeney, Aoife M, Tieges, Zoë, Van Dellen, Edwin, Wilcox, Mary Elizabeth, Zetterberg, Henrik, and Cunningham, Emma L

Published
2024

3. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.

Author

Babulal, Ganesh M, Babulal, Ganesh M, Quiroz, Yakeel T, Albensi, Benedict C, Arenaza-Urquijo, Eider, Astell, Arlene J, Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L, Brickman, Adam M, Chételat, Gaël, Ciro, Carrie, Cohen, Ann D, Dilworth-Anderson, Peggye, Dodge, Hiroko H, Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N, Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R, Head, Elizabeth, Hendrix, James A, Hofer, Scott M, Johnson, Leigh A, Jutten, Roos, Kilborn, Kerry, Lanctôt, Krista L, Manly, Jennifer J, Martins, Ralph N, Mielke, Michelle M, Morris, Martha Clare, Murray, Melissa E, Oh, Esther S, Parra, Mario A, Rissman, Robert A, Roe, Catherine M, Santos, Octavio A, Scarmeas, Nikolaos, Schneider, Lon S, Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M, Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Terrera, Graciela Muniz, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M, Zetterberg, Henrik, O'Bryant, Sid E, International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Babulal, Ganesh M, Babulal, Ganesh M, Quiroz, Yakeel T, Albensi, Benedict C, Arenaza-Urquijo, Eider, Astell, Arlene J, Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L, Brickman, Adam M, Chételat, Gaël, Ciro, Carrie, Cohen, Ann D, Dilworth-Anderson, Peggye, Dodge, Hiroko H, Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N, Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R, Head, Elizabeth, Hendrix, James A, Hofer, Scott M, Johnson, Leigh A, Jutten, Roos, Kilborn, Kerry, Lanctôt, Krista L, Manly, Jennifer J, Martins, Ralph N, Mielke, Michelle M, Morris, Martha Clare, Murray, Melissa E, Oh, Esther S, Parra, Mario A, Rissman, Robert A, Roe, Catherine M, Santos, Octavio A, Scarmeas, Nikolaos, Schneider, Lon S, Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M, Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Terrera, Graciela Muniz, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M, Zetterberg, Henrik, O'Bryant, Sid E, and International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association

Abstract

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise "state-of-the-science" report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.

Published
2019

4. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Author

Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chetelat, Gael, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko H., Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctot, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle M., Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Muniz Terrera, Graciela Muniz Terrera, Muniz Terrera, Graciela, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, O’Bryant, Sid E., International Society to Advance Alzheimer’s Research and Treatment, Alzheimer’s Association, Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chetelat, Gael, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko H., Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctot, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle M., Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Muniz Terrera, Graciela Muniz Terrera, Muniz Terrera, Graciela, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, O’Bryant, Sid E., and International Society to Advance Alzheimer’s Research and Treatment, Alzheimer’s Association

Abstract

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise “state-of-the-science” report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations. © 2018 The Authors

Published
2019

5. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.

Author

Babulal, Ganesh M, Babulal, Ganesh M, Quiroz, Yakeel T, Albensi, Benedict C, Arenaza-Urquijo, Eider, Astell, Arlene J, Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L, Brickman, Adam M, Chételat, Gaël, Ciro, Carrie, Cohen, Ann D, Dilworth-Anderson, Peggye, Dodge, Hiroko H, Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N, Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R, Head, Elizabeth, Hendrix, James A, Hofer, Scott M, Johnson, Leigh A, Jutten, Roos, Kilborn, Kerry, Lanctôt, Krista L, Manly, Jennifer J, Martins, Ralph N, Mielke, Michelle M, Morris, Martha Clare, Murray, Melissa E, Oh, Esther S, Parra, Mario A, Rissman, Robert A, Roe, Catherine M, Santos, Octavio A, Scarmeas, Nikolaos, Schneider, Lon S, Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M, Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Terrera, Graciela Muniz, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M, Zetterberg, Henrik, O'Bryant, Sid E, International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Babulal, Ganesh M, Babulal, Ganesh M, Quiroz, Yakeel T, Albensi, Benedict C, Arenaza-Urquijo, Eider, Astell, Arlene J, Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L, Brickman, Adam M, Chételat, Gaël, Ciro, Carrie, Cohen, Ann D, Dilworth-Anderson, Peggye, Dodge, Hiroko H, Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N, Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R, Head, Elizabeth, Hendrix, James A, Hofer, Scott M, Johnson, Leigh A, Jutten, Roos, Kilborn, Kerry, Lanctôt, Krista L, Manly, Jennifer J, Martins, Ralph N, Mielke, Michelle M, Morris, Martha Clare, Murray, Melissa E, Oh, Esther S, Parra, Mario A, Rissman, Robert A, Roe, Catherine M, Santos, Octavio A, Scarmeas, Nikolaos, Schneider, Lon S, Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M, Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Terrera, Graciela Muniz, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M, Zetterberg, Henrik, O'Bryant, Sid E, and International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association

