Search

Your search keyword '"Oudijk, MA"' showing total 20 results
Start Over Author "Oudijk, MA" Publication Type Electronic Resources
20 results on '"Oudijk, MA"'

1. Induction of labor with Foley catheter and risk of subsequent preterm birth: follow-up study of two randomized controlled trials (PROBAAT-1 and -2)

Author

de Vaan, MDT, Blel, D, Bloemenkamp, KWM, Piso - Józwiak, Marta, ten Eikelder, MLG, Leeuw, JW, Oudijk, MA, Bakker, JJH, Rijnders, RJP, Papatsonis, DN, Woiski, M, Mol, BW, de Heus, R, de Vaan, MDT, Blel, D, Bloemenkamp, KWM, Piso - Józwiak, Marta, ten Eikelder, MLG, Leeuw, JW, Oudijk, MA, Bakker, JJH, Rijnders, RJP, Papatsonis, DN, Woiski, M, Mol, BW, and de Heus, R

Abstract

Objective: To evaluate the rate of preterm birth (PTB) in a subsequent pregnancy in women who had undergone term induction using a Foley catheter compared with prostaglandins. Methods: This was a follow-up study of two large randomized controlled trials (PROBAAT-1 and PROBAAT-2). In the original trials, women with a term singleton pregnancy with the fetus in cephalic presentation and with an indication for labor induction were randomized to receive either a 30-mL Foley catheter or prostaglandins (vaginal prostaglandin E2 in PROBAAT-1 and oral misoprostol in PROBAAT-2). Data on subsequent ongoing pregnancies > 16 weeks’ gestation were collected from hospital charts from clinics participating in this follow-up study. The main outcome measure was preterm birth < 37 weeks’ gestation in a subsequent pregnancy. Results: Fourteen hospitals agreed to participate in this follow-up study. Of the 1142 eligible women, 572 had been allocated to induction of labor using a Foley catheter and 570 to induction of labor using prostaglandins. Of these, 162 (14%) were lost to follow-up. In total, 251 and 258 women had a known subsequent pregnancy > 16 weeks' gestation in the Foley catheter and prostaglandin groups, respectively. There were no differences in baseline characteristics between the groups. The overall rate of PTB in a subsequent pregnancy was 9/251 (3.6%) in the Foley catheter group vs 10/258 (3.9%) in the prostaglandin group (relative risk (RR), 0.93; 95% CI, 0.38–2.24), and the rate of spontaneous PTB was 5/251 (2.0%) vs 5/258 (1.9%) (RR, 1.03; 95% CI, 0.30–3.51). Conclusion: In women with term singleton pregnancy, induction of labor using a 30-mL Foley catheter is not associated with an increased risk of PTB in a subsequent pregnancy, as compared to induction of labor using prostaglandins.

Published
2021

2. Temporizing management vs immediate delivery in early-onset severe preeclampsia between 28 and 34 weeks of gestation (TOTEM study): An open-label randomized controlled trial

Author

Duvekot, J.J., Duijnhoven, RG, van Horen, E, Bax, CJ, Bloemenkamp, KW, Brussé, Ingrid, Dijk, PH, Franssen, MT, Franx, A (Arie), Oudijk, MA, Porath, MM, Scheepers, HCJ, van Wassenaer-Leemhuis, AG, van Drongelen, J, Mol, BW, Ganzevoort, W, Duvekot, J.J., Duijnhoven, RG, van Horen, E, Bax, CJ, Bloemenkamp, KW, Brussé, Ingrid, Dijk, PH, Franssen, MT, Franx, A (Arie), Oudijk, MA, Porath, MM, Scheepers, HCJ, van Wassenaer-Leemhuis, AG, van Drongelen, J, Mol, BW, and Ganzevoort, W

