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9 results on '"Opmeer BC"'

4. Laparoscopy to predict the result of primary cytoreductive surgery in advanced ovarian cancer patients (LapOvCa-trial): a multicentre randomized controlled study

Author

Rutten, MJ, Gaarenstroom, KN, Van Gorp, T, van Meurs, HS, Arts, HJG, Bossuyt, PM, ter Brugge, HG, Hermans, RHM, Opmeer, BC, Pijnenborg, JMA, Schreuder, HWR, Schutter, EMJ, Spijkerboer, AM, Wensveen, Celesta, Zusterzeel, P, Mol, BWJ (Ben), Kenter, GG, Buist, MR, Rutten, MJ, Gaarenstroom, KN, Van Gorp, T, van Meurs, HS, Arts, HJG, Bossuyt, PM, ter Brugge, HG, Hermans, RHM, Opmeer, BC, Pijnenborg, JMA, Schreuder, HWR, Schutter, EMJ, Spijkerboer, AM, Wensveen, Celesta, Zusterzeel, P, Mol, BWJ (Ben), Kenter, GG, and Buist, MR

Abstract

Background: Standard treatment of advanced ovarian cancer is surgery and chemotherapy. The goal of surgery is to remove all macroscopic tumour, as the amount of residual tumour is the most important prognostic factor for survival. When removal off all tumour is considered not feasible, neoadjuvant chemotherapy (NACT) in combination with interval debulking surgery (IDS) is performed. Current methods of staging are not always accurate in predicting surgical outcome, since approximately 40% of patients will have more than 1 cm residual tumour after primary debulking surgery (PDS). In this study we aim to assess whether adding laparoscopy to the diagnostic work-up of patients suspected of advanced ovarian carcinoma may prevent unsuccessful primary debulking surgery for ovarian cancer. Methods: Multicentre randomized controlled trial, including all gynaecologic oncologic centres in the Netherlands and their affiliated hospitals. Patients are eligible when they are planned for PDS after conventional staging. Participants are randomized between direct PDS or additional diagnostic laparoscopy. Depending on the result of laparoscopy patients are treated by PDS within three weeks, followed by six courses of platinum based chemotherapy or with NACT and IDS 3-4 weeks after three cour Discussion: Patients who have disease considered to be resectable to less than one centimetre should undergo PDS to improve prognosis. However, there is a need for better diagnostic procedures because the current number of debulking surgeries leaving more than one centimetre residual tumour is still high. Laparoscopy before starting treatment for ovarian cancer can be an additional diagnostic tool to predict the outcome of PDS. Despite the absence of strong evidence and despite the possible comp

Published
2012

5. Chlamydia antibody testing and diagnosing tubal pathology in subfertile women : an individual patient data meta-analysis

Author

Broeze, KA, Opmeer, BC, Coppus, SFPJ, Van Geloven, N, Alves, MFC, Anestad, G, Bhattacharya, S, Allan, J, Guerra-Infante, MF, Den Hartog, JE, Land, JA, Idahl, Annika, Van der Linden, PJQ, Mouton, JW, Ng, EHY, Van der Steeg, JW, Steures, P, Svenstrup, HF, Tiitinen, A, Toye, B, Van der Veen, F, Mol, BW, Broeze, KA, Opmeer, BC, Coppus, SFPJ, Van Geloven, N, Alves, MFC, Anestad, G, Bhattacharya, S, Allan, J, Guerra-Infante, MF, Den Hartog, JE, Land, JA, Idahl, Annika, Van der Linden, PJQ, Mouton, JW, Ng, EHY, Van der Steeg, JW, Steures, P, Svenstrup, HF, Tiitinen, A, Toye, B, Van der Veen, F, and Mol, BW

Abstract

BACKGROUND The Chlamydia IgG antibody test (CAT) shows considerable variations in reported estimates of test accuracy, partly because of the use of different assays and cut-off values. The aim of this study was to reassess the accuracy of CAT in diagnosing tubal pathology by individual patient data (IPD) meta-analysis for three different CAT assays. METHODS We approached authors of primary studies that used micro-immunofluorescence tests (MIF), immunofluorescence tests (IF) or enzyme-linked immunosorbent assay tests (ELISA). Using the obtained IPD, we performed pooled receiver operator characteristics analysis and logistic regression analysis with a random effects model to compare the three assays. Tubal pathology was defined as either any tubal obstruction or bilateral tubal obstruction. RESULTS We acquired data of 14 primary studies containing data of 6191 women, of which data of 3453 women were available for analysis. The areas under the curve for ELISA, IF and MIF were 0.64, 0.65 and 0.75, respectively (P-value < 0.001) for any tubal pathology and 0.66, 0.66 and 0.77, respectively (P-value = 0.01) for bilateral tubal pathology. CONCLUSIONS In Chlamydia antibody testing, MIF is superior in the assessment of tubal pathology. In the initial screen for tubal pathology MIF should therefore be the test of first choice.