Abstract

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise "state-of-the-science" report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.

Published
2019

6. Bayesian Model Averaging for Selection of a Risk Prediction Model for Death within Thirty Days of Discharge: The SILVER-AMI Study

Author

Murphy, Terrence E., Tsang, Sui W., Leo-Summers, Linda S., Geda, Mary, Kim, Dae H., Oh, Esther, Allore, Heather G., Dodson, John, Hajduk, Alexandra M., Gill, Thomas M., Chaudhry, Sarwat I., Murphy, Terrence E., Tsang, Sui W., Leo-Summers, Linda S., Geda, Mary, Kim, Dae H., Oh, Esther, Allore, Heather G., Dodson, John, Hajduk, Alexandra M., Gill, Thomas M., and Chaudhry, Sarwat I.

Abstract

We describe a selection process for a multivariable risk prediction model of death within 30 days of hospital discharge in the SILVER-AMI study. This large, multi-site observational study included observational data from 2000 persons 75 years and older hospitalized for acute myocardial infarction (AMI) from 94 community and academic hospitals across the United States and featured a large number of candidate variables from demographic, cardiac, and geriatric domains, whose missing values were multiply imputed prior to model selection. Our objective was to demonstrate that Bayesian Model Averaging (BMA) represents a viable model selection approach in this context. BMA was compared to three other backward-selection approaches: Akaike information criterion, Bayesian information criterion, and traditional p-value. Traditional backward-selection was used to choose 20 candidate variables from the initial, larger pool of five imputations. Models were subsequently chosen from those candidates using the four approaches on each of 10 imputations. With average posterior effect probability ≥ 50% as the selection criterion, BMA chose the most parsimonious model with four variables, with average C statistic of 78%, good calibration, optimism of 1.3%, and heuristic shrinkage of 0.93. These findings illustrate the utility and flexibility of using BMA for selecting a multivariable risk prediction model from many candidates over multiply imputed datasets.

Published
2019

7. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Author

Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chetelat, Gael, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko H., Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctot, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle M., Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Muniz Terrera, Graciela Muniz Terrera, Muniz Terrera, Graciela, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, O’Bryant, Sid E., International Society to Advance Alzheimer’s Research and Treatment, Alzheimer’s Association, Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chetelat, Gael, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko H., Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctot, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle M., Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Muniz Terrera, Graciela Muniz Terrera, Muniz Terrera, Graciela, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, O’Bryant, Sid E., and International Society to Advance Alzheimer’s Research and Treatment, Alzheimer’s Association

Abstract

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise “state-of-the-science” report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations. © 2018 The Authors

Published
2019

8. Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges.

Author

O'Bryant, Sid E, O'Bryant, Sid E, Lista, Simone, Rissman, Robert A, Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Henrik, Lovestone, Simon, Gupta, Veer, Graff-Radford, Neill, Martins, Ralph, Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D, Hampel, Harald, O'Bryant, Sid E, O'Bryant, Sid E, Lista, Simone, Rissman, Robert A, Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Henrik, Lovestone, Simon, Gupta, Veer, Graff-Radford, Neill, Martins, Ralph, Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D, and Hampel, Harald