Abstract

Introduction: There is little evidence to guide the timing of delivery of women with early-onset severe preeclampsia. We hypothesize that immediate delivery is not inferior for neonatal outcome but reduces maternal complications compared with temporizing management. Material and methods: This Dutch multicenter open-label randomized clinical trial investigated non-inferiority for neonatal outcome of temporizing management as compared with immediate delivery (TOTEM NTR 2986) in women between 27+5 and 33+5 weeks of gestation admitted for early-onset severe preeclampsia with or without HELLP syndrome. In participants allocated to receive immediate delivery, either induction of labor or cesarean section was initiated at least 48 hours after admission. Primary outcomes were adverse perinatal outcome, defined as a composite of severe respiratory distress syndrome, bronchopulmonary dysplasia, culture proven sepsis, intraventricular hemorrhage grade 3 or worse, periventricular leukomalacia grade 2 or worse, necrotizing enterocolitis stage 2 or worse, and perinatal death. Major maternal complications were secondary outcomes. It was estimated 1130 women needed to be enrolled. Analysis was by intention-to-treat. Results: The trial was halted after 35 months because of slow recruitment. Between February 2011 and December 2013, a total of 56 women were randomized to immediate delivery (n = 26) or temporizing management (n = 30). Median gestational age at randomization was 30 weeks. Median prolongation of pregnancy was 2 days (interquartile range 1-3 days) in the temporizing management group. Mean birthweight was 1435 g after immediate delivery vs 1294 g after temporizing management (P =.14). The adverse perinatal outcome rate was 55% in the immediate delivery group vs 52% in the temporizing management group (relative risk 1.06; 95% confidence interval 0.67-1.70). In both groups there was one neonatal death and no maternal deaths. In the temporizing treatm

Published
2021

3. Effects of tocolysis with nifedipine or atosiban on child outcome: follow‐up of the APOSTEL III trial

Author

Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, Oudijk, Ma, Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, and Oudijk, Ma

Abstract

Objective To compare the long‐term effects of tocolysis with nifedipine or atosiban on child outcome at age 2.5–5.5 years. Design The APOSTEL III trial was a multicentre randomised controlled trial that compared tocolysis with nifedipine or atosiban in 503 women with threatened preterm birth. Neonatal outcomes did not differ between both treatment arms, except for a higher incidence of intubation in the atosiban group. Methods Parents were asked to complete four questionnaires regarding neurodevelopment, executive function, behaviour problems and general health. Main outcome measures The main long‐term outcome measure was a composite of abnormal development at the age of 2.5–5.5 years. Results Of the 426 women eligible for follow‐up, 196 (46%) parents returned the questionnaires for 115 children in the nifedipine group and 110 children in the atosiban group. Abnormal development occurred in 32 children (30%) in the nifedipine group and in 38 children (38%) in the atosiban group (OR 0.74, 95% CI 0.41–1.34). The separate outcomes for neurodevelopment, executive function, behaviour, and general health showed no significant differences between the groups. Sensitivity analysis for all children of the APOSTEL III trial, including a comparison of deceased children, resulted in a higher rate of healthy survival in the nifedipine group (64 versus 54%), but there was no significant difference in the overall mortality rate (5.4 versus 2.7%). There were no significant subgroup effects. Conclusion Outcomes on broad child neurodevelopment, executive function, behaviour and general health were comparable in both groups. Neither nifedipine nor atosiban can be considered as the preferred treatment for women with threatened preterm birth. Tweetable abstract Nifedipine‐ and atosiban‐exposed children had comparable long‐term outcomes, including neurodevelopment, executive function and behaviour.

Published
2020

4. Effects of tocolysis with nifedipine or atosiban on child outcome: follow‐up of the APOSTEL III trial

Author

Development and Treatment of Psychosocial Problems, Leerstoel Baar, Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, Oudijk, Ma, Development and Treatment of Psychosocial Problems, Leerstoel Baar, Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, and Oudijk, Ma

Published
2020

5. Effects of tocolysis with nifedipine or atosiban on child outcome: follow‐up of the APOSTEL III trial

Author

Development and Treatment of Psychosocial Problems, Leerstoel Baar, Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, Oudijk, Ma, Development and Treatment of Psychosocial Problems, Leerstoel Baar, Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, and Oudijk, Ma

Published
2020

6. Effects of tocolysis with nifedipine or atosiban on child outcome: follow‐up of the APOSTEL III trial

Author

Development and Treatment of Psychosocial Problems, Leerstoel Baar, Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, Oudijk, Ma, Development and Treatment of Psychosocial Problems, Leerstoel Baar, Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, and Oudijk, Ma