Published
2011
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6. IMproving PArticipation of patients in Clinical Trials - rationale and design of IMPACT

Author

Oude Rengerink, K, Opmeer, BC, Logtenberg, SL, Hooft, L, Bloemenkamp, KWM, Haak, MC, Oudijk, MA, Spaanderman, M, Duvekot, J.J., Willekes, C, van Pampus, MG, Porath, MM, van Eyck, J, Sikkema, MJ, Mol, BWJ (Ben), Oude Rengerink, K, Opmeer, BC, Logtenberg, SL, Hooft, L, Bloemenkamp, KWM, Haak, MC, Oudijk, MA, Spaanderman, M, Duvekot, J.J., Willekes, C, van Pampus, MG, Porath, MM, van Eyck, J, Sikkema, MJ, and Mol, BWJ (Ben)

Published
2010

7. Assessment of perinatal outcome after sustained tocolysis in early labour( APOSTEL-II trial)

Author

Roos, C (Carolien), Scheepers, LH, Bloemenkamp, KWM, Bolte, AC, Cornette, JMJ, Derks, JB, Duvekot, JJ, van Eyck, J, Kok, JH, Kwee, A, Meriën, Tony, Opmeer, BC, van Pampus, MG, Papatsonis, Dimitri, Porath, MM, Van der Post, JAM, Scherjon, SA, Sollie, KM, Spaanderman, M, Vijgen, SM, Willekes, C, Mol, BWJ (Ben), Lotgering, FK (Fred), Roos, C (Carolien), Scheepers, LH, Bloemenkamp, KWM, Bolte, AC, Cornette, JMJ, Derks, JB, Duvekot, JJ, van Eyck, J, Kok, JH, Kwee, A, Meriën, Tony, Opmeer, BC, van Pampus, MG, Papatsonis, Dimitri, Porath, MM, Van der Post, JAM, Scherjon, SA, Sollie, KM, Spaanderman, M, Vijgen, SM, Willekes, C, Mol, BWJ (Ben), and Lotgering, FK (Fred)

Published
2009

8. Cost-effectiveness of fibronectin testing in a triage in women with threatened preterm labor: alleviation of pregnancy outcome by suspending tocolysis in early labor (APOSTEL-I trial)

Author

Vis, JY, Wilms, FF, Oudijk, MA, Porath, MM, Scheepers, HC, Bloemenkamp, KWM, Bolte, AC, Cornette, JMJ, Derks, JB, Duvekot, JJ, van Eyck, J, Kwee, A, Opmeer, BC, van Pampus, MG, Lotgering, FK (Fred), Scherjon, SA, Sollie, KM, Spaanderman, M, Willekes, C, Van der Post, JAM, Mol, BWJ (Ben), Vis, JY, Wilms, FF, Oudijk, MA, Porath, MM, Scheepers, HC, Bloemenkamp, KWM, Bolte, AC, Cornette, JMJ, Derks, JB, Duvekot, JJ, van Eyck, J, Kwee, A, Opmeer, BC, van Pampus, MG, Lotgering, FK (Fred), Scherjon, SA, Sollie, KM, Spaanderman, M, Willekes, C, Van der Post, JAM, and Mol, BWJ (Ben)

Published
2009

9. Induction of labour versus expectant management in women with preterm prelabour rupture of membranes between 34 and 37 weeks (the PPROMEXIL-trial)

Author

van der Ham, DP, Nijhuis, JG, Mol, BWJ (Ben), van Beek, JJ, Opmeer, BC, Bijlenga, D, Groenewout, M (Mariette), Arabin, B, Bloemenkamp, KWM, van Wijngaarden, WJ, Wouters, MGAJ, Pernet, PJM, Porath, MM, Molkenboer, JFM, Derks, JB, Kars, MM, Scheepers, HCJ, Weinans, MJN, Woiski, MD, Wildschut, Hajo, Willekes, C, van der Ham, DP, Nijhuis, JG, Mol, BWJ (Ben), van Beek, JJ, Opmeer, BC, Bijlenga, D, Groenewout, M (Mariette), Arabin, B, Bloemenkamp, KWM, van Wijngaarden, WJ, Wouters, MGAJ, Pernet, PJM, Porath, MM, Molkenboer, JFM, Derks, JB, Kars, MM, Scheepers, HCJ, Weinans, MJN, Woiski, MD, Wildschut, Hajo, and Willekes, C

Published
2007

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