Abstract

IntroductionThis study investigated the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms.MethodsNonfasting serum and plasma samples from 300 participants (150 AD patients and 150 controls) were analyzed. Proteomic markers were obtained via electrochemiluminescence or Luminex technology. Comparisons were conducted via Pearson correlations. The relative importance of proteins within an AD diagnostic profile was examined using random forest importance plots.ResultsOn the Meso Scale Discovery multiplex platform, 10 of the 21 markers shared >50% of the variance across blood fractions (serum amyloid A R(2) = 0.99, interleukin (IL)10 R(2) = 0.95, fatty acid-binding protein (FABP) R(2) = 0.94, I309 R(2) = 0.94, IL-5 R(2) = 0.94, IL-6 R(2) = 0.94, eotaxin3 R(2) = 0.91, IL-18 R(2) = 0.87, soluble tumor necrosis factor receptor 1 R(2) = 0.85, and pancreatic polypeptide R(2) = 0.81). When examining protein concentrations across platforms, only five markers shared >50% of the variance (beta 2 microglobulin R(2) = 0.92, IL-18 R(2) = 0.80, factor VII R(2) = 0.78, CRP R(2) = 0.74, and FABP R(2) = 0.70).DiscussionThe current findings highlight the importance of considering blood fractions and assay platforms when searching for AD relevant biomarkers.

Published
2016

9. Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges

Author

O'Bryant, Sid E., Lista, Simone, Rissman, Robert A., Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Herik, Lovestone, Simon, Gupta, Veer Bular, Graff-Radford, Neill, Martins, Ralph N., Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D., Hampel, Harald, O'Bryant, Sid E., Lista, Simone, Rissman, Robert A., Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Herik, Lovestone, Simon, Gupta, Veer Bular, Graff-Radford, Neill, Martins, Ralph N., Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D., and Hampel, Harald

Abstract

Introduction: This study investigated the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms. Methods: Nonfasting serum and plasma samples from 300 participants (150 AD patients and 150 controls) were analyzed. Proteomic markers were obtained via electrochemiluminescence or Luminex technology. Comparisons were conducted via Pearson correlations. The relative importance of proteins within an AD diagnostic profile was examined using random forest importance plots. Results: On the Meso Scale Discovery multiplex platform, 10 of the 21 markers shared > 50% of the variance across blood fractions (serum amyloid A R2 = 0.99, interleukin (IL)10 R2 = 0.95, fatty acid-binding protein (FABP) R2 = 0.94, I309 R2 = 0.94, IL-5 R2 = 0.94, IL-6 R2 = 0.94, eotaxin3 R2 = 0.91, IL-18 R2 = 0.87, soluble tumor necrosis factor receptor 1 R2 = 0.85, and pancreatic polypeptide R2 = 0.81). When examining protein concentrations across platforms, only five markers shared > 50% of the variance (beta 2 microglobulin R2 = 0.92, IL-18 R2 = 0.80, factor VII R2 = 0.78, CRP R2 = 0.74, and FABP R2 = 0.70). Discussion: The current findings highlight the importance of considering blood fractions and assay platforms when searching for AD relevant biomarkers.

Published
2016

10. Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges.

Author

O'Bryant, Sid E, O'Bryant, Sid E, Lista, Simone, Rissman, Robert A, Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Henrik, Lovestone, Simon, Gupta, Veer, Graff-Radford, Neill, Martins, Ralph, Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D, Hampel, Harald, O'Bryant, Sid E, O'Bryant, Sid E, Lista, Simone, Rissman, Robert A, Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Henrik, Lovestone, Simon, Gupta, Veer, Graff-Radford, Neill, Martins, Ralph, Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D, and Hampel, Harald