Published
2020

7. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

Author

Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiú, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackienė, J, Koster, M, Kowalska-Kańka, A, Kupčinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Yayla Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Seed, PT, Estiú, MC, Hague, WM, Kebapcilar, AG, Kondrackienė, Jūratė, Koster, Maria P H, Kowalska-Kańka, Aneta, Kupčinskas, Limas, Lee, Richard H, Macias, RIR, Marschall, HU, Oudijk, MA, Thornton, JG, Chappell, LC, Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiú, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackienė, J, Koster, M, Kowalska-Kańka, A, Kupčinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Yayla Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Seed, PT, Estiú, MC, Hague, WM, Kebapcilar, AG, Kondrackienė, Jūratė, Koster, Maria P H, Kowalska-Kańka, Aneta, Kupčinskas, Limas, Lee, Richard H, Macias, RIR, Marschall, HU, Oudijk, MA, Thornton, JG, and Chappell, LC

Abstract

Background: Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth. Methods: We did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available. Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritus and elevated serum bile acid concentrations, with or without raised liver aminotransferase concentrations. Eligible studies were case-control, cohort, and population-based studies, and randomised controlled trials, with at least 30 participants, and that reported bile acid concentrations and perinatal outcomes. Studies at potential higher risk of reporter bias were excluded, including case reports, studies not comprising cohorts, or successive cases seen in a unit; we also excluded studies with high risk of bias from groups selected (eg, a subgroup of babies with poor outcomes were explicitly excluded), conference abstracts, and Letters to the Editor without clear peer review. We also included unpublished data from two UK hospitals. We did a random effects meta-analysis to determine risk of adverse perinatal outcomes. Aggregate data for maternal and perinatal outcomes were extracted from case-control studies, and individual patient data (IPD) were requested from study authors for all types of study (as no control group was required for the IPD analysis) to assess associations between biochemical markers and adverse outcomes using logistic and

Published
2019

8. Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with 'refractoriness to treatment': a cohort study

Author

Henriquez, D, Gillissen, A, Smith, SM, Cramer, RA, van den Akker, T, Zwart, JJ, van Roosmalen, JJ, Bloemenkamp, KW, Bom, JG, Adriaanse, HJ, Akker, ESA, Baas, MI, Bank, CMC, Beek, E, de Boer, BAG, Boer, K, van der Borden, DMR, Bremer, HA, Brons, JTJ, Burggraaff, JM, Ceelie, H, Chon, H, Cikot, JLM, Delemarre, FMC, Diris, JHC, Doesburg-van Kleffens, M, van Dooren, IMA, van Duijnhoven, JLP, van Dunn, FM, Duvekot, J.J., Engbers, P, Hulst, MJW, Feitsma, H, Fouraux, MA, Franssen, MT, Frasa, MAM, van Gammeren, AJ, Gemund, N, Graaf, F, Groot, CJM, Hackeng, CM, van der Ham, DP, Hanssen, M, Hasaart, THM, Hendriks, HA, Henskens, YMC, Hermsen, BBJ, Hogenboom, S, Hooker, A, Hudig, F, Huijssoon, AMG, Huisjes, AJM, Jonker, N, Kabel, PJ, van Kampen, C, de Keijzer, MH, van de Kerkhof, DH, Keuren, JFW, Kleiverda, G, Klinkspoor, JH, Koehorst, SGA, Kok, M, Kok, RD, de Kok, JB, Koops, A, Kortlandt, W, Langenveld, J, Leers, MPG, Leyte, A, de Mare, A, Martens, GDM, Meekers, JH, van Meir, CA, Metz, GCH, Michielse, E, Mostert, LJ, Bijvank, S, Oostenveld, E, Osmanovic, N, Oudijk, MA, Mirani-Oostdijk, CP, van Pampus, E C M, Papatsonis, DNM, Peters, RHM, Ponjee, GA, Pontesilli, M, Porath, MM, Post, MS, Pouwels, JGJ, Prinzen, L, Roelofsen, JMT, Rondeel, JJM, van der Salm, PCM, Scheepers, HCJ, Schippers, DH, Schuitemaker, NWE, Sikkema, JM, Slomp, J, Smit, JWA, Snuif-de Lange, YS, van der Stappen, JWJ, Steures, P, Tax, GHM, Treskes, M, Ulenkate, H, van Unnik, GA, van der Veen, BS, Verhagen, TEM, Versendaal, J, Visschers, B, Visser, O, Visser, H, De Vooght, KMK, Vries, MJ, Waard, H, Weerkamp, F, Weinans, MJN, de Wet, H, Wijnen, M (Mandy), van Wijngaarden, WJ, de Wit, AC, Woiski, MD, TeMp, OHSG, Henriquez, D, Gillissen, A, Smith, SM, Cramer, RA, van den Akker, T, Zwart, JJ, van Roosmalen, JJ, Bloemenkamp, KW, Bom, JG, Adriaanse, HJ, Akker, ESA, Baas, MI, Bank, CMC, Beek, E, de Boer, BAG, Boer, K, van der Borden, DMR, Bremer, HA, Brons, JTJ, Burggraaff, JM, Ceelie, H, Chon, H, Cikot, JLM, Delemarre, FMC, Diris, JHC, Doesburg-van Kleffens, M, van Dooren, IMA, van Duijnhoven, JLP, van Dunn, FM, Duvekot, J.J., Engbers, P, Hulst, MJW, Feitsma, H, Fouraux, MA, Franssen, MT, Frasa, MAM, van Gammeren, AJ, Gemund, N, Graaf, F, Groot, CJM, Hackeng, CM, van der Ham, DP, Hanssen, M, Hasaart, THM, Hendriks, HA, Henskens, YMC, Hermsen, BBJ, Hogenboom, S, Hooker, A, Hudig, F, Huijssoon, AMG, Huisjes, AJM, Jonker, N, Kabel, PJ, van Kampen, C, de Keijzer, MH, van de Kerkhof, DH, Keuren, JFW, Kleiverda, G, Klinkspoor, JH, Koehorst, SGA, Kok, M, Kok, RD, de Kok, JB, Koops, A, Kortlandt, W, Langenveld, J, Leers, MPG, Leyte, A, de Mare, A, Martens, GDM, Meekers, JH, van Meir, CA, Metz, GCH, Michielse, E, Mostert, LJ, Bijvank, S, Oostenveld, E, Osmanovic, N, Oudijk, MA, Mirani-Oostdijk, CP, van Pampus, E C M, Papatsonis, DNM, Peters, RHM, Ponjee, GA, Pontesilli, M, Porath, MM, Post, MS, Pouwels, JGJ, Prinzen, L, Roelofsen, JMT, Rondeel, JJM, van der Salm, PCM, Scheepers, HCJ, Schippers, DH, Schuitemaker, NWE, Sikkema, JM, Slomp, J, Smit, JWA, Snuif-de Lange, YS, van der Stappen, JWJ, Steures, P, Tax, GHM, Treskes, M, Ulenkate, H, van Unnik, GA, van der Veen, BS, Verhagen, TEM, Versendaal, J, Visschers, B, Visser, O, Visser, H, De Vooght, KMK, Vries, MJ, Waard, H, Weerkamp, F, Weinans, MJN, de Wet, H, Wijnen, M (Mandy), van Wijngaarden, WJ, de Wit, AC, Woiski, MD, and TeMp, OHSG

