1. Simvastatin Nanoparticles Loaded Polymeric Film as a Potential Strategy for Diabetic Wound Healing:In Vitro and In Vivo Evaluation
- Author
-
Tufail, Saima, Siddique, Muhammad Irfan, Sarfraz, Muhammad, Sohail, Muhammad Farhan, Shahid, Muhammad Nabeel, Omer, Muhammad Ovais, Katas, Haliza, Rasool, Fatima, Tufail, Saima, Siddique, Muhammad Irfan, Sarfraz, Muhammad, Sohail, Muhammad Farhan, Shahid, Muhammad Nabeel, Omer, Muhammad Ovais, Katas, Haliza, and Rasool, Fatima
- Abstract
Introduction: The pleiotropic effects of statins are recently explored for wound healing through angiogenesis and lymph-angiogenesis that could be of great importance in diabetic wounds. Aims: The aim of the present study is to fabricate nanofilm embedded with simvastatin-loaded chitosan nanoparticles (CS-SIM-NPs) and to explore the efficacy of SIM in diabetic wound healing. Methods: The NPs, prepared via ionic gelation, were 173 nm ± 2.645 in size with a zeta potential of-0.299 ± 0.009 and PDI 0.051 ± 0.088 with excellent encapsulation efficiency (99.97%). The optimized formulation (CS: TPP, 1:1) that exhibited the highest drug release (91.64%) was incorporated into the polymeric nanofilm (HPMC, Sodium alginate, PVA), followed by in vitro characterization. The optimized nanofilm was applied to the wound created on the back of diabetes-induced (with alloxan injection 120 mg/kg) albino rats. Results: The results showed a significant (p < 0.05) improvement in the wound healing process compared to the diabetes-induced non-treated group. The results highlighted the importance of nanofilms loaded with SIM-NPs in diabetic wound healing through angiogenesis promotion at the wound site. Conclusion: Thus, CS-SIM-NPs loaded polymeric nanofilms could be an emerging diabetic wound healing agent in the industry of nanomedicines.
- Published
- 2022