Abstract

IntroductionThis study investigated the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms.MethodsNonfasting serum and plasma samples from 300 participants (150 AD patients and 150 controls) were analyzed. Proteomic markers were obtained via electrochemiluminescence or Luminex technology. Comparisons were conducted via Pearson correlations. The relative importance of proteins within an AD diagnostic profile was examined using random forest importance plots.ResultsOn the Meso Scale Discovery multiplex platform, 10 of the 21 markers shared >50% of the variance across blood fractions (serum amyloid A R(2) = 0.99, interleukin (IL)10 R(2) = 0.95, fatty acid-binding protein (FABP) R(2) = 0.94, I309 R(2) = 0.94, IL-5 R(2) = 0.94, IL-6 R(2) = 0.94, eotaxin3 R(2) = 0.91, IL-18 R(2) = 0.87, soluble tumor necrosis factor receptor 1 R(2) = 0.85, and pancreatic polypeptide R(2) = 0.81). When examining protein concentrations across platforms, only five markers shared >50% of the variance (beta 2 microglobulin R(2) = 0.92, IL-18 R(2) = 0.80, factor VII R(2) = 0.78, CRP R(2) = 0.74, and FABP R(2) = 0.70).DiscussionThe current findings highlight the importance of considering blood fractions and assay platforms when searching for AD relevant biomarkers.

Published
2016

11. Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges

Author

O'Bryant, Sid E., Lista, Simone, Rissman, Robert A., Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Herik, Lovestone, Simon, Gupta, Veer Bular, Graff-Radford, Neill, Martins, Ralph N., Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D., Hampel, Harald, O'Bryant, Sid E., Lista, Simone, Rissman, Robert A., Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Herik, Lovestone, Simon, Gupta, Veer Bular, Graff-Radford, Neill, Martins, Ralph N., Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D., and Hampel, Harald

Abstract

Introduction: This study investigated the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms. Methods: Nonfasting serum and plasma samples from 300 participants (150 AD patients and 150 controls) were analyzed. Proteomic markers were obtained via electrochemiluminescence or Luminex technology. Comparisons were conducted via Pearson correlations. The relative importance of proteins within an AD diagnostic profile was examined using random forest importance plots. Results: On the Meso Scale Discovery multiplex platform, 10 of the 21 markers shared > 50% of the variance across blood fractions (serum amyloid A R2 = 0.99, interleukin (IL)10 R2 = 0.95, fatty acid-binding protein (FABP) R2 = 0.94, I309 R2 = 0.94, IL-5 R2 = 0.94, IL-6 R2 = 0.94, eotaxin3 R2 = 0.91, IL-18 R2 = 0.87, soluble tumor necrosis factor receptor 1 R2 = 0.85, and pancreatic polypeptide R2 = 0.81). When examining protein concentrations across platforms, only five markers shared > 50% of the variance (beta 2 microglobulin R2 = 0.92, IL-18 R2 = 0.80, factor VII R2 = 0.78, CRP R2 = 0.74, and FABP R2 = 0.70). Discussion: The current findings highlight the importance of considering blood fractions and assay platforms when searching for AD relevant biomarkers.

Published
2016

12. Deep brain stimulation targeting the fornix for mild Alzheimer dementia: design of the ADvance randomized controlled trial

Author

Holroyd,Kathryn, Fosdick,Lisa, Smith,Gwenn, Leoutsakos,Jeannie-Marie, Munro,Cynthia, Oh,Esther, Drake,Kristen, Rosenberg,Paul, Anderson,William, Salloway,Stephen, Pendergrass,J Cara, Burke,Anna, Wolk,David, Tang-Wai,David, Ponce,Francisco, Asaad,Wael, Sabbagh,Marwan, Okun,Michael, Baltuch,Gordon, Foote,Kelly, Targum,Steven, Lozano,Andres, Lyketsos,Constantine, Holroyd,Kathryn, Fosdick,Lisa, Smith,Gwenn, Leoutsakos,Jeannie-Marie, Munro,Cynthia, Oh,Esther, Drake,Kristen, Rosenberg,Paul, Anderson,William, Salloway,Stephen, Pendergrass,J Cara, Burke,Anna, Wolk,David, Tang-Wai,David, Ponce,Francisco, Asaad,Wael, Sabbagh,Marwan, Okun,Michael, Baltuch,Gordon, Foote,Kelly, Targum,Steven, Lozano,Andres, and Lyketsos,Constantine