Published
2019

9. Balloon catheter for induction of labor in women with one previous cesarean and an unfavorable cervix

Author

Huisman, CMA, ten Eikelder, MLG, Mast, K, Rengerink, KO, Jozwiak, M, Dunne, F, Duvekot, J.J., Eyck, J, Gaugler-Senden, I, Groot, CJM, Franssen, MTM, Gemund, Nicolette, Langenveld, J, Leeuw, JW, Lohuis, EJO, Oudijk, MA, Papatsonis, D, van Pampus, M, Porath, M, de Weerd, S, van Roosmalen, JJ, van der Salm, PCM, Scheepers, HCJ, Sikkema, MJ, Sporken, J, Stigter, RH, van Wijngaarden, WJ, Woiski, M, Mol, BWJ (Ben), Bloemenkamp, KWM, Huisman, CMA, ten Eikelder, MLG, Mast, K, Rengerink, KO, Jozwiak, M, Dunne, F, Duvekot, J.J., Eyck, J, Gaugler-Senden, I, Groot, CJM, Franssen, MTM, Gemund, Nicolette, Langenveld, J, Leeuw, JW, Lohuis, EJO, Oudijk, MA, Papatsonis, D, van Pampus, M, Porath, M, de Weerd, S, van Roosmalen, JJ, van der Salm, PCM, Scheepers, HCJ, Sikkema, MJ, Sporken, J, Stigter, RH, van Wijngaarden, WJ, Woiski, M, Mol, BWJ (Ben), and Bloemenkamp, KWM

Published
2019

10. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

Author

Ovadia, C, Seed, PT, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiu, MC, Grymowicz, M, Gunaydin, B, Hague, WM, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, AG, Kebapcilar, L, Kondrackiene, J, Koster, Wendy, Kowalska-Kanka, A, Kupcinskas, L, Lee, RH, Locatelli, A (Alberta), Macias, RIR, Marschall, HU, Oudijk, MA, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Abide, CY, Yenidede, I, Thornton, JG, Chappell, LC, Williamson, C, Ovadia, C, Seed, PT, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiu, MC, Grymowicz, M, Gunaydin, B, Hague, WM, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, AG, Kebapcilar, L, Kondrackiene, J, Koster, Wendy, Kowalska-Kanka, A, Kupcinskas, L, Lee, RH, Locatelli, A (Alberta), Macias, RIR, Marschall, HU, Oudijk, MA, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Abide, CY, Yenidede, I, Thornton, JG, Chappell, LC, and Williamson, C

Published
2019

11. Low dose aspirin in the prevention of recurrent spontaneous preterm labour the APRIL study: a multicenter randomized placebo controlled trial

Author

Visser, L, de Boer, MA, de Groot, CJM, Nijman, TAJ, Hemels, MAC, Bloemenkamp, KWM, Bosmans, JE, Kok, M, van Laar, JO, Sueters, M, Scheepers, H, van Drongelen, J, Franssen, MTM, Sikkema, JM, Duvekot, J.J., Bekker, MN, van der Post, JAM, Naaktgeboren, C, Mol, BWJ (Ben), Oudijk, MA, Visser, L, de Boer, MA, de Groot, CJM, Nijman, TAJ, Hemels, MAC, Bloemenkamp, KWM, Bosmans, JE, Kok, M, van Laar, JO, Sueters, M, Scheepers, H, van Drongelen, J, Franssen, MTM, Sikkema, JM, Duvekot, J.J., Bekker, MN, van der Post, JAM, Naaktgeboren, C, Mol, BWJ (Ben), and Oudijk, MA

Published
2017

12. Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Author

Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, Oudijk, Ma, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, and Oudijk, Ma

Abstract

Objective To evaluate long-term effects of maintenance tocolysis with nifedipine on neurodevelopmental outcome of the infant. Design, Setting and Population Follow up of infants of women who participated in a multicentre randomised controlled trial on maintenance tocolysis with nifedipine versus placebo. Methods Two years after the APOSTEL II trial on maintenance tocolysis with nifedipine versus placebo, we asked participants to complete the Ages and Stages Questionnaire. Main outcome measures Infant development was measured in five domains. Developmental delay was defined as a score of ≤1 SD in one or more developmental domains. We performed exploratory subgroup analysis in women with preterm prolonged rupture of the membranes, and in women with a cervical length <10 mm at study entry. Results Of the 276 women eligible for follow up, 135 (52.5%) returned the questionnaire, encompassing data of 170 infants. At 2 years of age, infants of women with nifedipine maintenance tocolysis compared with placebo had a higher overall incidence of fine motor problems (22.2 versus 7.6%, OR 3.43, 95% CI 1.29–9.14, P = 0.01), and a lower incidence of poor problem-solving (21.1 versus 29.1%, OR 0.27, 95% CI 0.08-0.95, P = 0.04). Conclusions This follow-up study revealed no clear benefit of nifedipine maintenance tocolysis at 2 years of age. As short-term adverse perinatal outcome was not reduced in the original APOSTEL II trial, we conclude that maintenance tocolysis does not appear to be beneficial at this time. Tweetable abstract No clear benefit of nifedipine maintenance tocolysis in preterm labour on 2-year infant outcome.

Published
2016

13. Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, Oudijk, Ma, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, and Oudijk, Ma

Published
2016

14. Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, Oudijk, Ma, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, and Oudijk, Ma

Published
2016

15. Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, Oudijk, Ma, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, and Oudijk, Ma

Published
2016

16. Early nasogastric tube feeding in optimising treatment for hyperemesis gravidarum: the MOTHER randomised controlled trial (Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding)

Author

Grooten, IJ, Mol, BW, van der Post, JAM, Ris-Stalpers, C, Kok, M, Bais, JMJ, Bax, CJ, Duvekot, J.J., Bremer, HA, Porath, MM, Heidema, WM, Bloemenkamp, KWM, Scheepers, HCJ, Franssen, MTM, Oudijk, MA, Roseboom, TJ, Painter, RC, Grooten, IJ, Mol, BW, van der Post, JAM, Ris-Stalpers, C, Kok, M, Bais, JMJ, Bax, CJ, Duvekot, J.J., Bremer, HA, Porath, MM, Heidema, WM, Bloemenkamp, KWM, Scheepers, HCJ, Franssen, MTM, Oudijk, MA, Roseboom, TJ, and Painter, RC