Abstract

Kathryn B Holroyd,1 Lisa Fosdick,2 Gwenn S Smith,1 Jeannie-Marie Leoutsakos,1 Cynthia A Munro,1 Esther S Oh,1 Kristen E Drake,2 Paul B Rosenberg,1 William S Anderson,1 Stephen Salloway,3–5 J Cara Pendergrass,6 Anna D Burke,7 David A Wolk,8 David F Tang-Wai,9–11 Francisco A Ponce,12 Wael F Asaad,13,14 Marwan N Sabbagh,15 Michael S Okun,16 Gordon Baltuch,17 Kelly D Foote,18 Steven D Targum,2,6 Andres M Lozano,10,11 Constantine G Lyketsos1 1Johns Hopkins University Memory and Alzheimer's Treatment Center, Baltimore, MD, 2Functional Neuromodulation Ltd, Minneapolis, MN, 3Department of Neurology, Butler Hospital, 4Department of Neurology, Rhode Island Hospital, 5Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, 6Clintara LLC, Boston, MA, 7Banner Alzheimer's Institute, Phoenix, AZ, 8Penn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA; 9Department of Neurology, 10Department of Neurosurgery, University of Toronto, 11Division of Neurology, University Health Network Memory Clinic, Toronto, ON, Canada; 12Division of Neurological Surgery, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, 13Department of Neurosurgery, Rhode Island Hospital, 14Department of Neurosurgery, Warren Alpert Medical School of Brown University, Providence, RI, 15Banner Sun Health Research Institute, Sun City, AZ, 16Center for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida – Gainsville, Gainsville, FL, 17Center for Functional and Restorative Neurosurgery, University of Pennsylvania, Philadelphia, PA, 18Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainsville, FL, USA Background: There are currently few available treatments and no cure for Alzheimer disease (AD), a growing public health burden. Animal models and an open-label human trial ha

Published
2015

13. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Author

Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chetelat, Gael, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko H., Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctot, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle M., Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Muniz Terrera, Graciela Muniz Terrera, Muniz Terrera, Graciela, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, O’Bryant, Sid E., International Society to Advance Alzheimer’s Research and Treatment, Alzheimer’s Association, Babulal, Ganesh M., Quiroz, Yakeel T., Albensi, Benedict C., Arenaza-Urquijo, Eider, Astell, Arlene J., Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L., Brickman, Adam M., Chetelat, Gael, Ciro, Carrie, Cohen, Ann D., Dilworth-Anderson, Peggye, Dodge, Hiroko H., Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N., Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R., Head, Elizabeth, Hendrix, James A., Hofer, Scott M., Johnson, Leigh A., Jutten, Roos, Kilborn, Kerry, Lanctot, Krista L., Manly, Jennifer J., Martins, Ralph N., Mielke, Michelle M., Morris, Martha Clare, Murray, Melissa E., Oh, Esther S., Parra, Mario A., Rissman, Robert A., Roe, Catherine M., Santos, Octavio A., Scarmeas, Nikolaos, Schneider, Lon S., Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M., Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Muniz Terrera, Graciela Muniz Terrera, Muniz Terrera, Graciela, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M., Zetterberg, Henrik, O’Bryant, Sid E., and International Society to Advance Alzheimer’s Research and Treatment, Alzheimer’s Association

Abstract

Babulal, G. M., Quiroz, Y. T., Albensi, B. C., Arenaza-Urquijo, E., Astell, A. J., Babiloni, C., . . . International Society to Advance Alzheimer's Research and Treatment,Alzheimer's Association. (2019). Perspectives on ethnic and racial disparities in alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimer's and Dementia, 15(2), 292-312. Available here

14. Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges

Author

O'Bryant, Sid E., Lista, Simone, Rissman, Robert A., Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Herik, Lovestone, Simon, Gupta, Veer Bular, Graff-Radford, Neill, Martins, Ralph N., Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D., Hampel, Harald, O'Bryant, Sid E., Lista, Simone, Rissman, Robert A., Edwards, Melissa, Zhang, Fan, Hall, James, Zetterberg, Herik, Lovestone, Simon, Gupta, Veer Bular, Graff-Radford, Neill, Martins, Ralph N., Jeromin, Andreas, Waring, Stephen, Oh, Esther, Kling, Mitchel, Baker, Laura D., and Hampel, Harald

Abstract

O'Bryant, S. E., Lista, S., Rissman, R. A., Edwards, M., Zhang, F., Hall, J., ... & Martins, R. (2016). Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 3, 27-34. Available here

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