Abstract

Background: Hyperemesis gravidarum (HG), or intractable vomiting during pregnancy, is the single most frequent cause of hospital admission in early pregnancy. HG has a major impact on maternal quality of life and has repeatedly been associated with poor pregnancy outcome such as low birth weight. Currently, women with HG are admitted to hospital for intravenous fluid replacement, without receiving specific nutritional attention. Nasogastric tube feeding is sometimes used as last resort treatment. At present no randomised trials on dietary or rehydration interventions have been performed. Small observational studies indicate that enteral tube feeding may have the ability to effectively treat dehydration and malnutrition and alleviate nausea and vomiting symptoms. We aim to evaluate the effectiveness of early enteral tube feeding in addition to standard care on nausea and vomiting symptoms and pregnancy outcomes in HG patients. Methods/Design: The MOTHER trial is a multicentre open label randomised controlled trial (www.studies-obsgyn.nl/mother). Women >= 18 years hospitalised for HG between 5 + 0 and 19 + 6 weeks gestation are eligible for participation. After informed consent participants are randomly allocated to standard care with intravenous rehydration or early enteral tube feeding in addition to standard care. All women keep a weekly diary to record symptoms and dietary intake until 20 weeks gestation. The primary outcome will be neonatal birth weight. Secondary outcomes will be the 24-h Pregnancy Unique Quantification of Emesis and nausea score (PUQE-24), maternal weight gain, dietary intake, duration of hospital stay, number of readmissions, quality of life and side-effects. Also gestational age at birth, placental weight, umbilical cord plasma lipid concentration and neonatal morbidity will be evaluated. Analysis will be according to the intention to treat principle. Discussion: With this trial we aim to clarify whether early enteral tube feeding is more eff

Published
2016

17. Using vaginal Group B Streptococcus colonisation in women with preterm premature rupture of membranes to guide the decision for immediate delivery:a secondary analysis of the PPROMEXIL trials

Author

Tajik, P., van der Ham, DP, Zafarmand, MH, Hof, MHP, Morris, J, Franssen, MTM, de Groot, CJM, Duvekot, J.J., Oudijk, MA, Willekes, C, Bloemenkamp, KWM, Porath, M, Woiski, M, Akerboom, BM, Sikkema, JM, Bijvank, BN, Mulder, ALM, Bossuyt, PM, Mol, BWJ (Ben), Tajik, P., van der Ham, DP, Zafarmand, MH, Hof, MHP, Morris, J, Franssen, MTM, de Groot, CJM, Duvekot, J.J., Oudijk, MA, Willekes, C, Bloemenkamp, KWM, Porath, M, Woiski, M, Akerboom, BM, Sikkema, JM, Bijvank, BN, Mulder, ALM, Bossuyt, PM, and Mol, BWJ (Ben)

Abstract

Objective To investigate whether vaginal Group B Streptococcus (GBS) colonisation or other baseline characteristics of women with preterm premature rupture of membranes (PPROM) can help in identifying subgroups of women who would benefit from immediate delivery. Design Secondary analysis of the PPROMEXIL trials. Setting Sixty hospitals in the Netherlands. Population Women with PPROM between 34 and 37 weeks of gestation. Methods Random assignment of 723 women to immediate delivery or expectant management. Main outcome measures Early onset neonatal sepsis. Results Vaginal GBS colonisation status was the only marker which was significantly associated with the benefit of immediate delivery (P for interaction: 0.04). GBS colonisation was observed in 14% of women. The risk of early onset neonatal sepsis in GBS-positive women was high (15.2%) when they were managed expectantly but this risk was reduced to 1.8% with immediate delivery. The early onset neonatal sepsis risk was much lower in neonates of GBS-negative women: 2.6% after expectant management and 2.9% with immediate delivery. We estimated that by inducing labour only in GBS-positive women, there would be a 10.4% increase in term delivery rate, while keeping neonatal sepsis and caesarean delivery rates comparable to a strategy of labour induction for all. Conclusions Our post hoc findings suggest that women with PROM between 34 and 37 weeks might benefit from immediate delivery if they have GBS vaginal colonisation, while in GBS-negative women labour induction could be delayed until 37 weeks.

Published
2014

18. Preventing preterm birth with progesterone: costs and effects of screening low risk women with a singleton pregnancy for short cervical length, the Triple P study

Author

van Os, MA, van der Ven, JA, Kleinrouweler, CE, Pajkrt, E, de Miranda, E, van Wassenaer, A, Porath, M, Bossuyt, PM, Bloemenkamp, KWM, Willekes, C, Woiski, M, Oudijk, MA, Bilardo, KM, Sikkema, MJ, Duvekot, J.J., Veersema, D, Laudy, JAM, Kuiper, Ronella, de Groot, CJA, Mol, BWJ (Ben), Haak, MC, van Os, MA, van der Ven, JA, Kleinrouweler, CE, Pajkrt, E, de Miranda, E, van Wassenaer, A, Porath, M, Bossuyt, PM, Bloemenkamp, KWM, Willekes, C, Woiski, M, Oudijk, MA, Bilardo, KM, Sikkema, MJ, Duvekot, J.J., Veersema, D, Laudy, JAM, Kuiper, Ronella, de Groot, CJA, Mol, BWJ (Ben), and Haak, MC

Abstract

Background: Women with a short cervical length in mid-trimester pregnancy have a higher risk of preterm birth and therefore a higher rate of neonatal mortality and morbidity. Progesterone can potentially decrease the number of preterm births and lower neonatal mortality and morbidity. Previous studies showed good results of progesterone in women with either a history of preterm birth or a short cervix. However, it is unknown whether screening for a short cervix and subsequent treatment in mid trimester pregnancy is effective in low risk women. Methods/Design: We plan a combined screen and treat study among women with a singleton pregnancy without a previous preterm birth. In these women, we will measure cervical length at the standard anomaly scan performed between 18 and 22 weeks. Women with cervical length <= 30 mm at two independent measurements will be randomly allocated to receive either vaginal progesterone tablets or placebo between 22 and 34 weeks. The primary outcome of this trial is adverse neonatal condition, defined as a composite outcome of neonatal mortality and severe morbidity. Secondary outcomes are time to delivery, preterm birth rate before 32, 34 and 37 weeks, days of admission in neonatal intensive care unit, maternal morbidity, maternal admission days for preterm labour and costs. We will assess growth, physical condition and neurodevelopmental outcome of the children at two years of age. Discussion: This study will provide evidence for the usefulness and cost-effectiveness of screening for short cervical length at the 18-22 weeks and subsequent progesterone treatment among low risk women.

Published
2011

19. IMproving PArticipation of patients in Clinical Trials - rationale and design of IMPACT

Author

Oude Rengerink, K, Opmeer, BC, Logtenberg, SL, Hooft, L, Bloemenkamp, KWM, Haak, MC, Oudijk, MA, Spaanderman, M, Duvekot, J.J., Willekes, C, van Pampus, MG, Porath, MM, van Eyck, J, Sikkema, MJ, Mol, BWJ (Ben), Oude Rengerink, K, Opmeer, BC, Logtenberg, SL, Hooft, L, Bloemenkamp, KWM, Haak, MC, Oudijk, MA, Spaanderman, M, Duvekot, J.J., Willekes, C, van Pampus, MG, Porath, MM, van Eyck, J, Sikkema, MJ, and Mol, BWJ (Ben)

Published
2010

20. Cost-effectiveness of fibronectin testing in a triage in women with threatened preterm labor: alleviation of pregnancy outcome by suspending tocolysis in early labor (APOSTEL-I trial)

Author

Vis, JY, Wilms, FF, Oudijk, MA, Porath, MM, Scheepers, HC, Bloemenkamp, KWM, Bolte, AC, Cornette, JMJ, Derks, JB, Duvekot, JJ, van Eyck, J, Kwee, A, Opmeer, BC, van Pampus, MG, Lotgering, FK (Fred), Scherjon, SA, Sollie, KM, Spaanderman, M, Willekes, C, Van der Post, JAM, Mol, BWJ (Ben), Vis, JY, Wilms, FF, Oudijk, MA, Porath, MM, Scheepers, HC, Bloemenkamp, KWM, Bolte, AC, Cornette, JMJ, Derks, JB, Duvekot, JJ, van Eyck, J, Kwee, A, Opmeer, BC, van Pampus, MG, Lotgering, FK (Fred), Scherjon, SA, Sollie, KM, Spaanderman, M, Willekes, C, Van der Post, JAM, and Mol, BWJ (Ben)

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results